Browsing by Author "Kucukoglu, Mehmet Emin"

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Abnormal Liver Function Test in Hydatidiform Moles: a Retrospective Study Comparing the Hyperthyroid State and the Euthyroid State
(informa Healthcare, 2014) Kucukoglu, Mehmet Emin; Dulger, Ahmet Cumhur; Aslan, Mehmet; Olmez, Sehmus; Guler, Ayse; Aldemir, Mehmet Naci; Demirkiran, Davut
Introduction: The effect of a hyperthyroid or euthyroid state on liver function tests in patients with hydatidiform moles (HM) is not known. The aim of this study was to determine the effect of hyperthyroidism on liver transaminases in HM. Patients and methods: We retrospectively reviewed aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in 80 patients with HM (23 complete moles and 57 partial moles). Results: Of the 80 HM patients, 52 (65%) were euthyroid and 28 (35%) were hyperthyroid. The number of gravida and the levels of serum beta-human chorionic gonadotropin (beta-HCG), AST, and ALT were significantly higher in the hyperthyroid state than in the euthyroid state (p = 0.033, p = 0.001, p = 0.001 and p = 0.001; respectively). Number of gravida, serum TSH and total T4 were significantly higher in complete HM than partial HM (p < 0.05, p < 0.001, p < 0.05; respectively). Conclusions: Our results demonstrated that HM-related beta-HCG may activate thyroid cells via TSH-related signalling, resulting in the release of high levels of FT4, FT3, TT3 and TT4, and a subsequent decrease in TSH.
The Assessment of the Diet Knowledge Level and Daily Dietary Practice of the Relatives of Hemodialysis Patients
(Drunpp-sarajevo, 2012) Emre, Habib; Soyoral, Yasemin Usul; Begenik, Huseyin; Erdur, Mehmet Fatih; Kucukoglu, Mehmet Emin; Erkoc, Reha
Objectives: In this study, we aimed to investigate the level of nutrition and diet knowledge and the daily dietary practices of the relatives of hemodialysis patients. Material and Methods: We recruited 39 relatives whose patients receiving hemodialysis, and who provided the patient's dietary needs. The questionnaire containing questions regarding daily salt, water, potassium and phosphate intakes was conducted to the patient's relatives. The questionnaire results were reflected to the graphics with numbers and percentages. Results: The patient's relatives had sufficient information about the salt and water intakes, but they were not very sensitive to use their dietary knowledge during their daily practice. The relatives did not have enough information about the foods which containing phosphate and potassium and the clinical situations/complications related to the phosphor and potassium. Conclusions: The nutrition and diet education should be also provided to the patients' relatives. Besides the education, the patients and the relatives should be followed up periodically to see if they apply their knowledge. The relatives especially should be instructed about foods containing salt, phosphate and potassium.
Coexistence of the Poems Syndrome With Hepatitis B: a Rare Case Report
(Springer Wien, 2016) Celik, Yilmaz; Aslan, Mehmet; Sayin, Refah; Cifci, Adem; Canbaz, Esra Turan; Kucukoglu, Mehmet Emin; Dulger, Ahmet Cumhur
POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) is a rare multisystemic disease of unknown pathogenesis. Proinflammatory and proangiogenic cytokines play important roles in its pathogenesis. POEMS syndrome is a rare cause of ascites. Until now, the coexistence of POEMS syndrome and hepatitis B has not been reported. In this case report, we present a 48-year-old male patient who presented with malaise, fatigue, diarrhea, and abdominal swelling. Organomegaly, endocrinopathy, ascites, skin changes, and polyneuropathy were identified, and we arrived at a diagnosis of POEMS syndrome. The patient was administered methylprednisolone 64 mg/day, lamivudine 100 mg/day, calcium 1.5 g/day, and calcitriol 0.5 A mu g/day. The patient's clinical manifestations had moderately resolved at the follow-up visits. At the end of 6 months of follow-up, his ascites was minimally reduced, and his neurologic manifestations had not lessened. The present case shows that accurate diagnosis is required for the management of patients with coexisting POEMS syndrome and hepatitis B.
Peripheral Lymphocyte Dna Damage and Oxidative Status in Football Players After a Three-Day Football Tournament
(Japan Soc internal Medicine, 2013) Atli, Mustafa; Aslan, Mehmet; Kucukoglu, Mehmet Emin; Temur, Haci Bayram; Taskin, Abdullah; Celik, Hakim
Objective Regular physical activity is well known to play a cardioprotective role. The objective of this study was to investigate peripheral lymphocyte DNA damage and oxidative status in adult football players a three-day football tournament. Methods Twenty-five adult male football players and 25 sedentary male subjects were enrolled in the present study. Plasma total antioxidant status (TAS), total oxidant status (TOS) and the oxidative stress index (OSI) were determined. Peripheral lymphocyte DNA damage was determined using an alkaline comet assay. Results Plasma TOS, OSI and peripheral lymphocyte DNA damage were significantly lower in the adult football players than in the sedentary subjects (all: p<0.001), while TAS was significantly higher in the football players (p<0.001). The plasma TAS levels were inversely correlated with TOS, OSI and peripheral lymphocyte DNA damage (r =-0.683, p<0.001; r =-0.909, p<0.001; r =-0.608, p<0.001; respectively) in the adult football players. Conclusion These results indicate that physical activity is associated with increased antioxidant capacity and decreased oxidative stress. Such conditions are important for a healthy life. Further studies are needed to clarify the mechanisms underlying this association.
Pulmonary Embolism Associated With Pandemic H1n1 Influenza a Virus Infection: a Case Report
(Galenos Publ House, 2011) Dulger, Ahmet Cumhur; Avcu, Serhat; Arslan, Harun; Ozbay, Bulent; Gunbatar, Hulya; Kucukoglu, Mehmet Emin; Bartin, Mehmet Kadir
On May 15, 2009, the Turkish Ministry of Health reported the first case of 2009 pandemic influenza A (H1N1) virus infection in the Republic of Turkey. Pandemic H1N1virus is a new and mutant influenza virus and has many epidemiologic and clinic features. These cases have been reported in multiple geographic regions of the world. School children are more affected than adults. In the elderly, it has a higher mortality rate. The clinical aspects of infection with H1N1 influenza A virus remains to be understood. A few cases of pulmonary embolism associated with H1N1 influenza A virus infection were reported. We herein report a pulmonary embolism in a patient with pandemic influenza A (H1N1) virus infection. A 42-year-old Turkish woman was admitted to our emergency department with dyspnea and pleuritic chest pain. She complained of fever, myalgia, sore throat and cough of four days duration on admission to our hospital. She was tested for pandemic influenza A (H1N1) virus by a polymerase chain reaction (PCR) test which revealed a positive result. Chest tomography showed pulmonary embolism. She was successfully treated with intravenous heparin and oseltamivir. This case report demonstrates the importance of considering pulmvonary embolism as a diagnosis in 2009 pandemic influenza A (H1N1) virus infected persons who present with sudden onset of dyspnea, fever and chest pain.
Relationship Between Visfatin and Some Clinical and Biochemical Parametres in Peritoneal Dialysis Patients
(Pakistan Medical Assoc, 2012) Soyoral, Yasemin Usul; Erkoc, Reha; Begenik, Huseyin; Aldemir, Mehmet Naci; Kucukoglu, Mehmet Emin
Objective: To characterise the relationship between visfatin levels and various clinical and biochemical parameters in peritoneal dialysis patients. Methods: The case-control study was conducted at the Medical Faculty Hospital, Yuzuncu Yil University, Van, Turkey, between May 2007 and December 2008, and involving 41 patients on peritoneal dialysis, 20 haemodialysis patients and 20 healthy controls. Fasting visfatin level was measured with enzyme-linked immunosorpent assay (ELISA) method, and patients on peritoneal dialysis were separated into two groups according to the visfatin levels - high and low. The groups were compared in terms of some clinical (height, weight, body mass index, waist circumference, hip circumference, waist/hip ratio, heart rate, systolic and diastolic blood pressure and the kt/V and CrCl (creatanine clearance) parameters which are indicative of the dialysis adequacy) and biochemical parameters (glucose, triglycerides, cholesterol, low density lipoprotein, high density lipoprotein, aspartate aminotransferase, alanine transminase, blood urea nitrogen, creatinine, total protein, albumin, globulin, sodium, potassium, magnesium, calcium, phosphorus, ferritin, venous blood gas, parathyroid hormone and insulin). SPSS 15 was used for statistcal analysis. Results: No statistically significant difference in the visfatin levels was found between the patients and controls (7.71 +/- 4.04, 7.36 +/- 3.71, 7.70 +/- 1.61, respectively, p = 0.63). The triglyceride level of the high-visfatin group was significantly higher than that of the low-visfatin group (243.8 +/- 133.2, 150.8 +/- 65.8, respectively, p < 0.05). However, there was no correlation between visfatin and triglyceride levels. No difference in the other clinical and biochemical parametres was observed between the two groups of peritoneal dialysis patients. Conclusions: No significant difference in the serum visfatin levels of peritoneal dialysis patients compared to haemodialysis patients or healthy individuals was noticed. Further studies are needed to confirm the effect of visfatin on triglyceride levels, and, if confirmed, the mechanism of this relation.
Seasonal Variability of Parathyroid Hormone and Its Related Biochemical Parameters in Hemodialysis Patients
(Drunpp-sarajevo, 2012) Soyoral, Yasemin Usul; Emre, Habib; Demirkiran, Davut; Begenik, Huseyin; Kucukoglu, Mehmet Emin; Erkoc, Reha
Objective: We aimed to investigate the seasonal variability of the parathyroid hormone levels and its related biochemical parameters in hem dialysis patients. Methods: We retrospectively analyzed the data of 81 hemodialysis patients (36 female, 45 male; the mean age: 54, 8 +/- 19, 3) between 2008 and 2009 years. We compared the seasonal variability of the mean levels of parathyroid hormone (PTH), calcium (Ca), phosphor (P), and alkaline phosphatase (ALP). Results: The lowest level of PTH (163 pg/ml (26-1894 pg/ml) was detected during the summer, followed by the fall, and then by the winter (273 pg/ml (23.7-2500 pg/ml); 275 pg/ml (17.9-2122 pg/ml) respectively). The highest level of PTH (292 pg/ml (9, 8-2289 pg/ml) was detected during the spring. Similar to PTH, the peak level of ALP was detected during the summer. The lowest level of Ca was detected during the spring. The level of P did not demonstrate any seasonal variability. Conclusions: We observed that the level of PTH was showed seasonal variability. The seasonal variability of PTH and its related biochemical parameters should be considered in medical treatment of secondary hyperparathyroidism in hemodialysis patients.
Serum Cystatin C Measurement in Differential Diagnosis of Intra and Extrahepatic Cholestatic Diseases
(Mexican Assoc Hepatology, 2010) Buyukberber, Mehmet; Koruk, Irfan; Cykman, Oztekin; Koruk, Mehmet; Kucukoglu, Mehmet Emin; Sakman, Abdullah; Sahinoz, Saime
Objective. Cystatin C is a very potent inhibitor of cysteine proteinases and, it has been clinically applied as a sensitive marker in monitoring of renal and liver functions. The aim of this study was to reveal whether cystatin C may be a useful marker for distinguishing intra- versus extrahepatic cholestasis. Materials and methods. Serum cystatin C concentrations were determined by nephelometric immunoassay using N latex cystatin C kit in 53 patients with cholestatic disorder that included 18 patients with intrahepatic cholestasis, 17 patients with malignant extrahepatic cholestasis, 18 patients with benign extrahepatic cholestasis. Serum cystatin C concentration was also determined in 20 healthy volunteers. Results. Mean serum cystatin C concentration was 2.82 +/- 0.24 mg/l (SD) in patients with intrahepatic cholestasis, 2.05 +/- 0.15 mg/l in patients with extrahepatic malignant cholestasis, 1.37 +/- 0.13 mg/l in extrahepatic benign cholestatic patients and 0.93 +/- 0.24 mg/l in control group. Serum cystatin C concentrations in patients with cholestatic disease were significantly higher than those in the healthy controls (p < 0.001). Moreover, mean serum cystatin C concentration in patients with intrahepatic cholestasis was higher than those in extrahepatic cholestasis groups (p < 0.001). Serum cystatin C concentrations were significantly higher in patients with malignant extrahepatic cholestasis than in patients with benign extrahepatic cholestasis (p < 0.001). There were no correlations patients among serum cystatin C concentrations and serum levels of AST, ALT, ALP, GGT, total and conjugated bilirubin. Conclusion. Our results suggested that serum cystatin C level may be a potential biochemical marker both to point out an intrahepatic origin by excluding an extrahepatic source of cholestasis in patients with jaundice and to possibly differentiate bening and malignant extrahepatic cholestatic disorders.
Serum Myeloperoxidase Activity and Oxidative Stress in Patients With Acute Brucellosis
(Pergamon-elsevier Science Ltd, 2012) Karahocagil, Mustafa Kasim; Aslan, Mehmet; Ceylan, Mehmet Resat; Cikman, Aytekin; Sunnetcioglu, Mahmut; Kucukoglu, Mehmet Emin; Taskin, Abdullah
Objectives: The role of infection in the pathogenesis of atherosclerosis has been increasingly discussed. Previous studies have suggested that increased myeloperoxidase activity plays an important role in the pathogenesis of atherosclerosis. The aim of this study was to investigate the serum myeloperoxidase activity and catalase activity along with lipid hydroperoxide (LOOH) levels in patients with acute brucellosis. Design and methods: Thirty-two patients with brucellosis and 33 healthy controls were enrolled. Serum myeloperoxidase activity, catalase activity and LOOH levels were determined. Results: Serum myeloperoxidase activity and LOOH levels were significantly higher in patients with brucellosis than controls (p<0.05, p<0.001), while catalase activity were significantly lower (p<0.001). LOOH levels were found to be significantly positively correlated with MPO activity (r = 0.297, p = 0.016) in patients. Conclusions: These results indicate that increased myeloperoxidase activity and decreased catalase activity is associated with increased oxidative stress, which may have a role in atherosclerotic processes in brucellosis patients. (C) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Serum Paraoxonase Activity, Total Thiols Levels, and Oxidative Status in Patients With Acute Brucellosis
(Springer Wien, 2015) Esen, Ramazan; Aslan, Mehmet; Kucukoglu, Mehmet Emin; Cikman, Aytekin; Yakan, Umit; Sunnetcioglu, Mahmut; Selek, Sahbettin
It is well known that paraoxonase-1 (PON1) activity may decrease during the course of infection and inflammation. The aim of this study was to investigate serum PON1 activity, oxidative status, and thiols levels in patients with acute brucellosis. In addition, we investigated the PON1 phenotype in patients with acute brucellosis. Thirty patients with acute brucellosis and 35 healthy controls were enrolled. Serum paraoxonase and arylesterase activities, thiols levels, lipid hydroperoxide levels, total antioxidant capacity (TAC), total oxidant status (TOS) and oxidative stress index (OSI) were determined. Serum basal and salt-stimulated paraoxonase-arylesterase activities, TAC levels and thiols levels were significantly lower in patients with acute brucellosis than controls (for all, p < 0.05), while LOOH levels, TOS levels, and OSI values were significantly higher (for all, p < 0.05). We concluded that oxidative stress is increased, while serum PON1 activity is decreased in patients with acute brucellosis. These results indicate that lower PON1 activity is associated with oxidant-antioxidant imbalance.
Serum Prolidase Enzyme Activity and Oxidative Stress Levels in Patients With Diabetic Neuropathy
(Springer, 2014) Sayin, Refah; Aslan, Mehmet; Kucukoglu, Mehmet Emin; Luleci, Arda; Atmaca, Murat; Esen, Ramazan; Demir, Halit
Previous studies have suggested that prolidase and nitric oxide (NO) regulate many processes, such as collagen synthesis and matrix remodeling. Oxidative stress plays an important role in the development of microvascular complications in diabetic patients. Data on serum prolidase activity in patients with diabetes mellitus or diabetic neuropathy (DN) are limited and conflicting. The aim of this study was to measure serum prolidase activity, NO, total antioxidant status (TAS), and malondialdehyde (MDA) levels in patients with DN. Forty-five patients with DN and 40 healthy controls were enrolled. Serum prolidase activity, TAS, MDA, and NO levels were determined. Serum MDA and NO levels were significantly higher in DN patients than controls (p = 0.002, p = 0.001, respectively), while prolidase activity and TAS levels were lower (p = 0.003, p = 0.001, respectively). Prolidase activity was negatively correlated with NO and MDA (r = -0.911, p < 0.001; r = -0.905, p < 0.001, respectively), while positively correlated with TAS (r = 0.981, p < 0.001) in DN patients. The current study is the first showing the decreased serum prolidase enzyme activity. Our results suggest that decreased collagen turnover may occur in DN patients, who have increased oxidative stress and increased NO levels. Decreased prolidase activity seems to be associated with increased NO levels and oxidative stress along with decreased antioxidant levels in DN. Therefore, decreased prolidase activity may play a role in pathogenesis of DN. Prospective clinical studies are necessary to confirm these findings.
Skin Bleeding Time for the Evaluation of Uremic Platelet Dysfunction and Effect of Dialysis
(Sage Publications inc, 2012) Soyoral, Yasemin Usul; Demir, Cengiz; Begenik, Huseyin; Esen, Ramazan; Kucukoglu, Mehmet Emin; Aldemir, Mehmet Naci; Erkoc, Reha
Introduction: In patients with chronic kidney disease (CKD) predisposition to bleeding is frequently seen due to disturbances in platelet adhesion and aggregation. Various tests have been utilized to evaluate the disturbance of hemostasis in end-stage renal disease patients. In this trial; we evaluated skin bleeding time in patients admitted to our hospital with uremic symptoms and having hemodialysis (HD) for the first time. We also examined the effects of HD and uremia on this test and investigated its effectiveness in predicting the hemorrhagic complications before implementation of invasive procedures in uremic patients. Material-Method: Twenty nine patients (13 men, 16 women; mean age 59.7 +/- 18.1) with CKD who presented with symptoms of uremia and treated with HD for the first time were enrolled in this trial. The skin bleeding time were measured before initiation of first hemodialysis and after the second hemodialysis session. Results: The skin bleeding time after the second dialysis was significantly shorter when compared to pre-dialysis values (p < 0.05). Correlation analysis between the skin bleeding time and urea, creatinine, hemoglobin, platelet, and bicarbonate showed no correlation. Conclusions: Skin bleeding time could reveal the uremic platelet dysfunction and beneficial effect of dialysis in the patients who presented with uremic symptoms and treated with HD for the first time. We suggest that skin bleeding time may be an appropriate test for the evaluation of hemostasis disturbance in uremic patients and prediction of the bleeding risk before invasive procedures.
Syndrome of Inappropriate Secretion of Antidiuretic Hormone Cholestasis and Pericardial Effusion Due To Brucellosis Infection: a Case Report
(Hindawi Ltd, 2010) Dulger, Ahmet Cumhur; Kemik, Ozgur; Sumer, Aziz; Akdeniz, Huseyin; Kucukoglu, Mehmet Emin; Canbaz, Esra Turan; Aytemiz, Enver
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is an extremely rare complication of infectious diseases. A rare case of brucellosis complicated by syndrome of inappropriate secretion of antidiuretic hormone (SIADH) cholestasis and pericardial involvement is reported. A 27-year-old woman was admitted for fever, abdominal pain, and scleral icterus. Hermedical history revealed no recent use of diuretic agents. In addition to cholestasis and elevated liver enzymes, euvolemic hyponatremia, hypouricemia, low plasma osmolality, and high urinary osmolality were also detected. Surrenal and thyroid tests were also within normal range. Echocardiography revealed minimal pericardial effusion with normal cardiac functions. The final diagnosis was SIADH due to Brucellosis. Hyponatremia, cholestasis, and pericardial disease were resolved with effective antibrucellar treatment with streptomycine and doxycycline. After completing treatment of brucellosis, there was not any more evidence of cholestasis and pericardial fluid.