WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14720/3

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Serum Myeloperoxidase and Adenosine Deaminase Activities in Polycystic Ovary Syndrome
(CIC-Edizioni Int SRL, 2012) Kurdoglu, Z.; Ozkol, H.; Kurdoglu, M.
New Chlorpyrifos-Degrading Bacteria Isolated from Turkish Soil
(Wiley, 2025) Bicek, A. G.; Ozaktas, T.
Evaluation of the Relationship Between Endogenous Gonadotropins and Female Sexual Function and Psychological Status in Predialysis and Hemodialysis Patients
(CIC-Edizioni Int SRL, 2012) Kurdoglu, Z.; Soyoral, Usul Y.; Tasdemir, M.; Kurdoglu, M.
Could Alpha-L be Useful as a Diagnostic and Stage Discriminative Factor for Lung Cancer
(Kuwait Medical Assoc, 2025) Iliklerden, Duygu Mergan; Kalayci, Tolga; Cilingir, Buket Mermit
Objective: To investigate the relationship between clinicopathological variables of patients with lung cancer and Alpha-L-fucosidase (AFU) serum levels and to examine AFU usability in distinguishing between early-stage and advanced-stage lung cancer. Design: This was a prospective observational study. Setting: Van Yuzuncu Yil University Department of Thoracic Surgery, between June 2020 and December 2020. Subjects: Fifty healthy volunteers as the control group and seventy-five lung cancer patients confirmed and staged by imaging methods. Interventions: The patients' demographic (age, gender) and clinicopathological characteristics were determined by physical examination, biochemical tests, pathological examination and imaging studies. The TNM staging system is used in cancer staging. Main outcome measures: Serum AFU levels were measured in both the control and lung cancer groups. Results: The mean AFU level of lung cancer patients was 13.35 +/- 0.61 ng/mL, while the mean AFU level of the control group was 1.86 +/- 0.35 ng/mL (P<0.001). AFU levels were significantly higher in the lung cancer group with increasing depth of invasion, lymph node metastasis, distant metastasis and TNM stages (P<0.001). Conclusions: This study is the first to show that AFU can detect lung cancer early and predict the cancer stage. AFU can be an essential diagnostic and stage discriminative marker for lung cancer.
Bounded Solutions to Nonlinear Delay Differential Equations of Third Order
(Juliusz Schauder Ctr Nonlinear Studies, 2009) Tunc, Cemil
This paper gives some sufficient conditions for every solution of delay differential equation (x) triple over dot (t) + f(t, x(t), x(t -r), (x) over dot (t - r), (x) over dot (t- r), x(t), x(t-r)) + b(t)g(x(t-r), (x) over dot(t - r)) + c(t)h(x(t)) = p(t,x(t), x(t - r), (x) over dot (t), (x) over dot (t -r), x(t)) to be bounded.
Platelet-to-Ratio May Predict the Severity of Calcific Aortic Stenosis
(Int Scientific Literature, inc, 2015) Akdag, Serkan; Akyol, Aytac; Asker, Muntecep; Duz, Ramazan; Gumrukcuoglu, Hasan Ali
Background: Platelet-to-lymphocyte ratio (PLR) is an emerging inflammatory indicator which is closely associated with adverse cardiovascular events. Therefore, we aimed to investigate the relationship between PLR and the severity of calcific aortic stenosis (AS). Material/Methods: The study was designed as a retrospective study. A total of 86 consecutive patients with calcific AS were divided into two groups as mild-to-moderate AS and severe AS according to the transaortic mean pressure gradient. PLR levels were calculated from the complete blood count (CBC). Results: Platelet to lymphocyte ratio was significantly higher in severe and mild-to-moderate AS groups when compared to the control subjects (151 +/- 31.2, p<0.001, 138 +/- 28.8 vs. 126 +/- 26.5, p=0.008, respectively). In the subgroup analysis of AS patients, PLR was found to be higher in the severe AS group compared to mild-to-moderate group (p<0.001). A significant correlation was found between PLR and transaortic mean pressure gradient in patients with AS (r=0.421, p<0.001). Conclusions: Our study results demonstrated that increased PLR correlates with the severity of calcific AS.
Enhanced Classification in IF-ARCA and IF-KNN with Fuzzy Metrics and Cosine Similarity Through Dual Stage Optimization Using Harris Hawks Algorithm
(Springer London Ltd, 2025) Kutlu, Fatih; Goleli, Kubra; Castillo, Oscar
This study proposes a dual-stage optimization framework for uncertainty-aware classification by integrating the Intuition-istic Fuzzy Any Relation Clustering Algorithm (IF-ARCA) with Intuitionistic Fuzzy K-Nearest Neighbors (IF-KNN). In the first stage, Harris Hawks Optimization (HHO) calibrates IF-ARCA parameters to construct reliable membership and non-membership matrices, while in the second stage HHO independently tunes IF-KNN parameters, ensuring decoupled and stable convergence. HHO was chosen for its effective exploration-exploitation balance in high-dimensional search spaces, and the dual-stage design uniquely enables clustering and classification to be optimized without mutual interfer-ence. Extensive experiments on eight benchmark datasets (seven from UCI, plus Yeast and Credit Fraud for scalability) confirm the superiority of the proposed approach: the fuzzy metric variant achieved F1 = 0.993 on Credit Fraud and 0.946 on MONK's Problems, while cosine similarity reached 0.989 on Digits. Compared with established FKNN variants, the framework yielded 20-35% relative improvements and demonstrated statistically significant gains on challenging datas-ets (Iris, MONK's, Yeast; Wilcoxon p < 0.05). These results highlight the framework's robustness under class overlap and imbalance, while maintaining competitive performance in high-dimensional domains, establishing a novel contribution to clustering-guided classification and nature-inspired optimization.
The Effect of Oxytocin Infusion and Misoprostol on Neonatal Bilirubin Levels
(Springer Heidelberg, 2009) Sahin, H. Guler; Kolusari, Ali; Kamaci, Mansur; Kaynak, Canev; Tuncel, Hatice
Purpose To investigate the association of neonatal bilirubin levels with oxytocin and misoprostol use for labour induction. Methods A total of 100 neonates were included in the study. The first group consisted of 50 healthy babies of women who had received oxytocin infusion, and the second group consisted of 50 healthy babies of women who had received 25 mu g misoprostol every 4 h placed in the posterior fornix for labour induction. Bilirubin and haematocrit levels were measured in all on days 1 and 4 of the neonatal period. Results The levels of bilirubin in the oxytocin group were significantly higher than those in the misoprostol group on day 1 [4.42 +/- 0.27 vs. 3.55 +/- 0.28 mg/dl (P = 0.035)] while they were higher also on day 4 but not significantly so [7.47 +/- 0.63 vs. 6.86 +/- 0.65 mg/dl (P = 0.525)]. The mean haematocrit levels on day 1 were 50.62 +/- 1.23 and 58.04 +/- 1.30 in groups 1 and 2, respectively, with a significant difference between them. The levels were 52.31 +/- 1.27 and 58.96 +/- 1.14 on day 4 and the difference was again significant. P < 0.05 indicated statistical significance. Conclusions Labour induction with misoprostol and oxytocin does not seem to have harmful effects on bilirubin levels in the neonate.
An Innovative Approach in Arts Education: Student Experiences of Abstract Art Practices Supported by Generative Artificial Intelligence
(Sage Publications inc, 2025) Hicyilmaz, Yahya
This study aimed to identify the experiences of students on the reflections of arts education supported by generative artificial intelligence in their abstract art practices. As a qualitative research method, the case study design was used in the study. The sample of the study included 12 last-year students in the Art Education Program of a state university in T & uuml;rkiye. The implementation process took place within the scope of a 12-week arts major workshop course. Data were collected in semi-structured interviews and using reflective journals and analyzed using the inductive content analysis method. It was determined that the participants were initially prejudiced against generative artificial intelligence and inexperienced in using it, while these attitudes became more positive over time. The participants stated that generative artificial intelligence tools were a source of inspiration, offered support in composition development, and had a guiding role in terms of aesthetics and style. On the other hand, some participants reported that during the arts education process supported by artificial intelligence, they experienced challenges such as communication problems, lack of technical knowledge, and concerns about originality. The results of the study revealed that generative artificial intelligence could be utilized as an educational tool that could support artistic creativity and learning. Hence, it is recommended that elective courses supported by generative artificial intelligence be integrated into the curricula of programs in arts education.
Biological Defence Against Cadmium Stress in Wheat with Arbuscular Mycorrhizal Fungi and Trichoderma: Synergistic Effects on Plant and Soil Health
(Elsevier France-editions Scientifiques Medicales Elsevier, 2025) Boyno, Gokhan
Cadmium (Cd) contamination in agricultural soils presents a serious threat to crop productivity, soil health, and ecological sustainability. This study aims to elucidate the synergistic potential of two beneficial microorganisms-Funneliformis mosseae (Fm), an arbuscular mycorrhizal fungus (AMF), and Trichoderma harzianum (Th)-in mitigating Cd-stress in wheat (Triticum aestivum L.) under controlled conditions. Unlike previous studies that examined these microorganisms individually, this research focuses on their combined application to explore potential interactive effects on plant and soil health. Wheat plants were inoculated with Fm and treated with Th under Cd-stress. After ten-weeks, comprehensive physiological, biochemical, and rhizospheric evaluations were conducted. Cd exposure significantly reduced shoot length by 10 %, total dry-biomass by 24 %, and chlorophyll content by 14 % while increasing oxidative stress markers. In contrast, the Fm + Th treatment significantly improved plant-biomass (by 81 %), restored chlorophyll content (by 16 %), and reduced Cd-translocation from roots to shoots (by 20 %) compared to Cdonly. Antioxidant enzyme activities and phenolic compound levels were also enhanced, indicating co-activation of oxidative stress mitigation pathways. Additionally, Fm and Th acted as indicators of improved soil health, demonstrating increased enzyme activities, organic matter content, and enhanced glomalin production and mycorrhizal colonization. Significant increase in phosphorus uptake was observed in the Fm + Th treatment. This study thus indicates novel synergistic mechanisms of Fm and Th as opposing agents against Cdtoxicity in wheat. These results suggest that integrated microbial approaches can be efficient and sustainable tools for the remediation of plant resilience and soils functionality in contaminated agroecosystems.
Renal Artery Originating from the Thoracic Aorta: A Critical Variant for Preoperative Awareness
(Wolters Kluwer Medknow Publications, 2025) Durmaz, Fatma; Kurt, Ebru; Dundar, Ilyas
This case report highlights a rare variation, in which the right renal artery originates from the thoracic aorta, passing through the diaphragm to reach the renal hilum, identified through contrast-enhanced computed tomography (CT). While renal artery variations are common, this particular variant, with the kidney in its normal position, is exceedingly rare. The origin of renal arteries typically occurs at the L1-L2 vertebral level, with variations often arising from the persistence of mesonephric arteries. This case adds to the literature and underscores the importance of recognizing such anomalies, particularly as these variations can impact surgical procedures, including laparoscopic nephrectomies and renal transplantation. Multidetector CT angiography is recommended as a valuable tool for accurately visualizing renal vascular anatomy, aiding in preprocedural planning, and improving clinical outcomes.
Physiological Effects of Arbuscular Mycorrhizal Fungi (AMF), Plant Growth-Promoting Rhizobacteria (PGPRs), and Trichoderma Harzianum on Tomato (Solanum Lycopersicum L.) Infected with Branched Broomrape [Phelipanche Ramosa (L.) Pomel]
(Ankara Univ, Fac Agriculture, 2025) Fidan, Enes; Tepe, Isik
Tomato (Solanum lycopersicum L.), one of the most produced and consumed vegetables in the world, belongs to Family Solanaceae. Branched broomrape [Phelipanche ramosa (L.) Pomel; Syn: Orobanche ramosa L.] parasitizes many cultivated plants, especially tomatoes. The parasitic weeds, for which there is no effective control method, cause serious yield and quality losses in their host crops. In this study, two different mycorrhizal (AMF) species, Funneliformis mosseae, and a commercial product, Endo Roots Soluble (ERS), along with Trichoderma harzianum T22, two different plant growth-promoting rhizobacteria (PGPR) isolates (Pseudomonas caspiana V30G2 and Bacillus velezensis V40K2), were applied to tomatoes. Additionally, a commercial product, Plant Success Great White Premium Mycorrhiza, and their combinations were used to determine the changes occurring in both the plants and the broomrape. This study investigated the number of tubercles, the levels of several oxidative stress enzymes (catalase, CAT; superoxide dismutase, SOD; and ascorbate peroxidase, APX), the level of lipid peroxidation (malondialdehyde, MDA), and the total phenolic and antioxidant contents of tomato plants infected and not infected with broomrape. Compared to the control group, the treatments were found to prevent tubercule formation at rates ranging from 60 to 72.7%. Broomrape infection caused oxidative stress in the tomatoes; the CAT and MDA contents in the broomrape-contaminated plants were higher than those in the noncontaminated plants. The results revealed that the bioproducts including some microorganisms and biological preparations applied to tomatoes responded differently to broomrape stress through enzymatic and nonenzymatic antioxidant activities.
Antifungal Potential of Hydrothermal Liquefaction Wastewater in Plant Protection
(Springer, 2025) Durak, Emre Demirer
This study investigates the antifungal potential of hydrothermal liquefaction (HTL) wastewater against Verticillium dahliae and its effects on the growth of pepper plants (Capsicum annuum L.). The HTL process generates wastewater containing various antimicrobial compounds, which can offer a sustainable alternative for plant protection. In this research, the biological control agent Trichoderma virens and HTL wastewater were applied both individually and in combination to assess their impact on plant growth and pathogen suppression. The results demonstrated that specific HTL wastewater treatments significantly enhanced root and shoot growth, biomass, and chlorophyll content in pepper plants. Plant growth observed in pathogen-free conditions may be related to the stimulation of plant physiology by biologically active components contained in wastewater, indicating a biostimulatory effect. Notably, the 4th wastewater mixture (wm) exhibited the highest efficacy, promoting plant development and mitigating the negative effects of V. dahliae. The combination of T. virens and wastewater also showed synergistic effects, reducing disease severity by up to 64% and improving plant biomass and structural parameters. Statistical analysis revealed significant differences among treatments, highlighting the potential of HTL wastewater as a natural and sustainable strategy for managing soil-borne pathogens. These findings suggest that integrating HTL wastewater with biocontrol agents could offer a promising approach to sustainable agriculture.
Determination of Aflatoxin M1 Presence and Concentration in Van Herby Cheese
(Czech Academy Agricultural Sciences, 2025) Akdag, Murat; Cakmak, Tuncer
Aflatoxins are considered the most toxic secondary metabolites of concern to food safety due to their wide distribution and high toxicity in foods and feeds. The aim of this study is to identify the prevalence of aflatoxin M-1 (AFM(1)) in Van Herby cheeses (brined/dry salted). A total of 90 brined and dry salted Van Herby cheese samples offered for retail sale were analysed. The AFM(1) level in the samples was determined by the chromatographic [High-Performance Liquid Chromatography (HPLC)/Fluorescent Detection (FLD)] method. Brined Van Herby cheese samples contained AFM(1) in amounts ranging from < LOD to 0.573 ngg(-1) with a mean of 0.165 +/- 0.206 ngg(-1), while dry salted Van Herby cheese samples contained < LOD to 0.017 ngg(-1) AFM(1). The analysis of the prevalence of AFM(1) in brined and dry salted Van Herby cheese samples was 17.78% (n = 8) and 2.22% (n = 1), respectively. In Van Herby cheese production, standardisation, quality improvement and food safety control procedures need to be used effectively and disseminated. In addition to good agricultural and storage practices to prevent mycotoxin formation, measures must be taken to prevent aflatoxin contamination in animal feed. These applications and systems will provide positive contributions in terms of total quality, nutrients and public health, as well as different advantages such as technological superiority.
Evaluation of Clinical Response according to Category and Level of Evidence for Therapeutic Plasma Exchange Indications: A Single-Center Experience
(Professional Medical Publications, 2025) Dogan, Ali; Aydeniz, Gokhan
Objective: The present study investigates the indications of patients who underwent therapeutic plasma exchange (TPE) based on the category and level of evidence outlined in the 2023 guidelines of the American Society for Apheresis (ASFA) and evaluates their treatment responses. Methodology: This retrospective study, the records of patients who underwent TPE at Van Yuzuncu Y & imath;l University Medical Faculty Hospital between January 2020 to December 2024 were reviewed, including their demographic characteristics, indications, plasmapheresis procedure data and complications. The indications were classified according to the categories, levels of evidence and treatment responses laid out in the ASFA 2023 guidelines. Results: A total of 234 adult patients were included in the study, of whom 56.4% were female. Hematological (41.9%) and neurological (38.5%) disorders accounted for the majority of the conditions treated with TPE. Of the total, 53% of the patients were classified as Category-I, while the total proportion of patients with Grade-IA, IB and IC evidence levels was 64.5%. The complete response rate was 35.5% in Category-I patients, the partial response rate was 48.6% in Category-II patients and the no response rate was 50% in Category-III patients. Patients with hematological and neurological disorders recorded high clinical response rates, while rarer conditions showed low clinical response rates. A significant relationship was found between category and level of evidence and clinical response (p<0.05). Conclusion: The clinical efficacy of TPE is significantly associated with the ASFA category and the level of evidence of the indications. The findings of the present study highlight the need to refer to evidence-based guidelines when planning TPE procedures.
Remediation of Gentamicin from Wastewater Using Magnetic Molecularly Imprinted Polymers
(Wiley-VCH verlag GmbH, 2025) Oter, Cigdem
In this study, magnetic molecularly imprinted polymers (magGe-MIP) were synthesized and used as adsorbents for the removal of gentamicin, an aminoglycoside. After characterization of the synthesized magnetically imprinted polymer, the rebinding ability and the fitting of the adsorption process to the kinetic and isothermal models were determined and compared with a non-imprinted reference polymer (mag-NIP). Accordingly, it was found that the pseudo-second order kinetic model and the Langmuir isothermal model provide a better fit to the adsorption process. The adsorption capacities (q e) for magGe-MIP and mag-NIP were 60.21 mg/g and 15.63 mg/g, respectively. The high selectivity of the prepared magGe-MIP adsorbent toward the template molecule gentamicin was determined by testing its adsorption capacity toward different antibiotics (amoxicillin, nafcillin and neomycin). These results show that the prepared magnetically imprinted polymer offers a new and effective approach for the removal of antibiotics from contaminated waters and environmental remediation.
Frequency of Intestinal Parasites in Patients with Pemphigus Vulgaris
(Springer, 2025) Sahin, Maksut; Ozkol, Hatice Uce; Afsar, Milad; Aydemir, Selahattin; Ekici, Abdurrahman
It is known that opportunistic parasites are more effective in immunocompromised individuals, infections are more severe and treatment is negatively affected. There is a limited number of studies on the relationship between parasitosis and Pemphigus Vulgaris (PV), most of which are case reports. The aim of this study was to investigate the prevalence of intestinal parasites in patients with PV. Thirty patients with PV and 30 healthy individuals without any chronic disease as a control group were included in the study. Stool samples taken from the patients were evaluated by the native-Lugol method. Then, nested PCR was used to determine G. intestinalis and Cryptosporidium spp. positivity in stool samples, conventional PCR was used to determine Blastocystis and microsporidia positivity, and ELISA was used to determine E. histolytica positivity. One or more parasite species were detected in 23 (76.7%) of 30 PV patients and 10 (33.3%) of 30 healthy individuals in the control group (P = 0.0001). More than one parasite was seen in 12 patients (40%) in the patient group and in 5 individuals (16.7%) in the control group (P = 0.038). In the patient group, Blastocystis and G. intestinalis were detected in 8 (26.7%) individuals each, microsporidia in 12 (40%) individuals, Cryptosporidium spp. in 5 (16.7%) individuals, E. histolytica in 4 (13.3%) individuals, E. coli in 1 (3.33%) individual and Taenia spp. in 1 (3.33%) individual. Microsporidia were detected in 5 (16.7%) of the individuals in the control group, Blastocystis in 3 (10%), E. histolytica in 3 (10%), G. intestinalis in 2 (6.7%), Cryptosporidium spp. in 2 (6.7%) and E. coli in 1 (3.33%). Statistical significance was found between the patient and control groups in terms of microsporidia and G. intestinalis positivity. The parasite rate was higher in individuals aged 40 years and over in the control group (P = 0.024). The results obtained in the study show that parasitic infections are an important risk factor for patients with PV due to the characteristics of the disease and the treatment applied. Therefore, we believe that all patients with PV should be evaluated for intestinal parasites for early diagnosis of intestinal parasites in PV patients.
Correlation of Transfontanel Ultrasonography and Brain Magnetic Resonance Imaging Measurements in Neonates with Hydrocephalus
(Turkish Neurosurgical Soc, 2025) Aycan, Nur; Arslan, Harun; Yurekturk, Eyyup; Basaranoglu, Murat; Ates, Ali; Karaman, Serap; Aycan, Abdurrahman
AIM: To evaluate whether transfontanel ultrasonography could serve as a practical and less complex alternative to brain magnetic resonance imaging in infants with hydrocephalus. MATERIAL and METHODS: In this prospective study, 54 infants diagnosed with hydrocephalus underwent both transfontanel ultrasonography and brain magnetic resonance imaging. A neonatologist and a radiologist independently assessed ventricular measurements, including the Evans index, frontooccipital horn ratio, bilateral ventricular index, anterior horn width, thalamooccipital distance, callosal angle, and corpus callosum length. RESULTS: Among the 54 infants, 48 (88.9%) received a ventriculoperitoneal shunt. A strong correlation was found between transfontanel ultrasonography and magnetic resonance imaging for most ventricular measurements: Evans index (r=0.875, r=0.937, right r=0.944; p=0.0001 for both), bilateral anterior horn width (left r=0.918, right r=0.908; p=0.0001 for both), and bilateral thalamooccipital distance (left r=0.956, right r=0.919; p=0.0001 for both). The correlation for corpus callosum length was statistically CONCLUSION: Our study emphasizes that transfontanel ultrasonography-which achieves better results in experienced hands- should be widespread and an excellent alternative to unnecessary and repeated imaging methods.
Investigation of Preschool Teachers' Beliefs related to Developmentally Appropriate Practice and Self-Regulation Skills of Children in Their Classrooms
(Springer, 2025) Cakin, Gamze Ulu; Sak, Ramazan
The objective of this study was to investigate the beliefs held by preschool teachers about Developmentally Appropriate Practice (DAP) and the self-regulation skills of children in their classrooms. In this quantitative study, sample comprised 276 preschool teachers and 276 preschoolers. It was found that preschool teachers exhibited elevated levels of beliefs pertaining to DAP. These beliefs displayed substantial variations based on gender across all sub-dimensions as well as the overall scale. Significant variations in some sub-dimensions can be seen based on factors, such as age, age group of children under their care, professional experience, and the type of educational institution that they are affiliated with. There was a significant difference in the self-regulation skills of preschool children based on the educational level of their mothers and fathers. Furthermore, a noteworthy and statistically significant correlation was seen between preschool teachers' beliefs related to DAP and the level of self-regulation skills of preschoolers.
A New Scale for Preschool Children's Questioning Tendencies
(Wiley, 2025) Sak, Ramazan
As well as being important tools for information acquisition, children's questions can also lead to profound learning. Nevertheless, no scale for measuring their questioning tendencies has hitherto been developed. Accordingly, this study pioneers one for use with preschool children. To establish construct validity, data from 544 children were used in exploratory factor analysis, and from an additional 237 children in confirmatory factor analysis. Of the original 25 questions, 10 were eliminated, and the remaining 15 items had a three-factor structure that explained 67.59% of the total variance. The internal consistency coefficient of the final Questioning Tendencies Scale was 0.894, establishing it as a valid and reliable instrument for use with children aged three to six.

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