WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14720/3

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Design, Synthesis, and Evaluation of Pyrrolopyrazine-Substituted Benzoxazole/Benzothiazole Derivatives Targeting Aurora Kinase a in Mcf-7 Cells
(Wiley-V C H Verlag Gmbh, 2025) Kuzu, Burak; Kostekci, Sedat; Karakus, Fuat; Tuluce, Yasin
This study reports the synthesis, characterization, and biological evaluation of 19 benzoxazole/benzothiazole hybrids (19a-s). The compounds were synthesized through a multi-step process and structurally confirmed via NMR, elemental, and MS analyzes. Their antiproliferative effects were assessed on MCF-7 breast cancer and HME1 healthy epithelial cells. MTT assays identified 15 compounds with significant cytotoxic activity, among which 19e, 19g, 19i, 19j, and 19k exhibited high selectivity for MCF-7 cells. ELISA results demonstrated that 19g, 19i, 19j, and 19k significantly reduced AURKA protein levels in MCF-7 cells, while sparing healthy cells, suggesting their role in inhibiting cancer cell proliferation. These findings highlight 19g, 19i, 19j, and 19k as promising selective AURKA-targeted agents for breast cancer therapy.
Effectiveness of Cardiac Rehabilitation in Enhancing Adherence and Improving Clinical Outcomes Post-Acute Coronary Syndrome: a Randomized Controlled Trial
(Wiley, 2025) Tuner, Hasim; Polat, Fuat; Alic, Enes; Kaya, Ali Nail; Cakmak, Cigdem Bahar; Coskun, Ferhat; Ozbek, Emrah
Background:Acute coronary syndrome (ACS) remains a major contributor to cardiovascular morbidity and mortality. Cardiacrehabilitation programs have shown promise in improving adherence to lifestyle and medical recommendations, yet theirimpact on clinical outcomes and complications requires further investigation. Methods:This prospective, randomized, single-center study evaluated the effects of cardiac rehabilitation on adherence andclinical outcomes in ACS patients. A total of 340 patients were randomized into a Cardiac Rehabilitation Group or ControlGroup. The Cardiac Rehabilitation Group underwent supervised exercise, dietary counseling, and education, while the ControlGroup received standard recommendations. Outcomes, including adherence rates and complications, were assessed over 1 year,with additional interim analyses to evaluate early sustainability of behavioral changes. Results:Patients in the Cardiac Rehabilitation Group demonstrated significant improvements in adherence to dietary rec-ommendations (73.5% vs. 52.4%,p< 0.01) and physical activity (85.3% vs. 68.2%,p< 0.01). Cardiac Rehabilitation Grouppatients also experienced fewer instances of weight gain (22.9% vs. 34.7%,p= 0.017) and access site complications (21.2% vs.40%,p< 0.01). Hospital readmissions were reduced in the Cardiac Rehabilitation Group compared to the Control Group (18.8%vs. 31.2%,p= 0.015). Non-adherence to dietary recommendations (HR: 2.42, 95% CI: 1.08-5.41,p= 0.032) and medical treat-ments (HR: 2.84, 95% CI: 1.32-6.11,p= 0.007) were significantly associated with increased risk of revascularization. Conclusion:Cardiac rehabilitation significantly enhances adherence to medical and lifestyle recommendations, reducescomplications, and improves outcomes in ACS patients. These findings emphasize the critical role of structured rehabilitation inpost-ACS management.
Therapeutic Potential of Young Plasma in Reversing Age-Related Liver Inflammation Via Modulation of Nlrp3 Inflammasome and Necroptosis
(Springer, 2025) Baba, Burcu; Ceylani, Taha; Teker, Hikmet Taner; Keskin, Seda; Genc, Aysun Inan; Gurbanov, Rafig; Acikgoz, Eda
The phenomenon of inflammaging, characterized by an increase in low-grade chronic inflammation, is closely associated with diseases related to liver dysfunction. This study investigated daily plasma exchange between 5-week-old and 24-month-old Sprague Dawley rats for 30 days, focusing on protein secondary structures, NLRP3 inflammasome, and necroptosis. Conformation changes in protein secondary structures were identified by infrared spectroscopy-based pattern recognition analysis. Liver biopsies with histochemical and immunohistochemical staining were used to assess molecules associated with inflammation, necroptosis and NLRP3 inflammasome complex. Expression levels of NLRP3 components were determined by qPCR. Enhanced random coils, 310 helices, beta-turns, and loop structures were identified in old rats and young rats with old plasma. Young rats and old rats with young plasma displayed higher alpha-helices and beta-sheet structures. Young rats with old plasma showed increased NLRP3, ASC, caspase-1, IL-1 beta, and IL-18 mRNA levels, indicating an inflammatory response. Whereas old rats with young plasma exhibited lower inflammation levels. Histological evaluations revealed that young rats receiving aged plasma showed significantly increased levels of NLRP3, ASC, caspase-1, IL-1 beta, TNF-alpha, VEGFR2, RIPK1, and MLKL immunoreactivity, whereas decreased immunoreactivity in aged rats receiving young plasma. These findings suggest that young plasma reduces NLRP3 inflammasome activation and necroptosis in aged rats.
The Negative Effects of Subclinical Pregnancy Toxaemia on Fetal Skeletal Muscle Development and Evaluation of the Protective Effects of Dietary L-Carnitine Supplementation in Sheep
(Wiley, 2025) Turgut, Ali Osman; Kandil, Banu; Bilen, Ebru Karakaya; Koca, Davut; Unver, Ali; Isbilir, Fatma; Wehrend, Axel
This study evaluated the effects of subclinical pregnancy toxaemia (SPT) on fetal skeletal muscle development and assessed the potential protective role of L-carnitine supplementation during gestation. A total of 18 crossbred Hamdani ewes underwent oestrous synchronisation, natural mating and pregnancy confirmation via ultrasonography on day 45 post-mating. The ewes were managed according to NRC (2007) dietary guidelines until day 100 of gestation, after which they were assigned to three experimental groups: subclinical PT group (group 1; G1, n = 6), treatment group (subclinical PT + L-carnitine, group 2; G2, n = 6) and control group (group 3; G3, n = 6). Blood beta-hydroxybutyrate (beta HBA) concentrations were measured on day 100 and 138 of the gestation. Then, all ewes were slaughtered for fetal muscle sampling from the Musculus Longissimus Dorsi (MLD) and Vastus Lateralis (VL). Results indicated a significant reduction in muscle fibre number and fibre diameter in both MLD and VL in the SPT group (G1) compared to the control (G3) (p < 0.05). No significant differences were observed between G1 and G2 or between G2 and G3 for these parameters (p > 0.05). On the other hand, large effect sizes for group and pairwise comparisons imply that SPT may negatively affect prenatal muscle development and L-carnitine supports muscle development during the prepartum period. These findings highlight the negative effects of SPT and protective effects of L-carnitine supplementation on fetal skeletal muscle development in ewes with SPT. The observed deficits may negatively impact postnatal growth, survival rates and meat quality. Further investigations are warranted to optimise maternal nutrition strategies and evaluate therapeutic interventions aimed at mitigating the adverse impacts of SPT on fetal muscle development in ruminants. Furthermore, L-carnitine supplementation may be a useful in compensating for the negative effects of SPT.
Development of Benzoxazole Derivatives Targeting Mtor: a Promising Approach for Breast Cancer Therapy
(Wiley-V C H Verlag Gmbh, 2025) Alagoz, Mehmet Abdullah; Resitoglu, Meryem Temiz; Kuzu, Burak; Sabrie, Zainab; Yetkin, Derya; Zobi, Cengiz; Algul, Oztekin
Clinical use of mTOR inhibitors in cancer treatment is well established due to the critical role of mTOR signaling in tumor progression. In this study, we report the structure-based design and biological evaluation of a series of benzoxazole derivatives as potential mTOR inhibitors. Cytotoxicity studies using MTT assays showed that compounds B4, B11, B12, and B20 exhibited significant antiproliferative effects against breast cancer cell lines with IC50 values between 4.96 and 9.82 mu M. Colorimetric enzymatic assays further revealed that among these, only B12 and B20 effectively inhibited mTOR phosphorylation at Ser2448 in MCF-7 cells. Additionally, both compounds modulated the expression of key apoptotic proteins, including Bax, caspase-3, p53, and Bcl2. Molecular docking studies against the 4JT5 protein demonstrated binding affinities with docking scores ranging from -7.084 to -7.426 kcal/mol, comparable to the reference compound P2X (-7.309 kcal/mol). Molecular dynamics simulations over 150 ns confirmed the stability of B12 and B20 in the active site, with an average RMSD of 2.8 & Aring; and 3.0 & Aring;, respectively. The absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of the synthesized compounds were evaluated in silico. Among them, B4, B11, B12, and B20 exhibited drug-like characteristics and showed no undesirable toxic effects. These findings highlight the potential of B12 and B20 as lead compounds for the development of novel mTOR inhibitors in breast cancer therapy.
Turkish Physicians Approach To Lesbian, Gay, Bisexual, Transgender, and Other Gender and Sexual Minority Individuals and Their Sexual Health
(Oxford Univ Press, 2025) Ceker, Gokhan; Arda, Ersan; Cakici, Ozer Ural; Gul, Murat; Ibis, Muhammed Arif; Kutman, Kerem Gencer; Bal, Harun
Background: Lesbian, gay, bisexual, transgender, and other gender and sexual minority (LGBT+) individuals often face healthcare disparities, and physicians' knowledge, attitudes, and clinical preparedness significantly impact access to competent care. Aim: This study evaluated Turkish physicians' perspectives, knowledge, and clinical approaches to LGBT+ sexual health, highlighting educational and clinical gaps. Methods: A nationwide cross-sectional survey was conducted among physicians from 10 specialties involved in LGBT+ sexual health. The survey, administered anonymously via Google Forms between June 4, 2024, and February 1, 2025, included sociodemographic questions and items assessing attitudes, clinical experience, and guideline familiarity. Statistical analyses included descriptive statistics, chi-square, Fisher's exact tests, and binary logistic regression to identify predictors of physician attitudes and perceived competence. Outcomes The primary outcome was to assess physicians' perspectives, competency, and willingness to provide LGBT+ healthcare, including gender-affirming procedures. Results: Among 745 participants, 58.8% considered LGBT+ identities normal, while 22.9% classified them as psychiatric disorders. Perceiving LGBT+ identities as normal was significantly associated with being female (OR = 3.12, 95% CI: 1.96-4.96, P < .001), prior experience treating LGBT+ patients (OR = 2.22, 95% CI: 1.60-3.07, P < .001), and physician specialty. This view was most common among psychiatrists (P = .012) and child and adolescent psychiatrists (P = .015). Physicians' views were primarily shaped by education (43.2%) and socio-cultural environment (40.9%). Although 63.9% had treated LGBT+ patients, only 28.2% felt competent, and 11.5% were aware of relevant guidelines. Only 18% of surgical specialists supported gender-affirming procedures. The most commonly cited reason for reluctance was lack of surgical experience (44.8%), along with concerns related to religious beliefs, absence of a surgical team, and potential surgical complications. Ethical dilemmas were evident, as 58.3% believed LGBT+ patients face discrimination in healthcare, and 21.9% supported a physician's right to refuse care based on personal beliefs. Clinical Implications: Enhancing physicians' education and competency in LGBT+ healthcare through structured training and standardized guidelines is crucial to improving equitable healthcare delivery. Strengths and Limitations: This study provides novel insights into physicians' attitudes and practices regarding LGBT+ healthcare in Turkey. However, self-reported data may introduce response bias, and findings may not be fully generalizable to other regions. Conclusion: Significant educational and clinical gaps persist in LGBT+ healthcare. Addressing these through structured training programs, standardized protocols, and multidisciplinary collaboration is essential to ensuring competent, inclusive, and ethical medical care.
Bruxism and Stress: Ultrasonographic Masseter Muscle Assessment and Salivary Melatonin-Cortisol Dynamics
(Wiley, 2025) Kaya, Sema; Koc, Alaettin; Huyut, Zuebeyir
BackgroundBruxism is a parafunctional activity characterised by teeth grinding or clenching, often associated with stress and neurophysiological factors. Its aetiology is multifactorial, with recent studies emphasising neurotransmitters and hormonal imbalances, particularly melatonin and cortisol. This study assesses masseter muscle thickness using ultrasonography and examines the relationship between salivary melatonin and cortisol levels in bruxism. ObjectiveThis study aimed to evaluate the ultrasonographic characteristics of the masseter muscle in individuals with bruxism and investigate the association between salivary melatonin and cortisol levels. MethodsThis cross-sectional study included 80 participants (38 bruxists, 42 controls), aged 20-25 years. Bruxism was diagnosed through clinical examination and self-reported questionnaires. Masseter muscle thickness was measured via ultrasonography in relaxed and contracted states. Salivary melatonin and cortisol levels were analysed using enzyme-linked immunosorbent assay (ELISA). Group comparisons were conducted using independent t-tests and ANOVA, with correlation analyses using Pearson's tests. ResultsSalivary melatonin levels showed no significant difference between groups (p = 0.067), while salivary cortisol levels were significantly higher in the bruxism group (p = 0.001). No significant differences in masseter muscle thickness were observed in either state (p > 0.05). A weak but significant positive correlation existed between melatonin and cortisol levels (p < 0.05). ConclusionAlthough not statistically significant, melatonin levels tended to be higher in bruxist patients, possibly due to a negative feedback mechanism to prevent the side effects of cortisol such as oxidative stress or a balancing process of these hormones by cytokines involved such as IL-1 beta.
Metal-Organic Framework Mil-101 as an Efficient Heterogeneous Catalyst for Clean Synthesis of Benzothiazoles and Single Crystal X-Ray Diffraction, Quantum Chemical Studies, Electrochemical Performance, Molecular Docking and Dna Interactions
(Wiley-V C H Verlag Gmbh, 2025) Akbas, Esvet; Ruzgar, Adem; Sahin, Ertan; Levent, Abdulkadir
Benzothiazoles have emerged as a prominent area of research in recent years due to their broad spectrum of biological activities. These heterocyclic compounds, which contain thiazole and benzene rings in their molecular structure, exhibit a wide range of pharmacological effects, including anticancer, antimicrobial, antifungal, antiparasitic, anti-inflammatory, and antitubercular activities. In this study, benzo[d]thiazole derivatives 1 and 2 were synthesized in good yield using catalyst MIL101. The structures of these compounds were analyzed using elemental analysis, IR, 1H, 13C NMR and single crystal X-ray diffraction. The quantum chemical calculations of these compounds were performed density functional theory method, DGDZVP base set and B3LYP functions with Gaussian09W software package. The electrochemical properties of these compounds were investigated by cyclic voltammetry technique on a glassy carbon electrode. In addition, the interactions of the compounds with DNA were investigated by electrochemical, spectrophotometric and molecular docking techniques. It was observed that the chemical calculations and molecular docking results were compatible with each other.
Morphologic Evaluation of the Coccyx in the Pediatric Population
(Springer France, 2025) Meylani, Nevzat; Ten, Baris; Temel, Gulhan; Yuksek, Hasan Husnu; Comert, Ali Danyal; Beger, Burhan; Beger, Orhan
Purpose This computed tomography study aimed to display the alteration in the coccyx morphology (its ossification process, dimension and angulation) in children with advancing age. Methods Pelvic radiologic scans of 180 children aged 1-18 years were retrospectively evaluated to observe changes in the coccyx morphology with age, and to measure the linear length (LL), curvilinear length (CLL), sacrococcygeal angle (SCA), and intercoccygeal angle (ICA). Results The present study divides the postnatal evolution of the coccyx into three phases as follows: (a) in the first stage when the coccyx is of the shortest, it is completely cartilage until the age of 2 (infancy period) and its first segment begins to ossify by the age of 3 (early childhood period), (b) in the second stage when the coccyx is of medium size, its first segment is completely ossified by the age of 6 (late childhood period) and the ossification of its all segments is completed from the age of 11 (prepubescent period), and (c) in the third stage when the coccyx is of the longest, it reaches to adult size (postpubescent period). Linear functions were calculated as y = 15.647 + 1.145 x age (p < 0.001, R-2 = 0.561) for LL, and as y = 16.829 + 1.243 x age (p < 0.001, R2 = 0.559) for CLL. Conclusion Considering that morphological features of the coccyx, such as ICA, can be used in the diagnosis of coccydynia, our dataset may facilitate the identification of children with suspected coccydynia.
Volatile Organic Compounds Released From Cabbage Plants Infested With Wingless Green Peach Aphid (Myzus Persicae) Attracts More Conspecifics
(John Wiley & Sons Ltd, 2025) Ahmed, Nazeer; Darshanee, Hewa Lunuwilage Chamilla; Smagghe, Guy; Atlihan, Remzi; Al-Mekhlafi, Fahd A.; Wadaan, Mohammed A.; Liu, Tong-Xian
BACKGROUNDPlants release a diverse array of volatile organic compounds (VOCs) that play a role in interactions with other plants and arthropod herbivores. The potential of using plants that emit either repellent or attractive VOCs to help managing insect populations have been shown. However, the response of the green peach aphid (Myzus persicae), a major sucking insect pest worldwide, to VOCs from cabbage and infested with conspecific remains unknown. This study investigated how VOCs released by cabbage infested or uninfested by Myzus persicae influenced host selection in seven different cultivars. and compared under infested and non-infested conditions.RESULTSUsing headspace solid-phase microextraction gas chromatography coupled with mass spectrometry (SPME-GC-MS), we identified 22 VOCs from non-infested cabbage plants and 33 from aphid-infested plants across the seven cabbage cultivars. Infested plants emitted a greater diversity and higher amounts of volatiles, dominated by terpenes and green leaf volatiles. Caryophyllene was the only compound common in both infested and non-infested plants. In olfactometer assays, wingless Myzus persicae showed a significant attraction to conspecific-infested plants with the strongest response to the cultivar QG 80. However, this increased attraction was not consistent across all cultivars, highlighting the need for further studies to understand the ecological implications and potential benefits or drawbacks of this attraction.CONCLUSIONOur findings highlight the potential of using VOC-emitting trap crops for the targeted management of Myzus persicae. By identifying key volatiles that attract aphids, this study provides a foundation for developing eco-friendly pest control strategies. (c) 2025 Society of Chemical Industry.
Analysis of the Integro-Differential Jaulent-Miodek Evolution Equation by Nonlinear Self-Adjointness and Lie Theory
(Springer, 2025) Junaid-U-Rehman, Muhammad; Riaz, Muhammad Bilal; Tunc, Osman; Martinovic, Jan
The current exploration is related to the extraction of the exact explicit solutions of the Integrodifferential Jaulent-Miodek evolution (IDJME) equation. In general, the Jaulent-Miodek equation has many applications in many divisions of physics, for example optics and fluid dynamics. The symmetries of this (2 + 1)-dimensional (IDJME) equation are derived, and it admits the 8th Lie algebra. The similarity transformation method is considered to convert the NLPDE to the nonlinear ODE by using the translational symmetries. Then, we calculated the traveling-wave solutions by an analytical method, namely the extended direct algebraic method. Some obtained solutions are represented by giving suitable parameter values to understand their physical interpretation. The results obtained from this method involve various types of functions, for example, exponential, logarithmic, hyperbolic, and trigonometric. The self-adjointness theory is employed to classify and help us to compute the conserved quantities of the assumed model. A similar work related to this does not exist in the literature.
Design and Control of Single Dc Source 19-Level Puc Inverter With Sr-Based Level Synthesis
(Springer Singapore Pte Ltd, 2025) Hatas, Hasan
In multilevel inverters, the number of levels can be increased by diversifying the input source voltages in topologies that cannot be extended. In this article, a switched rectifier (SR) with 1 switch was added to a PUC circuit with 8 switches and producing a maximum of 13 levels, increasing the output level to 19 levels. This topology, developed using a single DC source, produces more than one DC voltage level from the input DC source using SR and normal rectifiers with the help of high frequency link. In the PUC circuit, which normally cannot reach high levels, it was possible to increase the number of levels and successfully synthesize the intermediate levels that cannot be synthesized thanks to the SR module. The idea of the proposed topology, which can produce outputs with different amplitudes and frequencies, was verified both in simulation and experimentally using the Genesys-2 FPGA development board. The proposed topology provides high power quality with 4.4% THD by supporting the fundamental frequency control method without ant filter. It is observed that an efficiency of over 96% is achieved in the MLI loss analysis. In high power applications, the SR-PUC MLI structure's efficiency and harmonic performance make it a reliable and cost-effective option.
Türkiye's Competitive Power in the World Fig Market and Comparison With Selected European Union Countries
(Springer, 2025) Terin, Mustafa
Fig can be produced in a few countries in the world, especially T & uuml;rkiye, due to its climate and ecological demands. T & uuml;rkiye realizes 28.2% of the world's fig production amount and 48.8% of the world's fig export amount. Therefore, fig is a very important product for Turkish agriculture and economy. The aim of this research is to determine T & uuml;rkiye's competitiveness in international fig trade and to compare its competitiveness with Spain, Greece, Italy, France and Portugal, which are important fig producers in the European Union. In the research, the competitiveness of the countries was calculated for the period 2004-2023 using the Export Share Market (ESM), Revealed Comparative Advantage (RCA), and Trade Balance Index (TBI). In the research, T & uuml;rkiye's average ESM, RCA and TBI index results for 2004-2023 were determined as 51.02%, 60.58 and 0.95, respectively. These results show that T & uuml;rkiye has a strong comparative advantage in fig exports and is a net exporter in international fig trade. The average RCA results of EU members Spain, Greece, Italy, France and Portugal for 2004-2023 are 1.81, 14.45, 0.59, 0.67 and 0.37, respectively. According to these results, Spain and Greece have a comparative advantage in fig exports. According to the TBI index results, Greece and Spain are net exporters in international fig trade, while Italy, France and Portugal are net importers. In order for T & uuml;rkiye to increase and maintain its competitiveness in international fig markets, it is necessary to increase yield and quality in production, concentrate on high-value-added fig products (such as organic or processed figs) in exports, and diversify the market.
Modeling Benzene Physicochemical Properties Using Zagreb Upsilon Indices
(De Gruyter Poland Sp Z O O, 2025) Ciftci, Idris; Yamac, Kerem; Denizler, Ismail Hakki
Quantitative structure-property relationship (QSPR) frameworks leverage topological indices to model the physicochemical attributes of molecular structures. In this study, we introduce the concept of upsilon degree and define the Zagreb upsilon indices based on this concept. Our findings demonstrate that the second Zagreb upsilon index exhibits the highest predictive accuracy for the pi-electron energy of benzenes, surpassing existing degree-based topological indices with correlation coefficients exceeding 0.93. This accuracy was measured using statistical correlation analysis, and a direct comparison with the Randi & cacute; and geometric-arithmetic indices further supports the superior performance of the second Zagreb upsilon index. Furthermore, structural sensitivity and abruptness analyses, which assess the stability and variation of an index across different molecular structures, indicate that Zagreb upsilon indices offer superior performance compared to alternative indices. These results suggest that Zagreb upsilon indices have significant potential as a new and effective tool for QSPR research.
A Novel Solution To Enhance the Oxidative and Physical Properties of Cookies Using Maltodextrin-Based Nano-Sized Oils as a Fat Substitute
(Amer Chemical Soc, 2025) Meral, Raciye; Ekin, Mehmet Mustafa; Ceylan, Zafer; Alav, Aslihan; Kina, Erol
This study investigated the effects of maltodextrin-based nanoemulsions as fat substitutes in cookies, focusing on the oxidative stability and physical properties. Full-fat cookies (control, C) and 50% fat-reduced cookies with nanoemulsions (FC) were produced. The addition of nanoemulsions increased the cookie diameter from 46.3 mm (control) to 56.1 mm and reduced the thickness, resulting in a desirable texture. Initial hardness values (30.3 and 45.8 N) were lower in nanoemulsion samples and remained reduced over a 90 day storage period. Black cumin oil-loaded nanoemulsions provided the lowest peroxide values (1.7, 2.7, and 2.4 mequiv O2/kg), maintaining oxidative stability during storage. Final free fatty acid (FFA) values ranged from 0.23% to 0.44% after storage. Thiobarbituric acid (TBA) values indicated slower lipid oxidation, with values ranging from 1.47 to 2.51 mg MDA/kg on day 0 and increasing to a maximum of 4.13 mg MDA/kg by day 90 in fat-reduced cookies. Among the tested formulations, nanoemulsions enriched with black cumin oil demonstrated the highest effectiveness, yielding enhanced oxidative stability and improved quality characteristics. This study presents an innovative strategy by utilizing maltodextrin-based nanoemulsions containing naturally antioxidant-rich oils as fat replacers, offering a clean-label alternative to improve the oxidative resilience and physical quality of cookies.
Ovine ENSOARG00020011332 rs427117280-GG Provides an Increase in Weaning Weight and Average Daily Gain Until Weaning Weight in a Multi-Breed Sheep Population
(Copernicus Gesellschaft Mbh, 2025) Akyuz, Bilal; Daldaban, Fadime; Ozdemir, Mustafa; Karakus, Ferda; Bayram, Davut; Yagci, Serdar; Cinar, Mehmet Ulas
Lamb meat, which is consumed as widely as pork, beef and poultry, has a very important place in red-meat consumption worldwide. Sheep can survive without consuming green fodder in geographies with poor pastures and very harsh continental climate conditions. In lambs reared for meat purposes, the average daily weight gain (ADG) from birth to weaning and their live weight at weaning are crucial economic traits that affect the profitability of breeders. Additionally, lamb live weight at weaning age could be vital for the lamb's subsequent live weight gain and survival rate. Therefore, improving the live weight at weaning age is desired to increase lamb meat production. However, information on animals' genetic background that affects the weaning weight is limited in many sheep breeds. The aim of this study was to investigate the association of the rs427117280 single nucleotide polymorphism (SNP) on chromosome 2 (OAR2) with live weight gain at different time points (live weight at birth and on the 30th, 60th and 90th days post-birth) in indigenous sheep breeds (Akkaraman, & Scedil;avak Akkaraman, Morkaraman, Karayaka and & Idot;vesi) in T & uuml;rkiye. In total, 1973 lambs were genotyped using Custom TaqMan SNP genotyping assays for the rs427117280 SNP. Association analysis showed that lambs with a GG genotype had the highest weight on the 90th day (BW90) and the highest ADG from birth to the 90th day (ADGB-90) (P <= 0.01). It was concluded that rs427117280 could be considered as a candidate quantitative trait nucleotide (QTN) for the BW90 and ADGB-90 traits. Therefore, these findings suggested that variation in the rs427117280 SNP might be used as novel genetic marker for improving pre-weaning and weaning growth traits in sheep.
A Strain Energy Framework for Evaluating Rock Mass Stability During Earthquakes
(Springer Heidelberg, 2025) Kayabali, Kamil; Habibzadeh, Farhad; Selcuk, Levent
This study examines the strain energy principle to address complex challenges in rock mechanics. Compared to conventional stress-strain assessments, the strain energy approach offers a more comprehensive perspective, representing a significant innovation in rock mechanics. The strain energy approach enhances reliability by considering energy accumulation and release alongside traditional strength analysis. Experimental studies indicate that the maximum energy stored and released during rock joint failure is comparable to earthquake energy capacities. This perspective introduces a novel approach for assessing rock mass stability during seismic events. The effectiveness of the energy-based approach is assessed using the hysteresis curves of rock joints under seismic loads. Experimental data reveal that the surface roughness of rock joints significantly influences the variation in strain energy with increasing normal stress. Moreover, evaluating the cyclic nature of earthquakes is essential for measuring strain energy, as the release of kinetic energy during an earthquake is inherently tied to its cyclic behavior. In this context, earthquake energy capacity is determined by analyzing the acceleration-time history of significant seismic events. Given that the strain energy from rock joint failure produces results comparable to earthquake energy capacities, the strain energy principle offers a more practical and realistic approach for assessing rock mass stability during earthquakes.
Analytical Optical Soliton Solution & Stability Analysis of the Dimensionless Time-Dependent Paraxial Equation
(Indian Assoc Cultivation Science, 2025) Abdullah, Ghaus ur; Rahman, Ghaus U.; Tunc, Osman
This study investigates the analytical solutions of optical solitons governed by the a time-dependent Paraxial Equation incorporating Kerr law nonlinearity. A rigorous analytical method is developed to obtain these solutions, offering insights into the behavior of optical solitons in nonlinear media. Here, we have applied the eMETEM approach for the first time to create robust solutions to the time-dependent Paraxial Equation. Building an efficient plan to solve the governing model has been our main goal. The Kerr law nonlinearity, which describes the intensity-dependent refractive index, profoundly affects the propagation characteristics of optical pulses. Through systematic analysis, key properties such as soliton formation, stability, and evolution are elucidated. The derived analytical solutions provide a valuable framework for understanding the intricate dynamics of optical solitons in nonlinear media, facilitating advancements in various applications including optical communication and signal processing.
Meaning in Life as a Mediator Between Death Anxiety and Life Satisfaction
(Routledge Journals, Taylor & Francis Ltd, 2025) Yagan, Ferdi; Kaya, Zohre; Kaya, Selim Firat
Research based on Terror Management Theory suggests that death anxiety is a fundamental existential concern that threatens individuals' life satisfaction and that, in the process of coping with this anxiety, individuals tend to seek meaning in life. However, studies directly examining the impact of death anxiety on life satisfaction and the mediating role of meaning are lacking. This study aims to investigate the relationship between death anxiety and life satisfaction among adults and to test the mediating role of meaning in life in this relationship. 396 participants completed online scales measuring death anxiety, life satisfaction, and meaning in life. The findings revealed that death anxiety significantly predicted life satisfaction and that meaning in life partially mediated this relationship. The results suggest that meaning in life may play a buffering role in the association between death anxiety and life satisfaction.
Numerical Solution of Fractional Order Multi-Point Boundary Value Problems Using Reproducing Kernel Method With Shifted Legendre Polynomials
(Springer Int Publ Ag, 2025) Sakar, Mehmet Giyas; Saldir, Onur; Ata, Ayse
This article presents an efficient numerical method for obtaining numerical solutions to multi-point boundary problems with multi-fractional orders of Caputo derivatives.The novelty of the suggested method is based on the application of shifted Legendre polynomials in the reproducing kernel theory, as well as the use of extra basis functions for homogeneous or nonhomogeneous boundary conditions. The approximate solution for both linear and nonlinear cases of the considered problem is given in the form of a finite series sum. Convergence and error analysis of the presented method are given. The numerical outcomes obtained with the proposed method are compared with other results found in the literature. The obtained results for linear and nonlinear examples support the method's efficiency.

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