Browsing by Author "Yegin, E"

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Effect of Estrogen on Fibrinogen Clotting Time in Rabbits
(Scientific Technical Research Council Turkey, 1998) Ercan, M; Yegin, E; Akdeniz, H; Irmak, H; Bayiroglu, F; Tuncer, I
The aim of this study was to examine the effect of estrogen on fibrinogen clotting time in rabbit model experimentally, The study was performed on 14 white New Zealand race female prepubertary rabbits at two months old weighing meanly 1.4+/-0.3 kg. Blood samples was taken from ear veins of the rabbits and first fibrinogen clotting time levels were measured to obtain control values. Next day, female sex hormone preparate estradiol valerinate at a dose of 0.3 mg/kg were injected to the rabbits IM. In their examinations made on 10(th) day of injection, they were evaluated as in oestrus and under the maximal effects of estrogen, acid their blood samples were taken again to measure their fibrinogen clotting time levels. Fibrinogen clotting time levels were determined from blood samples taken before and after female sex hormone administration. Samples taken from ear veins of the rabbits were used for measurement of fibrinogen clotting time. In the study, fibrinogen clotting time values were found meanly 18.13+/-1.00 sec. from blood samples taken before estrogen injection versus 18.87+/-0.61 sec. from blood samples after 10 days of estrogen injection, in statistical assessment performed, there were not statistically significant differences (t=0.94, p>0.05) between fibrinogen clotting time values before and after estrogen administration. Our data revealed that estrogen administration caused a silghtly but insignificantly increase in fibrinogen clotting time values in the rabbits.
Effects of Propylthiouracil-Induced Hypothyroidism on Plasma Lipid Table in Rabbits
(Tubitak Scientific & Technological Research Council Turkey, 2000) Çelik, I; Türkoglu, V; Yegin, E
Hypothyroidism is commonly associated with hyperlipidemia. The aim of this study was to investigate the effect of Propylthiouracil-induced hypothyroidism on the plasma lipid profile in rabbits. This investigation was performed on male, white New Zealand (Oryctolagus cuniculus huxley) rabbits, Twenty rabbits were used; each of the two groups (hypothyroidism and control) consisted of ten animals, Hypothyroidism was induced by oral administration of Propylthiouracil 50 mg.kg(-1) for three weeks. The mean values of Triiodothyronine (T-3), thyroxine (T-4), free T-3 (FT3) and free T-4 (FT4) were 121.7+/-32.7 ng/dl, 1.81+/-0.60 mu g/dl, 2.36+/-9b92 ng/dl and 0.43+/-0.22 p mol/dl in the control group, and 88.4+/-19.2 ng/dl, 1.15+/-0.37 mu g/dl, 1.48+/-0.44 ng/dl and 0.18+/-0.11p mol/dl in the hypothyroidism group, respectively (p<0.05 for all). Levels of total plasma triglyseride (TG), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC) and apolipoprotein-B (Apo-B) were recorded as 44.2+/-8.57, 12.2+/-2.7, 40.4+/-14.9 and 87.2+/-19.2 mg.dl(-1) in the control group, and 97.9+/-29.8. 23.2+/-2.9, 67.2+/-13.5 and 147.4+/-55.7 mg.dl(-1) in the hypothyroidism group, respectively (p<0.001 for all parameters). The results showed that T-3, T-4, FT3 and FT4 decreased in the hypothyroidism group, but lipid fractions were higher than in the control group. In addition, a significant negative correlation was found between T-4-TC (r=-0.739, p<0.05) and T-4-Apo-B (r=-0.666, p<0.05).
The Effects of Some Pesticites on the Activity of Liver and Erythrocyte Enzymes (In Vitro)
(Taylor & Francis inc, 1996) Celik, I; Camas, H; Arslan, O; Yegin, E; Kufrevioglu, OI
The effect of pomarsol (tetramethyltriurem disulphide), Benlate 1-(N-Butlycarbomoyl) 2-(Metoxycarboxamido)-bezimidazol, meothrin (alpha-cyanophenoxbenzyl 2.2.3.3.-tetramethyl cyclopropanecarbonylate), Imperator [alpha-cyano 3-phenoxybenzyl-cis, trans-3- (2.2-dichroinyl)-2.2- dimetil research on GOT, GPT (liver enzymes) and CA-I, CA-II (Human erythrocyt) BCA (Bovine erythrocyt). Among the chemicals meothrin, imperator, sumicidin were determined to have inhibitory effect, on bovine CA, human CA and GOT enzymes, but ineffective on GPT enzyme. The I-50 values of chemicals caused inhibition were determined by means of activity percentage [I] diagrams. The values were 3.2x10(-2) M, 3.5x10(-2) M, 2.7x10(-2) M for GOT respectively. The values of same chemicals were 5.8x10(-3) M, 1.00x10(-2) M, 1.22x10(-2) M for CA-I, and 7.11x10(-3) M, 2.68x10(-2) M, 1.22x10(-2) M for CA-II respectively on the order nand, these chemical were 9.25x10(-3) M, 8.65x10(-3) M and 1.63x10(-2) M for bovine CA.