Browsing by Author "Yayik, Ahmet Murat"

Now showing 1 - 2 of 2

Efficacy of Preemptive Intravenous Ibuprofen and Dexketoprofen on Postoperative Opioid Consumption in Laparoscopic Cholecystectomy: Randomized Controlled Study
(Public Library of Science, 2025) Soyalp, Celaleddin; Yayik, Ahmet Murat; Oksüz, Ersoy; Yüzkat, Nureddin
Background To compare the effects of preemptive single-dose intravenous (IV) ibuprofen and dexketoprofen on postoperative pain and opioid consumption in patients undergoing laparoscopic cholecystectomy (LCC). Methods The study included 90 patients aged 18–65 years with an ASA score of I or II who underwent LCC. Patients were equally divided into three groups: Control Group (Group P), 100 cc 0.9% NaCl was infused intravenously over 30 min, Dexketoprofen Group (Group D), 50 mg dexketoprofen in 100 cc 0.9% NaCl was infused intravenously over 30 min, and Ibuprofen Group (Group I), 800 mg ibuprofen in 100 cc 0.9% NaCl was administered intravenously over 30 min. Visual Analog Scale (VAS) scores and opioid requirement were recorded at 1, 2, 4, 6, 12 and 24 hours postoperatively. Results There was no significant difference between the Dexketoprofen and Ibuprofen groups with regard to VAS scores, whereas VAS scores were higher in the control group than other groups in the 1st, 2nd, 4th, 6th,12th, and 24th hours. In addition, fentanyl consumption was higher in the control group at 0–6 hours and at 24 hours compared to the other two groups. Conclusion Preemptive ibuprofen and dexketoprofen administration reduce pain scores and opioid consumption compared with the control group, however, they are non-inferiority to each other. © 2025 Elsevier B.V., All rights reserved.
A New Described Mechanisms of Intestinal Glandular Atrophy Induced by Vagal Nerve/Auerbach Network Degeneration Following Subarachnoid Hemorrhage: the First Experimental Study
(Elsevier Sci Ltd, 2019) Cakir, Murtaza; Ahiskalioglu, Ali; Karadeniz, Erdem; Aydin, Mehmet Dumlu; Malcok, Umit Ali; Soyalp, Celaleddin; Yayik, Ahmet Murat
Stress ulcers is a trouble complication of subarachnoid hemorrhage (SAH). Although gastrointestinal ulcerations may be attributed to increased HCL secretion in SAH; the exact mechanism of that complication has not been investigated definitively. We studied if vagal network degeneration may cause intestinal atrophy following SAH. Study was conducted on 25 rabbits, with 5 control group (Group-A), 5 SHAM group (Group-B), and 15 SAH group via injection of autologue blood to cisterna magna. Seven animals followed for seven days (Early Decapitated-Group-C) and eight animals followed 21 days (Late Decapitated-Group-D). The vagal nodosal ganglia (NGs), Auerbach plexuses and goblet cells of duodenums were examined by current stereological methods and compared statistically. The mean numbers of degenerated axon density/mm(2) of gastric branches of vagal nerves was 8 +/- 2, 34 +/- 11, 189 +/- 49 and 322 +/- 81 in the Group A, B, C, and D respectively. The mean numbers of degenerated neuron density/mm(3) of NGs was 5 +/- 2, 54 +/- 7, 691 +/- 87 and 2930 +/- 410 in the Group A, B, C, and D respectively. The mean numbers of degenerated Auerbach neurons 2 +/- 1, 4 +/- 1, 12 +/- 3 and 27 +/- 5/mm(3) in the Group A, B, C, and D respectively. The mean numbers of degenerated goblet cells/mm(3) were 4.3 +/- 1.02, 11.5 +/- 0.26, 143 +/- 26 and 937 +/- 65 Group A, B, C, and D respectively. Statistical analysis showed that vagal network ischemia could cause intestinal bleeding and so atrophy in SAH progression. Statistical analyses of groups were; Group-D/Group-A < 0.001, Group-D/Group-B < 0.005, Group-C/Group-A < 0.005. Undiscovered effect of ischemic vagal network injuries should be regarded as a major cause of stress ulcerations following SAH which has not been mentioned in the literature. (C) 2018 Elsevier Ltd. All rights reserved.