Browsing by Author "Kufrevioglu, OI"

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Affinity To Some Inhibitors of Human Carbonic Anhydrase-1 and Bovine Carbonic Anhydrase
(Marcel dekker inc, 1996) Arslan, O; Kufrevioglu, OI
The carbonic anhydrase Isoenzymes employed here have been purifield in high yields by affinity chromatograpy using different affinity gels(Sepharose4B-L-tyrosine-Benzensulfonamide). Inhibition effect of 2-Substituted-1,3,4-Thiadiazole-5-Sulfonamides on human carbonic anhydrase-I (HCA-I) and bovine carbonic anhydrase (BCA) have been determined. It was found that inhibition effects of these compounds on BCA and CA-I were very great.
The Effects of Some Pesticites on the Activity of Liver and Erythrocyte Enzymes (In Vitro)
(Taylor & Francis inc, 1996) Celik, I; Camas, H; Arslan, O; Yegin, E; Kufrevioglu, OI
The effect of pomarsol (tetramethyltriurem disulphide), Benlate 1-(N-Butlycarbomoyl) 2-(Metoxycarboxamido)-bezimidazol, meothrin (alpha-cyanophenoxbenzyl 2.2.3.3.-tetramethyl cyclopropanecarbonylate), Imperator [alpha-cyano 3-phenoxybenzyl-cis, trans-3- (2.2-dichroinyl)-2.2- dimetil research on GOT, GPT (liver enzymes) and CA-I, CA-II (Human erythrocyt) BCA (Bovine erythrocyt). Among the chemicals meothrin, imperator, sumicidin were determined to have inhibitory effect, on bovine CA, human CA and GOT enzymes, but ineffective on GPT enzyme. The I-50 values of chemicals caused inhibition were determined by means of activity percentage [I] diagrams. The values were 3.2x10(-2) M, 3.5x10(-2) M, 2.7x10(-2) M for GOT respectively. The values of same chemicals were 5.8x10(-3) M, 1.00x10(-2) M, 1.22x10(-2) M for CA-I, and 7.11x10(-3) M, 2.68x10(-2) M, 1.22x10(-2) M for CA-II respectively on the order nand, these chemical were 9.25x10(-3) M, 8.65x10(-3) M and 1.63x10(-2) M for bovine CA.