Van Yüzüncü Yıl Üniversitesi

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Clinical, Angiographical, and Procedural Causes of Acute Vessel Closure During Transluminal Coronary Intervention
(Russian Heart Failure Soc, 2004) Batyraliev, TA; Pershukov, IV; Niyazova-Karben, ZA
Aim. To elucidate factors related to acute vessel closure (AVC) after transluminal coronary intervention. Methods. From population of 10439 patients subjected to transluminal coronary intervention 2 groups were formed: with (n=885) and without (n=885) acute vessel closure (AVC). Twenty five clinical, angiographical and procedural characteristics of patients of these 2 groups were included into mono and multifactorial logistic regression analysis. Result and conclusion. The following factors were univariate predictors of acute vessel closure: smoking [odds ratio (OR) 1.42], unstable angina (OR=2.130, acute myocardial infarction within previous 24 hours (OR 2.76), cardiogenic shock (OR 4.31), urgent procedure (OR 1.94), eccentric stenosis (OR 1.67), calcified lesion (OR 2.21), preexisting thrombosis (OR 3.79), lacerated complicated stenosis (OR 2.02), tortuous lesion (OR 1.35), low operator experience (OR 3.37), balloon angioplasty as sole procedure (OR 1.66), concomitant rheolytic thrombectomy (OR 1.95), urgent stenting (OR 1.45). Elective stenting significantly lowered risk of acute vessel thrombosis. Multifactorial step-tip analysis selected the following independent predictors of AVC: smoking, acute myocardial infarction within previous 24 hours, cardiogenic shock, preexisting thrombosis, lacerated complicated stenosis, and concomitant rheolytic thrombus extraction. Thus only elective stenting significantly reduced risk of AVC.
Comparison of Effects of Nebivolol and Atenolol on P-Wave Dispersion in Patients With Hypertension
(Russian Heart Failure Soc, 2008) Tuncer, M.; Fettser, D.; Gunes, Y.; Batyraliev, T. A.; Guntekin, U.; Gumrukcuoglu, H. A.; Sidorenko, B. A.
Background. P-wave dispersion has been shown to be a noninvasive electrocardiographic predictor for development of atrial fibrillation. Thus it may be possible to attenuate atrial fibrillation risk through normalization of P-wave variables and improvement in P-wave dispersion may be an important goal in treatment of hypertension. Objective. To compare the effects of nebivolol, a new P-blocker that have additional vasodilating activity via acting on endothelium and nitric oxide release, and atenolol on P-wave duration and dispersion in patients with mild-to-moderate hypertension. Methods. A total of 34 newly-diagnosed hypertensive patients were enrolled in the study. The patients were randomly assigned to receive treatment with either nebivolol (5 mg) or atenolol (50 mg). P-wave durations (Pmin and Pmax) and P-wave dispersion were measured before and one month after treatment. Results. While Pmin increased (50,6 +/- 11,2 ms to 54,7 +/- 9,1 ms, p=0,05), Pmax decreased (111,9 +/- 9,1 ms to 104,0 +/- 12,4 ms, p=0,003) and P-wave dispersion decreased (62,5 +/- 10,6 ms to 51,3 +/- 8,9 ms, p<0,001) with nebivolol, Pmin increased (44,4 +/- 9,8 ms to 58,0 +/- 15,5 ms, p=0,02), Pmax didn't change (106,1 +/- 13,8 ms to 107,0 +/- 11,6 ms, p=NS) and P-wave dispersion decreased (61,7 +/- 15,0 ms to 49,0 +/- 13,7 ms, p<0.001) with atenolol. However, there was no statistical difference between pre- and post-treatment values of two groups. Conclusions. Both nebivolol and atenolol are effective in improvement of P-wave dispersion in patients with hypertension and there's no significant difference between them.
Effectiveness of Excimer Laser Coronary Angioplasty in Treatment of Patients With In-Stent Restenosis
(Izdatelstvo Meditsina, 2003) Pershukov, IV; Niyazova-Karben, ZA; Batyraliev, TA; Eryonucu, B; Guler, N; Temamogullari, A; Sidorenko, BA
In-stent restenosis (ISR), when treated with balloon angioplasty (PTCA) alone, has an angiographic recurrence rate of 30-85%. Ablating the hypertrophic neointimal tissue prior to PTCA is an attractive alternative, however late outcomes of such treatment have not been fully determined. This multicenter case control study assessed angiographic and clinical outcomes of 137 consecutive procedures in 125 patients treated for ISR with either PTCA alone (n=58) or excimer laser assisted coronary angioplasty (ELCA, n=67). Demographics were similar. Lesions selected for ELCA compared with those selected for \PTCA were longer (17.1+/-9.9 mm vs. 13.6+/-9.1 mm; p=0,034), more complex (ACC/AHA type C: 36,5% vs. 14,3%; p=0,006), and with reduced antegrade flow (TIMI flow <3: 18,9% vs. 4,8%; p=0,025). IELCA- and PTCA treated patients had similar rates of procedural success (98,5 and 98,3%, respectively, p=1,0), major clinical complications (3,0% and 8,6%; respectively, NS), major cardiac events at 1 year (37,3 and 46,6%. respectively, ISIS), and target lesion revascularization (32,8 and. 34,5%; respectively, NS). These data suggest that ELCA in patients with complex in-stent restenosis is as safe and effective as PTCA. Despite higher lesion complexity in ELCA-treated patients, no increase in event rates was observed.
The Image of Peter The Great in The Historical Memory of The Dagestan Population
(Daghestan Federal Research Centre of Russian Academy of Sciences (RAS), 2020) Polchaeva, F.A.; Kasymov, J.A.
The Persian campaign of Peter I has been the subject of numerous studies, as well as his influence on Russia-Dagestan relations, social-economic and cultural development of the region. However, the question of the place of the Russian emperor in the historical memory of the population of Dagestan, which was largely influenced by the Persian campaign, remains unexplored. The present paper, basing on indirect material of written evidence and principles of historicism, taking into account regional features, attempts to recreate the image of Peter the Great. Having examined the events of the campaign in chronological order and applying common scientific methods of analysis, abstraction and inductive approach, the authors identified events and actions that are descriptive of the emperor's personality. Determining the place of Peter I in the historical memory of the people of Dagestan, a concept of the French sociologist M. Halbwachs on “mnemonic sites” is used. In the course of the study, a number of such “sites of memory” were revealed on the territory of Dagestan associated with Peter I. The authors also consider some acts of commemoration, directed on preserving mnemonic places and the development of historical memory of the population. © F.A. Polchaeva, J.A. Kasymov, 2020 © Daghestan Federal Research Centre of RAS, 2020 Creative Commons Attribution 4.0 International License.
P Wave Dispersion in Hypertensive Urgency
(Russian Heart Failure Soc, 2008) Tuncer, M.; Fettser, D.; Gunes, Y.; Batyraliev, T.; Guntekin, U.; Gumrukcuoglu, H. A.; Guler, N.
Background and purpose: P wave dispersion (PWD) has been accepted as a predictor for atrial fibrillation (AF) in hypertension and some other cardiac diseases. The aim of this study was to compare the P wave parameters between patients with mild-moderate hypertension and those with hypertensive crises. Methods: A total of 48 patients, 24 of who presented to the emergency department with hypertensive urgency and 24 patients who were followed in the cardiology clinic with mild-moderate essential hypertension were included in this study. P wave durations were measured manually by two investigators blinded to data of patients. Results: The maximal duration of P wave (P-max) and the PWD were found to be significantly different between groups, being longer in patients with hypertensive urgency (p=0,05 and 0,02; respectively). Conclusions: PWD increases in hypertensive urgency states. Clinical implication of this finding should be addressed with further, prospective studies conducted on larger samples.
Prognosis of Unstable Angina Resulting From Restenosis After Percutaneous Angioplasty of Saphenous Vein Grafts
(Russian Heart Failure Soc, 2004) Peresypko, MK; Niyazova-Karben, ZA; Petrakova, LN; Batyraliev, TA; Pershukov, IV; Guler, N; Sidorenko, BA
Aim. To assess frequency of unstable angina due to restenosis after percutaneous angioplasty of venous grafts and to elucidate risk factors of its development. Material and methods. Percutaneous interventions were successfully performed in 100 out of 106 patients with venous graft stenoses. These patients were followed up for 17+/-11 (maximum 36) months. Results. Unstable angina due to venous graft restenosis developed in 24% of patients. Patients with unstable angina compared with those without were characterized by higher frequency of hyperlipidemia (83 vs. 51%, respectively, p=0.032), lower rate of stenting (46 and 72%, respectively, p=0.032), greater residual stenosis (15+/-13 and 9+/-8%, respectively, p=0.008). At multifactorial regression analysis the following factors were significant predictors of unstable angina: hyperlipidemia (odds ratio [OR] 3.55, 95% confidence interval [CI] 1.64-8.39), and residual stenosis after intervention (OR 1.04, 95% CI 1.01-1.07, p=0.04). In a subgroup of patients with hyperlipidemia there was a tendency to greater rate of unstable angina among patients not taking statins compared with users of statin (50 and 29%, respectively, p=0.083). Conclusion. Unstable angina developed in 1/4 of patients after balloon dilatation of venous grafts and hyperlipidemia was its most powerful predictor.
Rheolytic Thrombectomy With Angiojet Catheter During Transluminal Coronary Revascularization in Patients With Acute Myocardial Infarction
(Russian Heart Failure Soc, 2003) Batyrailiev, TA; Pershukov, IV; Niyazova-Karben, ZA
Background Although balloon angioplasty and stenting are effective in the treatment of acute myocardial infarction (M1), reduced coronary flow and distal embolization frequently complicate interventions when thrombus is present. Adjunctive treatment with mechanical thrombectomy devices was suggested to reduce these complications. Methods We evaluated immediate angiographic, in-hospital and 30-day follow-up clinical outcomes of 185 patients with acute MI and angiographically evident thrombus who were treated with Angiolet rheolytic thrombectomy followed by immediate definitive treatment. Results. Procedural success (residual diameter stenosis <50% and Thrombolysis in Myocardial Infarction [TIMI flow >2 after final treatment) was 97%. Rheolytic thrombectomy success was achieved in 7% of patients. Subsequent definitive treatment included stenting in 67% and balloon angioplasty alone in 26% of patients. Final TIMI 3 flow was achieved in 89%. Angiolet treatment resulted in mean thrombus area reduction from 69,6 mm(2) at baseline to 17,3 mm(2) post-thrombectomy (p<0,001). Procedural complications included distal embolization (7,6%) and perforation (1,1%). Clinical success (procedure success without major in-hospital cardiac events) rate was 88%, in-hospital mortality - 7,0%. There were no further major adverse events during 30-day follow-up. Conclusion. Rheolytic thrombectomy can be performed safely and effectively in patients with acute MI, allowing for immediate definitive treatment of thrombus-containing lesions.

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