Browsing by Author "Mermit, B."

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Evaluation of Platelet Distribution Width(Pdw) and Mean Platelet Volume(Mpv) in Patients With Obstructive Sleep Apnea Syndrome(Osas): a Retrospective Clinical Study
(Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Mermit, B.
This study aimed to evaluate the association between PDW and MPV with Obstructive Sleep Apnea Syndrome (OSAS). The study’s design is a retrospective evaluation of OSAS patients admitted to our pulmonology department between January 2022 and June 2024. The data and clinical-laboratory parameters of patients diagnosed with polysomnography were evaluated. The PDW and MPV measurements were retrieved from the complete blood counts’ of the patients. OSAS patients were divided into three groups according to the Apnea-hypopnea Index(AHI) score as mild, moderate and severe OSAS. Healthy subjects with no known chronic disease admitted to our outpatient clinic were enrolled as control group. In total, 140 patients with OSAS and 120 healthy subjects as control group were included in the study. The OSAS groups consisted of as 60 mild, 45 moderate, and 35 severe. The mean age of OSAS group and control group were as 51.8 ±12 and 47.6±11, respectively which was not statistically significant. There was statistically significant difference between OSAS and control group with respect to the BMI(31.8±5.0 vs 26.4±4.2, p:0.01). The male/female patients were 96/44 in OSAS and 86/34 in control group which was not statistically different (p:0.04). The mean PDW and MPW were 18.8±2.5 and 10.7±1.2 in OSAS group. The mean PDW and MPV were 14.6±1.7 and 7.8±2.4 in control group. There was statistically significant difference between OSAS and control group with respect to mean PDW and MPV values (p:0.02 and p:0.01). The subgroup analysis showed that MPV increased statistically significant as OSAS severity got impaired. This study showed that increased PDW and MPV was associated with OSAS and also the activation of platelets has potential effect on the severity of OSAS. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Radiology, Laboratory, Clinical Course, and Outcomes of Covid-19 in Chronic Hemodialysis Patients: a Retrospective Case-Control Study
(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) İncecik, Ş.; Mermit, B.
Coronavirus disease 2019 causes higher mortality in chronic hemodialysis patients. Previous studies on this subject generally covered 30 days or a hospital stay. This study compares the 100-day mortality of chronic hemodialysis patients with patients without kidney disease with the same disease s everity. This retrospective case-control study is conducted in a single center, including 24 chronic hemodialysis in-patients and 48 control in-patients without renal disease, all diagnosed with coronavirus disease 2019. According to the findings, the 100-day mortality rate of the hemodialysis group was significantly higher than that of the control group (odds ratio 4,53; %95 confidence interval 1.17-17.47). Multivariable regression analysis in Model A showed that chronic hemodialysis and critical illness were significantly associated with 100-day mortality, while cardiovascular disease comorbidity was a significant factor only in univariable analysis. The pneumonia severity index score was beneficial in predicting the in-hospital mortality of hemodialysis patients (odds ratio 1.07; %95 confidence interval 1.01-1.14). In addition, while all the patients in the control group were alive in the 90-day follow-up after discharge, three hemodialysis patients died at home due to sudden cardiac death. Patients undergoing chronic hemodialysis are at a higher mortality risk than those without kidney disease, even with the same severity of coronavirus disease 2019. Monitoring deaths among chronic hemodialysis patients during their hospital stay and the first three months after discharge is crucial. Clinicians can predict in-hospital mortality and manage patients more effectively by evaluating the pneumonia severity index scores. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.