Browsing by Author "Toprak, M."

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Aseptic Spondylodiscitis (Andersson Lesion) Mimicking Vertebral Malignancy: Case Report
(2009) Hiz, Ö.; Toprak, M.; Erden, M.; Alpayci, M.; Tekeoǧlu, I.
A well known complication in cases with ankylosing spondylitis is the development of vertebral and discovertebral lesions localized on the spine. In this report, we have presented a 24 year-old case that had undergone an operative procedure four years ago with the pre-diagnosis of malignancy of the vertebrae, but which had later turned out to be non-malignant after histopathological examinations. The case was diagnosed as ankylosing spondylitis due to the presence of radiological findings of romanus lesion and spondylodiscitis (Andersson lesion), continuous back pain and morning stiffness. When a vertebral-intervertebral disc lesion is detected in cases with chronic back pain, clinical, radiological and laboratory findings should be evaluated together and aseptic spondylodiscitis due to AS should be kept in mind. Copyright © 2009 by Türk Tibbi Rehabilitasyon Kurumu Derneǧi.
Coexistence of Familial Mediterranean Fever and Guillain Barre Syndrome
(Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Tunçekin, İ.; Toprak, M.
Familial Mediterranean Fever (FMF) is the most common autoinflammatory disease characterized by recurrent episodes of abdomin al pain, fever and serositis. FMF is an autosomal recessively inherited and self-limiting disease. It is more common in countries around the Mediterranean. Guillain Barre Syndrome (GBS) is an acute, immune-mediated polyneuropathy affecting peripheral nerves and nerve roots. GBS is usually characterized by progressive flaccid paralysis and decreased deep tendon reflexes. Central nervous system involvement is not common in the course of FMF. Guillain Barre Syndrome developed in a patient who was followed with colchicine treatment fo r 1 year due to Familial Mediterranean Fever. In the literature review, no association of these two dise ases was found. This case is presented to draw attention to the coexistence of immune-mediated Familial Mediterranean Fever and Guillain Barre Syndrome. In this case, it was thought that two inflammatory diseases may have affected each other or autoinflammatory diseases can be seen together. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
A Comparative Perspective on Brucellar, Pyogenic, and Tuberculous Spondylodiscitis
(Verduci Editore s.r.l, 2024) Baran, A.I.; Celik, M.; Arslan, Y.; Incecik, S.; Binici, I.; Toprak, M.; Sunnetcioglu, M.
OBJECTIVE: Non-specific features of spondylodiscitis lead to a delay and challenge in the diagnosis/differential diagnosis/treatment processes, and thus, serious complications may arise. This study aims to compare brucellar, pyogenic, and tuberculous types of spondylodiscitis, considering their demographic, clinical, and laboratory differences. This may provide more rapid management and good outcomes. PATIENTS AND METHODS: A total of 131 patients with infectious spondylodiscitis were included in the study. The patients were divided into brucellar (n=63), pyogenic (n=53), and tuberculous (n=15) types of spondylodiscitis and compared for demographic, clinical, laboratory, and imaging features. RESULTS: Tuberculous spondylodiscitis had higher scores for weight loss, painless palpation, thoracic spine involvement, and psoas abscess formation than other spondylodiscitis. Also, tuberculous spondylodiscitis had higher rates of neurologic deficit and lower rates of lumbar involvement than brucellar spondylodiscitis. Pyogenic spondylodiscitis is more likely to occur in patients who have a history of spine surgery compared to other forms of spondylodiscitis. Also, pyogenic spondylodiscitis had higher rates of fever, erythema, paraspinal abscess, white blood cell (WBC), and erythrocyte sedimentation rate (ESR) than brucellar spondylodiscitis. On the other hand, brucellar spondylodiscitis had higher rates of rural living and sweating than pyogenic spondylodiscitis. CONCLUSIONS: Weight loss, painless palpation, involved thoracic spine, psoas abscess, and neurologic deficit are symptoms favoring tuberculous spondylodiscitis. History of spine surgery, high fever, skin erythema, and paraspinal abscess are findings in favor of pyogenic spondylodiscitis. Rural living, sweating, and involved lumbar spine are symptoms that indicate brucellar spondylodiscitis. These symptoms can be used to distinguish the types of spondylodiscitis. © 2024 Verduci Editore s.r.l. All rights reserved.
Effect of Weekly Alendronate on Knee Symptoms in Patients With Osteoporosis and Knee Osteoarthritis Coexistence
(2010) Ediz, L.; Hiz, Ö.; Toprak, M.; Tekeoǧlu, I.
Aim: The aim of this study was to examine the effect of alendronate 70 mg weekly on knee symptoms in elderly women with osteoporosis and knee OA coexistence. Material and Methods: Elderly women who diagnosed as osteoporosis between 60-75 years old, underwent radiography of the knee if they reported symptoms of knee OA. Radiographs were read for Kellgren and Lawrence grade and individual features of OA. Osteoporotic patients with Knee OA treated with 70 mg alendronate once weekly for one year. Knee symptoms were assessed by interview before the treatment and 6 and 12 months after the treatment, and knee pain severity was evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Lequense index, VAS at rest and at movement. Results: Alendronate 70 mg once weekly use was associated with less severity of knee pain as assessed by WOMAC scores, Lequense index, VAS at rest and at movement at 6th and 12th month assessments. Conclusion: This current study has shown that Alendronate 70 mg once weekly use was associated with less severity of knee symptoms in elderly women with osteoporosis and knee OA coexistence. Additional long-term randomised, placebo controlled clinical trials are needed to confirm this effect of weekly Alendronate.
Investigation of Relationship Between Lumbar Modic Changes and Serum Vitamin D Concentrations
(Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Ilter, S.; Delen, V.; Toprak, M.; Akçalı, R.
Introduction: There is limited and inconsistent data on the relationship between vitamin D deficiency and Modic changes (MCs). Also, which type of MCs is associated with vitamin D is not clear. Vitamin D has anti-inflammatory effects, while type 1 MCs has inflammatory nature. Accordingly, patients with type 1 may have lower vitamin D levels than those with type 2 MCs. This study aimed to com pare type 1 and type 2 MCs for serum vitamin D concentrations. Materials and Methods: Between May 2019 and July 2020, a total of 53 patients with type 1 or type 2 MCs were included in this study. Patients’ demographics were recorded, and back pain severity was assessed by using visual analog scale. Serum levels of vitamin D were measured as total 25-hydroxy vitamin D. Accordingly, serum levels of vitamin D (µg/L) are graded as deficient (<20), insufficient (20-30), and sufficient (30-80). Results: Type 1 MCs (n=26) and type 2 MCs (n=27) groups were similar in age (p=0.199), gender, BMI, work status, pain duration, vitamin D concentration, degree of vitamin D deficiency (p=0.773), and spinal levels. Type 1 MCs patients had more painful low back than type 2 MCs patients. Conclusion: Type 1 MCs are similar to type 2 MCs for serum vitamin D concentration. The more painful low back of type 1 MCs may be related to its inflammatory nature, but may not be associated with vitamin D insufficiency. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Musculoskeletal Health Committee Report on Evaluation of Musculosketeal Disability in Van
(Yuzuncu Yil Universitesi Tip Fakultesi, 2019) Toprak, M.; Erden, M.
Our aim in this study report of the medical board is to evaluate the characteristics of disabled people with musculoskeletal disability related to age, sex, and to determine the reasons for the application. Between January 01, 2014, and June 31, 2014, a total of 4717 patients admitted to the health board of our hospital were retrospectively reviewed by using hospital information system and health board report records. 2703 patients evaluated from 4717 patients were male (57.3%), 2014 were women (42.7%) and the mean age was 40.75 ± 6.06 years. The most common reason for admission to disabled Health Board in 2074 (43.9%) was to take advantage of the law and in 1903 (40.3%) were identified as to benefit from self care salaries. The most common excuse presenting symptoms were as; osteoarthritis 584 (19.7%), cerebral palsy 387 (13.1%), hemiplegia 291 (9 .8%) and developmental dysplasia of the hip 241 (8.2%), respectively. Severe disability rate 726 (15.4%) was found. The permanent disability rate was found to be 64.4% (n=3045). Musculoskeletal disability is a major problem in our country as in the whole w orld. This study aimed to contribute to the musculoskeletal system disability epidemiologically. We need to take necessary measures for the musculoskeletal system disabilities, necessary laws, training and physical measures and social and physical rehabili tation of disabled people. © 2019, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Postpartum Septic Sacroiliitis: a Case Report
(2007) Tekeoǧlu, I.; Toprak, M.
In this report we presented a patient with post-partum sacroiliitis. Pyogenic sacroiliitis occurs infrequently during the peripartum period. Pyogenic sacroiliitis often presents unilaterally, but it can also occur bilaterally. It is usually accompanied with pain in the buttocks. A 28-year-old female patient gave birth to her fourth child through vaginal delivery. Eight days postpartum, she had pyrexia, sweating, coxalgia and low back pain. On admission she had tenderness in the left hip and sacral area with a body temperature of 38.5 °C, a total white cell count of 21.800/mm3, a C-reactive protein level of 120 mg/dl (N: 0-5), and an erythrocyte sedimentation rate of 40 mm/h. She was found negative for brucellosis. The patient who had been hospitalized in the infection disease clinic due to high fever on the postpartum eighth day was transferred to Physical Medicine and Rehabilitation/Rheumatology clinic because of hip and low back pain on the postpartum twentieth day. Sacroiliac magnetic resonance imaging examination was consistent with left sacroiliitis and fluid collection in left psoas muscle. She responded positively to the treatment, obviating any need to artrosynthesis.
The Relationship Between Shoulder Impingement Syndrome and Sleep Quality
(verduci Publisher, 2013) Tekeoglu, I.; Ediz, L.; Hiz, O.; Toprak, M.; Yazmalar, L.; Karaaslan, G.
BACKGROUND AND OBJECTIVES: The aim of this study was to examine potential relationship between subjective sleep quality and degree of pain in patients with shoulder impingement syndrome (SIS). MATERIALS AND METHODS: Fourty patients with shoulder impingement syndrome were evaluated using the Pittsburgh Sleep Quality Index (PSQI) and the Shoulder Disability Questionnaire (SDQ). Forty three of age and sex matched healthy subjects were included in the control group. RESULTS: There was a significant difference between the patient and control groups in terms of all PSQI global scores and subdivisions (p < 0.01). The pain scores assessed by SDQ were positively correlated with the scores for subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, and sleep disturbance (r = 0.49/p < 0.01, r = 0.44/p < 0.01, r = 0.36/p < 0.05, r = 0.40/p < 0.05, and r = 0.37/p < 0.05 respectively). The comparison of total SDQ pain and global PSQI scores also revealed a significant correlation (r = 0.54/p < 0.01). CONCLUSIONS: Subjective sleep disturbance connected to shoulder pain was found obviously in patients with SIS. For this reason, patients with shoulder pain due to SIS may benefit from the pain killers and cognitive-behavioral interventions that specifically target sleep disturbances. Further studies which contain polysomnographic assessments, as well as determine psychologic status are still needed to put forth sleep quality in patients with SIS.
Restless Legs Syndrome in Behcet's Disease
(Field House Publishing Llp, 2011) Ediz, L.; Hiz, O.; Toprak, M.; Ceylan, M. F.; Yazmalar, L.; Gulcu, E.
The prevalence of restless legs syndrome (RLS) and its association with the clinical features of Behcet's disease (BD) has not previously been elucidated. The inflammatory character, central nervous system involvement and neuropathies of BD led to this investigation of RLS risk in BD patients. A total of 116 BD patients and 104 healthy control subjects were included; seven BD patients were excluded because of concurrent diseases, pregnancy or alcohol misuse that might cause RLS symptoms, and the remaining 109 BD patients were included in the analysis. The prevalence of RLS was significantly higher in patients with BD (32/109; 29.4%) than in controls (5/104; 4.8%). No significant differences were found between BD patients with and without RLS with regard to the clinical features of BD. RLS severity positively correlated with age in BD patients. In conclusion, BD-related RLS should be considered in symptomatic RLS secondary to rheumatological disorders and BD patients should be examined for RLS. Further studies are needed to clarify the pathogenetic mechanisms underlying BD-related RLS.
A Route of Genotyping of Entamoeba Histolytica
(Blackwell Publishing, 2007) Tanyuksel, M.; Ulukanligil, M.; Toprak, M.; Ali, I. K. M.; Araz, E.; Guclu, Z.; Petri, W. A., Jr.
Seasonal Disease Activity and Serum Vitamin D Levels in Rheumatoid Arthritis, Ankylosing Spondylitis and Osteoarthritis
(Makerere Univ, Fac Med, 2013) Yazmalar, L.; Ediz, L.; Alpayci, M.; Hiz, O.; Toprak, M.; Tekeoglu, I
Background: Vitamin D is a steroid hormone that plays essential roles in calcium and phosphorus metabolism, bone formation and mineralization homeostasis, also has a role in the maintenance of immune-homeostasis. Objective: We aimed to investigate seasonal serum vitamin D levels and seasonal disease activity in patients with Rheumatoid Arthritis, Ankylosing Spondylitis, and Osteoarthritis. Methods: Seventy-one Rheumatoid Arthritis patients, 72 Ankylosing Spondylitis patients, 74 knee Osteoarthritis patients and 70 healthy controls were recruited for the study. Bi-seasonal measurements of serum 25(OH)D vitamin were checked in either in July or August or September for summertime and either in December or January or February for wintertime. Disease activity were evaluated by Disease Activity Score-28, Bath Ankylosing Spondylitis Disease Activity Index, and Western Ontario and McMaster Universities Osteoarthritis Index in groups of Rheumatoid Arthritis, Ankylosing Spondylitis, and Osteoarthritis respectively. Results: We did not find any correlation between serum 25(OH)D levels and Disease Activity Score-28, Bath Ankylosing Spondylitis Disease Activity Index, and Western Ontario and McMaster Universities Osteoarthritis Index scores in winter and summer. The difference of Disease Activity Score-28 and Western Ontario and McMaster Universities Osteoarthritis Index scores between winter and summer seasons were not significant in Rheumatoid Arthritis and Osteoarthritis patients (p>0.05). The mean Bath Ankylosing Spondylitis Disease Activity Index score was significantly higher in winter than in summer (p<0.05). Consequently we did not find any correlation between variations of seasonal serum 25(OH)D and the disease activity in the patients with Rheumatoid Arthritis, Ankylosing Spondylitis, and Osteoarthritis. Conclusion: These results suggest that vitamin D does not have an important role in the seasonal disease activity of these diseases and that seasonal changes in disease activity may play an important role in evaluating Ankylosing Spondylitis patients rather than Rheumatoid Arthritis and Osteoarthritis patients and should be taken into account when examining these patients. These conclusions need to be validated in multicenter studies with high number of patients.
Sleep Quality, Pain, Anxiety, Depression and Quality of Life in Patients With Frozen Shoulder
(Ios Press, 2019) Toprak, M.; Erden, M.
Background: Nocturnal shoulder pain could play an essential role in frozen shoulder (FS) and can lead to disturbed sleep, anxiety, depression and reduced quality of life (QoL). OBJECTIVE: The aim of this study was to examine anxiety, depression, sleep quality and quality of life in patients with FS and compare these to healthy controls. METHODS: We prospectively evaluated 148 participants (76 FS patients and 72 healthy controls). We obtained Visual Analogue Scale (VAS) pain score, Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Pittsburgh Sleep Quality Index (PSQI) and World Health Organization Quality of Life Scale short form (WHOQoL-BREF). RESULTS: FS patients had significantly higher scores for VAS and BAI (p < 0.001) than the control group. There was no significant difference between the BDI scores of the groups (p = 0.067). The WHOQoL-BREF scale of the physical, mental and environmental fields were significantly lower in the FS group (p < 0.001). FS patients had significantly lower sleep efficiency, and sleep disorders in terms of PSQI section scores (p < 0.001). CONCLUSION: Our study demonstrated that there is a high prevalence and close relationships of pain, anxiety and sleep disturbance in patients with FS. Adding a psychiatric evaluation to the treatment of patients with FS may be beneficial.