Browsing by Author "Yilmaz, Ozkan"

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Colon Cancer Presented With Sigmoid Volvulus: a Case Report
(Elsevier Sci Ltd, 2015) Aras, Abbas; Kiziltan, Remzi; Batur, Abdussamet; Celik, Sebahattin; Yilmaz, Ozkan; Kotan, Cetin
Introduction: Sigmoid volvulus is the most prevalent type of colonic volvulus. Colon cancer is seen less where sigmoid volvulus is common, so it is rare to see that colon cancer is synchronous with sigmoid volvulus. PRESENTATION OF CASE: We would like to present a case of sigmoid volvulus caused by colon cancer in a male patient aged 80 who was referred to the hospital with toxaemic shock presentation. DISCUSSION: Sigmoid cancer can be presented as sigmoid volvulus to the emergency department. In intestinal obstruction early diagnosis is of crucial importance. Computarized tomography is a diagnosis tool that should be preferred both in the diagnosis of obstruction and in detecting its cause, localisation, degree and complications. CONCLUSION: When surgery is performed due to the urgent colonic obstruction in colonic volvulus diagnosed patients, a colon tumour should be considered in the same column loops or in the distal colon. We believe that CT is the method that should be preferred in large-bowel obstruction suspected patients. (C) 2015 The Authors. Published by Elsevier Ltd.
Effect of Thymoquinone on the Healing of Left Colon Anastomosis: an Experimental Study
(Springer international Publishing Ag, 2016) Kiziltan, Remzi; Yilmaz, Ozkan; Celik, Sebahattin; Yildirm, Serkan; Alp, Hamit Hakan; Aras, Abbas; Kotan, Cetin
Aim: To evaluate the effect of thymoquinone on the healing of experimental left colon anastomosis in rats. Methods: Forty Wistar albino rats weighing 250-300 g were randomly divided into four groups (10 rats/group). Group 1 (control group) rats were not administered Thymoquinone (TQ) for 3 days after the operation. Group 2 was administered daily TQ for 3 days starting from the first day after the operation. Group 3 was not administered TQ for 7 days after the operation. Group 4 was administered daily TQ for 7 days starting from the first day after the operation. Thymoquinone was administered as a single dose oral gavage through a 4F feeding catheter per each day. The bursting strength of the anastomosis was measured on 3rd and 7th postoperative days (POD) and resection was performed. Subsequently, the hydroxyproline level in the resected tissue was measured and a histological evaluation was performed. Results: The bursting pressures of the anastomoses were measured to be statistically significantly greater on 7th POD in TQ administered groups compared to those without TQ administration. Tissues were stained with Masson's trichrome dye in order to evaluate the amount of fibrous tissue reaction for histopathological examination; there was no significant difference in the amount of fibrous tissue between groups 1 and 2, while a very marked increase in the fibrous tissue was detected in groups 3 and 4. Mean tissue hydroxyproline levels of the groups 3 and 4 on 7th POD were 1.30 and 2.72 mu g/g-protein, respectively. The difference between the groups was statistically significant (p = 0.001). Conclusions: TQ significantly increased the bursting pressure of the anastomosis, tissue hydroxyproline level, and fibrous tissue production.
Inflammatory Myofibroblastic Tumor: a Rare Cause of Invagination in Adults
(Professional Medical Publications, 2016) Kiziltan, Remzi; Yilmaz, Ozkan; Almali, Necat; Peksen, Caghan
Inflammatory myofibroblastic tumor (IMT) is a distinct pseudosarcomatous lesion arising in the soft tissues and interior organs of children and young adults. It is rarely seen in adults. It was first described in lungs. IMT can occur in any location in the body. However, it is seen most commonly in lungs, intestinal mesentery and liver. Non-mesenteric alimentary tract IMT's are quite rare. The presented case is an ileal IMT that caused small bowel invagination. A 38 year-old male patient presented to the emergency department with the complaint of diffuse abdominal pain, distension and no passage of gas or stools for two days. An abdominal examination revealed distension and tenderness in the abdomen with no guarding or rebound tenderness. Computerized tomography (CT) of the abdomen was ordered. CT revealed an image compatible with invagination of the right lower quadrant of the abdomen and a mass inside the lumen measuring 4x3x3cm. The mass causing invagination was detected during the surgical operation. A segmentary small bowel resection and ileoileal anastomosis was performed. The patient was discharged uneventfully on the postoperative sixth day. The diagnosis of IMT was confirmed histologically and immunochemically.
Ingested Intraabdominal Foreign Bodies That Require Surgical Intervention
(Turkish Assoc Trauma Emergency Surgery, 2016) Kiziltan, Remzi; Yilmaz, Ozkan; Aras, Abbas; Toktas, Osman; Batur, Abdulsamet; Agar, Fatma; Kotan, Cetin
BACKGROUND: The aim of the present study was to review cases that required surgical intervention to remove ingested foreign bodies. METHODS: Medical records of 7 patients who underwent surgical intervention at the Yuzuncu Yil University Department of General Surgery between 2009 and 2014 after ingesting foreign bodies were reviewed. RESULTS: Female: male ratio was 5:2; mean age was 25 (16-35). Four patients had swallowed pins, 1 patient had swallowed a sewing pin, 1 patient had swallowed a safety pin, and 1 patient had swallowed a wristwatch. The patient who had swallowed the wristwatch had psychiatric disorders. All other patients stated that they had swallowed the objects by accident. CONCLUSION: Most ingested foreign bodies pass smoothly through the gastrointestinal (GI) tract within a week, but those that migrate out of the lumen require surgical intervention due to complications including perforation, abscess, fistula, and peritonitis. Early diagnosis and intervention is crucial to reduce morbidity and mortality. It is believed that sharp and pointed objects that migrate outside of the lumen ought to be removed, lest they cause complications.
Intraperitoneal Infusion of Neutral-Ph Superoxidized Solution in Rats: Evaluation of Toxicity and Complications on Peritoneal Surface and Liver
(int Scientific information, inc, 2017) Aras, Abbas; Karaman, Erbil; Yildirim, Serkan; Yilmaz, Ozkan; Kiziltan, Remzi; Karaman, Kamuran
Background: Superoxidized water (SOW) is known to be a potent disinfectant. The aim of this study was to evaluate the toxicity and complications on the peritoneal surface and liver after infusion of pH-neutral SOW into the peritoneal cavity of rats. Material/Methods: Thirty Wistar-Albino rats weighing 250-300 g were randomly divided into 3 groups (10 rats/group). Group1 (control group) rats received single dose of 10 mg/kg saline solution intraperitoneally. Group 2 (single-dose group) rats received a single dose of 10 mg/kg pH-neutral SOW intraperitoneally. Group 3 (multiple-doses group) rats received multiple doses of 10 mg/kg pH-neutral SOW intraperitoneally on days 1, 3, and 5. All animals were killed at 1 week after infusion. Blood specimens were taken to the laboratory and macroscopic and microscopic examinations were performed on each rat. Results: All 30 rats survived after the infusion. The gross-macroscopic examinations revealed no pathologic findings in any of the 3 groups. The microscopic examination of peritoneum and liver showed no signs of toxicity or complications in any of the 3 groups. There were no statistically significant differences among the 3 groups with regards to the blood biochemistry, including hemoglobin, hematocrit, platelets, aspartate aminotransferase, alanine aminotransferase, urea, or creatinine levels (p>0.05). However, the leucocyte counts were lower in group 3 than in groups 1 and 2, but this was not statistically significant (p=0.189). Conclusions: Intraperitoneal infusion of pH-neutral SOW does not result in any significant toxicity or complications on the liver and peritoneal surface. However, multiple infusions lead to low leucocyte counts and future studies with longer follow-up times are needed.
Laminin: a New Biomarker for Gastric Cancer
(Kuwait Medical Assoc, 2024) Kalayci, Tolga; Yilmaz, Ozkan; Iliklerden, Umit Haluk; Kemik, Ozgur; Kotan, Mehmet Cetin
Objective: To evaluate the diagnostic and prognostic utility of serum laminin levels in gastric cancer Design: A prospective and observational study Setting: Department of General Surgery, Van Yuzuncu Yil University Medical Faculty, Van, Turkey Subjects: Between June 2018 and September 2018, eighty patients who were diagnosed with gastric cancer as the patient group, and forty volunteers as the control group were included in the study. Intervention: From each patient, 3 ml of peripheral blood sample was collected. Main outcome measures: Enzyme-linked immunosorbent assay kit for human laminin were used for the detection of laminin in samples of serum. Data on patient demographics (age, gender) and serum laminin levels were recorded in both control and gastric cancer groups. In gastric cancer patients, serum laminin levels were further analyzed with respect to tumor stages and tumor size. Results: Serum laminin levels were significantly higher in gastric cancer patients [median (min-max): 205 (165-483) vs. 12 (9-18) ng/mL, P <0.001]. Laminin levels were higher in patients with advanced invasion depth, distant organ metastasis and lymph node metastasis ( P <0.001). The sensitivity and specificity determined from the receiver operating characteristic curves at cut-off level of 70 were 95% and 97% for serum laminin, respectively. Conclusion: The serum concentration of laminin can be used as a biomarker at the time of diagnosis for gastric cancer with high sensitivity and specificity. In addition, laminin can be used to discriminate between earlier, advanced or metastatic stages of gastric cancer.
Pleural Effusion Resultant After Upper Abdominal Surgery: Analysis of 47 Cases
(derman Medical Publ, 2011) Cobanoglu, Ufuk; Bartin, Mehmet Kadir; Mergan, Duygu; Yilmaz, Ozkan; Demir, Ali; Toktas, Osman
Aim Postoperative pulmonary complications, following upper abdominal surgery, occur at a rate which is higher, than lower abdominal surgery. One of these complications is pleural effusion. In this study, the frequency and causes of pleural effusions and the changes of the blood gas values and pulmonary functions of the patients with pleural effusions, occured after upper abdominal surgery are discussed in the accompaniment of the literature. Material and Methods 148 patients to whom upper adominal surgery is performed and in 47 of these patients pleural effusion is developed (31.75%), were examined restrospectivitely. Preoperative and postoperative pulmonary function tests (PFT) and arterial blood gas (ABG) results and the blood proteins, albumin values were recorded. The anesthesia type, the surgery properties, involving type of surgery and the surgical incision were determined. Results Pleural effusion is detected bilaterally in 8 patients (17: 02), at the right side in 21 patients (44.69%), and at the left side in 18 patients (38.29%). The 40.42% (19 cases) of the patients who has pleural effusion in the postoperative period, had liver and gallbladder surgery, the % 23.41 (11 cases) had spleen and pancreas surgery and the % 36.17 (17 cases) had the other surgical procedures. Conclusions While the upper abdominal surgery, impairment of the integrity of the diaphragm's peritoneum that covers the abdominal cavity where there is a highliquid pressure, may cause the liquid transition to the pleural space that has a negative pressure. Hypoalbuminemia and hipoproteinemia, that will occur due to the changes of oral intake and diet regulation in the postoperative period, may cause a reason for the pleural effusion. For this reason, doctors who performed these surgery procedures, should not ignore this complication, in the period of postoperative follow-ups of the patients.
Potential Diagnostic and Prognostic Significance of Plasma Prolidase Activity in Gastric Cancer
(Future Medicine Ltd, 2017) Celik, Sebahattin; Kiziltan, Remzi; Yilmaz, Eyup M.; Yilmaz, Ozkan; Demir, Halit
Aim: Plasma prolidase activities (PPAs) in cases of gastric cancer. Methodology/results: This study was based on a prospective design. 60 patients with gastric cancer (operable cases: 48; inoperable: 12) and 60 healthy controls were included in the study. Prolidase activity was analyzed. The mean PPA levels in the operable, inoperable and control groups were 45.60 +/- 4.20, 54.35 +/- 4. 9 and 10.92 +/- 0.79 U/l, respectively (p < 0.001). PPA decreased significantly after tumor resection. PPA level was significant in differentiating operable cases from inoperable (sensitivity: 91.7%; specificity: 85.2%). Discussion/conclusion: PPA was significantly higher in patients with inoperable gastric cancer than in operable cases and the control group. A strong correlation was found between tumor volume and PPA.
A Rare Complication of Biliary Stent Migration: Small Bowel Perforation in a Patient With Incisional Hernia
(Hindawi Ltd, 2015) Yilmaz, Ozkan; Kiziltan, Remzi; Aydin, Oktay; Bayrak, Vedat; Kotan, Cetin
Endoscopic biliary stents have been recently applied with increasing frequency as a palliative and curable method in several benign and malignant diseases. As a reminder, although most of the migrated stents pass through the intestinal tract without symptoms, a small portion can lead to complications. Herein, we present a case of intestinal perforation caused by a biliary stent in the hernia of a patient with a rarely encountered incarcerated incisional hernia.
Serum Ykl-40 Levels in Patients With Esophageal Squamous Cell Carcinoma
(Libertas Acad, 2011) Yilmaz, Ozkan; Kemik, Ozgur; Kemik, Ahu; Sumer, Aziz; Dulger, A. Cumhur; Asirci, Ismail; Kotan, Cetin
Aims and background: YKL-40 is a glycoprotein secreted by macrophages, neutrophils and malignant tumor cells. YKL-40 is expressed and secreted by several types of tumors. The aim of this study examined the clinical usefulness of YKL-40 for detection in esophageal squamous cell carcinoma (ESCC). Methods: Using ELISA kits, we measured the concentration of YKL-40 in serum from 100 patients with ESCC and compared this concentration with healthy population. Results: We found significantly higher serum levels of YKL-40 in patients with ESCC compared to the healthy population (P < 0.0001). Conclusions: These results suggested that regarding serum YKL-40 as a tumor marker could be benefical in the early clinical diagnosis.
Successful Treatment of a Large Pelvic Abscess Using Intraluminal Vac: a Case Report
(Premchand Shantidevi Research Foundation, 2016) Aras, Abbas; Celik, Sebahattin; Kiziltan, Remzi; Yilmaz, Ozkan; Kotan, Cetin
The most feared complication of the surgical treatment of rectal cancer is anastomotic leakage, which is related to high rates of mortality and morbidity. Here, we present a patient who could not be treated with surgical drainage but treated by intraluminal Vacuum Associated Closure (VAC). A 34-year-old male patient was treated for rectal cancer by low anterior resection, colorectal anastomosis, and diverting ileostomy following neoadjuvant CRT. The patient reported with a postoperative anastomotic disruption and a large pelvic abscess. Due to the continuation of foul-smell drainage inspite of perianal incision and drainage, intraluminal VAC was applied and the pelvic abscess and the foul-smell were successfully treated. The presence of an adequate anal sphincter tonus is a disadvantage in anastomotic leakage, since it prevents the emptying of the intestinal content and also precludes the drainage of the pelvic abscess. The endoluminal application of VAC, similar to the results of application of VAC in open wounds, has been demonstrated to decrease fibrin and necrotic tissue in the pelvic cavity and increase granulation tissue. VAC, which has long been used in the treatment of open wounds, is a promising method in the treatment of large pelvic abscesses due to anastomotic leakage following rectum resection.
Torsion of Wandering Spleen as a Rare Reason for Acute Abdomen: a Presentation of Two Cases
(Aves, 2013) Yilmaz, Ozkan; Bayrak, Vedat; Dastan, Ertugrul; Kotan, Cetin
Wandering spleen is a rare disease that is clinically characterized by torsion of the pedicle. The congenital absence of ligaments anchoring the spleen to the left sub-phrenic area or an acquired looseness is the major reason behind its mobilization. Unless splenic torsion occurs and acute abdominal clinical symptomatology develops, clinical diagnosis is highly challenging due to lack of symptoms. This study aims to share the information acquired from two encountered cases accompanied by the relevant literature.
Uncommon Caecum Diverticulitis Mimicking Acute Appendicitis
(Hindawi Ltd, 2016) Yilmaz, Ozkan; Kiziltan, Remzi; Bayrak, Vedat; Celik, Sebahattin; Calli, Iskan
Diverticulum of the cecum is a rarely seen reason of acute abdomen and it is difficult to be distinguished from appendicitis. The diagnosis is generally made during operation. We have presented this case in order to remember that it is a disease which should be kept in mind in cases of right lower quadrant pain.