Browsing by Author "Ozbilgin, S"

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    The in Vivo and in Vitro Comparative Nephrotoxicity of Cefazolin and Gentamicin
    (Comparative Toxicology Lab, 1999) Yilmaz, O; Cabalar, M; Ozbilgin, S
    Biochemical, histopathological and cell culture evaluations compared the nephrotoxicity of cefazolin with that of gentamicin. New Zealand rabbits were dosed with 250 mg cefazolin/animal im twice daily, 3 mg gentamicin/kg im twice daily, or 0.9% NaCl solution for 10 d. The rabbits in drug-treated groups had necrosis of proximal kidney tubules and elevated urinary-gamma glutamyl transferase (uGGT) levels. The results of the histopathological examinations, uGGT analyses and effects in cell culture indicated the nephrotoxicities of both antibiotics were similar.