Akademik Çıktılar (WoS, Scopus, TR Dizin, PubMed)

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Acute Effects of Methyl Parathion and Diazinon as Inducers for Oxidative Stress on Certain Biomarkers in Various Tissues of Rainbowtrout (Oncorhynchus Mykiss)
(Academic Press inc Elsevier Science, 2008) Isik, Ismail; Celik, Ismail
Present study aimed mainly to assess oxidative stress pesticides such as methyl parathion (MP) and diazinon, which are widely used insecticides and contaminate aquatic ecosystems, on certain biomarkers in various tissues of rainbowtrout (Oncorhynchcus mykiss). Biomarkers selected for stress monitoring were malondialdehyde (MDA) and antioxidant defense system (ADS) mainly reduced glutathione (GSH), glutathione reductase (GR), peroxidase (GSH-PX), transferase (GST) and superoxidedismutase (SOD) activities in the liver, gills and muscle of fishes exposed to 0.5 and 1 ppm dosages of MP and diazinon for 24,48 and 72 h. According to these results, after the administrations of MP and diazinon promote MDA content in some of the tissues of fishes treated with both dosages of MP and diazinon. With regard to the ADS, GSH-Px, GST, SOD, GR activities and GSH levels fluctuated after 24, 48 and 72 h in all the treatment groups compared with controls. Collective results demonstrated that exposure of fish to pesticides induced an increase in MDA joined with fluctuated ADS. This may reflect the potential role of these parameters as useful biomarkers for assessment of water pollution. (C) 2008 Elsevier Inc. All rights reserved.
Ameliorative Effects of Foliar Application of Ascorbic Acid on Agronomic Characteristics, Paste Quality, and Gene Expression Related to Ripening in Tomato
(Academic Press inc Elsevier Science, 2025) Pirdawd, Amin Raof; Erdinc, Ceknas; Kka, Noura Masseh Ellya
This study aimed to compare determinate local varieties with commercial hybrid cultivars, under the hypothesis that applying ascorbic acid (AsA) at different growth stages would enhance the quality of both tomato fruits and paste. Four local varieties (Soran, Gwer, Khabat, and Ankawa) and four commercial cultivars (SV1521, SV6714, Marwaa F1, and FDR8565) were cultivated in an open farm during the 2021 growing season. To evaluate the influence of AsA on growth and development, a number of morphological, physiological, and molecular analyses were performed on both tomato fruit and paste. AsA promoted a progressive improvement in all morphological and biochemical parameters, along with certain quality attributes of the tomato paste, across both varieties and cultivars, relative to the control group. It was found that the properties of tomato paste, such as its dry matter (DMP), total soluble solids (TSS_P, 0Brix), pH, titratable acidity (TA), and taste index (TI), were the same for both commercial and local cultivars. In terms of morphological features, 1.5 mM AsA resulted in an increase ranging from 21.60 % to 83.90 % relative to untreated plants, whereas 2.5 mM AsA elevated these ratios between 22.20 % and 71.90 %. Lycopene and /3-carotene exhibited a substantial increase at 1.5 and 2.5 mM AsA concentrations compared to the control. 1.5 mM AsA yielded the highest enhancement of TSS_F, measuring 5.03 degrees Brix, while 2.5 mM AsA resulted in the greatest increase in ascorbic acid (AsA) in the fruit, quantified at 11.47 mg per 100 g of fresh weight (FW). The findings of gene expression revealed that the SlFSR (fruit shelf-life regulator) was overexpressed in the Ankawa and Marwaa F1 (4.64 and 3.88, respectively), but the RIN (ripening inhibitor) was overexpressed in SV6714 (4.51). Furthermore, the E8 (ethylene-related gene) exhibited overexpression in SV1521TD (4.24).
Antioxidant and Immune Potential Marker Enzymes Assessment in the Various Tissues of Rats Exposed To Indoleacetic Acid and Kinetin: a Drinking Water Study
(Academic Press inc Elsevier Science, 2006) Celik, Ismail; Tuluce, Yasin; Turker, Musa
In the present study, the influence of two different PGRs, indoleacetic acid (IAA) and kinetin (Kn) on immune potential enzymes, adenosine deaminase (ADA) and myeloperoxidase (MPO), and antioxidant defense enzymes such as glutathione peroxidase (GPx), glutathione reductase (GR), and superoxide dismutase (SOD) in various tissues of rats were investigated during the treatment as a drinking water model. 100 ppm of IAA and Kn as drinking water were administered orally to rats (Sprague-Dawley albino) ad libitum for 21 days continuously. The PGRs treatments caused different effects on the immune potential and antioxidant defense enzymes of experimented rats compared to controls. Results show that IAA caused a significant decrease in GR activity in the lungs and liver and an increase in the spleen. Also, IAA caused a significant decline in GPx activity in the lungs and an increase in the heart. SOD was significantly reduced in the heart, while increased in the lungs. Furthermore, IAA caused a significant decrease in ADA activity in the heart and blood whereas an increase in the kidney and spleen. MPO activity was also significantly increased in the heart by IAA treatment. The activity of enzymes were also seriously affected by Kn; GR activity decreased in the lungs, brain, and blood while GPx activity decreased in the spleen, brain, and heart. ADA activity was also significantly reduced in the blood whereas MPO activity rose in the spleen. In addition, SOD activity lowered in all tissues except for lungs where a significant increment was determined. As a conclusion, the results indicate that PGRs might affect on antioxidant and immune potential enzymes. These data, along with the determined changes suggest that PGRs produced substantial systemic organ toxicity in the erythrocyte, liver, brain, heart, lungs, spleen, and kidney during the period of a 21-day subacute exposure. (c) 2006 Elsevier Inc. All rights reserved.
Antioxidant, Antimicrobial, Cytotoxic and Protective Effects of Truffles
(Academic Press inc Elsevier Science, 2022) Fidan, Mehmet; Ali, Muhammad Muddassir; Erez, Mehmet Emre; Cigerci, Ibrahim Hakki; Ozdemir, Sadin; Sen, Fatih
Fungi can be used as a potent chemotherapeutic agent to treat various cancers. In current study acetone and methanol extracts of Terfezia claveryi, Terfezia boudieri, Terfezia olbiensis, Picoa lefebvrei, Picoa juniperi were used to assess total phenolic contents, antioxidant activity, ion-chelating impact, antimicrobial activity, the cytotoxic and protective effects. Both methanol and acetone extracts of T. boudieri had the highest FRAP and DPPH scavenging abilities. Dose-dependent increased ion-chelating impact of all tested truffles species was found. Extracts of T. boudieri, T. claveryi, and T. albiensis exhibited higher antimicrobial activities. T. claveryi and T. boudieri showed the highest protective effects against H2O2-induced genotoxicity (P < 0.05), in S. cerevisiae BY4741. The least protective effect was showed by the acetone extracts of T. olbiensis (144 +/- 8); methanol ex-tracts of P. lefebvrei (140 +/- 8) and P. juniperi (140 +/- 10). MCF 7 cells showed more sensitivity against to methanol extracts of T. boudieri at 10-100 mu g/mL concentrations. HepG2 cells showed more sensitivity against the methanolic extracts of T. boudieri at both doses. Overall, P. lefebvrei and P. juniperi extracts had the least cytotoxic effects. The species of Terfezia exhibit significant protective effects against DNA damage and also have the potential of cytotoxicity effects.
Assessment of Stigmatization and Self-Esteem in Patients With Epilepsy
(Academic Press inc Elsevier Science, 2024) Atan, Gulden; Oruc, Fatma Gunduz; Atan, Kemal
Aim: This study was conducted to examine the relationship between stigmatization and self-esteem of patients with epilepsy. Methods: This cross-sectional study was conducted with 216 patients at a university hospital in Van, a province in eastern Turkey. The researcher prepared the data collection tools, including a personal information form, Jacoby Stigma Scale and the Rosenberg self-esteem scale, in line with the literature. The Jacoby stigma scale was applied to assess stigma. Data analysis was performed using t-test, one-way analysis of variance (ANOVA), and Tukey, LSD coefficient. Results: The mean total stigmatization score of patients with epilepsy was 21.11 +/- 10.00, while the mean total self-esteem score was 20.26 +/- 5.16. The study found a significant negative correlation between stigmatization and self-esteem scores (r = -0.411; p < 0.05). Conclusion: The research study revealed that patient with epilepsy have a high perception of stigma and low selfesteem levels.
Biochemical Composition Influenced by Different Locations in Uzun Pistachio Cv. (Pistacia Vera L.) Grown in Turkey
(Academic Press inc Elsevier Science, 2006) Seferoglu, S.; Seferoglu, H. G.; Tekintas, F. E.; Balta, F.
Uzun is one of the major pistachio varieties of Turkey. In this study conducted in seven different locations of the Buyuk Menderes River Basin of western Anatolia (Turkey), some biochemical and fruit quality traits were assessed. Biochemical contents such as protein, fat, dry matter and ash contents, unsaturated and saturated fatty acid compositions in this variety were determined based on locations over a period of 2 years. Biochemical composition such as protein, fat, dry matter and ash contents differed significantly by locations (P < 0.05). The mean protein content ranged from 23.2%-31.7%. The mean fat content varied from 46.8%-66.5%. The unsaturated fatty acid composition as percent showed averagely a range of 72.2-75.0 for oleic acid, 11.2-13.1 for linoleic acid, 0.27-0.34 for linolenic acid, 0.21-0.28 for arachidic acid, 0.40-0.43 for gadoleic acid and 0.11-0.14 for behenic acid depending on locations. The saturated fatty acids as percent composed a range of 0.06-0.08 in myristic acid, 8.25-9.52 in palmitic acid, 0.59-0.76 in palmitoleic acid, 0.05-0.07 in heptadecanoic acid and 2.36-3.71 in stearic acid. The contents of saturated fatty acids (palmitic, palmitoleic and stearic) except for myrictic and heptadecanoic acid, and all unsaturated fatty acids (oleic, linoleic, linolenic, arachidic and behenic) except for gadoleic acid also differed significantly by locations (P < 0.05). Consequently, the biochemical composition was significantly affected by different growing areas. (c) 2006 Elsevier Inc. All rights reserved.
Carbon-Nanotube Rhodium Nanoparticles as Highly-Active Catalyst for Hydrolytic Dehydrogenation of Dimethylamineborane at Room Temperature
(Academic Press inc Elsevier Science, 2018) Gunbatar, Serdar; Aygun, Aysenur; Karatas, Yasar; Gulcan, Mehmet; Sen, Fatih
In this study, we present a carbon nanotube-based Rh nanomaterial as a highly active catalyst for the hydrolytic dehydrogenation of dimethylamine - borane (DMAB) at room temperature. The prepared multi-walled carbon nanotube based Rh nanoparticles, called Rh NPs@ MWCNT, was readily prepared, stabilized and effectively used for the hydrolytic dehydrogenation of DMAB under ambient conditions. Monodisperse Rh NPs@ MWCNT nanocatalyst was characterized by using advanced analytical methods such as X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HR-TEM) etc. These analytical methods revealed that Rh nanoparticles on the surface of MWCNT were well dispersed and the average particle size was found to be 1.44 +/- 0.17 nm. The catalytic experiments revealed that the new Rh NPs@MWCNT nanocatalyst has a high catalytic effect to obtain hydrogen in 3.0 equation from DMAB, and the record catalytic TOF value for the catalytic reaction catalyzed by Rh NPs@MWCNT nanocatalyst was found to be 3010.47 h(-1) at room temperature. The current study presents the detailed kinetic studies of the hydrolytic dehydrogenation of DMAB catalyzed by Rh NPs@MWCNT, the results of catalytic experiments were performed at different temperatures, substrate and catalyst concentrations, the Rh NPs@MWCNT nanocatalyst was effectively used in the completion of the hydrolytic dehydrogenation of DMAB, and activation energy, enthalpy and entropy parameters. The experimental results showed that monodisperse Rh NPs@MWCNT nanocatalyst have record catalytic activity with TOF value of 3010.47 h(-1), and Rh(0) nanoparticles were well dispersed on the multi-walled carbon nanotubes. (C) 2018 Elsevier Inc. All rights reserved.
Characterization of Peripheral Blood T Follicular Helper (Tfh) Cells in Patients With Type 1 Gaucher Disease and Carriers
(Academic Press inc Elsevier Science, 2023) Uzen, Ramazan; Bayram, Fahri; Dursun, Huseyin; Kardas, Fatih; Cakir, Mustafa; Cucer, Nurhan; Donmez-Altuntas, Hamiyet
Background: Gaucher disease (GD) is the most common autosomal recessive lipid storage disease. In this study, the changes in TFH cells and IL-4 and IL-21 cytokines in blood samples of GD patients, carriers and healthy volunteers were investigated.Methods: Two pretreatment type 1 GD patients, 20 currently treated type 1 GD patients, 6 carriers, and 27 healthy volunteers were enrolled in the study. TFH cell (CD45RA- CD4+CXCR5+) number, phenotype (PD1, ICOS expression), and cytokine production (IL-21, IL-4) were assessed via flow cytometric assays.Results: No significant differences were found between the groups with respect to the number, frequency and PD1 or ICOS expression of TFH cells between healthy controls, patients and carriers. However, IL-4+ TFH cells were significantly reduced both in percent and number in the treated GD patients compared with healthy controls (p < 0.05). Interestingly, the IL-21+ TFH cell number was increased in treated GD patients. When TFH cells were examined based on CXCR3 expression, the frequency of the PD1+Th17-Th2-like fraction (CXCR3-) was found to be significantly increased in treated GD patients. Conclusion: To our knowledge, this is the first study to assess TFH cells in GD patients, and to show that the production of IL-4 and IL-21 by TFH cells and their subsets may be altered in type 1 GD patients.
Characterization of Rheum Ribes With Zno Nanoparticle and Its Antidiabetic, Antibacterial, Dna Damage Prevention and Lipid Peroxidation Prevention Activity of in Vitro
(Academic Press inc Elsevier Science, 2022) Meydan, Ismet; Burhan, Hakan; Gur, Tugba; Seckin, Hamdullah; Tanhaei, Bahareh; Sen, Fatih
This study aims to investigate the antidiabetic, antimicrobial, DNA damage, and lipid peroxidation prevention activity of ZnO NPs/Rr formed as a result of the interaction of Rheum ribes (R.ribes) plant with ZnO. The ZnO NPs/Rr obtained as a result of the reaction were confirmed using high-reliability characterization methods. According to the data obtained as a result of the study, it is seen that the activity of ZnO NPs/Rr to prevent lipid peroxidation is quite strong. Lipid peroxidation inhibition activity of ZnO NPs/Rr at the highest concentration of 250 mu g/ml was calculated as % 89.1028. It was observed that ZnO NPs/Rr prevented DNA damage by % 92.1240 at the highest concentration of 100 mu g/ml. It was determined that the antidiabetic effect of ZnO NPs/Rr formed by ZnO of R. ribes plant, which is used as a medicinal plant as an antidiabetic, was significant. It appears to have a strong antidiabetic property compared to the positive control acarbose. In our current study, it was observed that ZnO NPs/Rr formed zones ranging from 8 +/- 3.0 to 21 +/- 4.5 against Gram-positive and Gram-negative microorganisms. It has been determined that ZnO nanoparticles have an antibacterial effect.
Comparison of Two Methods (Microscopy and Enzyme-Linked Immunosorbent Assay) for the Diagnosis of Amebiasis
(Academic Press inc Elsevier Science, 2005) Tanyuksel, M; Yilmaz, H; Ulukanligil, M; Araz, E; Cicek, M; Koru, O; Petri, WA
Diagnosis of amebiasis is usually performed on a clinical basis alone in most endemic countries having limited economic resources. This epidemiological study was conducted using modern diagnostic tests for amebiasis in the southeastern region of Turkey, an endemic area for amebiasis. The population of this study included patients with symptomatic diarrhea/dysentery attending both Yuzuncu Yil University, Van and Harran University, Sanliurfa, Turkey. A total of 380 stool specimens were collected and examined for Entamoeba by light microscopy (fresh, lugol, and trichrome staining) and stool antigen detection based- enzyme-linked immunosorbent assay (EIA) test (TechLab Entamoeba histolytica 11). 24% (91/380) of stool specimens were positive for E. histolytical Entamoeba dispar trophozoites/cysts microscopically using trichrome staining. 13% (51/380) of the stool specimens were found to be positive for E. histolytica by the EIA test, including 15% (14/91) of microscopy (+) stool specimens and 13% (37/289) of microscopy (-) stool specimens. Enteric parasites were common in these populations with 66% (251/380) of the study population harboring more than one parasite. In addition to the 13% (51/380) of patients determined to have E. histolytica by EIA, eighty-six patients (22.6%) had Blastocystis hominis, 54 (14.2%) Entamoeba coli, 44 (11.5%) Giardia lamblia, 16 (4.2%) Chilomastix mesnili, 15 (3.9%) Iodamoeba butschlii, 12 (3.1%) Hymenolepis nana, 9 (2.3%) Endolimax nana, 9 (2.3%) Dientamoeba fragilis, and 8 (2.1%) had Ascaris lumbricoides. We concluded that E histolytica infection was found in 13% of the patients presenting with diarrhea in Van and Sanliurfa Turkey. (c) 2005 Elsevier Inc. All rights reserved.
Composition Dependent Activity of Pdagni Alloy Catalysts for Formic Acid Electrooxidation
(Academic Press inc Elsevier Science, 2018) Ulas, Berdan; Caglar, Aykut; Sahin, Ozlem; Kivrak, Hilal
In the present study, the carbon supported Pd, PdAg and PdAgNi (Pd/C, PdAg/C and PdAgNi/C) electrocatalysts are prepared via NaBH4 reduction method at varying molar atomic ratio for formic acid electrooxidation. These as-prepared electrocatalysts are characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), inductively coupled plasma mass spectrometry (ICP-MS), N-2 adsorption desorption, and X-ray electron spectroscopy (XPS), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), chronoamperometry (CA), and lineer sweep voltammetry (LSV). While Pd-50,Ag-50/C exhibits the highest catalytic activity among the bimetallic electrocatalyst, it is observed that Pd70Ag20Ni10/C electrocatalysts have the best performance among the all electrocatalysts. Its maximum current density is about 1.92 times higher than that of Pd/C (0.675 mA cm(-2)). Also, electrochemical impedance spectroscopy (EIS), chronoamperometry (CA) and lineer sweep voltammetry (LSV) results are in a good agreement with CV results in terms of stability and electrocatalytic activity of Pd50Ag50/C and Pd70Ag20Ni10/C. The Pd70Ag20Ni10/C catalyst is believed to be a promising anode catalyst for the direct formic acid fuel cell. (C) 2018 Elsevier Inc. All rights reserved.
Detailed Study on Cold Storage of Mulberry Fruits: Effect of Postharvest Putrescine Treatments on Quality Characteristics and Biochemical Properties of Mulberry Fruits
(Academic Press inc Elsevier Science, 2024) Yavic, Adnan
Product loss during the post-harvest preservation process of fruits produced in the world causes difficulties in people's access to sufficient food. Mulberry is one of the fruits with the shortest storage life among fruit types and is difficult to preserve. In this study, the effect of post-harvest putrescine application (0.5, 1, 1.5 mM) on the quality characteristics and biochemical contents of cold stored mulberry fruits was examined. After putrescine application, the fruits were stored at cold conditions (0 +/- 0.5 degrees C and 90 +/- 5% RH) for 7, 14, and 21 days. Among the fruit quality characteristics, weight loss was determined to be 3.72% on the 21st day at a dose of 1.5 mM putrescine, while it was 6.39% in the control group, indicating a reduction of approximately 2.67%. Putrescine doses also significantly inhibited the decay rate and prevented an increase in respiration rate. The organic acid and phenolic compound content in the fruits decreased during the storage period. In this study, 1.5 mM putrescine dose (8.29 mg 100 g(-1)) preserved the malic acid content, which decreased during storage, by approximately 14% compared to the control group (7.25 mg 100 g(-1)) on the 21st day. At the end of storage, the 1.5 mM putrescine dose prevented a 10% decrease in chlorogenic acid content. As a result, this research has determined that post-harvest putrescine applications preserved the quality characteristics and biochemical content of mulberries during storage.
Determination of Complementary and Alternative Medicine Use Frequency and Related Factors in Children With Epilepsy: a Descriptive Cross-Sectional Study From Eastern Turkey
(Academic Press inc Elsevier Science, 2024) Can, Veysel; Bulduk, Mehmet; Aysin, Nesrullah; Can, Emine Kurt; Aydin, Nihal
Purpose: The aim of this study is to determine the complementary and alternative medicine (CAM) methods used in epilepsy patients admitted to a paediatric neurology clinic in Turkey and to examine the factors affecting these methods. Methods: This study was conducted between October 2022 and March 2023 by using a questionnaire form prepared in line with the literature to the parents (n = 172) of children who were under the age of 18 and who had been diagnosed with epilepsy for at least 1 year and who were followed up in the paediatric neurology outpatient clinic of a secondary care hospital in Van province of Turkey. The principles of scientific ethics and confidentiality of data were complied with in all stages of the study. Results: The study included 172 parents of 172 children with a mean age of 2.95 +/- 0.93 years. In the study, it was found that 37.2 % of the parents had previously used CAM themselves, almost all of the parents (98.8 %) had not discussed the use of CAM with their physician or nurse, half of the parents considered CAM to be dangerous, and 28.2 % wanted to receive counselling to learn more about CAM. It was also found that 28.5 % of the parents used CAM in the treatment of their children. The most commonly preferred CAM among parents in the treatment of epilepsy was religious healing (79.6 %) which is among mind/body practices. It was found that the most common technique used by parents was regular praying (71.4 %). Religious beliefs were effective in the use of CAM in our patient population, while confidence in medical treatment was effective in not using CAM. More than half of the parents who used CAM in their child's treatment reported benefits and reduced seizure frequency. The factors significantly associated with CAM use in children with epilepsy were parental education level, parental CAM use and disease duration. In univariate and multivariate analyses, it was found that a degree below high school increased the likelihood of CAM use by 0.017 and 0.024 times, respectively, compared to being illiterate. Conclusions: Pediatric nurses' routine examination of CAM methods used in paediatric epilepsy patients and the factors affecting these methods is very important in terms of preventing negative effects on child health, effective management of the disease process, ensuring safe use and strengthening communication to improve the quality of care.
Determination of Fatty Acid Compositions, Oil Contents and Some Quality Traits of Hazelnut Genetic Resources Grown in Eastern Anatolia of Turkey
(Academic Press inc Elsevier Science, 2006) Balta, M. F.; Yarilgac, T.; Askin, M. A.; Kucuk, M.; Balta, F.; Ozrenk, K.
Located in eastern Anatolia, Bitlis province presents microclimatic conditions for hazelnut cultivation. This microclimatic zone results from the mild effects of Lake Van and Suphan Mountain. With native hazelnut population of 2750 da, Hizan County is surrounded by high mountains, and is a special microclimatic zone where all plantations consisting of thousands of hazelnut plants are native. Bitlis can therefore be said to be rich in wild genetic resources of hazelnut. The aim of this study was to select promising genotypes within the native hazelnut population, describe the desirable nut characteristics, and provide some chemical traits with respect to nutritional values for future breeding efforts. In this study, some nut quality characteristics, protein, ash and oil contents, and fatty acid compositions of 20 Corylus avellana L. genotypes selected from native hazelnut population of Bitlis (eastern Anatolia, Turkey) were described. The hazelnut genotypes showed nut weight in a range from 1.85 to 3.63 g; kernel weight, 0.80-1.46 g; kernel percentage, 32.26-46.11 %; shell thickness, 1.20-2.04 mm; nut length, 16.1-23.4 mm; nut width, 15.9-21.0 mm; nut thickness, 12.9-18.5 mm; kernel length, 13.0-18.7 mm; kernel width, 10.3-15.4 mm; kernel thickness, 9.4-12.8 mm; nut shape index, 0.99-1.50; kernel shape index, 0.96-1.73; shrivelled kernel, 0-10%, and double kernels, 0-6%. With respect to nutritional analyses, the hazelnuts contained oil in the range from 57.5% to 74.1%; protein, 15.7-19.2%, ash, 0.79-3.21%; palmitic acid, 4.39-8.85%; stearic acid, 1.67-3.18%; oleic acid, 73.48-81.57%; linoleic acid, 10.46-14.95%: linolenic acid, 0.02-0.34%, and myristic acid, 0.01-0.16%. All genotypes had light-brown colored kernels, and kernel flavor was "medium satisfactory" and "satisfactory". The findings revealed that some genotypes are promising in nut and kernel characteristics as well as in nutritional value for future breeding efforts. (c) 2005 Elsevier Inc. All rights reserved.
Determination of Toxicity of Trichloroacetic Acid in Rats
(Academic Press inc Elsevier Science, 2007) Celik, Ismail
This study aims to investigate the effects of the trichloroacetic acid (TCA) on serum marker enzymes [aspartate aminotransferase (AST), alanin aminotransferase (ALT), creatine phosphokinase (CPK), acid phosphatase (ACP), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH)], antioxidant defense systems [Reduced glutathione (GSH), glutathione reductase (GR), superoxide dismutase (SOD), glutathione-S-transferase (GST) and catalase (CAT)] and lipid peroxidation content (Malondialdehyde, MDA) in various tissues of rats. TCA (2000 ppm) as drinking water was administered orally to rats (Sprague-Dawley albino) ad libitum for 50 days continuously. TCA treatments caused different effects on the serum marker enzymes, antioxidant defense systems and the MDA content in experimented rats compared to controls. Results showed that TCA caused a significant increase in serum AST, ALT, CPK and ACP activity. The lipid peroxidation end product MDA slightly increased in the erythrocytes, liver and kidney of rats treated with TCA, whereas did not change in the brain. In addition, antioxidant enzyme activity such as CAT and SOD significantly increased in the brain, liver and kidney tissues of TCA induced group whereas the ancillary enzyme GR and the drug metabolizing enzyme GST activity did not significantly change in the all tissues. The observations presented led us to conclude that the administration of subchronic TCA promotes lipid peroxidation content, elevates tissue damage serum marker enzymes and fluctuates in the antioxidative systems in rats. Also the rats resisted to oxidative stress via antioxidant mechanism but the antioxidant mechanism could not prevent the increases in lipid peroxidation in rat's tissues. These data, along with the determined changes suggest that TCA produced substantial systemic organ toxicity in the erythrocyte, liver, brain and kidney during the period of a 50-day subchronic exposure. (C) 2007 Elsevier Inc. All rights reserved.
A Different Method for Calculation of the Deflection Angle of Light Passing Close To a Massive Object by Fermat's Principle
(Academic Press inc Elsevier Science, 2013) Akkus, Harun
We introduce a method for calculating the amount of deflection angle of light passing close to a massive object. It is based on Fermat's principle. The varying refractive index of medium around the massive object is obtained from the Buckingham pi-theorem. (C) 2013 Elsevier Inc. All rights reserved.
Differential Inequalities in Lp-Spaces
(Academic Press inc Elsevier Science, 2014) Mustafayev, H. S.
In this article, we present inequalities related to the continuous representations of one-parameter groups. As an application, we obtain some differential inequalities of Bernstein type in L-p-spaces: We define the spectrum Sigma(f) of f is an element of L-p (R) (1 <= p < infinity), as Sigma(f) = boolean OR sp(B) {f * k} (1/P + 1/Q = 1), k is an element of L-q (R) where sp(B){.} is the Beurling spectrum. It is shown that if tau is an element of R satisfies the condition 0 <= tau sigma < pi, then f' is an element of L-p(R) and parallel to f'parallel to(p) <= sigma/2 sin tau sigma parallel to f(. + tau) - f(. - tau)parallel to(p), where sigma := sup{vertical bar lambda vertical bar: lambda is an element of Sigma(f)}. Some related problems are also discussed. (C) 2013 Elsevier Inc. All rights reserved.
Direct Oxidation of Methanol To Formaldehyde by N2o on [Fe]1+ and [Feo]1+ Sites in Fe-Zsm Zeolite: a Density Functional Theory Study
(Academic Press inc Elsevier Science, 2011) Fellah, Mehmet Ferdi
Density functional theory (DFT) calculations were carried out in a study of the mechanism of direct oxidation of methanol to formaldehyde by N2O over an extra-framework species in ZSM-5 zeolite represented by a [(SiH3)(4)AIO(4)(Fe) or (FeO)] cluster models. The major difference between these two sites is that in the case of the [Fa](1+) site, a reaction is present that leads to the formation of the thermodynamically highly stable grafted OH and methoxy (OCH3) species. Moreover, the vibrational frequencies for grafted species on the surface match well with the experimental values. The theoretical calculations achieved in this study obviously show that [Fe-O](1+) site in Fe-ZSM-5 catalyst has a significant role on the catalytic oxidation of methanol to formaldehyde by N2O. (C) 2011 Elsevier Inc. All rights reserved.
Dissipative Operators on Banach Spaces
(Academic Press inc Elsevier Science, 2007) Mustafayev, Heybetkulu
A bounded linear operator T on a Banach space is said to be dissipative if parallel to e(tT)parallel to <= 1 for all t >= 0. We show that if T is a dissipative operator on a Banach space, then: (a)lim(t)->infinity parallel to e(tT) T parallel to = {vertical bar lambda vertical bar: lambda epsilon sigma (T) boolean AND i R} (b) If sigma (T) boolean AND i R is contained in [-i pi/2, i pi/2], then [GRAPHICS] Some related problems are also discussed. (c) 2007 Elsevier Inc. All rights reserved.
Doxorubicin-Induced Senescence Promotes Resistance To Cell Death by Modulating Genes Associated With Apoptotic and Necrotic Pathways in Prostate Cancer Du145 Cd133+/Cd44+cells
(Academic Press inc Elsevier Science, 2023) Tatar, Cansu; Avci, Cigir Biray; Acikgoz, Eda; Oktem, Gulperi
Cancer stem cells (CSCs) are the most important cause of cancer treatment failure. Traditional cancer treatments, such as chemotherapy and radiotherapy, damage healthy cells alongside malignant cells, leading to severe adverse effects. Therefore, inducing cellular senescence without triggering apoptosis, which further damages healthy cells, may be an alternative strategy. However, there is insufficient knowledge regarding senescence induction in CSCs that show resistance to treatment and stemness properties. The present study aims to elucidate the effects of senescence induction on proliferation, cell cycle, and apoptosis in prostate CSCs and non-CSCs. Prostate CSCs were isolated from DU145 cancer cells using the FACS method. Subsequently, senescence induction was performed in RWPE-1, DU145, prostate CSCs, and non-CSCs by using different concentrations of Doxorubicin (DOX). Cellular senescence was detected using the senescence markers SA-beta-gal, Ki67, and senescence-associated heterochromatin foci (SAHF). The effects of senescence on cell cycle and apoptosis were evaluated using the Muse Cell Analyzer, and genes in signaling pathways associated with the apoptotic/necrotic pathway were analyzed by real-time PCR. Prostate CSCs were isolated with 95.6 +/- 1.4% purity according to CD133+/CD44+ characteristics, and spheroid formation belonging to stem cells was observed. After DOXinduced senescence, we observed morphological changes, SA-beta-gal positivity, SAHF, and the lack of Ki67 in senescent cells. Furthermore; we detected G2/M cell cycle arrest and downregulation of various apoptosis-related genes in senescent prostate CSCs. Our results showed that DOX is a potent inducer of senescence for prostate CSCs, inhibits proliferation by arresting the cell cycle, and senescent prostate CSCs develop resistance to apoptosis.

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