Browsing by Author "Ugurluer, Gamze"

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The Comparison of Brain and Lens Doses in Whole Brain Radiotherapy With Different Treatment Plannings
(Akad Doktorlar Yayinevi, 2009) Ugurluer, Gamze; Izmirli, Mustafa; Palamik, Zehra A.; Cakir, Tahir
The aim of study was to evaluate the effects ontarget volume (brain) and lens doses with different treatment plannings in patients who received whole brain radiotherapy because of brain metastases. The system tomography scans of 14 patients at 0.5 cm intervals, were transferred to three-dimensional treatment planning computer and the normal tissues and target volumes were outlined. Seven different treatment plannings were done for each patient. Plan I: Angled blocked plan; Plan II: Non-angled blocked plan; Plan III: Helmet plan; Plan IV: Blocked plan with the inferior border at the inferior orbital ridge; Plan V: Angled unblocked plan; Plan VI: Non-angled unblocked plan; Plan VII: Conventially planned non-angled unblocked plan. Brain and lens minimum, maximum and mean doses and brain V95 and D95 doses were recorded for each plan using dose-volume histograms. When the plans were compared according to the brain minimum, mean, V95 and D95 doses, it was observed that the doses in Plan VII were lower than the others (mean 1171.57 cGy, mean 3294.64 cGy, 97.48% and mean 2990.57 cGy respectively, p < 0.05). When the plans were compared according to the lens doses, the minimum, maximum and mean doses were higher in the unblocked plans (p < 0.05). It was seen that with the angling of beams five degrees to the posterior the lens doses decreased (p < 0.05). This study shows that using 3 dimensional treatment planning, brain minimum doses increases and the dose inhomogenity decreases, and lens doses decreases using customized blocks and angling of beams five degrees posteriorly.
Cutaneous Metastases From Transitional Cell Carcinoma of the Bladder (In a Case With Two Primaries)
(Aves, 2010) Ugurluer, Gamze; Dogan, Erkan; Turan, Nedim
Cutaneous metastases from primary genitourinary malignancies are rare and, like all metastases, have a poor prognosis. Very few cases of skin metastases from urothelial carcinoma have been reported in the past and most of them were treated with chemotherapy. Here we present a case of cutaneous metastases from a primary bladder transitional cell carcinoma who was admitted to our clinic with pain and bleeding of the lesion on the dorsum of the hand which did not respond to chemotherapy and was treated with palliative radiotherapy.
Neuroprotective Effects of Erythropoietin Against Oxidant Injury Following Brain Irradiation: an Experimental Study
(Termedia Publishing House Ltd, 2016) Ugurluer, Gamze; Cebi, Aysegul; Mert, Handan; Mert, Nihat; Serin, Meltem; Erkal, Haldun Sukru
Introduction: Radiation therapy (RT) is a major treatment modality, and the central nervous system is a dose-limiting organ in clinical RT. This experimental study aims to present the evaluation of the neuroprotective effects of erythropoietin (EPO) against oxidant injury following brain irradiation in rats. Material and methods: Forty Wistar rats were randomly assigned to four groups (n = 10 each). In group 1 the rats received no EPO and underwent sham RT. The rats in groups 2 and 3 received EPO. In group 2 rats underwent sham RT, while in group 3 rats received RT. The rats in group 4 received no EPO and underwent RT. Rats were irradiated using a Cobalt-60 teletherapy machine using a single fraction of 20 Gy covering the whole brain. Cervical dislocation euthanasia was performed. The nitrite and malondialdehyde (MDA) levels and the superoxide dismutase (SOD) and glutathione peroxidase (GSHPX) activities were evaluated in dissected brain tissues. Results: The nitrite and MDA levels were higher in the RT group (2.10 +/-0.62 ppm, 26.02 +/-2.16 nmol/ml; p < 0.05) and lower in the EPO + RT group (1.45 +/-0.12 ppm, 25.49 +/-1.90 nmol/ml; p < 0.05). The SOD and GSHPX activity was higher in the EPO + RT group (2.62 +/-0.49 U/mg, 1.75 +/-0.25 U/mg, p < 0.05). Conclusions: This study supports the probable neuroprotective effects of EPO against oxidant injury following brain irradiation in a rat model, presumably through decreasing free radical production and increasing expression of antioxidant enzymes.
Praying as Complementary and Alternative Medicine
(Mary Ann Liebert inc, 2008) Edirne, Tamer; Ugurluer, Gamze; Keskin, Siddik; Kusaslan, Dilek; Baloglu, Mahir