Browsing by Author "Ozbek, H."

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Anti-Inflammatory Activities of Diethyl-Ether Extracts of Helichrysum Plicatum Dc. and Tanacetum Balsamita L. in Rats
(Academic Journals inc, 2009) Karaca, M.; Ozbek, H.; Akkan, H. A.; Tutuncu, M.; Ozgokce, F.; Him, A.; Bakir, B.
The aim of this study was to investigate anti-inflammatory activity of the diethyl ether extract of Tanacetum balsamita L. subsp. (TB) and Helichrysum plicatum DC. subsp. (HP) in carrageenan-induced inflammation in rats. Lambda carrageenan (0.05 mL) was injected into the subplantar region of the right hind paw to induce inflammation. Control group and the reference group were administered isotonic saline solution and indomethacin, respectively. TB extract was injected in doses of 25, 50 and 100 mg kg(-1) in the groups TB-25, TB-50 and TB-100, respectively. HP-25 HP-50 and HP-100 groups were injected HP extract in doses of 25, 50 and 100 mg kg(-1). Before the injections and 3 h after the injections the volume of right hind-paw of rats was measured using a plethysmometer. TB and HP had anti-inflammatory effects matching to that of the reference agent at all doses. It was found that reduction in the inflammation was 95.21% with indomethacin, 51.93% with TB-25, 52.55% with TB-50, 61.51% with TB-100, 70.73% with HP-25, 73.15% with HP-50 and 82.90% with HP-100. Median effective dose (ED50) value of TB and HP were found to be 81.484 and 73.030 mg kg(-1), respectively. The results showed that Tanacetum balsamita L. subsp. and Helichrysum plicatum DC. subsp. had a significant anti-inflammatory activity.
Antinociceptive Activity of Alpha-Pinene and Fenchone
(2008) Him, A.; Ozbek, H.; Turel, I.; Oner, A.C.
We aimed to investigate antinociceptive activities of some components of Foeniculum vulgare Mill., commonly known as fennel. In this study, alpha-pinene, limonene, fenchone, trans-anethol and alpha-copaene were investigated for analgesic effects in mice using tail-flick tests which is commonly employed as a pain model. The drugs were injected intraperitoneally in doses of 0.05, 0.1 and 0.2 ml.kg-1. Alpha-pinene and fenchone caused significant reduction in the nociceptive threshold in the tail-flick test. The other compounds tested did not show significant analgesic effects. The motor coordination of mice treated with alpha-pinene or fenchone, evaluated by using the "rotarod" test, was not impaired. The results obtained in the present study indicate that alpha pinene and fenchone, major constituents of Foeniculum vulgare essential oil, have antinociceptive activity in tail-flick test in mice.
Antinociceptive and Anti-Inflammatory Activities of Ballota Inaequidens
(Taylor & Francis Ltd, 2006) Yilmaz, B. Sever; Ozbek, H.; Citoglu, G. Saltan
The water extract of Ballota inaequidens Hub.-Mor. & Patzak (Lamiaceae) was investigated for antinociceptive and anti-inflammatory activities in mice and rats. The tail-flick test, acetic acid-induced writhing test, and the carrageenan-induced rat paw edema test were used to determine these effects. Our findings show that Ballota inaequidens caused dose-related inhibition in the acetic acid-induced abdominal stretching in mice. The medium effective dose (ED50) value of Ballota inaequidens was found to be 85.38 mg/kg. Ballota inaequidens showed no significant changes in the nociceptive threshold of the tail-flick test but did show an inhibition of paw edema induced by carrageenan. The ED50 value of Ballota inaequidens was found to be 99.42 mg/kg. The current study reveals that the water extract of Ballota inaequidens possesses promising antinociceptive and anti-inflammatory activities.
Antinociceptive and Anti-Inflammatory Activities of Viburnum Lantana
(Taylor & Francis Ltd, 2007) Yilmaz, B. Sever; Citoglu, G. Saltan; Altun, M. L.; Ozbek, H.
Water extract of Viburnum lantana L. ( Caprifoliaceae) ( VL) leaf was investigated for antinociceptive and anti-inflammatory activities in mice and rats. The tail-flick test, acetic acid-induced writhing test, and the carrageenan-induced rat paw edema test were used to determine these effects. Our findings show that VL causes dose-related inhibition in acetic acid-induced abdominal stretching in mice. VL inhibited abdominal stretching at 100 mg/kg, which is similar to that of aspirin, but this extract exhibited stronger antinociceptive activity than aspirin at a 200 mg/kg dose. VL showed powerful antinociceptive activity, which was quantified by a tail-flick test in 100 mg/kg dose. The anti-inflammatory activity of VL was not found to be significantly different at doses of 100 and 200 mg/kg. As a result, VL had shown slight anti-inflammatory activity compared with indomethacin. The LD50 of VL was determined as 2.169 g/kg.
Antinociceptive and Anti-Inflammatory Activities of Viburnum Opulus
(Taylor & Francis Ltd, 2009) Altun, M. L.; Citoglu, G. Saltan; Yilmaz, B. Sever; Ozbek, H.
Water extract of Viburnum opulus L. (Caprifoliaceae) (VO) leaf was investigated for antinociceptive and anti-inflammatory activities in mice and rats. The tail flick test, acetic acid-induced writhing test, and the carrageenan-induced rat paw edema test were used to determine these effects. Our findings show that VO causes dose related inhibition in acetic acid-induced abdominal stretching in mice. VO inhibited abdominal stretching at 100 and 200 mg/kg. VO showed antinociceptive activity, which was quantified by the tail-flick test at doses of 100 and 200 mg/kg. However, VO did not have an anti-inflammatory effect at these doses. The LD50 of VO was determined as 5.447 g/kg.
Drug Effects on Dreaming
(Springer US, 2006) Agargun, M.Y.; Ozbek, H.
Among the proposed functions of dreaming in human being, the most research supports are mood-regulation, problem-solving, learning, and memory construction. Recent imaging techniques have provided meaningful information on functional neuroanatomy and neurophysiology of REM sleep and dreaming. In addition to serotonin, norepinephrine, and acetylcholine in terms of a reciprocal interaction between the cholinergic REM-ON and aminergic REM-OFF neurons suggested by McCarley and Hobson, dopamine has recently began to think to play a significant role in modulation of dream functions, particularly nightmares. The disinhibition of REM physiology is due primarily to dopaminergic dysfunction, specifically the removal of dopaminergic inhibition on amygdalar sites in dopamine-related syndromes including parkinson disease, REM sleep behavior disorder, and narcolepsy. The disinhibited amygdala yields the affective and personality changes, and the unpleasant dreams associated with PD, RBD, and narcolepsy as well as depression. There is limited data in the literature on drugs and dreaming or dream content even if it is well-known that many antidepressant drugs may cause nightmares or frightening dreams. In this chapter, we review and discuss the effects of medications on dreaming. © 2006 Springer-Verlag US.
The Effects of Diethylether Extract of Helichrysum Plicatum Dc. Subsp Plicatum and Tanacetum Balsamita L. Subsp Balsamitoides (Sch Bip.) Grierson (Asteraceae) on the Acute Liver Toxicity in Rats
(Academic Journals inc, 2010) Tutuncu, M.; Ozbek, H.; Karaca, M.; Akkan, H. A.; Bayram, I.; Cengiz, N.; Him, A.
The aim of this study was to investigate the effects of the diethylether extract of Helichrysum plicatum DC. subsp. plicatum (HP) and Tanacetum balsamita L. subsp. balsamitoides (Sch. Bip.) Grierson (Asteraceae) (TB) in carbontetrachloride (CCl(4))-induced acute liver toxicity in rats. Acute liver toxicity was induced by injecting CCl(4) (0.8 mL kg(-1)) intraperitoneally for 7 days. The control group received isotonic saline only. The reference group received 50 mg kg(-1) silibinin. TB and HP extract was injected in doses of 25, 50 and 100 mg kg(-1). Body weights were measured daily during the experiment. On the 8th day of the experiments blood and liver samples were collected. Serum Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) were measured in serum samples. Tissue samples were evaluated histopathologically. Some of the rats in TB and HP groups died during the experiments. Serum ALT levels were higher in the TB and HP groups than those in the CCl(4) group. Histopathological findings were similar in the CCl(4), TB and HP groups. The body weight loss was more in the TB and HP groups compared to that of the CCl(4) group. It is concluded that the diethylether extract of Helichrysum plicatum DC. subsp. plicatum and Tanacetum balsamita L. subsp. balsamitoides (Sch. Bip.) Grierson (Asteraceae) did not have a protective effect in carbontetrachloride (CCl(4))-induced acute liver toxicity in rats and even exacerbated the toxicity.
Effects of Hyaluronic Acid on Postoperative Adhesion of Tendo Calcaneus Surgery: an Experimental Study in Rats
(2002) Tuncay, I.; Ozbek, H.; Atik, B.; Ozen, S.; Akpinar, F.
Adhesions are a significant problem after tendon surgery. The effects of hyaluronic acid on adhesion formation of the tendo calcaneus were investigated in this study. Twenty Wistar rats were utilized. Both tendo calcanei were incised transversely, and then repaired. Hyaluronic acid (0.2 cc) was injected into peritendinous tissue on the right side, while the same amount of normal saline was injected to the left side as a control. The animals were sacrificed 40days after the experiment. Both the right and left tendon adhesions were evaluated both macroscopically and microscopically for the presence of adhesions (grading scale 0-4). Throughout the experimental period, there was no difference in range of motion of the ankle between the two groups. Macroscopically, there were fewer adhesions in the experimental group (mean 0.6 ± 0.8) compared to the controls (mean 1.1 ± 0.2). This difference was not statistically significant (p =. 096). Histopathologically, these parameters were similar in both the experimental (mean 1.15 ± 0.98) and the control groups (mean 1.9 ± 1.25). This difference was significant (p =. 043). Hyaluronic acid may be effective for prevention of adhesions in the tendo calcaneus though this effect could not be demonstrated experimentally.
Evaluation of Analgesic and Anti Inflammatory Activity of Pimpinella Anisum Fixed Oil Extract
(indian veterinary Journal, 2006) Tas, A.; Ozbek, H.; Atasoy, N.; Altug, M. Enes; Ceylan, E.
Pimpinella anisum is a member of the Umbelliferae and is found in the northeastern Anatolia (Zeybek, 1960). In Turkish folk medicine, Pimpinella species have several uses such. as analgesic, anti-inflammatory, appetizing, hypnotic, antispasmodic, expectorant,. antibacterial and hepato-protective. Seeds of P. anisum contains 1.5 - 2.0 % essential oil, 10-20 % fixed oil, 18 % protein. No reports are available on the evaluation of this plant for possible anti-inflammatory and analgesic activity: In this study, fixed oil of P. anisum was investigated for anti-inflammatory activity using carrageenan-induced rat paw oedema test (Winter et al., 1962) and analgesic activity with a tail-flick apparatus using a method initially described by D'amour and Smith (1941).
Protective Effects of Antioxidants on the Experimental Liver and Kidney Toxicity in Mice
(Amer Assoc Clinical Chemistry, 2006) Balahoroglu, R.; Dulger, H. H.; Ozbek, H.; Bayram, I.; Sekeroglu, M. R.