Browsing by Author "Kurtuncu, M"

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    A Whole Genome Screen for Linkage in Turkish Multiple Sclerosis
    (Elsevier, 2003) Eraksoy, M; Kurtuncu, M; Akman-Demir, G; Kilinc, M; Gedizlioglu, M; Mirza, M; Sawcer, S
    Factors exerting recessive effects on susceptibility to complex traits are expected to be over-represented in communities having a higher frequency of consanguineous marriage. Multiple sclerosis, a typical complex trait, is relatively common in Turkey where cultural factors also determine a high rate of consanguineous marriage. Previous genetic studies of multiple sclerosis in Turkey have been confined to the search for associations with candidate genes. In order to exploit the special genetic features of the Turkish population, we performed a whole genome screen for linkage in 43 Turkish multiplex families employing 392 microsatellite markers. Two genomic regions where maximum lod score (MLS) values were suggestive of linkage were identified (chromosomes 13q and 18q23) along with a further 14 regions of potential linkage. Parametric analysis of these data using a recessive model, appropriate for populations with a high frequency of consanguinity, increased the LOD scores in four regions. (C) 2003 Elsevier B.V. All rights reserved.
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    Article
    A Genome Screen for Linkage Disequilibrium in Turkish Multiple Sclerosis
    (Elsevier Science Bv, 2003) Eraksoy, M; Hensiek, A; Kurtuncu, M; Akman-Demir, G; Kilinc, M; Gedizlioglu, M; Sawcer, S
    In order to screen the Turkish population for evidence of association with multiple sclerosis, we typed 6000 microsatellite markers in separately pooled DNA samples from 197 cases and 199 controls following the Genetic Analysis of Multiple sclerosis in Europeans (GAMES) protocol. Twelve markers showing evidence for association were identified. One of these markers lying directly in a region which is also implicated in the Turkish linkage screen (chromosome 5p15) and thus shows evidence for both linkage and association in independent data sets. (C) 2003 Elsevier B.V. All rights reserved.