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Investigation of Cyto-Toxicity of an Innovative Biofactor Mta Product in Different Human Cells: a Pilot Study

dc.authorscopusid 58512612700
dc.authorscopusid 57219447674
dc.authorscopusid 55317572200
dc.authorscopusid 57202749454
dc.authorscopusid 58513344000
dc.authorscopusid 56954780800
dc.authorscopusid 56954780800
dc.contributor.author Akyol, G.D.
dc.contributor.author Kolcu, M.I.B.
dc.contributor.author Alpaslan, N.Z.
dc.contributor.author Taşpınar, F.
dc.contributor.author Mızrak, R.Y.
dc.contributor.author Tunç, S.K.
dc.contributor.author İnanç, B.
dc.date.accessioned 2025-05-10T16:54:44Z
dc.date.available 2025-05-10T16:54:44Z
dc.date.issued 2023
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp Akyol G.D., Endodontics, Dentiora Dental Clinic, Turkey; Kolcu M.I.B., Department of Medical Education and Informatics, Süleyman Demirel University, Faculty of Medicine, Turkey; Alpaslan N.Z., Department of Periodontology, Van Yüzüncü Yıl University, Faculty of Dentistry, Turkey; Taşpınar F., Department of Physiology, Aksaray University, Faculty of Medicine, Turkey; Mızrak R.Y., Department of Oral and Maxillofacial Surgery, Hamidiye Faculty of Dentistry, University of Health Sciences, Turkey; Tunç S.K., Department of Oral and Maxillofacial Surgery, Hamidiye Faculty of Dentistry, University of Health Sciences, Turkey; İnanç B., Department of Periodontology, Trakya University, Faculty of Dentistry, Turkey en_US
dc.description.abstract Introduction: Mineral trioxide aggregate (MTA) is one of the most popular and convenient material among current endodontic materials. In addition to MTA advantages, there are also features that need to be improved. Color stability and consistency are notorious concerns in MTA, and materials need improvement regarding theses aspects. There are companies, which work on these contents. Objectives: The aim of this study was to investigate the cyto-toxicity of Biodentine, Angelus MTA, BIOfactor MTA on 3T3L-1 fibroblast, and Saos-2 osteosarcoma cell lines with different dilution of all products. Material and methods: 3T3-1 fibroblast was applied to stimulate pulp cells in cell viability test. In order to generate an osteoblastic cell-like model, only Saos-2 cells were used. MTT test was utilized to measure cell cytotoxicity in different dilution of all MTA products. SPSS package program was applied to perform Kruskal-Wallis, one-way ANOVA and two-way ANOVA tests. Results: According to results, while Biodentine, Angelus MTA and BIOfactor MTA showed cyto-toxic effects in 1: 1 and 1: 2 dilutions, they were not cyto-toxic in 1: 4 and 1: 8 dilutions. Conclusions: MTA products have similar cyto-toxicity. BIOfactor MTA has a cyto-toxic effect as other similar products. © 2023 Polish Dental Association. en_US
dc.identifier.doi 10.5114/jos.2023.128770
dc.identifier.endpage 76 en_US
dc.identifier.issn 0011-4553
dc.identifier.issue 2 en_US
dc.identifier.scopus 2-s2.0-85166248483
dc.identifier.scopusquality Q4
dc.identifier.startpage 71 en_US
dc.identifier.uri https://doi.org/10.5114/jos.2023.128770
dc.identifier.uri https://hdl.handle.net/20.500.14720/3217
dc.identifier.volume 76 en_US
dc.identifier.wosquality N/A
dc.language.iso en en_US
dc.publisher Termedia Publishing House Ltd. en_US
dc.relation.ispartof Journal of Stomatology en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Angelus Mta en_US
dc.subject Biodentine en_US
dc.subject Biofactor Mta en_US
dc.subject Cyto-Toxicity en_US
dc.subject Mtt Assay en_US
dc.title Investigation of Cyto-Toxicity of an Innovative Biofactor Mta Product in Different Human Cells: a Pilot Study en_US
dc.type Article en_US

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