Browsing by Author "Tekeoglu, I"

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Brucellar Oligoarthritis Involving the Left Temporomandibular, Left Sternoclavicular and Left Ankle Joints
(Clinical & Exper Rheumatology, 1997) Adak, B; Tekeoglu, I; Kutluhan, A; Akdeniz, H; Sakarya, ME; Ugras, S
Clinical Value of Pneumatic Compression and Modified Pneumatic Compression Tests in Carpal Tunnel Syndrome
(Bmj Publishing Group, 2004) Tekeoglu, I; Adak, B; Demir, G
Comparison of Cyclic and Continuous Calcitonin Regimens in the Treatment of Postmenopausal Osteoporosis
(Springer Heidelberg, 2005) Tekeoglu, I; Adak, B; Budancamanak, M; Demirel, A; Ediz, L
We aimed to compare and evaluate the efficacies of a continuous regimen of intranasal salmon calcitonin (SCT) and two cyclic regimens (different cyclic regimens from previous studies) based on alternating 15 days or on 10 days consecutively per month for 1 year in the treatment of postmenopausal osteoporosis. We performed an open-label, prospective, randomized clinical trial. A total of 120 postmenopausal osteoporotic participants between 50 and 65 years old were randomly assigned to one of three treatment groups. Patients in group 1 (n=40) received continuously SCT nasal spray at a dose of 200 IU/day, plus continuously 500 mg/day elementary calcium and 0.25 mu g/day 1-alpha hydroxyvitamin D3, for 1 year. Patients in group 2 (n=40) received cyclically SCT nasal spray at a dose of 200 IU/day on alternating 15 days per month, plus continuously 500 mg/day elementary calcium and 0.25 mu g/day 1-alpha hydroxyvitamin D3, for 1 year. Patients in group 3 (n=40) received cyclically SCT nasal spray on 10 days consecutively per month (20 days/month rest), plus continuously 500 mg/day elementary calcium and 0.25 mu g/day 1-alpha hydroxyvitamin D3, for 1 year. Data was evaluated by repeated analysis of variance (ANOVA). In addition, statistical differences between groups were assessed by the two-tailed Student's t test. After 1 year of the study, seven patients from group 1, eight patients from group 2 and five patients from group 3 withdrew from the study. No patient discontinued the study because of adverse drug effects. There was a statistically-significant improvement in pain intensity VAS scores at the end of the year to baseline scores in all three groups (p < 0.001). There was no significant difference in pain intensity VAS scores between groups at the end of the year (p > 0.05). Lumbar and femur neck BMD scores improved significantly at the end of treatment in all three groups (p < 0.05). There was no statistically-significant difference in BMD scores between groups at final (p > 0.05). Urinary DPD/Cre levels decreased significantly in all three groups by the end of the year (p < 0.05). There was no statistically-significant difference in urinary DPD/Cre final levels between groups (p > 0.05). According to the results of the present study, consecutive 10 days therapy with SCT, which is the first in the literature to our knowledge, is as effective as the other two regimens in the treatmnent of osteoporosis. Both cyclic regimens in our study (alternating 15 days and 10 consecutive days each month for 1 year) do appear to offer some advantages, especially economically and clinically, as compared to continuous treatment.
Comparison the Effects of Acetaminophen and Colchicine in the Management of Primary Knee Osteoarthritis
(B M J Publishing Group, 2004) Tekeoglu, I; Ediz, L; Adak, B
Continuous, Intermittant and Consecutive Calcitonin in Osteoporosis
(B M J Publishing Group, 2004) Tekeoglu, I; Adak, B; Ediz, L
Distraction of Lumbar Vertebrae in Gravitational Traction
(Lippincott Williams & Wilkins, 1998) Tekeoglu, I; Adak, B; Bozkurt, M; Gürbüzoglu, N
Study Design. Experimental study of 30 patients diagnosed with low back pain resulting from lumbar disc herniation, disc degeneration, and segmental instability. Patients underwent gravitational tractions and widening of the intervertebral space and posterior facets was measured on radiographs. This same procedure was performed with a group of 30 healthy individuals. Objectives. To determine the effect of gravitational traction on the widening of the intervertebral space and the other vertebral structures in patients with low back pain and in healthy individuals. Summary of Background Data. Gravitational traction is performed by suspending the patient in a hanging, upright position for an extended period of time. In spite of disagreement among authors about the effect of lumbar traction, recent innovations have enabled the distraction of vertebrae. Methods. A specially designed apparatus was used to apply gravitational traction. Pre- and post-traction radiographs were obtained to study the changes in the L2-L3, L3-L4, L4-L5, and L5-S1 intervertebral spaces; Ferguson's angle; L1-S1 total distance; and blood pressure. Results. Distraction was more than approximately 3 mm in each intervertebral space in both groups. Conclusion. Gravitational traction had a very apparent effect on intervertebral space and was found to be an effective method to distract lumbar vertebrae. Discomfort experienced by the patient during suspension may be overcome by making biomedical changes to the suspension corset.
Distraction of Lumbar Vertebrae in Gravitational Traction With Hips Flexed Position
(B M J Publishing Group, 2004) Tekeoglu, I; Adak, B; Mustafa, B; Tezelli, K; Ozdooan, S; Ünal, Ö
Effect of Transcutaneous Electrical Nerve Stimulation (Tens) on Barthel Activities of Daily Living (Adl) Index Score Following Stroke
(Sage Publications Ltd, 1998) Tekeoglu, I; Adak, B; Goksoy, T
Objective: To evaluate the effectiveness of transcutaneous electrical nerve stimulation (TENS) and placebo TENS on the level of activities of daily living (ADL) of stroke patients. Setting: A university hospital. Patients: Patients who had had a stroke 30-240 days before entry to a university rehabilitation centre. Design: Controlled design with block randomization and blinded assessment. Intervention: All patients had Todd-Davies exercises. In group 1 (n = 30) TENS with frequency of 100 Hz was used at an intensity that the patient could tolerate; in group 2 (n = 30) patients were given placebo TENS. The treatment protocol consisted of 40 sessions (eight weeks). Outcomes: The Barthel Index for daily living activities was used to measure functional changes over time, and the Ashworth Scale was used to measure spasticity in the elbow, knee and ankle. These measurements were made prior to and following the treatment by assessors unaware of the patient's group allocation. Results: There were 30 patients in each group. Patients in group 1 (active TENS) were more disabled at entry to the study. Statistically significant improvements were recorded in all parameters such as feeding, transfer, hygiene, toileting, bathing, walking, climbing stairs, dressing, bowel and bladder care for group 2 (p<0.001) but only in some items in group 2. The change in total score was significant in both groups but the difference in the change score between the two groups was statistically significant (p<0.001). Spasticity was reduced in the active treatment group. Conclusion: TENS appears to be an effective adjunct in the regaining of motor functions and improving ADL in hemiplegic patients, but the accidental imbalance in severity of disability at entry makes interpretation uncertain.
Fibromyalgia Frequency in Hepatitis B Carriers
(Lippincott Williams & Wilkins, 2005) Adak, B; Tekeoglu, I; Ediz, L; Budancamanak, M; Yazgan, T; Karahocagil, K; Demirel, A
Background: Fibromyalgia (FM) is characterized by diffuse musculoskeletal pain, fatigue, morning stiffness, and sleep disturbance. Chronic viral infections may trigger FM symptoms. Objectives: In this study, we aimed to evaluate whether there was an association between HBsAg seropositivity and fibromyalgia syndrome. Methods: Fifty hepatitis B carriers (HBsAg positivity and anti-HBs negativity in sera for at least 6 months) and 50 age- and sex-matched HbsAg-negative control subjects were enrolled in this study. The hepatitis B carriers with normal or slightly elevated aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were recruited from the infectious diseases outpatient clinic and the control group was recruited from the physical medicine and rehabilitation outpatient clinic. The relationship between groups was calculated by independent Student t test, chi-squared test, and Fisher exact test for comparing proportions. Alpha criterion for significance was set at P < 0.05. Results: There was no statistically significant difference between the groups according to sex, mean age, body mass index, serum ALT, and AST levels (P > 0.05). FM syndrome and FM-associated symptoms were much more prevalent in the hepatitis B group (P < 0.001). Conclusion: The present study suggests that chronic hepatitis B carriage appears to increase the risk of FM and many of the typically associated symptoms. Whether this association is related to altered liver function, viral infection, concerns associated with chronic disease, or other factors, physicians should be aware of this apparent association.
Hypnotizability, Pain Threshold, and Dissociative Experiences
(Elsevier Science inc, 1998) Agargün, MY; Tekeoglu, I; Kara, H; Adak, B; Ercan, M
Background: There may be all association between pain threshold, hypnotizability, and dissociative experiences. The purpose of the present study was to examine this association. Methods: Forty-one healthy subjects were included in the study, Pain thresholds M!ere determined using a manual algometer, The Dissociative Experiences Scale was administered to all subjects. Hypnotizability of the subjects was assessed by the eye roll sign of the Hypnotic Induction Profile. There were 14, 15, and 12 subjects in the Grade 1, 2, and 3 groups, respectively. Results: Highly hypnotizable subjects had lower pain thresholds and were more likely to report dissociative experiences than the less hypnotizable subjects. Conclusions: There is an association between pain threshold, hypnotizability, and dissociative experiences It may be suggested that dissociative and somatic symptoms may be integrally linked and related to hypnotic suggestibility. Biol Psychiatry 1998;44:69-71 (C) 1998 Society of Biological Psychiatry.
Increased Oxidative Stress in Patients With Familial Mediterranean Fever During Attack Period
(Makerere Univ, Coll Health Sciences,sch Med, 2011) Ediz, L.; Ozkol, H.; Tekeoglu, I; Tuluce, Y.; Gulcu, E.; Koyuncu, I
Objectives: We aimed to investigate the status of oxidant and antioxidants during attack period (AP) and attack free periods (AFP) in Familial Mediterranean fever (FMF) patients. Methods: Measured the levels of malondialdehyde (MDA), protein carbonyl (PC), glutathione (GSH) and antioxidant vitamins (A,C and E) as well as the activities of catalase (CAT) and glutathione peroxidase (GSH-Px) in serum and whole blood of FMF patients in FMF-AP and FMF-AFP. Results: Levels of MDA and PC were found significantly higher (p <0.05) both in serum and whole blood of FMF-AP group compared with other groups. The CAT and GSH-Px activities in FMF-AP group were found markedly lower (p <0.05) comparing to HC group. However, there were no statistically significant differences between the groups in terms of antioxidant vitamin levels. Conclusions: Our study demonstrated increased oxidative stress in patients with FMF during AP. Investigations are needed to establish the effect of antioxidant supplementation on FMF attack frequency and severity. We also suggest that these increased MDA and PC levels and decreased antioxidants may be used as supportive markers to differentiate AP from AFP. These conclusions need to be validated in further multicenter studies with high number of FMF patients.
Progressive Pseudorheumatoid Chondrodysplasia: a Hereditary Disorder Simulating Rheumatoid Arthritis
(Springer verlag, 1998) Adak, B; Tekeoglu, I; Sakarya, ME; Ugras, S
Progressive pseudorheumatoid chondrodysplasia is a rare hereditary disorder. This autosomal recessive condition is characterised by progressive arthropathy and platyspondyly. The symptoms are similar to those of rheumatoid arthritis but synovitis is absent. In this study a patient with inherited progressive pseudorheumatoid chondrodysplasia is presented.
Seasonal Disease Activity and Serum Vitamin D Levels in Rheumatoid Arthritis, Ankylosing Spondylitis and Osteoarthritis
(Makerere Univ, Fac Med, 2013) Yazmalar, L.; Ediz, L.; Alpayci, M.; Hiz, O.; Toprak, M.; Tekeoglu, I
Background: Vitamin D is a steroid hormone that plays essential roles in calcium and phosphorus metabolism, bone formation and mineralization homeostasis, also has a role in the maintenance of immune-homeostasis. Objective: We aimed to investigate seasonal serum vitamin D levels and seasonal disease activity in patients with Rheumatoid Arthritis, Ankylosing Spondylitis, and Osteoarthritis. Methods: Seventy-one Rheumatoid Arthritis patients, 72 Ankylosing Spondylitis patients, 74 knee Osteoarthritis patients and 70 healthy controls were recruited for the study. Bi-seasonal measurements of serum 25(OH)D vitamin were checked in either in July or August or September for summertime and either in December or January or February for wintertime. Disease activity were evaluated by Disease Activity Score-28, Bath Ankylosing Spondylitis Disease Activity Index, and Western Ontario and McMaster Universities Osteoarthritis Index in groups of Rheumatoid Arthritis, Ankylosing Spondylitis, and Osteoarthritis respectively. Results: We did not find any correlation between serum 25(OH)D levels and Disease Activity Score-28, Bath Ankylosing Spondylitis Disease Activity Index, and Western Ontario and McMaster Universities Osteoarthritis Index scores in winter and summer. The difference of Disease Activity Score-28 and Western Ontario and McMaster Universities Osteoarthritis Index scores between winter and summer seasons were not significant in Rheumatoid Arthritis and Osteoarthritis patients (p>0.05). The mean Bath Ankylosing Spondylitis Disease Activity Index score was significantly higher in winter than in summer (p<0.05). Consequently we did not find any correlation between variations of seasonal serum 25(OH)D and the disease activity in the patients with Rheumatoid Arthritis, Ankylosing Spondylitis, and Osteoarthritis. Conclusion: These results suggest that vitamin D does not have an important role in the seasonal disease activity of these diseases and that seasonal changes in disease activity may play an important role in evaluating Ankylosing Spondylitis patients rather than Rheumatoid Arthritis and Osteoarthritis patients and should be taken into account when examining these patients. These conclusions need to be validated in multicenter studies with high number of patients.
Traumatic Spinal Cord Injuries in Turkey
(Nature Publishing Group, 2000) Karacan, I; Koyuncu, H; Pekel, Ö; Sümbüloglu, G; Kirnap, M; Dursun, H; Tekeoglu, I
Study design: An epidemiological study conducted all over the country. Objective: The present retrospective study was conducted to survey the new traumatic spinal cord injury (SCI) cases during 1992 in Turkey. Setting: Intensive care units, emergency services and departments of orthopaedic surgery, neurosurgery and rehabilitation of state hospitals, rehabilitation centers: military and university hospitals. Methods: Postal questionnaires were used for data collection and the records from medical institutes nation-wide were reviewed for the analysis of the epidemiological factors. Results: Five hundred and eighty-one new traumatic SCI cases were reported in 1992. The annual incidence was found to be 12.7 per million population. Male to female ratio was 2.5 : 1 and the average age at injury was 35.5+/-15.1 (35.4+/-14.8 for males and 35.9+/-16.0 for females). The most common cause of injury was motor vehicle accidents (48.8%) followed by falls (36.5%), stab wounds (3.3%), gunshot injuries (1.9%) and injuries from diving (1.2%). One hundred and eighty-seven patients (32.18%) were tetraplegic and 394 patients (67.8%) were paraplegic. The most common level of injury was C5 among tetraplegics and T12 among paraplegics. The most prevalent associated injury was head trauma followed by extremity fractures. Severe head trauma resulting in death may obscure the real incidence of SCI and may cause underreporting of cases in epidemiological studies. Conclusion: Considering that motor vehicle accidents and falls were found to be the leading causes of traumatic SCI, it was concluded that the prevention measures should be focused mainly on these in order to reduce the frequency of SCI in Turkey.