Browsing by Author "Uygan, I"

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Chronic Hepatitis Delta Virus Infection in Eastern Turkey
(Elsevier Science Bv, 2003) Turkdogan, MK; Bozkurt, H; Tuncer, I; Uygan, I; Irmak, H; Buzgan, T; Akdeniz, H
The Effect of Autonomic Nervous System Activity on Exaggerated Blood Pressure Response To Exercise
(Taylor & Francis Ltd, 2000) Eryonucu, B; Bilge, M; Güler, N; Uygan, I
Objective - We investigated the effect of autonomic nervous system activity on exaggerated systolic blood pressure (SBP) response to exercise in healthy subjects using heart rate variability (HRV) analysis. Method and results - We studied 53 healthy volunteer subjects with exercise treadmill test according to the Bruce protocol. Time domain and frequency domain of HRV were measured for each 5-minute segment before (rest) and after exercise (recovery) and during the total exercise period. The mean change in SBP (Delta SBP) was 39 +/- 18 mm Hg. The Delta SBP above the value of mean (greater than or equal to 40 mm Hg) was defined as an exaggerated Delta SBP. According to the Delta SBP, subjects were classified into two groups. Group I consisted of 32 patients who showed a normal Delta SBP, group II consisted of 21 patients who showed exaggerated Delta SBP. There were no significant differences in baseline clinical characteristics and exercise duration between the two groups, There were no significant differences in the mean RR intervals, SDNN (standard deviation of all RR intervals), RMSSD (the square root of the mean of the sum of the squares of differences between adjacent RR intervals), and HF (high-frequency power, 0.15 to 0.40 Hz) at rest between the two groups. However, LF (low-frequency power, 0.04 to 0.15 Hz) and LF/HF ratio at rest were significantly higher at rest in group II than in group I. There were no significant differences in the mean RR intervals and HF at exercise between the groups. However, SDNN and RMSSD were significantly lower, LF and the LF/HF ratio were significantly higher at exercise in group II than in group I. No differences in these parameters were observed at recovery between the two groups, Conclusions - The sympathetic activity was higher at rest and during the total exercise period, parasympathetic activity was lower during the total exercise period in healthy subjects with exaggerated SBP response to exercise than in those with normal SBP response.
Effects of Nigella Sativa L. and Urtica Dioica L. on Lipid Peroxidation, Antioxidant Enzyme Systems and Some Liver Enzymes in Ccl4-Treated Rats
(Wiley, 2003) Kanter, M; Meral, I; Dede, S; Cemek, M; Ozbek, H; Uygan, I; Gunduz, H
This study was designed to investigate the effects Nigella sativa L. (NS) and Urtica dioica L. (UD) on lipid peroxidation, antioxidant enzyme systems and some liver enzymes in carbon tetrachloride (CCl4)-treated rats. A total of 60 healthy male Sprague-Dawley rats were utilized in this study. The rats were randomly allotted into one of four experimental groups: A (CCl4 -only treated), B (CCl4 + UD treated), C (CCl4 + NS treated) and D (CCl4 + UD + NS treated), each containing 15 animals. All groups received CCl4 [0.8 ml/kg of body weight, subcutaneously, twice a week for 90 days starting day 1]. In addition, B, C and D groups also received daily intraperitoneal injections of 0.2 ml/kg NS or/and 2 ml/kg UD oils for 45 days starting day 46. Group A, on the other hand, received only 2 ml/kg normal saline solution for 45 days starting day 46. Blood samples for the biochemical analysis were taken by cardiac puncture from five randomly chosen rats in each treatment group at beginning, at 45th and at 90th day of the experiment. The CCl4 treatment for 45 days increased the lipid peroxidation and liver enzymes, and also decreased the antioxidant enzyme levels. NS or UD treatments (alone or combination) for 45 days starting day 46 decreased the elevated lipid peroxidation and liver enzyme levels and also increased the reduced antioxidant enzyme levels. Live weights of the rats decreased in group A, and increased in groups B, C and D. It is concluded that NS and UD decrease the lipid peroxidation and liver enzymes, and increase the antioxidant defence system activity in the CCl4-treated rats.
Effects of Nigella Sativa L. and Urtica Dioica L. on Lipid Peroxidation, Antioxidant Enzyme Systems and Some Liver Enzymes in Ccl4-Treated Rats (Vol 50, Pg 264, 2003)
(Blackwell verlag Gmbh, 2003) Kanter, M; Meral, I; Dede, S; Gunduz, H; Cemek, M; Ozbek, H; Uygan, I
Epidemiological Aspects of Endemic Upper Gastrointestinal Cancers in Eastern Turkey
(H G E Update Medical Publishing S A, 2005) Türkdogan, MK; Akman, N; Tuncer, I; Uygan, I; Kösem, M; Özel, S; Memik, F
Background/Aims: The aim of our study was to present the epidemiological aspects of endemic upper gastrointestinal (esophageal and gastric) cancers in the Van region of Eastern Turkey. Methodology: The patients were diagnosed by esophagogastroscopy, biopsy and histopathological analysis. The control group consisted of 73 healthy subjects. Epidemiological characteristics (age, sex, dietary habits, educational status, life style) were evaluated by questionnaires. Helicobacter pylori infection was diagnosed in nontumoral gastric mucosal biopsy specimens by Giemsa staining. Results: 298 esophageal Ca and 384 gastric Ca patients were diagnosed in seven years (1994-2001). Most of the patients (90%) were of rural origin. Endoscopic prevalence rate of upper gastrointestinal (UGI) Ca was the highest (1 Ca per 7 esophagogastroscopy) in the Van region compared to other parts of Turkey. Esophageal Ca were 1.5 times more common in females whereas gastric Ca were 1.6 times more common in males. Ninety per cent of esophageal cancers were epidermoid and the remaining 10% were adenocarcinomas. Ninety-seven per cent of gastric Ca were adenocarcinomas. Helicobacter pylori infection was not significantly increased in gastric Ca patients compared to controls. Conclusions: Low educational and socioeconomic status, consumption of smoked, salted, hot, fatty foods, overdrinking hot tea and well water, cigarette smoking, poor intake of fresh fruits and vegetables and poor hygienic conditions were probable culprit factors.
Heavy Metals in Soil, Vegetables and Fruits in the Endemic Upper Gastrointestinal Cancer Region of Turkey
(Elsevier Science Bv, 2003) Türkdogan, MK; Kilicel, F; Kara, K; Tuncer, I; Uygan, I
The environmental exposure to heavy metals is a well-known risk factor for cancer. We investigated levels of seven different heavy metals, (Co, Cd, Pb, Zn, Mn, Ni and Cu) in soil, fruit and vegetable samples of Van region in Eastern Turkey where upper gastrointestinal (GI) cancers are endemic. Heavy metal contents of the samples were determined by flame atomic absorption spectrometer. Four heavy metals (Cd, Pb, Cu and Co) were present in 2- to 50-fold higher concentrations whereas zinc levels were present in 40-fold lower concentrations in soil. The fruit and vegetable samples were found to contain 3.5- to 340-fold higher amounts of the six heavy metals (Co, Cd, Pb, Mn, Ni and Cu) tested. The volcanic soil, fruit and vegetable samples contain potentially carcinogenic heavy metals in such a high levels that these elements could be related to the high prevalence of upper GI cancer rates in Van region. (C) 2002 Elsevier Science B.V. All rights reserved.
Hepatorprotective Effect of Foeniculum Vulgare Essential Oil
(Scandinavian Federation Laboratory Animal Science, 2004) Özbek, H; Ugras, S; Bayram, I; Uygan, I; Edrogan, E; Öztürk, A; Huyut, Z
Hepatoprotective activity of Foeniculum vulgare (fennel) essential oil was studied using a carbon tetrachloride-induced liver fibrosis model in rats. The hepatotoxicity produced by chronic carbon tetrachloride administration was found to be inhibited by Foeniculum vulgare essential oil with evidence of decreased levels of serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and bilirubin. Histopathological findings also suggest that Foeniculum vulgare essential oil prevents the development of chronic liver damage. The changes in body weights in the rats assigned to the study groups supported these biochemical and histopathological findings. The results of this study clearly indicate that Foeniculum vulgare essential oil has a potent hepatoprotective action against carbon tetrachloride-induced liver fibrosis in rats.
The Role of Urtica Dioica and Nigella Sativa in the Prevention of Carbon Tetrachloride-Induced Hepatotoxicity in Rats
(Wiley, 2003) Türkdogan, MK; Ozbek, H; Yener, Z; Tuncer, I; Uygan, I; Ceylan, E
The role of Nigella sativa L. (Ranunculaceae) (NS) and Urtica dioica L. was investigated (UD) in the prevention of carbon tetrachloride (CCl4) induced liver fibrosis and cirrhosis. Fifty Sprague-Dawley rats were allocated into five groups (I, IIA and B, IIIA and B) and CCl4 was injected biweekly to all groups. Group I (control, CCl4 only), group IIA and B (NS fixed oil and volatile oil), group IIIA and B (UD fixed oil and UD decoction extract) rats were killed at the end of week 12 and histopathological and immunohistochemical examinations of liver tissues were performed. In the control group, coagulation necrosis and hydropic degeneration were marked in the periacinar regions (zone 3) associated with fibrosis in the periacinar regions and in the portal tracts. In groups IIA-B and IIIA-B (NS and UD), none of the serious histopathological findings were detected except for sparse coagulation necrosis in the periacinar regions. ASMA-positive perisinusoidal cells with myofibroblastic transformation and lysosomal enzyme activity suggesting fibrogenesis were also significantly more common in the control group than in the NS and UD groups. UD and NS seem to be significantly effective in the prevention of carbon tetrachloride induced hepatotoxicity in rats. Copyright (C) 2003 John Wiley Sons, Ltd.