Browsing by Author "Turan, Mahfuz"

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Assessment of Adenosine Deaminase (Ada) Activity and Oxidative Stress in Patients With Chronic Tonsillitis
(Springer, 2014) Garca, Mehmet Fatih; Demir, Halit; Turan, Mahfuz; Bozan, Nazim; Kozan, Ahmet; Belli, Aeyda Bayel; Cankaya, Hakan
To emphasize the effectiveness of adenosine deaminase (ADA) enzyme, which has important roles in the differentiation of lymphoid cells, and oxidative stress in patients with chronic tonsillitis. Serum and tissue samples were obtained from 25 patients who underwent tonsillectomy due to recurrent episodes of acute tonsillitis. In the control group, which also had 25 subjects, only serum samples were taken as obtaining tissue samples would not have been ethically appropriate. ADA enzyme activity, catalase (CAT), carbonic anhydrase (CA), nitric oxide (NO) and malondialdehyde (MDA) were measured in the serum and tissue samples of patients and control group subjects. The serum values of both groups were compared. In addition, the tissue and serum values of patients were compared. Serum ADA activity and the oxidant enzymes MDA and NO values of the patient group were significantly higher than those of the control group (p < 0.001), the antioxidant enzymes CA and CAT values of the patient group were significantly lower than those of the control group (p < 0.001). In addition, while CA, CAT and NO enzyme levels were found to be significantly higher in the tonsil tissue of the patient group when compared to serum levels (p < 0.05), there was no difference between tissue and serum MDA and ADA activity (p > 0.05). Elevated ADA activity may be effective in the pathogenesis of chronic tonsillitis both by impairing tissue structure and contributing to SOR formation.
The Association of Obesity With Hearing Thresholds in Women Aged 18-40 Years
(Springer, 2016) Ucler, Rifki; Turan, Mahfuz; Garca, Fatih; Acar, Ismail; Atmaca, Murat; Cankaya, Hakan
An elevation in hearing thresholds and decrease in hearing sensitivity in adults, particularly due to aging, are quite common. Recent studies have shown that, apart from aging, various other factors also play a role in auditory changes. Studies on the association of hearing loss (HL) with obesity are limited in advanced age cases and present contradictions. In this study, the association between obesity and hearing thresholds in women aged 18-40 years has been assessed. Forty women diagnosed with obesity (mean age, 31.8 years) and 40 healthy non-obese female controls (mean age, 30.5 years) were included in this prospective study. Each subject was tested with low (250, 500, 1000 and 2000 Hz) and high (4000, 6000 and 8000 Hz) frequency audiometry. In the case and control groups, the average hearing thresholds at low frequencies were 16.03 +/- A 4.72 and 16.15 +/- A 2.72 (p = 0.885) for the right ear, respectively, and 16.15 +/- A 5.92 and 14.71 +/- A 3.18 (p = 0.180) for the left ear, respectively. The average hearing threshold levels at high frequencies were 20.70 +/- A 10.23 and 15.33 +/- A 3.87 (p = 0.003), respectively, for the right ear, and 22.91 +/- A 15.54 and 15.87 +/- A 4.35 (p = 0.007), respectively, for the left ear with statistical significance. This is the first report on the association of obesity with hearing threshold in women aged 18-40 years. We have demonstrated that obesity may affect hearing function, particularly that related to high frequencies. Hearing loss can be prevented by avoidance or control of obesity and its risk factors. Moreover, an auditory screening of obese cases at an early stage may provide early diagnosis of HL and may also contribute to their awareness in the fight against obesity.
Baş-boyunda Cilde Fistülize Olmuş Tularemi Olgu Sunumu
(2015) Bozan, Nazım; Turan, Mahfuz; Yuca, Köksal; Gür, Mehmet Hafit; Çankaya, Hakan
Tularemi Kulak Burun ve Boğaz (KBB) kliniklerinde nadir olarak görülen bir zoonozdur ve çeşitli formları mevcutdur; ülseroglandüler, orofarengeal, pnömotik ve septik form. Tularemi, etkeni Francisella tularensis olan zoonotik bir hastalıktır. Francisella tularensis gram-negatif, hareketsiz bir kokobasildir. Hastalığın bulaş yolları; kirli sular, kemirgenler, tavşan, kene, sivrisinek, kaplumbağa, koyun, inek, kuşlar ve geyik gibi hayvanlardır. Bu çalışmamızda baş boyun cildine fistülize olmuş ve aldığı çeşitli antibiyoterapilere rağmen düzelmeyen ve kontamine su tüketimi hikayesi olan bir tularemi olgusu sunulmuştur.
Blood Prestin Levels in Covid-19 Patients
(Lippincott Williams & Wilkins, 2023) Turan, Mahfuz; Alp, Hamit Hakan; Yildiz, Hanifi; Baran, Ali Irfan; Ekin, Selami; Akin, Ramazan; Bozan, Nazim
Background: Many studies have found that viral infections affect different tissues, including the inner ear. Coronavirus disease 2019 (COVID-19), a viral infection, is a significant health problem worldwide. Prestin is a motor protein with important functions both in the outer hair cells of the inner ear and in cardiac tissue. In addition, prestin is promising as an early biomarker in the detection of ototoxicity. To determine the severity of infection in COVID-19 patients and to determine whether other tissues are affected by the infection, lactate dehydrogenase (LDH), C-reactive protein (CRP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase MB (CK-MB), biochemical markers such as ferritin and D-dimer are used. This study aimed to compare prestin levels in patients with COVID-19 and healthy volunteers.Methods: In blood samples taken from 45 patients diagnosed with COVID-19 and 40 healthy volunteers, prestin levels were determined with the kit that used an enzyme-linked immunosorbent assay method and was commercially available. At the same time, LDH, CRP, ALT, AST, CK-MB, ferritin, and D-dimer levels were also detected in both patients and healthy control groups and correlations with prestin levels were examined.Results: The main result of our study is that serum prestin levels in COVID-19 patients are significantly higher than in healthy controls (p < 0.001). In addition, a statistically significant strong positive correlation was found between prestin-LDL (r = 0.537, p = 0.001), prestin-CRP (r = 0.654, p = 0.001), and prestin-D-dimer (r = 0.659, p = 0.001).Conclusion: The levels of prestin, a motor protein in inner ear outer hair cells and cardiac myocytes, were found to be higher in COVID-19 patients than in healthy volunteers. It also showed a positive correlation with CRP and D-dimer. This may be associated with systemic dysfunction.
Can Extracorporeal Shock Wave Therapy Be Effective in Temporomandibular Joint Disorder?: a Pilot Study
(Lippincott Williams & Wilkins, 2024) Keskin Tunc, Serap; Unalan Degirmenci, Beyza; Bilen, Mustafa; Toprak, Mehmet Emin; Kaplan, Sehmus; Turan, Mahfuz
Background:This study aimed to compare extracorporeal shock wave therapy (ESWT) with the use of stabilization splint in nonsurgical temporomandibular disorders treatments, and to evaluate the effects.Methods:In this study, individuals, who are diagnosed with disc displacements with reduction according to the diagnostic criteria for temporomandibular disorder examination criteria. The patients in the first control group (n = 36) were applied a medical treatment + stabilization splint. The second group (n = 25) was applied the ESWT (2 days a week for 4 weeks) + medical treatment + stabilization splint. Visual Analog Scale scores, painless maximum painless mouth opening, and passive-forced mouth opening measurements were recorded for the first and second weeks.Results:The ESWT application significantly contributed to pain-reducing (Visual Analog Scale) in patients at short notice (P = .030) in the second group. There were statistically significant differences between the groups in painless maximum active mouth opening (P = .009) and passive forced measurements (P = .004) in the second week.Conclusion:This pilot study showed that short-term ESWT addition to stabilization splint and medical treatment may yield satisfactory outcomes.
Effect of Inhaled Steroids on Laryngeal Microflora
(Taylor & Francis Ltd, 2016) Turan, Mahfuz; Ekin, Selami; Ucler, Rifki; Arisoy, Ahmet; Bayram, Yasemin; Yalinkilic, Abdulaziz; Cankaya, Hakan
Conclusions As is known, this study is the first study to evaluate the effect of inhaled steroids on laryngeal microflora. The data support that ICS usage causes changes in the larynx microflora. Purpose The aim of this study was to determine the alteration in larynx microbial flora of the patients treated with ICS comparing the culture results of a control group. In addition, laryngeal microflora was compared to the smears obtained from the vallecula and pharynx. Materials and methods The study included 39 patients (mean age = 45.5 +/- 12.76 years) who had been using a corticosteroid inhaler and control group consisting of 27 persons (mean age = 43.07 +/- 13.23 years). Culture samples were obtained from the pharynx, larynx, and vallecula in the patient and control groups, and they were evaluated in the microbiology laboratory. Obtained culture results were named by the same microbiologist according to the basic microorganism classification method. ResultsCoagulase-negative staphylococci (CNS), Streptococcus viridians (VGS) and candida albicans were detected to grow significantly more in the patient group in all three anatomic localizations compared to the control group. Neisseria spp, basillus spp, and Non-viridans alpha-hemolytic streptococcus were detected to grow significantly more in the control group in all three anatomic localizations compared to the patient group.
The Effect of Nitrous Oxide on the Outcomes of Underlay Tympanoplasty: a Prospective Study
(Sage Publications inc, 2019) Duzenli, Ufuk; Bozan, Nazim; Turan, Mahfuz; Agirbas, Semra; Tekeli, Arzu Esen; Kiroglu, Ahmet Faruk
The main aims of tympanoplasty are eradication of chronic middle ear disease, repair of the tympanic membrane, and restoration of hearing. Nitrous oxide (N2O) is not a commonly preferred anesthetic agent for tympanoplasty because this agent may increase middle ear pressure and displace the graft. In this study, we researched the surgical outcomes of the underlay tympanoplasty performed with N2O anesthesia. Patients who underwent tympanoplasty were included in this prospective study. A type 1 tympanoplasty was performed in all patients using the underlay technique. Patients were randomized to groups that did and did not receive N2O. Preoperative and postoperative hearing thresholds were evaluated, postoperative pain scores were recorded, and the differences between the groups were statistically evaluated. There were 44 patients who received N2O and 44 who did not. The graft success rate was 93.2% in the N2O-receiving group and 84.1% in the nonreceiving group (P > .05). Hearing levels improved significantly after surgery in each group (P < .05), but the difference between the groups was not significant (P > .05). The postoperative pain score was 3.72 +/- 1.3 in the N2O-receiving group and 4.45 +/- 2.3 in the nonreceiving group (P > .05). Nitrous oxide is a cheap, safe, and readily available anesthetic agent that provides acceptable success rates in patients undergoing tympanoplasty.
Effect of Silver Nitrate Application on the Success of Endoscopic Dacryocystorhinostomy
(Sage Publications inc, 2022) Cetin, Yaser S.; Akin, Ramazan; Duzenli, Ufuk; Turan, Mahfuz; Bozan, Nazim
Objectives To compare the clinical outcomes of patients undergoing additional procedures in endoscopic endonasal dacryocystorhinostomy (End-DCR) surgery and discuss the factors affecting the success of End-DCR surgery in light of relevant literature. Methods The study included 155 patients who underwent End-DCR surgery in our clinic due to epiphora. This was a prospective randomized, single-blind, controlled trial. Group I (control) included 54 patients who did not undergo silicone stent insertion or silver nitrate application, group II included 51 patients who underwent silicone stent insertion only, and group III included 50 patients who underwent silver nitrate application only. Statistical analysis was performed on follow-up data regarding anatomic and functional success rates. Results Revision surgery was performed in 16 patients who developed persistent epiphora in the postoperative period, including 6 in group I, 7 in group II, and 3 in group III (P = .4). The most common reason for revision surgery was stenosis of the neo-ostium (n = 8), followed by granulation tissue formation (n = 5) and synechia formation (n = 3). Granuloma formation was the most common postoperative complication, and a significant difference was found among the groups with regard to granuloma formation (P = .04). At postoperative month 12, the functional success rate was estimated to be 88%, 86%, and 94%, and the anatomic success rate was estimated to be 94%, 92%, and 96% in groups I, II, and III, respectively, with no significant difference, found among the 3 groups with regard to both rates (P = .79 and P = .76, respectively). Conclusion The results indicated that stenting and silver nitrate application did not affect surgical success. Our preliminary results on silver nitrate cauterization showed that it is an effective, inexpensive, and practical method to reduce granulation formation in the postoperative period.
The Effect of Tonsillectomy and Adenoidectomy on Right Ventricle Function and Pulmonary Artery Pressure by Using Doppler Echocardiography in Children
(Korean Soc Otorhinolaryngol, 2016) Acar, Onur Caglar; Uner, Abdurrahman; Garca, Mehmet Fatih; Ece, Ibrahim; Epcacan, Serdar; Turan, Mahfuz; Kalkan, Ferhat
Objectives. The purpose of the present study is to emphasize the efficacy of the myocardial performance index and tricuspid annular plane systolic excursion (TAPSE) in the determination of impaired cardiac functions and recovery period following the treatment in children with adenoid and/or tonsillar hypertrophy. Methods. Fifty-three healthy children after routine laboratory, imaging and clinical examinations, with adenoid and/or tonsillar hypertrophy were evaluated before and 3 months after adenotonsillectomy for cardiac functions using M mode and Doppler echocardiography. Results. The mean age of cases was 6.4 +/- 3.0 years, 34 (65%) were male, and 19 (35%) were female. Pulmonary hypertension was observed to be mild in 3 patients and moderate in 1 patient preoperatively. When the preoperative and postoperative echocardiographic measurements of the patients were compared, the tricuspid valve E wave velocity, the E/A ratio (E, early diastolic flow rate; A, late diastolic flow rate), and the TAPSE values were determined to be significantly higher postoperatively (P < 0.05). The tricuspid valve deceleration time, the isovolumetric relaxation time and the systolic pulmonary artery pressure were found to be significantly lower compared to the preoperative values (P < 0.05). Conclusion. Adenoidectomy and/or tonsillectomy may prevent cardiac dysfunctions that can develop in the later periods due to adenoid and/or tonsil hypertrophy in children, before the appearance of the clinical findings of cardiac failure.
Effects of Shock Waves on Oxidative Stress in Parotid Gland of Rat
(Sage Publications inc, 2014) Garca, M. Fatih; Kavak, Servet; Gecit, Ilhan; Meral, Ismail; Demir, Halit; Turan, Mahfuz; Cankaya, Hakan
This study was designed to investigate whether extracorporeal shock wave lithotripsy (ESWL) exposure to parotid gland produces an oxidative stress in parotid glands of rats. Twelve male Wistar-albino rats, 6 months of age with an average body weight of 250-300 g, were divided randomly into two groups, each consisting of six rats. The animals in the first group did not receive any treatment and served as control. The left parotid glands of animals in group 2 (ESWL treated) received a thousand 18 kV shock waves after anesthetizing the rats with 50 mg/kg of ketamine. The animals in both groups were killed 72 hours after the ESWL treatment, and the parotid glands were harvested for the determination of lipid peroxidation product malondialdehyde (MDA), antioxidant glutathione (GSH) levels and the activities of antioxidant enzymes such as superoxide dismutase (SOD), GSH-Px and catalase (CAT). It was found that MDA level increased in parotid glands of rats after the ESWL treatment. The SOD, GSH-Px and CAT enzyme activities, and the level of antioxidant GSH decreased in parotid gland of rats after the ESWL treatment. It was concluded that short-term ESWL treatment caused an increase in the free radical production and a decrease in the antioxidant enzyme activity in parotid glands of ESWL-treated rats.
The Evaluation of Oxidative Stress in the Serum and Tissue Specimens of Patients With Chronic Otitis Media
(Korean Soc Otorhinolaryngol, 2015) Garca, Mehmet Fatih; Turan, Mahfuz; Avsar, Baris; Kalkan, Ferhat; Demir, Halit; Kozan, Ahmet; Bozan, Nazim
Objectives. To underline the effect of oxidative stress in chronic otitis media with and without cholesteatoma and to compare the oxidative stress values in the serum and tissue specimens in these two faints. Methods. The study included a total of 75 individuals, 35 cases with chronic otitis media (COM; 16 females and 19 males) and a healthy control group of 40 cases (20 females and 20 males).The COM patient group was comprised of 18 patients with cholesteatoma and 17 patients without cholesteatoma. All patients underwent mastoidectomy. Serum specimens were taken prior to surgery and diseased tissue specimens from the ear were obtained during surgery from all patients. Only serum specimens were taken from the healthy control cases. The malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAI), and glutathione peroxidase (GHPx) were measured in the serum and tissue samples of the patient group and in the serum specimens of the control group. Results. The age ranged from 14 to 48 years in the patient group (mean age, 20.4 +/- 12.2 years) and from 19 to 40 years in the control group (mean age, 26.4 +/- d 4.64 years). When the serum values of all COM patients were compared with those of the control group, in the patient group MDA, which reflects lipid peroxidation, was found to be significantly higher (P<0.01) whereas the antioxidant enzymes SOD, CAT, and GHPx were found to be significantly lower (P<0.01).When the serum and tissue MDA, SOD, CAT, and GHPx values in patients with and without cholesteatoma were compared, no significant difference was found these parameters (P > 0.01). Conclusion. Although oxidative stress plays a role in the pathogenesis of COM with or without cholesteatoma, it may not reflect the severity of the disease. In patients with COM, the evaluation of only serum oxidative stress values without tissue evaluation may be sufficient for assessing oxidative stress.
Evaluation of Serum Prestin Level in Patients With Sudden Sensorineural Hearing Loss
(2019) Sonkaya, Yasin; Turan, Mahfuz
Giriş: Ani sensorinöral işitme kaybı (ASNİK), ani başlayan, tedavi edilmediğinde kalıcı işitme kaybına sebep olan, hastanın sosyal hayatını ve yaşam kalitesini bozan akut bir olaydır. Etyopatogenezde birçok faktör suçlanmış fakat halen tam olarak aydınlatılamamıştır. Bu yüzden halen kesinleşmiş bir tedavisi yoktur. Muhtemel etyolojiler göz önünde bulundurularak birçok ilacı barındıran kombine tedavi prosedürleri uygulanmaktadır. Erken dönem başlanan tedavinin en önemli prognostik faktörlerden biri olması erken tanıyı çok daha önemli kılmaktadır. Ani sensörinöral işitme kaybı gelişen hastalarda kokleadaki dış tüy hücreleri zarar görmektedir. Bu dış tüy hücrelerinin hareketinden sorumlu motor protein olan prestin molekülünün işitme kaybı ile ilişkisi önem arzetmektedir. Bu çalışmada ani sensorinöral işitme kaybı bulunan hastalarında serum prestin düzeyinin prognozu belirlemedeki değerini saptamak amaçlanmıştır. Gereç ve Yöntem: Bu çalışmaya Yüzüncü Yıl Üniversitesi Tıp Fakültesi Dursun Odabaş Tıp Merkezi K.B.B. Anabilim Dalı Polikliniği'ne başvurmuş ve Ani idiopatik sensorinöral işitme kaybı tanısı konulan 40 hasta birey vaka grubunu ve laboratuvarlara başvuran herhangi bir kalıtsal, edinsel veya kronik hastalığı bulunmayan yaş ve cinsiyetleri benzer 40 sağlıklı birey kontrol grubunu oluşturmak üzere çalışmaya dahil edilmiştir. Çalışmaya dahil edilen olgulardan açlık kanları, biyokimya tüplerine alındı. Alınan kanlar santrifüj edilerek serumları ayrıldı. Bu serumlardan prestin düzeyi ELISA yöntem ticari kit kullanılarak ölçüldü. Vaka grubuna tedavi öncesi ve tedavi sonrası 1. ayda olmak üzere iki kez, kontrol grubuna başvuru anında olmak üzere bir kez YYU Dursun Odabaş Tıp Merkezi Odyoloji Ünitesi'nde saf ses odyometri testi yapıldı. Bulgular: Vaka grubu ve kontrol grubu arasında yaş ve cinsiyet açısından istatiksel olarak anlamlı fark saptanmadı. ( Sırası ile P Değeri) Nötrofil Lenfosit Oranı (NLO) ve Platelet Lenfosit Oranı (PLO) tedavi öncesinde, tedavi sonrası ve kontrol grubuna göre istatiksel olarak anlamlı bir şekilde yüksek bulunmuştur. (p). 2. Haftada gelen hastaların serum prestin düzeyi 1. Haftada gelen hastalardan istatiksel olarak anlamlı düzeyde yüksek bulunmuştur (p). 2. Hafta gelen hastaların serum prestin düzeyi geç gelen gruptan ve kontrol grubundan yüksek olmasına rağmen bu yükseklik istatistiksel olarak anlamlı değildi (p>0.05). 1. Haftada gelen hastaların serum prestin düzeyi kontrol ve geç gelen hastalardan düşük olmasına rağmen istatistiksel olarak anlamlılık yoktu (p>0.05). Tedavi sonrası Prestin düzeyleri incelendiğinde, en düşük prestin seviyesi iyileşme olmayan grupta tespit edildi ancak diğer gruplarla karşılaştırıldığında istatiksel olarak anlamlı bir fark bulunmamıştır (p). En yüksek serum prestin düzeyi ise tam İyileşme olan grupta saptanmasına rağmen diğer gruplar ile karşılaştırıldığında istatiksel olarak anlamlı fark yoktu(p). Başvuru anında serum prestin düzeyi düşük olan hastalarda iyileşme düzeyi daha yüksek tespit edildi. Ancak bu fark istatistiksel olarak anlamlı değildi. (p). Sonuç: Çalışmamız ile ASNİK etyolojisindeki enflamatuar proçesinin varlığı ve NLO ve PLO düzeylerinin prognostik önemi istatiksel olarak tespit edildi. Hastaların tedavi sonrası ölçülen prestin düzeyleri ile tedaviye cevapları arasında korelasyon saptandı. Ayrıca, başvuru anında bakılan serum prestin düzeyinin düşük olması ile iyileşme arasında korelasyon tespit edildi. Bu nedenle, Prestin'in ASNİK için prognostik bir belirteç olabileceğini düşünmekteyiz. Anahtar kelimeler: Ani Sensorinöral İşitme Kaybı, Enflamasyon, Prestin, Prognoz
Gradenigo Syndrome Induced by Suppurative Otitis Media
(Lippincott Williams & Wilkins, 2018) Bozan, Nazim; Duzenli, Ufuk; Yalinkilic, Abdulzaziz; Ayral, Abdurrahman; Parlak, Mehmet; Turan, Mahfuz; Kiroglu, Ahmet Faruk
Gradenigo syndrome was defined as a clinical triad of otitis media, severe orbito-facial pain, and ipsilateral sixth cranial nerve palsy. It may occur as a complication of either acute or chronic otitis media. Herein, we will report a case of Gradenigo syndrome induced by suppurative chronic otitis media that was promptly diagnosed and aggressively treated.
Is Nasal Polyposis Related To Levels of Serum Vitamin D and Vitamin D Receptor Gene Expression
(int Scientific information, inc, 2016) Erdag, Omer; Turan, Mahfuz; Ucler, Rifki; Berkoz, Mehmet; Garca, Mehmet Fatih; Bozan, Nazim; Cankaya, Hakan
Background: Nasal polyposis (NP) is the most frequent cause of nasal masses. Despite considerable research on the subject, its etiology has not been fully elucidated, and effective treatment methods have not been developed. Some etiological factors causing low or high expression of genes in genetically predisposed individuals may play a role in the pathogenesis of the disease. The purpose of this study was to assess the relation between levels of vitamin D receptor (VDR) gene expression and serum vitamin D with NP. Material/Methods: The study included 46 subjects with NP (NP group) and 40 volunteers (control group). Nasal polyp tissue samples were taken from the NP group and nasal mucosa samples were taken from the control group. Levels of VDR gene expression in the tissue samples were assessed using the real-time polymerase chain reaction (RTPCR) method. Results: Mean serum 25(OH) D levels were 13.38 +/- 14.08 ng/ml in the NP group and 10.57 +/- 6.44 ng/ml in the control group (p=0.249). VDR gene expression was present in 17.5% of the NP group and 3.3% of the control group, and the difference between the 2 groups was statistically significant (likelihood ratio chi(2)=3.887; p=0.049). Conclusions: This is the first study to assess levels of VDR gene expression in subjects with NP. Our results suggest that VDR gene expression may be associated with the pathogenesis or progression of NP.
Is There a Relationship Between Obstructive Sleep Apnea (Osa) and Hearing Loss
(int Scientific Literature, inc, 2016) Ekin, Selami; Turan, Mahfuz; Arisoy, Ahmet; Gunbatar, Hulya; Sunnetcioglu, Aysel; Asker, Selvi; Yildiz, Hanifi
Background: Obstructive sleep apnea (OSA) is a common disorder with an estimated prevalence in the general population of 2-5%. Its main clinical features are loud snoring and breathing stoppage during sleep. Ischemia could be a consequence of noise-induced hearing loss because cochlear oxygen tension is reduced during and after noise exposure. In this study, we evaluated auditory function in patients affected by OSA and simple snoring. Material/Methods: A total of 66 participants (male to female ratio: 40: 26) were included in the study, of which 21 were in the control group, 18 were in the simple snoring group, and 27 were in the OSA patient group. Polysomnography and audiometric examination were performed in all participants. Results: The mean ages of the participants in the control, simple snoring, and OSA groups were 39.14 +/- 9.9, 37.28 +/- 8.2, and 41.56 +/- 8.99 years, respectively. There were no statistically significant differences among groups regarding age or sex; however, there were statistically significant differences among groups in body mass index, apnea-hypopnea index scores, mean saturation, and duration under 90% saturation. In addition, statistically significant differences were found between the patient group and the control and simple snoring groups concerning the mean saturation, duration under 90% saturation, and the extended high frequency of hearing. Conclusions: These data show that snoring may cause hearing loss at extended high frequencies.
Isolated Sensorineural Hearing Loss as a Sequela After Lightning Strike
(Hindawi Ltd, 2015) Turan, Mahfuz; Kalkan, Ferhat; Bozan, Nazim; Ozcalimli, Isa; Erdem, Mehmet Zeki; Yalinkilic, Abdulaziz; Garca, Mehmet Fatih
In most of the surviving patients after a lightning strike, audiovestibular abnormalities have been reported. The most frequently reported type of abnormalities is a tympanic membrane perforation with hearing loss and external ear canal burn. However a sensor neural hearing loss and mixed type hearing loss can also occur, but these occur rarely. A nineteen-year-old female patient had, after a lightning strike, serious burns on the left ear, behind the ear, and on the chest and neck. She also had in her left ear 108 dB hearing loss with irregular central perforation and in her right ear 52 dB sensorineural hearing loss. There was no hearing loss before the strike. A hearing aid was recommended for the right ear and good care and follow-up were recommended for the left ear. A lightning strike can cause serious audiological damage. Therefore, it is necessary to make a careful audiovestibular evaluation of the patients. Although there exist rarely healed cases from sensorineural hearing loss after lightning strike in literature, in our case hearing loss occurred bilaterally and then it healed unilaterally. This condition is quite rare in literature.
Kronik Lenfositik Lösemi'ye Bağlı Yumuşak Damakta Destrüktif Lezyon: Olgu Sunumu
(2016) Demir, Cengiz; Bozan, Nazim; Çankaya, Hakan; Kıroğlu, Ahmet Faruk; Turan, Mahfuz; Gür, Mehmet Hafit; Ebinç, Sennar
Kronik Lenfositik Lösemi sık görülen bir B hücre neoplazisidir. Bu çalışmada, kliniğimizde KLL nedeni ile takip edilen yumuşak damak, uvula ve tonsil lokalizasyonunda KLL ye bağlı destrüktif lezyonu olan, medikal tedavi sonrası remisyona giren bir hastayı tartıştık. Tedavi sonrası nazofarenks ve yumuşak damakta adezyon ve hava pasajının engellendiğini tespit ettik. Bu vakanın literatürde nadir rastlanan bir durum olması nedeni ile burada sunmak istedik
Kronik Otitis Mediada Dirençli Patojen: Stenotrophomonas Maltophilia
(2016) Gür, Mehmet Hafit; Reşat, Mehmet; Çankaya, Hakan; Bayram, Yasemın; Bozan, Nazım; Turan, Mahfuz; Özçalımlı, İsa
Stenotrophomonas maltophilia dirençli nazokomial enfeksiyonlara neden olabilen aerob, nonfermantatif Gram negatif bir basildir. Beta-laktamaz, aminoglikozit asetil transferaz ve eritromisini inaktive eden enzimleri ve aktif pompaları kodlayan genleri nedeni ile S. maltophilia birçok antibiyotiğe intrensek olarak dirençlidir. Bu nedenle tedavide birçok direnç sorunuyla karşılaşılmaktadır. Olgumuzda 8 yıldır her iki kulağında akıntı ve işitme kaybı olan 52 yaşındaki bayan hastanın yapılan sağ kulak kültüründe dirençli Stenotrophomonas maltophilia izole edildi. Bu olgu çoğul direnç gelişimi gösteren ve özellikle nozokomiyal enfeksiyonlarda giderek ön plana çıkan Stenotrophomonas maltophilia suşlarının, nozokomiyal infeksiyonlardaki rolünü araştırmak ve antibiyotiklere direnç durumunu ortaya koymak amacıyla sunulmuştur
Kronik Süpüratif Otitis Media Hastalarında Radyolojik ve Cerrahi Bulguların Karşılaştırılması
(2017) Bozan, Nazim; Kıroğlu, Ahmet Faruk; Kundi, Pınar; Özkan, Hüseyin; Turan, Mahfuz; Arslan, Ayşe; Batur, Abdussamet
Amaç: Kronik süpüratif otitis media (KSOM) tanısı alan ve ameliyat olmuş ve rutin temporal kemik tomografisine tabi tutulan hastaların verilerini retrospektif olarak tarayarak, KSOM cerrahisi öncesi rutin bilgisayarlı tomografi (BT) taramalarının etkinliğini değerlendirmektir. Gereç ve Yöntem: Kronik süpüratif otitis media tanısı konulan ve opere edilen 42 hastanın intraoperatif bulguları ve preoperatif temporal BT bulguları retrospektif olarak değerlendirildi. Bulgular: Operasyon sırasında hastaların 23'ünde (%54,76) kolesteatom gözlendi. Preoperatif BT ile bu hastaların 21'inde kolesteatom varlığı doğru tahmin edildi. Kolesteatom saptamada BT; %91,30 (güvenlik aralığı: %71,96-%98,93) duyarlılık ve %78,95 (güvenlik aralığı: %54,43-%93,95) özgüllük oranına sahipti. İntraoperatif ossiküler zincir hasarı 32 (%76,19) hastada gözlendi ve bu hastaların 27'sinde BT ile preoperatif dönemde kemikçik hasarı tespit edilmişti. Kemikçik hasarını tespit etmede BT; %84,38 (güvenlik aralığı: %67,21-%98,93) duyarlılık ve %80 (güvenlik aralığı: %44,39-%97,48) özgüllük oranına sahip olarak bulundu. Sonuç: Çalışmamızda, preoperatif dönemde çekilen BT'nin cerrahi tedavi karar sürecinde ve cerrahi sırasında yardımcı olabilecek kıymetli bilgiler verdiğini ve bu nedenle KSOM hastalarında BT'nin rutin olarak değerlendirilmesi gerektiğini düşünüyoruz.
Laringeal İnflamatuar Myofibroblastik Tümör: Nadir Bir Olgu
(2015) Bayram, İrfan; Erten, Remzi; Bulut, Mehmet Deniz; Turan, Mahfuz; Bulut, Gülay; Almalı, Ayşe Öter
İnflamatuar myofibroblastik tümör malignite potansiyeli belirsiz, borderline bir neoplazmdır. En sık yerleşim yeri akciğerlerdir. Baş-boyun bölgesinde larinks yerleşimi oldukça nadirdir. On-bir yaşında kız hastanın üç yıldır devam eden ses kısıklığı şikayeti vardı. Yapılan laringoskopide sol vokal kordu boylu boyunca tutan, geniş tabanlı polipoid doku izlendi. Polipoid doku tamamen eksize edildi. Yapılan histopatolojik incelemede miksoid bir stroma içerisinde mikst iltihabi infiltratla karışık halde, intranükleer psödoinklüzyonları olan çok sayıda miyofibroblast izlendi. Belirgin atipi, mitoz, nekroz görülmedi. Yapılan immünhistokimyasal incelemede neoplastik hücrelerde vimentin, ALK, EMA ile pozitif boyanma izlendi. Alcian blue ile miksoid stromada boyanma görüldü. Histopatolojik ve immünhistokimyasal bulgular eşliğinde olguya laringeal inflamatuar miyofibroblastik tümör tanısı konuldu. Nadir bir antite olan laringeal inflamatuar myofibroblastik tümör, malign laringeal tümörlerden mutlaka ayırt edilmelidir. Doğru teşhis, hastada gereksiz agresif tedavi yöntemlerinden kaçınmayı ve inflamatuar myofibroblastik tümör için yeterli olan organ koruyucu komplet rezeksiyon yapılmasını sağlar