Browsing by Author "Uslu, B"

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    Article
    Electroanalytical Characteristics of Amisulpride and Voltammetric Determination of the Drug in Pharmaceuticals and Biological Media
    (Wiley-v C H verlag Gmbh, 2004) Özkan, SA; Uslu, B; Sentürk, Z
    The electrochemical oxidation of antipsychotic drug amisulpride (AMS) has been studied in pH range 1.8 - 11.0 at a stationary glassy carbon electrode by cyclic, differential pulse and square-wave voltammetry. Two oxidation processes were produced in different supporting electrolyte media. Both of the oxidation processes were irreversible and exhibited diffusion controlled. For analytical purposes, very resolved voltammetric peaks were obtained using differential pulse and square-wave modes. The linear response was obtained in the range of 4 x 10(-6) to 6 x 10(-4) M for the first and second oxidation steps in Britton-Robinson buffer at pH 7.0 and pH 3.0 (20% methanol v/v), respectively, using both techniques. These methods were used for the determination of AMS in tablets. The first oxidation process was chosen as indicative of the analysis of AMS in biological media. The methods were successfully applied to spiked human serum, urine and simulated gastric fluid samples.
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    Conference Object
    Electrooxidation of the Antiviral Drug Valacyclovir and Its Square-Wave and Differential Pulse Voltammetric Determination in Pharmaceuticals and Human Biological Fluids
    (Elsevier, 2006) Uslu, B; Özkan, SA; Sentürk, Z
    The electrochemical properties of valacyclovir, an antiviral drug, were investigated in pH range 1.8-12.0 by cyclic, differential pulse and square-wave voltammetry. The drug was irreversibly oxidized at a glassy carbon electrode in one or two oxidation steps, which are pH-dependent. For analytical purposes, a very resolved diffusion controlled voltammetric peak was obtained in Britton-Robinson buffer at pH 10.0 using differential pulse and square-wave modes. Limits of detection were 1.04 x 10(-7) and 4.60 x 10(-8) M for differential pulse and square-wave voltammetry, respectively. The applicability to direct assays of tablets, spiked human serum and simulated gastric fluid, was described. (c) 2005 Elsevier B.V. All rights reserved.