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Browsing by Author "Uǧurluer, G."

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    The Importance of Selenium in Human Health and Role in Prevention of Cancer
    (2007) Çebi-Ilhan, A.; Uǧurluer, G.
    Selenium (Se) is an essential trace element for human health. Recently, lots of studies about Se have been performed; accumulating evidence indicates that Se compounds possess anticancer properties. The relation between Se deficiency and various problems such as cardiovascular pathologies, digestive disorders, rheumatism and cancer has been shown by researches. The effects of Se on cells are concentration-dependent. If taken excessive amounts it has toxic effects. Selenium which is part of selenoproteins is an important antioxidant right along with having enzymatic and structural roles. Selenium is found in active side of glutathione peroxidase (GPX) which is one of the detoxification enzymes.
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    Article
    Prevention of Cancer Through Lifestyle Changes
    (2006) Uǧurluer, G.; Şahin, H.A.
    Cancer is one of the leading causes of death and an abundance of evidence suggests that lifestyle factors including smoking, typical high-fat, refined-sugar diet and physical inactivity play role in the development of majority of cancers. It has been estimated that 30-40 percent of all cancers can be prevented by lifestyle and dietary measures. In this paper the effects of diet and physical inactivity on frequently seen cancers and protective effects of foods are reviewed. Diet and physical inactivity take place among major factors for cancer promotion by inducing insulin resistance and hyperinsulinemia. Elevated levels of serum insulin impact on liver primarily, increasing the production of insulin-like growth factor I (IGF-I) while reducing the production of insulin-like growth factor binding protein 1 (IGFBP-1) and resulting in stimulation of tumor cell growth and inhibition of apoptosis (programmed cell death). Adopting a diet low in fat and high in fiber-rich starch foods, combined with regular aerobic exercise might control insulin resistance, reduce serum markers of cancer and consequently the risk for many different cancers.