Browsing by Author "Koker, Sultan Aydin"

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Evaluation of Glut1, Igf-2, Vegf, Fgf 1, and Angiopoietin 2 in Infantile Hemangioma
(Elsevier France-editions Scientifiques Medicales Elsevier, 2021) Koker, Sultan Aydin; Komuroglu, Ahmet Ufuk; Koksoy, Adem Yasin; Siraz, Ulku Gul; Tekin, Emine; Koker, Alper
Introduction: Infantile hemangioma (IH) is a common vascular tumor in children. It is reported that IHs are associated with immunochemical markers such as vascular endothelial growth factor (VEGF)-A, glucose transporter isoform 1 (GLUT1), and insulin-like growth factor-2 (IGF-2). Material and methods: This cross-sectional study focused on pediatric patients with IH. A total of 46 patients (mean age 14.2 +/- 21.9 months) with IH and 45 healthy controls (mean age 21.8 +/- 15.08 months) were enrolled. Demographic data, clinical findings, and laboratory parameters were recorded. Blood samples were collected. Serum GLUT1, IGF-2, VEGF-A, fibroblast growth factor 1 (FGF1), and angiopoietin 2 levels were assessed by enzyme-linked immunosorbent assay. Results: Serum GLUT1, IGF-2, and VEGF-A levels were significantly higher in patients with IH than in healthy controls (8.80 +/- 4.07 pg/mL vs. 5.66 +/- 4.34 pg/mL, 281.10 +/- 84.12 pg/mL vs. 234.19 +/- 75.38 pg/mL, 1196.99 +/- 389.34 pg/mL vs. 996.99 +/- 349.16 pg/mL, respectively, p = 0.026, p = 0.030, and p = 0.036). Serum GLUT1, IGF-2, and VEGF-A levels in patients with complicated hemangioma were significantly higher than in healthy controls (9.69 +/- 3.94 pg/mL vs. 5.66 +/- 4.34 pg/mL, 289.94 +/- 83.18 pg/mL vs. 234.19 +/- 75.38 pg/mL, 1276.22 +/- 388.24 pg/mL vs. 996.99 +/- 349.16 pg/mL, respectively, p = 0.017, p = 0.022, and p = 0.011). Serum GLUT1, IGF-2, and VEGF-A levels in patients with hemangioma receiving propranolol treatment were significantly higher than in healthy controls. Serum FGF1 levels were higher in patients with IH, complicated hemangioma, and hemangioma receiving propranolol treatment than in healthy controls but the difference was not statistically significantly. Conclusion: Serum GLUT1, IGF-2, and VEGF-A levels were positively correlated with disease severity in patients with hemangioma, for example, in complicated hemangioma and hemangioma requiring propranolol treatment. However, further research on larger and different age subgroups is warranted to assess these markers. (C) 2021 French Society of Pediatrics. Published by Elsevier Masson SAS. All rights reserved.
Serum Zonulin Levels in Pediatric Migraine
(Elsevier Science inc, 2023) Tuncer, Gokcen Oz; Akbas, Yilmaz; Koker, Alper; Koker, Sultan Aydin; Kara, Tugce Tural; Coban, Yasemin; Komuroglu, Ahmet Ufuk
Background: Migraine is a complex neurogenic inflammatory disorder. There are strong neuronal, endocrine, and immunologic connections between the brain and gastrointestinal system. Damage to the intestinal barrier is thought to cause systemic immune dysregulation. Zonulin is a protein produced by the small intestine epithelium in humans that regulates intestinal permeability through intracellular tight junctions and is a potential marker for inflammation. Zonulin increases in positive correlation with permeability. In our study, we aimed to research the correlation between serum zonulin levels in the period between attacks in pediatric patients with migraine.Methods: The study included 30 patients with migraine and 24 healthy controls, matched in terms of sex and age. Demographic and clinical characteristics were recorded. Serum zonulin levels were studied with the enzyme-linked immunosorbent assay method. Results: Patients had a mean of 5.6 +/- 3.5 attacks per month. The mean serum zonulin was 5.68 +/- 1.21 ng/ mL in the migraine group and 5.72 +/- 2.1 ng/mL in the control group with no significant difference found (P 1/4 0.084). In the migraine group, no correlations were identified between serum zonulin levels and age, body mass index, pain frequency, pain duration, onset time, visual analog scale score, and presence of gastrointestinal systems apart from nausea-vomiting.Conclusions: More than 50 proteins were identified to affect the intestinal permeability apart from zonulin. There is a need for prospective studies encompassing the time of attack, but our study is important as it is the first study about zonulin levels in pediatric migraine.(c) 2023 Elsevier Inc. All rights reserved.