Investigation of the Effect of Aminoglycosides on Angiotensin Converting Enzyme (Ace)

Abstract

Objective: The research attention to nephrotoxicity from antibiotics (as aminoglycosides), non-steroidal anti-inflammatory drugs, and antifungals, angiotensin-converting enzyme (ACE) inhibitors. Several drugs have resulted in produce an adverse effect on kidneys. Angiotensin-converting enzyme (ACE) is a component of the renin-angiotensin system (RAS), which leads to the conversion of angiotensin-I to angiotensin-II in vascular tissues. The present study aimed to determine serum ACE activity in rats with an aminoglycosine. Material-Method: In this study, two different groups formed, the control group (10 rats/Wistar-albino female) and the experimental group (30 rats/Wistar-albino female) administered aminoglycosine (Amikacin). Aminoglycosine was administered intraperitoneally to the experimental group at a single dose of 15 mg/kg body weight at the same time each day for 14 days. The control group implemented physiological water instead of aminoglycosine at the same rate. Result: When the groups compared according to the statistic results, it is observed that there was a significant increase in the experimental group according to the control group (p˂0.001). Conclusion: As a result, it was determined that aminoglycosin administered increased serum ACE activity and it was concluded that it may be useful to investigate the possibilities to evaluate it as a risk factor and indicator in the development of hypertension