Browsing by Author "Sumer, Aziz"

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An Analysis of 13 Patients With Perforated Gastric Carcinoma: a Surgeon's Nightmare
(Bmc, 2008) Kotan, Cetin; Sumer, Aziz; Baser, Murat; Kiziltan, Remzi; Carparlar, M. Ali
Background and Objectives: Perforation is a rare complication of gastric carcinoma and generally not diagnosed preoperatively. To clarify the clinicopathologic characteristics of patients with this condition we reviewed 13 cases of gastric cancer perforation who required emergency surgery. Methods: A total of 13 patients with gastric cancer perforation were retrospectively reviewed. The clinicopathological features including tumor stage and survival and also the type of treatment were analyzed and compared to literature data. Results: There were 13 patients (10 males and 3 females) with a mean age of 59.0 +/- 9.56 years. The incidence of perforated gastric cancer was 9.6% among gastric carcinoma and 4.2% of all gastric perforation cases. The perforation was more frequently in stage III-IV (2-10), but one case of stage II (T3N0M0) gastric cancer was also observed. None of the patients had curative resection or radical lymph-node dissection. Six (46%) patients were treated by palliative, local surgery. Emergency gastrectomy were performed in 7 (54%) patients. Overall 30-day mortality rate was % 46. The overall survival time was 128.2 +/- 184.8 days for all patients, it was 52.8 +/- 52.9 days for locally treated group, and 192.9 +/- 235.4 days for patients who underwent resectional surgery. The difference between the treatment groups was not significant Conclusion: Perforation usually occurs in advanced stages of gastric cancer. These patients had a poor prognosis because of the presence of advanced cancer.
Comparison of Magenstrasse and Mill Gastroplasty and Sleeve Gastrectomy Techniques as an Experimental Study on Rabbits
(Edizioni Luigi Pozzi, 2020) Sumer, Aziz; Celik, Sebahattin; Aktokmakyan, Talar Vartanoglu; Peksen, Caghan; Sancak, Tunahan; Kuscu, Yagmur; Eren, Eryigit
AIM: Bariatric surgery is an important option when lift-style modification, diet, and medical treatment are inadequate in lose weight. Bariatric surgical methods have gained popularity in recent years. In this paper, we compared the Magenstrasse and Mill(M&M) technique, with performing a simpler and more physiological type of gastroplasty without implanted foreign material such as band and reservoir, to the Sleeve Gastrectomy (SG) technique. This study aimed to determine the effects of the M&M for obesity on the rabbits in comparison with the SG, which is accepted as a standard bariatric technique with creating a gastric tube. MATERIAL AND METHODS: The study was approved by the University of Van Yuzuncu Yil Regional Committee of Ethics (Institutional Animal Care and Use Committee). 20New Zealand Rabbits underwent operations. After prestudy with 2 rabbits, the remaining 18 rabbits were divided into 2 groups; Group 1 (SG) and Group 2 (M&M). RESULTS: Group 1 rabbits were observed to lose weight in all, while Group 2 rabbits; 2 of them died 5 of them lost weight, 2 of them gained weight. When the pre and post-operative weight of the rabbits were compared; preoperative median weight values of 9 rabbits in Group 1 were significantly higher than postoperative values. On the other hand, there was no significant change in the mean weight of Group 2 of 7 rabbits (living up to 8weeks). The mean weight of rabbits undergoing standard SG was significantly lower than the MeM technique. CONCLUSION: We believe that this animal experimental study, which we conducted intending to compare MeM and SG techniques, will contribute to the literature as a pilot study and determine the survey of M&M technique as a pioneer in other studies.
Derin Ven Trombozu Olan ve Olmayan Hastalarda D-dimer ve Tüm Hemostatik Faktörlerin Düzeyleri
(2010) Kemik, Ahu Sarbay; Kotan, Çetin; Kemik, Özgür; Tüzün, Sefa; Sumer, Aziz; Purisa, Sevim
Amaç: Gelişen tanı ve tedavi yöntemlerine rağmen, derin ven trombozu (DVT) hala önemli bir morbidite ve mortalite nedeni olmaya devam etmektedir. DVT sık karşılaşılan bir hastalık olup, Amerika Birleşik Devletlerinde her yıl 250 000’den fazla kişiyi etkilemektedir. DVT tanısında mevcut tanı araçlarının kısıtlılıklarından dolayı plazma D-dimer gibi laboratuar ölçümlerine son dönemlerde ilgi artmıştır. Bu nedenle biz, derin ven trombozlu hastalardaD-dimer düzeylerini ve tüm hemostatik faktörleri incelemeyi amaçladık. Gereç ve Yöntem: Derin ven trombozlu 120 hastanın ve derin ven trombozu olmayan 115 hastanın, D-dimer düzeylerini ve Von Willebrand faktör düzeylerini enzim bağlı immunosorbent assay (ELISA) yöntemi ile inceledik. Kolesterol, kreatinin, INR, faktör VIII: C oranı ve aPTT ölçümleri standard metod ile, fibrinojen ölçümü ise Clauss metodu ile ölçüldü. Bulgular: Yaş, vücut kitle indeksi (VKİ), aPTT, INR ve total kolesterol bakımından derin ven trombozlu hastalarla derin ven trombozu olmayan hastalar karşılaştırıldığında, anlamlı farklılık bulunamadı (p > 0,05). Plasma D-dimer düzeyleri, kreatinin, faktör VIII: C ve Von Willebrand faktör düzeylerini derin ven trombozlu hastalarda, derin ven trombozu olmayan hastalara göre anlamlı olarak yüksek bulduk (sırasıyla, p<0,001, p<0,01). Diğer taraftan, fibrinojen düzeylerini, derin ven trombozlu hastalarda düşük bulduk (p< 0,01). Sonuç: Derin ven trombozunun teşhis ve tedavisinde D-dimer düzeylerinin ve hemostatik faktörlerin önemli rol oynadığı kanısındayız.
Effect of Pentoxifylline and Vinpocetine on the Healing of Ischemic Colon Anastomosis: an Experimental Study
(Turkish Assoc Trauma Emergency Surgery, 2011) Sumer, Aziz; Altinli, Ediz; Senger, Serkan; Koksal, Neset; Onur, Ender; Eroglu, Ersan; Gunes, Pembegul
BACKGROUND In the current study, we aimed to investigate the influences of pentoxifylline, which increases the flexibility, deformability and viscosity of the erythrocytes while reducing the aggregation abilities of the platelets, and vinpocetine, which has neuroprotective and antioxidant effects, on healing of colonic anastomoses. METHODS We used 30 Albino Wistar rats. Subjects were divided into three groups of 10 rats each. Colonic ischemia was established in all the groups. Following colonic transection, anastomosis was performed. Group A received intraperitoneal saline, whereas Group B and Group C received pentoxifylline and vinpocetine, respectively. The subjects were sacrificed on the postoperative 5th day by ether anesthesia, and their colonic bursting pressures were measured. The anastomotic area was excised for hydroxyproline assay and histopathologic examination. RESULTS According to intergroup comparisons, colonic bursting pressure was found to be higher in the treatment groups than in the control group; however, the difference was not statistically significant. Intergroup comparisons regarding tissue hydroxyproline levels showed statistically significant differences between Groups A and B, Groups A and C and Groups B and C. CONCLUSION Similar to pentoxifylline, vinpocetine was also shown to have a beneficial effect over ischemic colon anastomoses.
Gossypiboma: Retained Surgical Sponge After a Gynecologic Procedure
(Hindawi Ltd, 2010) Sumer, Aziz; Carparlar, M. Ali; Uslukaya, Omer; Bayrak, Vedat; Kotan, Cetin; Kemik, Ozgur; Iliklerden, Umit
We report on a case of gossypiboma. A 54-year-old woman was admitted to our hospital with abdominal mass. She had undergone a caesarean operation 23 years previously. The mass in the right abdominal quadrant was suspected by abdominal computed tomography and magnetic resonance imaging. The mass was removed by laparotomy excision and the final diagnosis was gossypiboma.
Human Vascular Adhesion Protein-1 (vap-1): Serum Levels for Hepatocellular Carcinoma in Non-Alcoholic and Alcoholic Fatty Liver Disease
(Biomed Central Ltd, 2010) Kemik, Ozgur; Sumer, Aziz; Kemik, Ahu Sarbay; Itik, Veyis; Dulger, Ahmet Cumhur; Purisa, Sevim; Tuzun, Sefa
Background: The incidence of hepatocellular cancer in complicated alcoholic and non-alcoholic fatty liver diseases is on the rise in western countries as well in our country. Vascular adhesion protein-1 (VAP-1) levels have been presented as new marker. In our study protocol, we assessed the value of this serum protein, as a newly postulant biomarker for hepatocellular cancer in patients with a history of alcoholic and non-alcoholic fatty liver diseases. Methods: Pre-operative serum samples from 55 patients with hepatocellular cancer with a history of alcoholic and non-alcoholic fatty liver diseases and patients with cirrhosis were assessed by a quantitative sandwich ELISA using anti-VAP-1 mAbs. This technique is used to determine the levels of soluble VAP-1 (sVAP-1) in the serum. Results: sVAP-1 levels were evaluated in patients with hepatocellular cancer and liver cirrhosis. There was a significant difference in mean VAP-1 levels between groups. Serum VAP-1 levels were found higher in patients with hepatocellular cancer. Conclusion: These findings indicate that the serum level of sVAP-1 might be a beneficial marker of disease activity in chronic liver diseases.
Jejunal Diverticulum Perforation Resulting From Distal Mechanic Obstruction: a Case Report
(Aves, 2011) Olmez, Aydemir; Sumer, Aziz; Piskin, Turgut; Aydin, Cemalettin
Excluding Meckel's diverticulum, jejunum and ileum diverticula are acquired diverticula which are rarely observed and have an asymptomatic course. They are mostly observed in elderly patients. Men are twice as likely as women to have diverticula. The complications like inflammation, bleeding, obstruction and perforation may develop in less than 10% of patients with jejunal diverticula. Perforation, as an uncommon complication, may occur following diverticulitis in 82%, blunt trauma in 12%, and impact of foreign body in 6% of cases. Herein we present a 62 year old man operated emergently due to development of acute abdomen that resulted from perforation caused by an increased jejunal and diverticular pressure secondary to rectal obstruction without any common factors mentioned for diverticular perforation. We performed resection and anastomosis at operation.
Levels of Matrix Metalloproteinase-1 and Tissue Inhibitors of Metalloproteinase-1 in Gastric Cancer
(Baishideng Publ Grp Co Ltd, 2011) Kemik, Ozgur; Kemik, Ahu Sarbay; Sumer, Aziz; Dulger, Ahmet Cumhur; Adas, Mine; Begenik, Huseyin; Kotan, Cetin
AIM: To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric cancer. METHODS: One hundred gastric cancer patients who underwent gastrectomy were enrolled in this study. The serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent assay. RESULTS: Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls (P < 0.001). Serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance, tumor size, depth of wall invasion, lymph node metastasis, liver metastasis, perineural invasion, and pathological stage. They were not significantly associated with age, gender, tumor location, or histological type. CONCLUSION: Increased MMP-1 and TIMP-1 were associated with gastric cancer. Although these markers are not good markers for diagnosis, these markers show in advanced gastric cancer. (C) 2011 Baishideng. All rights reserved.
The Levels of the D-Dimer and All Haemostatic Factors in Patients With and Without Deep Venous Thrombosis
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2010) Kemik, Ozgur; Sumer, Aziz; Kemik, Ahu Sarbay; Purisa, Sevim; Tuzun, Sefa; Kotan, Cetin
Objective: Although improved diagnostic tools and treatment approach, deep venous thrombosis is still an important cause of morbidity and mortality. Deep venous thrombosis is a common condition that affects more than 250 000 patients each year in the United States. In spite of limitations of the available diagnostic tools for detecting deep venous thrombosis, laboratory tests such as plasma D-dimer has been gained much interest recently. So, we aimed to investigate the D-dimer and all hemostatic factors in patients with deep vein thrombosis. Material and Methods: We investigated the levels of the D-dimer and Von Willebrand factor by enzyme linked immunosorbent assay (ELISA) in 120 patients with deep venous thrombosis and in 115 patients without deep venous thrombosis. We used standard methods for detecting the levels of the cholesterol, creatinin, INR, factor VIII: C ratio, and aPTT. We used Clauss method for detecting the fibrinogen levels. Results: We obtained important results in patients with deep venous thrombosis compared to in patients without deep vein thrombosis. Age, BMI, aPTT, INR, and total cholesterol levels were not found statistically differences in patients with deep venous thrombosis (p> 0,05). Plasma D-dimer, creatinin, factor VII: C, and Von Willebrand factor levels were found higher in patients with deep venous thrombosis than in patients without deep venous thrombosis (respectively, p<0,001, p<0,01). But, plasma fibrinogen levels were not found lower in patients with deep venous thrombosis (p<0,01). Conclusion: In conclusion, we suggested that the plasma D-dimer and hemostatic factor levels may play an important role in diagnosis and treatment of deep venous thrombosis.
Matrix Metalloproteinases in Pathogenesis of Hemorrhoidal Disease
(Southeastern Surgical Congress, 2013) Kisli, Erol; Kemik, Ahu; Sumer, Aziz; Kemik, Ozgur
The aim of this study is to investigate the accuracy of serum matrix metalloproteinase (MMP) levels in an effort to find a reliable factor that may play an important role in pathogenesis of hemorrhoidal disease. Twenty control subjects and 21 Grade I, 19 Grade II, 20 Grade III, and 21 Grade IV patients with internal hemorrhoid were included in this prospective study. The mean ages of control subjects were 47.65 +/- 6.71 standard deviation (SD) years (range, 37 to 60 years). The mean age of internal Grade I, Grade II, Grade III, and Grade IV patients with internal hemorrhoid were 48.85 +/- 6.44, 47.20 +/- 6.75, 44.90 +/- 6.13, and 42.95 +/- 3.49 SD years (ranges, 38 to 58, 38 to 60, 34 to 55, and 38 to 50 years), respectively. Ten milliliters of blood was taken from all subjects. Enzymelinked immunosorbent assay (ELISA) for MMP-1, -2, -7, and -9 levels were performed using an ELISA kit (R&D Systems) following the manufacturer's instructions. There was an important difference between Grade I and Grade II groups in the serum levels of MMP-9 (P <0.01). Patients with Grade III hemorrhoidal disease had significantly higher serum levels of all MMP than patients with Grade I and Grade II hemorrhoidal disease (P < 0.001). Also, patients with Grade 4 hemorrhoidal disease had higher serum levels of MMP-7 and -9 according to Grade I, II, and III groups (P < 0.01, 0.001). High serum levels of MMP are present in patients with hemorrhoids, suggesting the possible mechanism in the pathogenesis of hemorrhoids.
Minimally Invasive Distal Pancreatectomy a Retrospective Review of 30 Cases
(Edizioni Luigi Pozzi, 2017) Sumer, Aziz; Barbaros, Umut; Conde, Salvador Morales; Celik, Sebahattin; Aksakal, Nihat; Alamo, Jose Maria; Budak, Demir
OBJECTIVES: Pancreatic surgery has been greatly influenced by the advent of laparoscopic surgery and increasing experience in its performance and by advances in techniques and surgical devices. This study aimed to represent two centers' initial experiences in laparoscopic distal pancreatic surgery. METHODS: This study was a bi-centric study including 30 patients undergoing distal pancreatectomy for pancreatic disorders. All the patients were operated on from November 2006 to November 2013 in Turkey and Spain. RESULTS: Laparoscopic spleen-preserving distal pancreatectomy was performed in 9 patients, laparoscopic distal pancreatectomy was performed in 14 patients, laparoscopic enucleation was performed in 4 patients, and single-incision laparoscopic distal pancreatosplenectomy with splenectomy was performed in 3 patients. CONCLUSIONS: Laparoscopic distal pancreatectomies for pancreatic disorders are feasible and safe procedures if performed by experienced laparoscopic surgeons.
A New Approach in Bariatric Operations: Bridged Mini Gastric By-Pass. Is Rabbit Model Suitable for an Experimental Study
(Turkish Surgical Assoc, 2021) Sumer, Aziz; Celik, Sebahattin; Aktokmakyan, Talar Vartanoglu; Peksen, Caghan; Savas, Osman Anil; Talih, Tutkun; Kuscu, Yagmur
Objective: Obesity is a global health epidemic with considerable co-morbidities. The increasing demand for bariatric surgery has led to the emergence of new techniques. We modified previously described Mini Gastric By-pass(MGB) technique via leaving a bridge at the most cranial 2 cm of the fundus of the human stomach to the follow-up and treatment of the remnant stomach and duodenum. We would like to entitle this new technique as Bridged MGB and aimed to apply on rabbits as an experimental study. Material and Methods: The study was performed in the experimental animal laboratory of university after ethical approval was taken from the local ethics committee. Described new technique was applied to 2.1 and 3.2 kg 2 New Zealand rabbits. Results: As a result of the operations, one of the rabbits died on the day of the operation; the other rabbit was exitus postoperatively on the third day. In autopsies, although no problem was detected at the anastomoses, necrosis was detected in the large curvature of both rabbits. Conclusion: Rabbit, one of the popular experimental animals, has been shown to be different from the human gastrointestinal system in both arterial and topographic aspects and it has been emphasized that it varies according to the species and even the diet and the climate. We believe that our study failed as a result of these differences and that animals more similar to humans should be used in gastrointestinal experimental studies.
A New Approach in Bariatric Operations: Bridged\rmini Gastric By-Pass. Is Rabbit Model Suitable for An\rexperimental Study
(2021) Talih, Tutkun; Sumer, Aziz; Peksen, Caghan; Sancak, Tunahan; Çelik, Sebahattin; Kuşcu, Yağmur; Aktokmakyan, Talar Vartanoglu
Objective: Obesity is a global health epidemic with considerable co-morbidities. The increasing demand for bariatric surgery has led to the emergence\rof new techniques. We modified previously described Mini Gastric By-pass(MGB) technique via leaving a bridge at the most cranial 2 cm of the fundus\rof the human stomach to the follow-up and treatment of the remnant stomach and duodenum. We would like to entitle this new technique as Bridged\rMGB and aimed to apply on rabbits as an experimental study.\rMaterial and Methods: The study was performed in the experimental animal laboratory of university after ethical approval was taken from the local\rethics committee. Described new technique was applied to 2.1 and 3.2 kg 2 New Zealand rabbits.\rResults: As a result of the operations, one of the rabbits died on the day of the operation; the other rabbit was exitus postoperatively on the third day.\rIn autopsies, although no problem was detected at the anastomoses, necrosis was detected in the large curvature of both rabbits.\rConclusion: Rabbit, one of the popular experimental animals, has been shown to be different from the human gastrointestinal system in both arterial\rand topographic aspects and it has been emphasized that it varies according to the species and even the diet and the climate. We believe that our study\rfailed as a result of these differences and that animals more similar to humans should be used in gastrointestinal experimental studies.
Outcome of Surgical Treatment of Intestinal Perforation in Typhoid Fever
(Baishideng Publishing Group inc, 2010) Sumer, Aziz; Kemik, Ozgur; Dulger, Ahmet Cumhur; Olmez, Aydemir; Hasirci, Ismail; Kisli, Erol; Kotan, Cetin
AIM: To represent our clinical experience in the treatment of intestinal perforation arising from typhoid fever. METHODS: The records of 22 surgically-treated patients with typhoid intestinal perforation were evaluated retrospectively. RESULTS: There were 18 males and 4 females, mean age 37 years (range, 8-64 years). Presenting symptoms were fever, abdominal pain, diarrhea or constipation. Sixteen cases were subjected to segmental resection and end-to-end anastomosis, while 3 cases received 2-layered primary repair following debridement, one case with multiple perforations received 2-layered primary repair and end ileostomy, one case received segmental resection and end-to-end anastomosis followed by an end ileostomy, and one case received segmental resection and end ileostomy with mucous fistula operation. Postoperative morbidity was seen in 5 cases and mortality was found in one case. CONCLUSION: Intestinal perforation resulting from Salmonella typhi is an important health problem in Eastern and Southeastern Turkey. In management of this illness, early and appropriate surgical intervention is vital. (C) 2010 Baishideng. All rights reserved.
Panniculectomy With Bariatric Surgery in Super Morbid Obesity Patients
(Edizioni Luigi Pozzi, 2023) Peksen, Caghan; Aktokmakyan, Talar Vartanoglu; Savas, Osman Anil; Okyay, Ozan; Datli, Asli; Elmali, Necat; Sumer, Aziz
OBJECTIVE: Panniculitis is an inflammation of the subcutaneous fat common in patients defined as super-super obese (>60 kg/m2). Poor hygiene and skin infections are common in the super morbidly obese group due to impaired metabolism of subcutaneous fat tissue, especially at abdominal folding. In our study, we will discuss the short-term results of panniculitis that develops as a result of these, simultaneously with bariatric surgery. MATERIAL AND METHODS: In our study, six super morbid obese patients with Body Mass Index (BMI) of 80 kg/m(2), 77 kg/m(2), 74 kg/m(2), 72 kg/m(2), 68 kg/m(2), 65 kg/m(2), respectively, and sub umbilical skin tissue panniculitis were evaluated. These patients underwent bariatric surgery as a result of the obesity council decision. In the preoperative evaluation of the patients, it was observed that the blood supply to the subcutaneous fat tissues under the umbilicus was impaired, and the dermis/epidermis was hypertrophied. RESULTS: Mean BMI of patients 73 kg/m(2). Sleeve Gastrectomy (SG) was performed in 4 patients, Mini Gastric Bypass (MGB) was performed in 1 patient, and modified transit bipartition was performed in 1 patient. Infected erythematous lesions were detected on the skin secondary to ischemia, especially in some areas. After the patients performed the operations, a panniculectomy of approximately 70x30x20 cm was performed from under the umbilicus to the transverse line and up to the fascia. CONCLUSION: Panniculectomy and bariatric surgery are recommended in the appropriate patient group. Extensive prospective studies are required to define further the burden of infectious morbidity and mortality conferred by obesity.
Preoperative Serum Placenta Growth Factor Level as a New Marker for Stage Ii or Iii Colorectal Cancer Patients
(Turkish Soc Gastroenterology, 2012) Kemik, Ozgur; Kemik, Ahu Sarbay; Sumer, Aziz; Purisa, Sevim; Tukenmez, Baris; Tuzun, Sefa
Background/aims: We first reported in this study that serum placenta growth factor and carcinoembryonic antigen in combination were useful markers for selecting early-stage colorectal cancer patients. The aim of the present study was to determine whether serum placenta growth factor could provide carcinoembryonic antigen-independent prognostic information on patients undergoing curative surgery. Methods: Serum and tissue samples were collected from 158 patients with colorectal cancer and from 50 controls. Serum and tissue levels of placenta growth factor were measured by enzyme-linked immunosorbent assay. The serum placenta growth factor levels in colorectal cancer patients were compared with those in healthy controls, and we retrospectively assessed the association between serum placenta growth factor levels and clinicopathological findings and survival. Results: Expression of placenta growth factor was significantly higher in colorectal cancer tissues compared with non-tumor tissues. The mean serum placenta growth factor level in patients was significantly higher than that in controls and significantly higher in patients with large tumor, lymph-node involvement and distant metastasis. Conclusions: Elevated serum placenta growth factor levels are significantly associated with colorectal cancer development, lymph or distant invasive phenotypes and survival, especially in stage II or III patients.
Preoperative Vascular Endothelial Growth Factor Levels as a Prognostic Marker for Stage Ii or Iii Colorectal Cancer Patients
(Libertas Acad, 2011) Kemik, Ozgur; Kemik, Ahu Sarbay; Sumer, Aziz; Purisa, Sevim; Dulger, A. Cumhur; Begenik, Huseyin; Tuzun, Sefa
Background: The aim of the present study was to determine whether serum vascular endothelial growth factor (VEGF) can provide prognostic information independent of carcinoembryonic antigen levels in patients undergoing curative surgery. Methods: Serum samples were collected from 158 patients with colorectal cancer and from 100 controls. Serum and tissue levels of VEGF were measured by enzyme-linked immunosorbent assay. Serum VEGF levels in colorectal cancer patients were compared with those in healthy controls, and we retrospectively assessed the association between serum VEGF levels and clinicopathologic findings and survival. Results: VEGF expression was significantly higher in colorectal cancer tissue compared with nontumor tissue. Mean serum VEGF levels in patients were significantly higher than those in controls, and significantly higher in patients with large tumors, lymph node involvement, and distant metastases. Conclusion: Elevated serum VEGF was significantly associated with poor survival, but was only an independent risk factor for poor survival in Stage II and/or III disease. Elevated serum VEGF is significantly associated with development of colorectal cancer, and lymph or distant invasive phenotypes and survival, especially in Stage II and III patients.
Prevention of Adhesion To Prosthetic Mesh: Comparison of Oxidized Generated Cellulose, Polyethylene Glycol and Hylan G-F 20
(Turkish Assoc Trauma Emergency Surgery, 2011) Altinli, Ediz; Sumer, Aziz; Koksal, Neset; Onur, Ender; Senger, Serkan; Eroglu, Ersan; Gumrukcu, Gulistan
BACKGROUND The aim of this study was to investigate the impact of oxidized generated cellulose, polyethylene glycol and hylan G-F 20 on adhesion formation, fibrosis and inflammation after repair of abdominal wall defect with polypropylene mesh in an animal model. METHODS Forty rats were divided into four groups and abdominal wall defect was established. The defect as repaired with polypropylene mesh alone (control group), polypropylene mesh and hylan G-F 20 as adhesion barrier, polypropylene mesh and oxidized generated cellulose as adhesion barrier, or polypropylene mesh and polyethylene glycol as adhesion barrier in Groups I, II, III, and IV, respectively. Rats were sacrificed on the 14th day in all groups. RESULTS A comparison of the groups in terms of macroscopic adhesion scores revealed statistically significant differences between the groups using an adhesion barrier and the control group. Severe fibroblast proliferation was seen in the control group and mild fibroblast proliferation was seen in polyethylene glycol group. CONCLUSION Polyethylene glycol is an effective adhesion prevention barrier. Laparoscopic surgery has become the standard method in most of the surgical field. With its laparoscopic apparatus, polyethylene glycol allows easy application on the damaged surface.
Primary Intraperitoneal Pelvic Hydatid Cyst Rupture: Case Report
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2011) Sumer, Aziz; Caglayan, Kasim; Celik, Atilla; Altinli, Ediz; Koksal, Neset
Hydatid disease is an endemic disease in Turkey. It is located mostly in the liver. Primary peritoneal hydatid cyst is rare and the mechanism of this infection is unknown. Ultrasonography and computerized tomography are the main diagnostic tools in identifying hydatid cyst. Surgical treatment is mandatory. In this article we report a case of primary intraperitoneal pelvic cyst hydatid rupture in a 25 years old male who admitted to the emergency department with a history of abdominal pain. At operation, ruptured pelvic hydatid cyst was found and excised. Partial omentectomy was applied. Peritoeal cavity was lavaged with hypertonic saline solution. Medical theraphy with albendazole was started. The postoperative course of the patient was uneventful. In endemic regions, hidatid cyst should be thought in differential diagnosis of pelvic cyst.
Primer İntraperitoneyal Pelvik Kist Hidatik Rüptürü: Olgu Sunumu
(2011) Çağlayan, Kasım; Altınlı, Ediz; Koksal, Neset; Çelik, Atilla; Sumer, Aziz
Kist hidatik Türkiye’de endemik bir hastalıktır. Çoğunlukla karaciğer yerleşimlidir. Primer peritoneyal kist hidatik nadirdir ve bunun mekanizması bilinmemektedir. Ultrasonografi ve bilgisayarlı tomografi hidatik kist hastalığının tanısında temel tanı araçlarıdır. Cerrahi tedavi esastır. Bu makalede biz karın ağrısı hikayesi ile acil servise başvuran 25 yaşında primer peritoneyal pelvik kist hidatik rüptürü olan erkek olguyu sunduk. Ameliyatta pelvik kist hidatik rüptürü saptandı ve çıkartıldı. Kısmi omentektomi uygulandı. Peritoneyal kavite hipertonik NaCI ile yıkandı. Albendazol ile medikal tedaviye başlandı. Olgunun postoperatif dönemi sorunsuzdu. Endemik bölgelerde kist hidatik pelvik kistlerin ayırıcı tanısında düşünülmelidir.