Browsing by Author "Yildizhan, K."

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Effect of Selenium and N-(p Anthranilic Acid on Doxorubicin-Induced Kidney Injury in Rats
(Inonu University, 2023) Yildizhan, K.; Huyut, Z.; Altindağ, F.; Uçar, B.
Doxorubicin (DOXR) is one of the essential antitumor drugs. However, its serious adverse effects in many organs limit the clinical use of DOXR. This study aimed to investigate the effect of selenium (Se) and N-(p-Amilcinnamoyl) anthranilic acid (ACA) on kidney tissue in DOXR-administered rats. The rats in the study were divided into six groups (n=10); Control, DMSO, DOXR, DOXR+Se, DOXR+ACA and DOXR+Se+ACA. At the end of the study, intracardiac blood was drawn from rats, and kidney tissues were removed. Urea and creatine levels were measured in serum samples of rats. In addition, histopathological examination of kidney tissue was determined by H&E staining, and 8-OHdG expression was determined by immunohistochemical analysis. Urea and creatine levels increased with DOXR decreased in serum samples after Se and ACA treatments (p< 0.05). While glomerular atrophy, tubular and glomerular dilatation, vascular occlusion and degeneration of tubular epithelial cells were observed in the DOXR group, significant improvement was observed in the Se and ACA treatment groups. In addition, Se and ACA treatments reduced DOXR-induced 8-OHdG expression (p< 0.05). These findings indicated that Se and ACA could be used as critical therapeutic agents to suppress renal dysfunction and oxidative DNA damage that can occur after DOXR-induced kidney injury. © 2023, Inonu University. All rights reserved.
Microglia and Its Role in Neurodegenerative Diseases
(Suleyman Demirel University, 2019) Yildizhan, K.; Naziroğlu, M.
Microglia are immune cells colonized in the central nervous system (CNS) during the development of the embryo. They make up about 12% of the glial cell population in the brain. These cells play an important role in eliminating the damage that may occur in the CNS or in carrying out normal functions. Microglia, which are in morphologically inactive form, are characterized by small cell body, small amounts of cytoplasm and cellular extensions that are released towards the environment. They undergo a significant morphological change and switch to the active form in a pathophysiological condition in the CNS, and they have the ability to migrate to the damaged area by ameboid movement. In today's studies, microglia in the active form has been stated to show neuroprotective and neurotoxic effects in neuronal structures in addition to carrying out phagocytosis of metabolic residues in the medium. It has also been mentioned in recent studies that microglia located in the CNS have a highly sensitive activation mechanism against inflammation and pathological conditions. Understanding the microglial activation mechanism in neurodegenerative diseases is thought to may contribute to the diagnosis / treatment of neurological diseases as well as being a diagnostic marker for the etiology of the diseases. In this review, the general characteristics and activation mechanism of microglia and their functional roles in Alzheimer's, Parkinson's, epilepsy and multiple sclerosis diseases were discussed in the current review. © 2019 Suleyman Demirel University. All rights reserved.