Browsing by Author "Tan Uygun, Meltem"

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Synthesis of Novel 1,3-Disubstituted Pyrrolo[1,2-A]pyrazine Derivatives and Antiproliferative Effects on Glioblastoma Cell Line
(Springer Wien, 2021) Tan Uygun, Meltem
Novel pyrrolopyrazine derivatives were synthesized according to a very simple protocol starting from N-propargylated-2-acyl-pyrroles. These derivatives were obtained in good to excellent yields (68-94%) in the presence of ammonium acetate and Cs2CO3, and then subjected to cytotoxicity testing against glioblastoma cell line T98G. Among the tested molecules, those that cause 68.9%, 59.1%, and 37.5% cell death, were identified as lead compounds. The structure-activity relationship (SAR) study revealed that conformation, pi-pi interactions, and halogen bonds could be important for efficiency. Finally, theoretical ADMET studies on pyrrolopyrazine derivatives demonstrated that pharmacokinetic phases are suitable.
Efficacy of Bakuchiol in a Rat Model of Chemical Eye Injury
(Taylor & Francis Inc, 2026) Bilmez Tan, Rumeysa; Tekin, Serek; Akman Ilik, Zehra; Batur, Muhammed; Seven, Erbil; Tan Uygun, Meltem
Purpose: To evaluate the therapeutic effects of bakuchiol on clinical and histopathological outcomes in a rat model of corneal alkali burn.MethodsCorneal alkali burns were induced in the right eyes of 35 male Wistar rats, which were randomized into five groups: control, carbomer, steroid, 0.14 mg/g bakuchiol, and 0.28 mg/g bakuchiol. Examinations were performed under stereomicroscopy with intraperitoneal ketamine anesthesia on days 0, 3, 7, and 14 to assess corneal epithelial defects and opacity; on day 14, corneal neovascularization was additionally evaluated. After the final examination, the eyes were enucleated, and the corneas were processed for hematoxylin-eosin and immunohistochemical staining. Epithelial necrosis, inflammatory cell density, corneal hemorrhage, stromal edema, and staining intensity for VEGF and TNF-alpha were semi-quantitatively scored.ResultsBakuchiol treatment, particularly at 0.28 mg/g, significantly reduced corneal opacity, neovascularization, hemorrhage, and stromal edema compared with the steroid-treated group.ConclusionsBakuchiol demonstrated promising anti-inflammatory and anti-angiogenic effects and may represent a potential adjunctive treatment for corneal chemical injuries.