Browsing by Author "Metin, A"

Now showing 1 - 20 of 22

About the Paper "elephantiasis Neuro-Matosa and Becker's Melanosis" (J Dermatol, 26: 396-398, 1999)
(Japanese dermatolgical Assoc, 2001) Metin, A; Tuncay, I; Ugras, S
Anti-Inflammatory Effects of Tretinoin (all-Trans Acid) 0.1% and Adapalene 0.1% in Rats
(Wiley, 2005) Akdeniz, N; Çalka, Ö; Özbek, H; Metin, A
In this study, the anti-inflammatory effects of tretinoin (all-trans-retinoic acid) 0.1% cream and adapalene 0.1% gel were compared in rats to determine whether there was a difference between these agents. Thirty-six rats of either sex were divided into six groups (two control groups, and an etodolac, indomethacin, tretinoin and adapalene group) of six animals each. Each group was given different drugs or chemicals. The inhibitory activities of the drugs were determined on carrageenan-induced rat-paw oedema. The inhibition rate (53.48%) in the tretinoin group was found to be higher than adapalene and controls (P < 0.05). Adapalene was found to have an inhibition rate of 10.28%, and when compared with the other groups, was found to have no statistically significant anti-inflammatory activity. We conclude that tretinoin has a higher anti-inflammatory activity than adapalene and thus should be preferred for the treatment of inflammatory lesions.
Atypical Fibroxanthoma of the Skin and the Lower Lip in Xeroderma Pigmentosum
(Wiley, 2000) Dilek, FH; Akpolat, N; Metin, A; Ugras, S
Xeroderma pigmentosum (XP) is a rare, usually autosomal recessive disorder related to DNA repair defects. Atypical fibroxanthoma (AFX) is a pleomorphic tumour that occurs infrequently on the limbs and trunk in children, We report a child with XP who presented with AFX of the facial skin and the lower lip, The diagnosis of AFX was confirmed using histological and immunohistochemical techniques. We discuss the possibility that ultraviolet-induced damage might be implicated in the pathogenesis of AFX.
A Case of Disseminated and Recurrent Infundibulofolliculitis Responsive To Treatment With Systemic Isotretinoin
(Wiley, 2002) Çalka, Ö; Metin, A; Özen, S
We report a 16-year-old Turkish patient who developed disseminated and recurrent infundibulofolliculitis (DRIF) and responded well to systemic isotretinoin therapy after three months.
Cutaneous Findings, Encountered in Brucellosis and Review of the Literature
(Wiley, 2001) Metin, A; Akdeniz, H; Buzgan, T; Delice, I
Background Human brucellosis is an infectious disease produced by Brucella species: small, coccoid or rod-like, aerobic, Gram-negative bacteria. The infection is common in developing countries, and can also affect the skin. Its prevalence is high in our region of where stockbreeding is one of the main economic sources, compared with the Turkey, industrially developed areas of Turkey, and dermatologic complaints due to brucellosis, are fairly common. Materials and methods One hundred and three patients with serologically and clinically confirmed brucellosis were studied in order to investigate the prevalence of cutaneous findings and their variability in brucellosis. Fifty-two (50.49%) were males and 51 (49.51%) were females with an age range of 4-70 years (mean, 30.45 +/- 15.08 years). Results Of these patients, 14 (13.59%) had cutaneous findings probably related to brucellosis. These findings were more frequent in females (11 cases) than males, and most of the females (eight cases) were housewives; three were students. Urticaria-like papules, and plaques were the most common findings; they were seen in six (35.3%) patients. One case had livedo reticularis and another palmar erythema, which have not been reported previously. No relationship was observed between the serologic, values and the cutaneous findings. Conclusions Cutaneous findings in our cases were more prevalent than in other reported studies. It is important to emphasize that cutaneous lesions are not specific to brucellosis and may be seen in a variety of other dermatologic diseases caused by many agents; therefore, these agents should be kept in mind in the differential diagnosis.
A Destructive Ulcer
(Blackwell Publishing, 2005) Akdeniz, N; Çalka, Ö; Metin, A; Yuca, K; Özen, S
Effect of Cyproheptadine on Serum Leptin Levels
(Springer, 2005) Çalka, Ö; Metin, A; Dülger, H; Erkoç, R
Leptin is a 167 amino acid protein encoded by the obesity gene that is synthesized in adipose tissue and interacts with receptors in the hypothalamus linked to the regulation of appetite and metabolism. It is known to suppress appetite and increase energy expenditure. Cyproheptadine is a piperidine antihistamine that increases appetite through its antiserotonergic effect on 5-HT2 receptors in the brain. Although both leptin and cyproheptacline are effective in controlling appetite, their interaction has not been addressed in clinical studies. This study evaluated serum leptin concentrations in patients who received cyproheptadine to treat a variety of disorders. Sixteen patients aged 7 to 71 years (mean, 26.25 years) were given cyproheptacline 2 to 6 mg/day for a minimum of 7 days. Body weight was measured and blood samples were obtained at baseline and after 1 week of treatment. Serum leptin levels were determined by leptin radioimmunoassay. The mean body weight at baseline (52.59 kg) did not differ significantly from that at 1 week after treatment (52.84 kg; P >.05), but the mean leptin level after 1 week of treatment with cyproheptacline (3.14 ng/mL) was 14.2% higher than that at baseline (2.75 ng/mL; P <.05). This increase may suggest that both leptin and cyproheptacline may affect appetite via similar receptors and that cyproheptacline does not impair leptin activity through these receptors. Further study will be necessary to clarify this relationship.
Juvenile Hyaline Fibromatosis in One Turkish Child
(Turkish J Pediatrics, 2000) Ugras, S; Akpolat, N; Metin, A
We describe a case of juvenile hyaline fibromatosis (JHF) in a Turkish child. Only about 40 cases of juvenile hyaline fibromatosis had been reported in English literature as of March 1998, and it had not been reported in English literature from Turkey as of November 1998. Juvenile hyaline fibromatosis characterized by multiple cutaneous masses is a rare hereditary disorder. This disease is usually found in children, and a malfunction of collagen synthesis is considered as the pathogenetic cause. In the presented case, light microscopy demonstrated an abundance of a homogeneous, amorphous, eosinophilic extracellular matrix in which fibroblasts were embedded. Well-formed collagen fibers could not be demonstrated with Gieson's method or with reticulin preparation. The hayalin material periodic acid-Schiff-positive and diastase-resistant, whereas the Congo red method was negative. Immunohistochemically, the spindle-shaped cells were actin (smooth muscle) negative.
Lichen Planopilaris Coexisting With Erythema Dyschromicum Perstans
(Blackwell Science Ltd, 2001) Metin, A; Çalka, Ö; Ugras, S
Mild Renal Injury in Behcet's Disease
(Taylor & Francis Ltd, 2004) Sahin, I; Noyan, T; Karaman, E; Yalçinkaya, AS; Metin, A; Akpolat, T
Aim: The aim of this study is to investigate the frequency of microalbuminuria and abnormal urinary beta(2)-microglobulin excretion in patients with Behcet's disease (BD). Materials and Methods: Twenty-eight patients and 27 healthy controls were included in this study. Urine albumin/creatinine and beta(2)-microglobulin/creatinine ratios were calculated. Results: The frequency of microalbuminuria and abnormal urinary beta(2)-microglobulin excretion was higher among patients with BD than in control group, but this was not statistically significant (p>0.05). Conclusion: Microalbuminuria and abnormal beta(2)-microglobulin excretion are markers of renal injury, which have not been investigated in BD previously. Renal injury in BD is more frequent than has been recognized and it is most often in mild nature.
Nasopharyngeal Rhabdomyosarcoma in a Patient With Hypohidrotic Ectodermal Dysplasia Syndrome
(Elsevier Sci Ltd, 2002) Çankaya, H; Kösem, M; Kiris, M; Üner, A; Metin, A
Hypohidrotic ectodermal dysplasia (Christ-Siemens-Touraine syndrome) is characterized by partial or complete absence of sweat glands, hypotrichosis, hypodontia, prominent frontal ridges and chin, saddle nose, sunken cheeks, thick, everted lips, large ears and sparse hair. While association of other ectodermal dysplasia syndromes with tumors such a non-Hodgkin's lymphoma, hamartoma, keratoakanthoma, Merkel-cell cancer, squamous-cell carcinoma, syringofibroadenomatosis has been reported, association of hypohidrotic ectodermal dysplasia and a tumor has not been reported. In a five-year-old male patient admitted with nasal obstruction and nasal mass complaints, we have reported firstly an association of hypohidrotic ectodermal dysplasia and nasopharyngeal. rhabdomyosarcoma. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Peripheral Nervous System Involvement in Patients With Beheet's Disease
(Elsevier, 2005) Anlar, O; Tombul, T; Akdeniz, N; Sayin, R; Calka, O; Metin, A
Phototoxic Dermatitis Due To Chenopodium Album in a Mother and Son
(Wiley, 2005) Çalka, Ö; Akdeniz, N; Metin, A; Behçet, L
Phytodermatitis From Ceratocephalus Falcatus
(Blackwell Publishing, 2005) Metin, A; Çalka, Ö; Akdeniz, N; Behçet, L
Ceratocephalus falcatus (L.) Pers. (Ranunculaceae) is a wild plant. It grows abundantly in the Van province. The species of Ceratocephalus genus possess irritant properties from the presence of an innocuous glycoside, ranunculin. Here, we document 3 patients who were admitted to our clinic in different times from different districts with a common complaint of a large irritant contact dermatitis, resembling second-degree burn injury after application of a plant poultice. The plant specimens in all patients were identified as C. falcatus and it was assessed worthwhile to report.
Phytodermatitis From Ranunculus Damascenus
(Munksgaard int Publ Ltd, 2001) Metin, A; Çalka, Ö; Behçet, L; Yildirim, E
Recurrent Impetigo Herpetiformis in a Pregnant Adolescent: Case Report
(Elsevier Sci Ireland Ltd, 2002) Sahin, HG; Sahin, HA; Metin, A; Zeteroglu, S; Ugras, S
Impedigo Herpetiformis is a rare pustular dermatosis that typically occurs in pregnant women with unknown ethiology. A 17 year old patient who developed Impedigo Herpetiformis for the second time in the 27th week of her 2nd pregnancy is presented. The patient improved with corticosteroids treatment but the lesions did not clear completely and had flare ups during stressful periods which brings us to conclusion that Impedigo Herpetiformis at least has a common pathway with Generalized Pustular Psoriasis in the pathogenesis as stress provoked exacerbations. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Report of a Turkish Child With Sjogren-Larsson Syndrome Associated With Peripheral Nerve Involvement
(Japanese dermatolgical Assoc, 2003) Akdeniz, N; Çalka, Ö; Anlar, Ö; Akbayram, S; Çaksen, H; Metin, A; Çinal, A
Sjogren-Larsson syndrome is a rare hereditary neurocutaneous disorder characterized by ichthyosis, spastic di- or tetra-plegia, and mild to moderate mental retardation. In this article, we present a nine-year-old girl with the classical features of the syndrome associated with peripheral nerve involvement because of its rare presentation. To the best of our knowledge, only three cases of Sjogren-Larsson syndrome with peripheral nerve involvement have been previously reported in the literature. We assume that Sjogren-Larsson syndrome involves extensive disorders of the ectodermal tissues, including the peripheral nerves as well as the skin and the central nervous system.
Rothmund Thomson Syndrome Associated With Esophageal Stenosis: Report of a Case
(Springer verlag, 1998) Guler, O; Aydin, M; Ugras, S; Kisli, E; Metin, A
Rothmund Thomson syndrome (RTS) is a rare autosomal recessive disorder which is primarily diagnosed by clinical manifestations that include poikiloderma, short stature, sparse hair distribution, juvenile cataracts, small hands and feet, bone defects, photosensitivity, hypogonadism, defective dentition, onychodystrophy, and hyperkeratosis. Although a few reports have been published on patients with RTS associated with gastrointestinal abnormalities, to our knowledge the case described herein is the first documentation of a patient with RTS having upper esophageal stenosis.
A Stop Codon in Xeroderma Pigmentosum Group C Families in Turkey and Italy: Molecular Genetic Evidence for a Common Ancestor
(Blackwell Science inc, 2001) Gozukara, EM; Khan, SG; Metin, A; Emmert, S; Busch, DB; Shahlavi, T; Kraemer, KH
Xeroderma pigmentosum family G from Van, Turkey had two severely affected children: a son with multiple skin cancers who died at age 10 (XP67TMA), and an 8 y old daughter who began developing skin cancer before 3 y of age (XP68TMA). XP67TMA and XP68TMA cells were hypersensitive to killing by ultraviolet and the post-ultraviolet DNA repair level was 12-16% of normal. Host cell reactivation of an ultraviolet-treated reporter plasmid cotransfected with a vector expressing wild-type XPC cDNA assigned XP67TMA to xeroderma pigmentosum complementation group C. The XPC mRNA level was markedly reduced. Sequencing of the 3.5 kb XPC cDNA from XP67TMA showed a C-T mutation in XPC exon 8 at base pair 1840. This mutation converts the CGA codon of arginine at amino acid 579 to a UGA stop codon resulting in marked truncation of the 940 amino acid xeroderma pigmentosum C protein. Restriction fragment length polymorphism analysis of XPC exon 8 DNA in XP67TMA and XP68TMA showed that both affected children had a homozygous mutation and that both parents had heterozygous normal and mutated sequences at the same position consistent with a history of consanguinity in the family. The mutated allele also contained two XPC single nucleotide polymorphisms. The same mutated XPC allele was reported in an Italian family. Studies of 19 microsatellite markers flanking the XPC gene on chromosome 3 suggest that the XPC allele passed between Italy and Turkey approximately 300-500 y ago. This XPC allele containing a nonsense mutation is associated with severe clinical disease with multiple skin cancers and early death.
Tinea Capitis in Van, Turkey
(Wiley, 2002) Metin, A; Subasi, S; Bozkurt, H; Çalka, Ö
Forty patients with an average age of 6.5 +/- 3.2 years (28 male 12 female) who applied to the YYU Medical Faculty Dermatology Department outpatient clinic were investigated. Tinea capitis profunda was determined as the most frequent clinical type. The isolated dermatophytic flora of the patients consisted of Trichophyton verrucosum (43%), T. violaceum (30%), T. rubrum (23%) and T. mentagrophytes (3%). The patients with tinea capitis profunda were mostly from rural areas.