Browsing by Author "Yilmaz, Eda"

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Protective Effects of Ace/Nep Dual Inhibitor Omapatrilat for Indomethacin-Induced Gastric Ulcer
(Galenos Publ House, 2023) Erkayman, Kadir Giray; Ugan, Ruestem Anil; Magden, Zeynep Berna Aksakkalı; Yilmaz, Eda; Bozkurt, Ayse; Cadirci, Elif
Aim: The renin-angiotensin-aldosterone system (RAAS) plays important roles in oxidative stress and various gastroenterological mechanisms. Omapatrilat, an RAAS-acting agent, inhibits both neprilysin neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE) and may therefore affect protective mechanisms against gastric ulcer. Therefore, this study examined the gastroprotective role of omapatrilat in a mouse model of gastric ulcer induced by indomethacin to reveal pharmacological and biochemical changes resulting from omapatrilat treatment. Materials and Methods: Forty-two BALB/c mice were divided into seven groups: control, 40 mg/kg omapatrilat only, 25 mg/kg indomethacin only, indomethacin and 40 mg/kg famotidine, and three groups with indomethacin and 10-40 mg/kg omapatrilat. All chemicals were administered by oral gavage in 0.5 mL of 0.9% NaCl solution at the determined doses. Stomach ulcers were induced by indomethacin in mice treated with famotidine (40 mg/kg) and omapatrilat (10-40 mg/kg). Stomach tissue samples were examined macroscopically. Oxidative stress biomarkers of malondialdehyde (MDA), glutathione (GSH), NEP and ACE levels as well as superoxide dismutase (SOD) activity were measured. Results: The best antiulcer activity was measured with 40 mg/kg omapatrilat, where the gastric damage observed in the ulcer groups was significantly reversed, and gave the most similar results to the specific famotidine treatment. In relation with the increasing omapatrilat dose, SOD activity was corrected as well as GSH and MDA levels. Also the levels of ACE and NEP decreased back towards those measured in the control group. Therefore, these macroscopic and biochemical findings indicating reversal of gastrotoxicity and gastric ulcer indications demonstrate the role of omapatrilat's NEP and ACE inhibition in indomethacin toxicity, and its strong gastroprotective potential. Conclusion: Dual inhibition of NEP and ACE by omapatrilat may suppress oxidative stress associated with indomethacin-induced gastric ulcer. Therefore, the protective effect of omapatrilat in the treatment of ulcers may lead to the search for new treatment strategies.
The Role of Mental Toughness, Sport Imagery and Anxiety in Athletic Performance: Structural Equation Modelling Analysis
(Springernature, 2025) Demir, Gonul Tekkursun; Namli, Sevinc; Cakir, Ergun; Batu, Batuhan; Ates, Fatih; Yilmaz, Eda; Cagin, Musab
Mental toughness (MT), anxiety, and sport imagery (SI) are characteristics that are effective in the ups and downs of athletes' lives. The fact that these three characteristics, which have a direct effect on the performance of athletes (especially elite athletes), have not been examined by structural equation modeling in the literature to the best of our knowledge has led to the need for this study. The present study investigates the relationship between MT, anxiety levels, and SI skills among elite athletes in the 19-26 age group. A total of 407 elite athletes (143 females and 264 males) actively competing participated in the study, which was conducted within the framework of a correlational research model. Data were collected using the Mental Toughness Scale (MTS), the Sports Imagery Inventory (SII) and Anxiety subscale of the Emotion in Sport Scale (ESS). The theoretical model proposed to examine the effects of MT on SI and anxiety was tested using Structural Equation Modelling (SEM). It was found that the fit indices of the model established in the study gave a good fit, and the coefficients obtained were statistically significant (p <.05). The study revealed that athletes with higher MT had lower levels of anxiety and anxiety had a negative effect on SI skills (p <.05). Moreover, athletes with higher MT show high levels of SI abilities (p <.05). The present study suggests that training programs aimed at improving SI skills may also contribute to the development of MT.