Browsing by Author "Ozmen, E."

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Effects of Acute Sleep Deprivation on Repolarisation Parameters
(Yuzuncu Yil Universitesi Tip Fakultesi, 2025) Avcı Demir, F.A.; Ozmen, E.; Ünlü, S.; Acar, U.; Tuner, H.; Çamkiran, V.; Çakıllı, Y.
Acute sleep deprivation is associated with various adverse physiological consequences, such as dysregulation of the autonomic nervous system and adverse cardiovascular events. Markers of ventricular repolarisation are widely accepted in clinical practice to assess the risk of developing malignant ventricular arrhythmias. The aim of this study was to investigate the arrhythmogenic potential of acute sleep deprivation. This was a prospective, observational study conducted in a single centre to investigate the relationship between acute sleep deprivation and ECG parameters. The included subjects did not have any acute or chronic diseases and ECG abnormalities. A 12lead ECG was performed after a sleepless period of 24 hours after the night shift and after seven days of normal sleep following the night shift. The 12-lead ECG was recorded using a Philips PageWriter TC20 at a rate of 50 mm/sec and ECG parameters evaluated included Tp-e/QT and Tp-e/QTc ratios, frontal QRS-T angle, PR, QT, QTc and Tp-e intervals. Fifty-nine nurses were included in the study. Qt and QTc duration, mean Tp-e and corrected Tp-e intervals were prolonged after acute sleep deprivation. In addition, Tp-e/Qt ratio and Tp-e/QTc were found to be longer after acute sleep deprivation compared to after normal sleep. The results of our study suggest that acute sleep deprivation has a significant effect on ECG parameters, especially on repolarisationrelated ECG parameters, but not on depolarisation parameters. © 2025, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Oxidative Stress and Antioxidant Enzyme Activities in Newborns With Oesophageal Atresia and Their Mothers
(Sage Publications Ltd, 2012) Melek, M.; Demir, H.; Bilici, S.; Beger, B.; Cobanoglu, U.; Meral, I.; Ozmen, E.
OBJECTIVE: To measure the oxidant/antioxidant status of newborn babies with oesophageal atresia and their mothers, compared with healthy control subjects. METHODS: This case control study included 40 participants: 10 newborns with oesophageal atresia and their mothers, and 10 healthy newborns and their mothers. Whole blood malondialdehyde (MDA) levels and the activities of antioxidant enzymes (catalase, carbonic anhydrase [CA], glucose-6-phosphate dehydrogenase [G-6-PD], and superoxide dismutase [SOD]) were measured. RESULTS: MDA levels and CA activity were significantly higher, and catalase, SOD and G-6-PD activities were significantly lower, in newborns with oesophageal atresia and their mothers than in healthy newborns and their mothers. Although CA activity was similar between the newborns and mothers in the patient group, it was significantly lower in newborns than in mothers in the healthy group. CONCLUSIONS: Increased lipid peroxidation might play an important role in the pathogenesis of oesophageal atresia. Impairment of the free radical/antioxidant balance may lead to increased free radical and decreased antioxidant levels in oesophageal atresia.