Determination of Maternal Lipid Peroxidation and Antioxidant Activities in Term and Preterm Birth in Different Weeks

Abstract

Aim: It has been suggested that oxidative stress may be associated with various pregnancy complications, including preterm birth (PTB). However, the rote of oxidative stress in preterm births and its effects on the pregnancy process are not conclusive. Material and Method: In this study, oxidative stress parameters were investigated in maternal blood samples who delivered at preterm and term. One hundred twelve mothers (<37 gestational weeks) diagnosed with preterm delivery were included in the study as a patient group. Also, sixty-four women who delivered at term as a control group were included in the study. Serum antioxidant enzymes (CAT (Catalase), SOD (Superoxide dismutase), GSHPx (Glutathione peroxidase), GSH (Glutathione) and MDA (Malondialdehyde) levels were determined spectrophotometrically. Results: Serum antioxidant activity was lower in the preterm groups than in the control group. Also, serum lipid peroxidation levels were higher in the preterm groups than the control group (p< 0.05). Discussion: Our findings show that women with preterm birth have higher levels of oxidative stress. These results suggest that oxidative stress is associated with preterm labor. However, It is still unclear whether oxidative stress is a cause or a result of preterm birth.