Coexistence of Familial Mediterranean Fever and Guillain Barre Syndrome

Abstract

Familial Mediterranean Fever (FMF) is the most common autoinflammatory disease characterized by recurrent episodes of abdomin al pain, fever and serositis. FMF is an autosomal recessively inherited and self-limiting disease. It is more common in countries around the Mediterranean. Guillain Barre Syndrome (GBS) is an acute, immune-mediated polyneuropathy affecting peripheral nerves and nerve roots. GBS is usually characterized by progressive flaccid paralysis and decreased deep tendon reflexes. Central nervous system involvement is not common in the course of FMF. Guillain Barre Syndrome developed in a patient who was followed with colchicine treatment fo r 1 year due to Familial Mediterranean Fever. In the literature review, no association of these two dise ases was found. This case is presented to draw attention to the coexistence of immune-mediated Familial Mediterranean Fever and Guillain Barre Syndrome. In this case, it was thought that two inflammatory diseases may have affected each other or autoinflammatory diseases can be seen together. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.