Browsing by Author "Uckan, Kazim"

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Association of Subclinical Markers of Inflammation With Preterm Premature Rupture of Membranes and Adverse Neonatal Results: a Case Control Study
(Springer Heidelberg, 2022) Uckan, Kazim; Baskiran, Yusuf; Celegen, Izzet
Aim The study aims to investigate the relationship between subclinical inflammatory factors, which are known to be closely related to inflammation, with preterm premature rupture of membranes (PPROM) and adverse postpartum outcomes. Materials and methods The case control type study was conducted between January 1, 2021, and January 2022. 525 pregnant women, including 272 PPROM and 253 normal patients, were added to the study. Results There was a positive relationship between PPROM and PCT (platelet crit), MPV (mean platelet volume), NLR (neutrophil-to-lymphocyte ratio), and MLR (monocytes to lymphocyte ratio) values. ROC analysis, PCT > 0.19, MPV > 8.78, NLR > 2.82, and MLR > 0.24 were significantly related to improved risk of PPROM (P < 0.05). In logistic regression analysis, a one-unit rise in PCT resulted in a 3.9-fold rise in RDS risk and a one-unit increase in NLR resulted in a 1.6-fold significant rise in sepsis risk (p < 0.05). Conclusion NLR and PCT parameters were found to be related to adverse neonatal outcomes.
Can Failure Be Predicted in Methotrexate Treatment With the Modified Parameter
(Springer Heidelberg, 2024) Baskiran, Yusuf; Uckan, Kazim; Celegen, Izzet
Objective The objective of the study was to increase the prediction of success of single-dose methotrexate therapy in ectopic pregnancy patients with modified parameters obtained from complete blood count and beta-human chorionic gonadotropin (beta-hCG) parameters. In this way, it was aimed to predict patients whose methotrexate treatment may fail and rupture, to avoid unnecessary methotrexate treatment, to shorten the duration of hospital stay and to reduce patient mortality. Materials and methods 233 patients diagnosed with ectopic pregnancy between January 1, 2017, and March 01, 2022, in the obstetrics and gynecology service of a tertiary center were included in the study. Results The mean of beta-hCG was 1976 in the methotrexate group and 2358 in the surgery group (p < 0.05). The ROC curve determined the effect of BW (beta-hCGxWBC/1000) and BP (beta-hCGx1000/PLT) markers in diagnosing patients who will need surgery in ectopic pregnancy. The areas under the ROC curve for beta-hCG, BW and BP were 0.86, 0.99 and 0.94, respectively (p < 0.05). beta-hCG > 2139.03, BW > 30.96 and BP > 10.17 values were significantly associated with the need for surgery in ectopic pregnancy patients (p < 0.05). Logistic regression analysis revealed that a 1-unit increase in BP caused a statistically significant 1.77-fold increase in surgical need in patients with ectopic pregnancy. In contrast, a 1-unit increase in BW caused a 2.34-fold increase in surgical need (p < 0.05). Conclusion The study results showed that BW and BP values together with beta-hCG are effective in predicting ectopic pregnancy patients who may undergo surgery.
Change of the Levels of Trace Elements and Heavy Metals in Threatened Abortion
(Lippincott Williams & Wilkins, 2019) Turan, Kasim; Arslan, Ayse; Uckan, Kazim; Demir, Halit; Demir, Canan
Backround: This study aimed to investigate the impact of changes in the serum levels of trace elements and heavy metals in threatened abortion, which is a common complication in early pregnancy. Earlier studies have shown that changes in the serum levels of some trace elements and increased serum concentrations of heavy metals are associated with spontaneous abortion; however, this relationship has not been fully clarified. Methods: The patient group consisted of 45 pregnant women diagnosed with threatened abortion. There were 40 healthy nonpregnant women in the control group. Blood samples were obtained from the patients and the healthy controls, and the concentrations of serum trace elements and heavy metals were measured using atomic absorption spectrophotometry. Results: Statistically significant decreases were found in the serum zinc (Zn), iron (Fe), magnesium (Mg) and manganese (Mn) levels, and significant increases were found in the serum copper (Cu), cadmium (Cd) and lead (Pb) levels in cases of threatened abortion in comparison to the controls (p < 0.001). However, there was no difference between the groups in terms of the serum cobalt (Co) levels (p > 0.001). Conclusion: Changes in the balance of some essential trace elements (especially decreases in Fe and Zn) and elevated concentrations of some toxic heavy metals in the blood may be important diagnostic and prognostic parameters for threatened abortion
Could Hpv Type 33 Be More Risky Than We Thought
(Sage Publications inc, 2023) Purut, Yunus Emre; Uckan, Kazim
Objective: The distribution of human papilloma virus (HPV) genotypes varies by country and region. HPV is the most important risk factor for cervical cancer and HPV 16/18 is the most common genotype. Other high risk HPVs (hrHPVs) other than HPV 16 and 18 contribute significantly to invasive disease. In this study, we aimed to reveal the frequency of association of HPV 16, 18 and other high-risk-HPV types with CIN 2 + (CIN 2 and above) cervical lesions in patients with cervical intraepithelial neoplasia (CIN) and to support the literature especially on the management of high-risk-HPV types other than 16 and 18. Materials and Methods: This retrospective study, which was conducted on 264 patients and 202 patients after the exclusion criteria, was conducted in the gynecology oncology outpatient clinic of the tertiary care hospital between March 2020 and May 2022. HPV 16, HPV 18 and other high-risk-HPV types with negative cytology between the ages of 25-65 were compared by taking a biopsy accompanied by colposcopy performed by the same gynecologist. As a result of colposcopy, CIN2 + patients who underwent excisional procedure were distributed according to HPV type. During this procedure, the patients who were positive for more than one HPV type were considered positive for the group with all subtypes (For example, if the patient was type 31 and 33 positive, they were included in both the 31 and 33 positive groups). The genotype distribution in the high-risk-HPV group was examined. Results: Colposcopy results showed HPV 16 positivity in 43.3%, HPV 33 positivity in 30% and HPV 18 positivity in 10% of the patients with CIN2 + and above lesions. It was observed that the incidence of CIN2 + lesions in the patients with HPV 33 positive was higher than the incidence of a lower-grade lesion (such as CIN1, chronic cervicitis) (p < 0.05). While HPV 33 (r = 0.290, p < 0.000) results were positively correlated with CIN2 + and above lesions, there was a negative correlation with HPV 45 (r = - 0.172, p < 0.015) results (p < 0.05). It was observed that HPV 33 and HPV 45 positivity was a statistically significant variable in predicting the probability of CIN2 + lesions in colposcopy results. It was determined that a HPV 33 positive patient increased the probability of having a CIN2 + lesion by 4.999 times (p < 0.000). Conclusion: In the literature, the role of high-risk -HPV types other than HPV 16 and HPV 18 with negative cytology in the women at risk of cervical preinvasive lesions has still not been fully determined. According to the results of the stuy, especially in women infected with high-risk -HPV types other than HPV 16/18, the relationship between HPV 33 type and CIN 2 + lesions was found to be high, and it was seen that colposcopic biopsy should be performed immediately instead of follow-up after 1 year.
Evaluation of Hbsag, Anti-Hcv, Anti-Hiv Seroprevalence and Perinatal Outcomes in Pregnant Women
(Galenos Publ House, 2021) Uckan, Kazim; Celegen, Izzet; Uckan, Taner
Objectives: Vertical transmission of hepatitis B virus, hepatitis C virus, (HBV, HCV) and human immunodeficiency viruses (HIV) infections is an important public health problem. The aim of this study was to determine the rates of hepatitis B, anti-HCV and anti HIV seropositivities in pregnant women in a city and to evaluate the infections in terms of perinatal outcomes. Materials and Methods: In this retrospective study, 8,464 patients who gave birth in obstetrics and gynecology clinic were recorded. Seropositivity rates of pregnant women were investigated according to the results of hepatitis B surface antigen (HBsAg), HCV antibody and anti-HIV antibody. The rates were determined according to years and perinatal results and statistical comparison was made. Results: HBsAg seropositivity in pregnant women included in the study was 2.8 % (n=55) in 2015, 2.2% (n=52) in 2016, 2.3% (n=47) in 2017 and 2.2% (n=49) in 2018. The 4 year average was found to be 2.3% (n=203). There was no significant difference between the years (p>0.05). Among all our patients, 4-year mean anti-HCV seropositivity was 0.57% (n=49) and there was no difference between years (p>0.05). Anti-HIV seropositivity was found to be 0.09% on average, and there was no statistically significant difference over the years (p>0.05). Conclusion: Since hepatitis B, which is a preventable viral disease, has a risk of transmission during delivery and if it is transmitted to the fetus, it may lead to fatal complications at later ages, it is necessary to screen all pregnant women in terms of HBsAg seropositivity and to include it in an antepartum planning program to protect and treat newborns from infection. Although the transmission rate of HCV is low in the society, considering its clinical course, screening of HCV together with HIV in risky groups and pregnant women antibody positivity is considered important for the health of the society and newborns.
Hormonal and Electrolyte Predictors for Methotrexate Versus Surgery in Ectopic Pregnancy
(Public Library Science, 2025) Baskiran, Yusuf; Uckan, Kazim; Celegen, Izzet; Tanoglu, Fatma Basak
This retrospective study investigates the association between maternal serum electrolyte and hormone levels and the success of methotrexate (MTX) treatment in ectopic pregnancies, aiming to identify predictive factors and improve clinical outcomes. A total of 372 patients treated with single-dose MTX between 2012 and 2023 were included, divided into two groups: those who successfully responded to MTX and those requiring surgical intervention. Significant differences were observed in beta-hCG levels, with a mean of 1376 in the MTX-successful group and 2358 in the surgical group. Electrolyte analysis showed that patients who responded successfully to MTX had higher potassium and albumin levels, whereas magnesium levels were lower compared to the surgical group. Haematological parameters also varied, with higher hemoglobin and hematocrit levels observed in the MTX-successful group. The findings suggest that serum potassium, magnesium, and albumin levels may be predictive markers for MTX efficacy. Higher potassium and albumin levels, along with lower magnesium levels, may contribute to improved treatment outcomes. These results support the potential role of dietary interventions-such as increasing potassium and albumin intake and moderating magnesium levels-in enhancing MTX success rates. This study underscores the importance of maternal biochemical profiles in guiding treatment strategies for ectopic pregnancy and highlights the value of individualized approaches to optimize outcomes and minimize the need for surgical intervention. Future research should aim to elucidate the biological mechanisms underlying these associations and validate the findings in larger and more diverse patient populations.
The Impact of Maternal Electrolyte and Albumin Levels on the Efficacy of Single-Dose Methotrexate Treatment for Ectopic Pregnancies
(Galenos Publ House, 2023) Baskiran, Yusuf; Uckan, Kazim; Karacor, Talip; Celegen, Izzet; Acar, Zuat
Objective: This study aims to investigate the impact of maternal albumin and serum electrolyte levels on the efficacy of single-dose methotrexate (SD-Mtx) therapy for ectopic pregnancies. Building on previous research, recommendations are provided to enhance the success of SD-Mtx therapy in the management of ectopic pregnancy. Materials and Methods: Conducted at a tertiary center gynecology clinic, the study included 353 patients diagnosed with ectopic pregnancy and treated with SD-Mtx from 2012 to 2023. Patients who responded positively to SD-Mtx treatment comprised Group 1 (n=313), while those requiring surgical intervention due to failed SD-Mtx therapy constituted Group 2 (n=40). Through the hospital's digital database, patient data including complete blood count, biochemistry, and hormone test results were retrospectively examined. Results: The mean beta-hCG value was 1996 IU/mL for Group 1 in contrast to 2058 IU/mL for Group 2. There was no statistically significant difference in beta-hCG levels between the two groups. Notably, Group 1 patients exhibited lower serum magnesium levels but higher potassium levels compared to Group 2 patients, with statistically significant differences. Furthermore, Group 1 patients had higher albumin levels than those in Group 2, with a statistically significant difference. Conclusion: Successful SD-Mtx treatment was associated with lower maternal serum magnesium levels and higher potassium and albumin levels. Considering electrolyte levels before administering SD-Mtx and addressing any imbalances could potentially enhance treatment success. Additionally, restoring low albumin levels might improve the efficacy of SD-Mtx treatment for ectopic pregnancies. While this study suggests these trends, further extensive studies with a larger sample size are necessary to establish more definitive evidence.
Increased Nuchal Translucency and Pregnancy Outcomes: a Tertiary Center Data
(Duzce Univ, Fac Medicine, 2024) Bagci, Mustafa; Uckan, Kazim; Sahin, Hanim Guler; Karaaslan, Onur; Karaman, Erbil
Aim: This study aimed to evaluate the pregnancy outcomes of patients who applied to our clinic between the 11th and 14th weeks of pregnancy and whose nuchal translucency (NT) measurement was >= 1.5 multiples of the median (MoM). Material and Methods: The study included 85 patients whose NT measurement was determined >= 1.5 MoM and pregnancy results were available. Demographic characteristics of the patients, prenatal invasive diagnostic test results, fetal anomaly screening, fetal echocardiography (ECHO) results, and neonatal and obstetric results were evaluated. Results: Abnormal karyotype was detected in 10.6% (n=9) of the patients. Trisomy 21 was the most common chromosomal anomaly. Fetal structural anomaly was detected in 29.4% (n=25) of the patients. A structural fetal anomaly was detected in 21% (n=13) of fetuses with normal karyotypes and 66.7% (n=6) of fetuses with abnormal karyotypes. Cardiac anomalies were found to be the most common anomalies with 9.7% (n=6) in patients with normal karyotype. NT and NT MoM values in patients with fetal structural (both p=0.001) or chromosomal anomalies (p=0.011, and p=0.019, respectively) were found significantly higher than those without. NT and NT MoM values in patients whose pregnancies resulted in fetal loss were found significantly higher than in patients who had a live birth (both p=0.001). Conclusion: Increasing NT or NT MoM values indicate an increase in the risk of chromosomal anomalies, structural anomalies, and poor pregnancy outcomes in the fetus. Fetal anomaly screening and fetal ECHO should be recommended in patients with increased NT, even if a normal karyotype is detected.
Investigation of Prolidase, Adenosine Deaminase, Glutathione S-Transferase and Glutathione Reductase Activities in Patients With Abortus Imminens
(derman Medical Publ, 2017) Turan, Kasim; Uckan, Kazim; Sarikaya, Eren; Demir, Halit; Demir, Canan
Aim: Abortus Imminens is a pregnancy-related disease, the pathophysiology of which has not yet been thoroughly determined. The aim of this study was to investigate possible relations between prolidase (PR) enzyme activity and adenosine deaminase (ADA), glutathione S-transferase (GST) and glutathione reductase (GR) activities in Abortus Imminens patients. Material and Method: Fifty patients with Abortus Imminens were examined in Ipekyolu Women's and Children's Hospital between June 2015 and September 2015. The age range of the patients selected was between 18 and 50. Prolidase (PR) enzyme activity and adenosine deaminase (ADA), glutathione S-transferase(GST) and glutathione reductase (GR) activities were measured in Abortus Imminens serums. Prolidase (PR), adenosine deaminase (ADA), glutathione-S-transferase (GST) and glutathione reductase (GR) activities were determined by spectrophotometry. Results: Glutathione S-transferase and glutathione reductase activities were found to be significantly decreased in Abortus Imminens patients compared to healthy subjects. Discussion: Changes in antioxidant enzyme activities may play a very important role in the pathogenesis of Abortus Imminens. The serum ADA levels can be used as a biochemical marker in Abortus Imminens. This is the first large-scale study in the literature of the relationship between Abortus Imminens and antioxidants.
Maternal and Neonatal Consequences of Cystocele and Rectocele in the Delivery Process
(Lippincott Williams & Wilkins, 2023) Baskiran, Yusuf; Uckan, Kazim; Celegen, Izzet; Tanoglu, Fatma Basak
The study aimed to investigate the effects of cystocele and rectocele on the stages of vaginal birth and maternal and newborn outcomes. A total of 672 multiparous pregnant women between the ages of 18 to 40 who underwent normal vaginal delivery in our tertiary center between November 2022 and February 2023, were included in this prospective study. Among the participants, 348 (51.8%) had no abnormalities, 78 (11.6%) had rectocele only, 112 (16.7%) had cystocele only, and 134 (19.9) had both cystocele and rectocele. Patients with the coexistence of cystocele and rectocele experienced a notably extended duration for both the first stage and second stage of labor, although the extension in the second stage was not statistically significant. Among the maternal complications, the development of maternal laceration and chorioamnionitis was significantly more common in the patient group with cystocele and rectocele compared to the other groups. When the groups were assessed for postpartum bleeding, while the bleeding risk increased from the normal group to the rectocele + cystocele group, this increase was not statistically significant. There was no difference between the groups in terms of neonatal outcomes. The delivery time of pregnant women with cystocele and rectocele, in the absence of additional risk factors, was determined to be significantly longer than that of the control group. We think that these patients should receive more vigilant monitoring, and this criterion should be kept in mind when assessing the indication for a cesarean section.
Maternal Serum Ischemia-Modified Albumin (Ima), Total-Sulphydryl Concentrations, and Some Subclinic Inflammatory Markers in Hyperemesis Gravidarum (Hg)
(Elsevier Taiwan, 2023) Uckan, Kazim; Demir, Halit; Demir, Canan
Objective: This study investigates the relationship between Ischemia Modified Albumin and Total-Sulphydryl levels with some subclinical inflammatory markers in patients with hyperemesis gravidarum. Materials and methods: A total of 258 pregnant women, 137 with hyperemesis gravidarum and 121 low-risk pregnancies, were included in this case-control study. The patients were divided into three groups according to the severity of hyperemesis gravidarum as mild (n = 53), moderate (n = 41) and severe (n = 43). Results: Serum Ischemia Modified Albumin levels were statistically different from the control group (P < 0.001). Among the subgroups, the highest Ischemia Modified Albumin value was observed in the severe hyperemesis gravidarum group, and the highest Total-Sulphydryl level was observed in the mild hyperemesis gravidarum group (P < 0.001). Serum potassium levels were higher in the control group (P < 0.001). While a negative correlation was observed between Ischemia Modified Albumin and Total-Sulphydryl, a positive correlation was observed in Platelet crit, C-reactive protein, and ketonuria. As the severity of the disease increases, Ischemia Modified Albumin, which is an oxidative stress factor, increases, and Total-Sulphydryl levels decrease (p < 0.001). Logistic regression analysis revealed that a one-unit increase in Ischemia Modified Albumin resulted in a statistically significant 1.9-fold increase in the risk of Severe hyperemesis gravidarum (OR 1.92, 95% CI 1.008-1.956; P = 0.01) Conclusion: This study shows that there is a condition in the pathophysiology of hyperemesis gravidarum, with an increase in Ischemia Modified Albumin and a decrease in Total-Sulphydryl levels, and oxidative stress occurs. It was important to detect increased Ischemia Modified Albumin and decreased antioxidant values in relation to the inflammatory factors that were effective in the severe hyperemesis gravidarum group. (c) 2023 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Relationship of Hyperemesis Gravidarum With Platelet Crit, Hemoglobin-to Cell Distribution Width Ratio, and Neutrophil-to Ratio
(Assoc Medica Brasileira, 2025) Uckan, Kazim; Baskiran, Yusuf; Celegen, Izzet
OBJECTIVE: The aim of this study was to investigate the relationship between the severity of hyperemesis gravidarum disease and subclinical inflammatory factors such as platelet crit, hemoglobin-to-red cell distribution width ratio, neutrophil-to-lymphocyte ratio, which are known to be closely associated with inflammation in patients with hyperemesis gravidarum. METHODS: This retrospective case-control study was conducted between December 2020 and December 2021. A total of 215 pregnant women, 102 with hyperemesis gravidarum and 113 healthy pregnant women, were included in the study. Hyperemesis gravidarum patients were divided into three groups according to the modified Pregnancy-Unique Quantification of Emesis and nausea classification as mild (n=38), moderate (n=32), and severe (n=32). RESULTS: Platelet crit, hemoglobin-to-red cell distribution width ratio, and neutrophil-to-lymphocyte ratio values were found to be statistically significantly higher in the hyperemesis gravidarum group compared to the control group (p<0.05). There was a mild-to-severe increase in platelet crit, hemoglobin-to-red cell distribution width ratio, and neutrophil-to-lymphocyte ratio values in hyperemesis gravidarum patients (p<0.05). Logistic regression analysis revealed that a one-unit increase in platelet crit, hemoglobin-to-red cell distribution width ratio, and neutrophil-to-lymphocyte ratio resulted in a 2.14-, 1.41-, and 2.36-fold increase in hyperemesis gravidarum risk, respectively. CONCLUSIONS: Platelet crit, hemoglobin-to-red cell distribution width ratio, and neutrophil-to-lymphocyte ratio are inflammatory markers that increase in patients with hyperemesis gravidarum and have predictive value for the development of hyperemesis gravidarum. In our study, we suggested the use of a new prognostic marker for patients with hyperemesis gravidarum. We believe that our study will be a source for future studies on hyperemesis gravidarum.
Reply To: "is Serum Level of Trace Elements and Heavy Metals Associated With Threatened Abortion
(Lippincott Williams & Wilkins, 2019) Turan, Kasim; Arslan, Ayse; Uckan, Kazim; Demir, Halit; Demir, Canan
Research of Some Trace Elements and Heavy Metal Levels at the Premature, Pre-Term and Term Births
(Parlar Scientific Publications (p S P), 2021) Turan, Kasim; Uckan, Kazim; Meydan, Ismet; Demir, Halit; Demir, Canan
The purpose of the study is to research some trace elements and heavy metal levels at the premature, preterm and term births. There are many genetic and environmental etiologic factors causing to the prematurity. This study was undertaken to understand how the unknown etiology is associated with heavy metal and trace element values in pre-term, preterm, and premature-preterm conditions. Measurement of the Zn, Cd, Fe, Mg, Mn, Pb, Co and Cu elements was determined with Atomic Absorption Spectrophotometer method. Fe, Co, Cu, Mg, Mn ve Zn levels of the premature preterm, preterm and term patients was found to be lower compared with the healthy control group (p<0.05). Pb and Cd levels were found higher at the premature preterm, preterm and term patients compared with the healthy control group (p<0.05). Some trace element and heavy metal levels at the premature preterm, preterm and term births may play an important role at the etiopathogenesy of the disease. This study is first and original at the literature.
Role of Oxidative Stress in Obese and Nonobese Pcos Patients
(Wiley, 2022) Uckan, Kazim; Demir, Halit; Turan, Kasim; Sarikaya, Eren; Demir, Canan
Objective. The aim of this study was to evaluate the relationship between the oxidant-antioxidant status, endothelial dysfunction, lipid metabolism, and metabolic syndrome risk in women with polycystic ovary syndrome (PCOS). Materials and Methods. Forty-five obese (BMI > 30 kg/m2) woman diagnosed with PCOS in the study, forty-five nonobese (BMI < 30 kg/m(2)) PCOS diagnosis working groups, and forty-nine healthy control groups were created with patients. Serum malondialdehyde (MDA) levels with antioxidant activities, such as SOD, GSH, GPx, and CAT activities, were measured by spectrophotometry. Results. There was a statistically significant difference in the mean serum MDA level in the obese PCOS group compared to the nonobese group and the control group (p < 0.001). When the antioxidant parameters, such as SOD, GPx, GSH, and CAT, were compared with the healthy control group, nonobese, and obese PCOS groups, the difference between the groups was statistically significant (p < 0.001). A positive correlation was observed between MDA and BMI, triglyceride, LDL, SBP, DBP, and HOMA-IR in the PCOS patient group. Conclusion. Oxidative stress and decreased antioxidant parameters in PCOS patients were correlated with hyperinsulinemia, hypertension, and dyslipidemia findings, and we think that this oxidative stress condition may contribute to metabolic syndrome and cardiovascular diseases in PCOS patients.
The Role of Ultrasound and Mitofusin-2 Levels To Predict Pregnancy Outcomes in Patients With Severe Preeclampsia: a Case-Control Study
(Assoc Medica Brasileira, 2024) Uckan, Kazim; Ozgokce, Cagdas; Baskiran, Yusuf; Eyisoy, Omer Gokhan; Celegen, Izzet; Akbay, Halil Ibrahim
OBJECTIVE: The aim of this study was to evaluate mitofusin-2 levels and fetal Doppler ultrasonography effects in patients with severe preeclampsia. METHODS: This single-center case-control study was conducted in the gynecology service of the university hospital in Van. A total of 90 pregnant women aged 18-40 years were included in the study. Of these, 30 are normal, 30 have mild preeclampsia, and 30 are pregnant with severe preeclampsia. In this study, especially in severe preeclampsia patients, serum mitofusin-2 levels and important fetal Doppler flows such as uterine arterial pressure, umbilical arterial pressure, and 1st and 5th minute Apgar scores, birth weight, and the relationship between postnatal outcomes such as week of birth and the number of patients in the neonatal intensive care unit were investigated. RESULTS: There was a significant difference between the three groups in terms of mitofusin-2 levels, which was the highest in the group (p<0.05). Maternal serum mitofusin-2 levels were positively correlated with uterine arterial pressure (r=0.543, p=0.007), umbilical arterial pressure (r=0.238, p=0.008), diastolic blood pressure, and systolic blood pressure (p<0.001). Receiver operating characteristic curve of mitofusin-2 in predicting preeclampsia is as follows: optimal cutoff 1.6 ng/mL; area under the curve: 0.861; 95%CI: 0.786-0.917; sensitivity: 83.9%; and specificity: 70.0%, (p <= 0.001). A one-unit increase in mitofusin-2 resulted in a statistically significant 4.21-fold increase in preeclampsia risk. CONCLUSION: This study recommends the use of mitofusin-2 together with fetal Doppler ultrasound findings as a reliable indicator of preeclampsia severity.
Serum Amyloid A, Procalcitonin, Highly Sensitive C Reactive Protein and Tumor Necrosis Factor Alpha Levels and Acute Inflammatory Response in Patients With Hemolysis, Elevated Liver Enzymes, Low Platelet Count (Hellp) and Eclampsia
(Wiley, 2018) Uckan, Kazim; Sahin, Hanim Guler
AimThe aim of this study was to determine the relationship between serum amyloid A (SAA), procalcitonin (ProC), highly sensitive C reactive protein (hsCRP) and tumor necrosis factor (TNF) alpha activity in patients with pre-eclampsia, eclampsia and hemolysis, elevated liver enzymes, low platelet count (HELLP), and the pathogenesis and severity of the disease. MethodNinety patients at 32 gestational weeks, according to the last date of menstruation and ultra-sonographic measurements, diagnosed with pre-eclampsia (30 patients), eclampsia (30 patients) or HELLP syndrome (30 patients) were included in the study. Thirty healthy pregnant women from the outpatient clinic during the same period were recruited as the control. The age, gravida, parity, gestational age, systolic and diastolic blood pressures, proteinuria, hemoglobin, thrombocyte count, liver function tests (aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, SAA, TNF alpha, ProC and hsCRP levels during pregnancy) were determined and recorded. ResultsNo statistically significant differences were detected between the four groups in terms of age, gravida, parity, gestational age and hemoglobin parameters (P>0.05). When compared to the control, systolic and diastolic blood pressures, spot and 24h urine protein levels, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, SAA, ProC, hsCRP and TNF alpha levels were significantly high and thrombocyte levels were low in the pre-eclamptic, eclamptic and HELLP groups (P<0.05). ConclusionThe investigated parameters were useful to gain an understanding of the maternal inflammatory profile of pre-eclampsia and might be beneficial as markers to predict complications such as HELLP and eclampsia and to provide the necessary preventive approach in these patients.