Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14720/4

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Foreword
(Springer Singapore, 2020) Atlihan, R.
[No abstract available]
Could Alpha-L be Useful as a Diagnostic and Stage Discriminative Factor for Lung Cancer
(Kuwait Medical Assoc, 2025) Iliklerden, Duygu Mergan; Kalayci, Tolga; Cilingir, Buket Mermit
Objective: To investigate the relationship between clinicopathological variables of patients with lung cancer and Alpha-L-fucosidase (AFU) serum levels and to examine AFU usability in distinguishing between early-stage and advanced-stage lung cancer. Design: This was a prospective observational study. Setting: Van Yuzuncu Yil University Department of Thoracic Surgery, between June 2020 and December 2020. Subjects: Fifty healthy volunteers as the control group and seventy-five lung cancer patients confirmed and staged by imaging methods. Interventions: The patients' demographic (age, gender) and clinicopathological characteristics were determined by physical examination, biochemical tests, pathological examination and imaging studies. The TNM staging system is used in cancer staging. Main outcome measures: Serum AFU levels were measured in both the control and lung cancer groups. Results: The mean AFU level of lung cancer patients was 13.35 +/- 0.61 ng/mL, while the mean AFU level of the control group was 1.86 +/- 0.35 ng/mL (P<0.001). AFU levels were significantly higher in the lung cancer group with increasing depth of invasion, lymph node metastasis, distant metastasis and TNM stages (P<0.001). Conclusions: This study is the first to show that AFU can detect lung cancer early and predict the cancer stage. AFU can be an essential diagnostic and stage discriminative marker for lung cancer.
September 25, 2024 Yumrukaya-Tatvan (Bitlis, Türkiye) Earthquake and a Seismo-Tectonic Evaluation of Its Impact on the Earthquake Hazard in the Region; 25 Eylül 2024 Yumrukaya-Tatvan (Bitlis, Türkiye) Depremi ve Bölgedeki Deprem Tehlikesine Etkisi Üzerine Sismo-Tektonik bir Değerlendirme
(Gumushane University, 2025) Öztürk, S.; Alkan, H.
The current and future earthquake hazard in and around Bitlis were tired to reveal by utilizing the September 25, 2024, Yumrukaya-Tatvan earthquake (Mw=4.5) and its aftershocks, b-value and Z-value distributions, occurrence probabilities and recurrence periods of earthquakes and variations in Coulomb stress within the scope of this study. Also, it was tried to determine which fault systems in the study area is related to the Yumrukaya-Tatvan mainshock, characterized by strike-slip faulting. b-value in G-R relation was computed as 0.84∓0.06 and small b-values (<1.0) were imaged in the north-northwest-southeast directions throughout the South East Anatolian Thrust Zone and Muş Fault Zone, and west of Lake Van. At the beginning of 2025, significant seismic quiescence was observed near the Muş Fault Zone and the south and southeast of the South East Anatolian Thrust Zone. Recurrence periods for the events with the magnitudes of Mw=5.0, 5.5 and 6.2 were computed as ~10, ~26 and ~100 years, respectively. Additionally, occurrence probabilities of earthquakes with these magnitudes in the intermediate-term (~10 years) were calculated as ~64%, ~32% and ~10%, respectively. Positive Coulomb stress changes carry out a movement from the Kavakbaşı Fault zone in the west and the Beğendik segment in the east toward the South East Anatolian Thrust Zone in the east-southeast. In this region, there is no active fault/fault system according to the General Directorate of Mineral Research and Exploration. Thus, these findings are significant clues showing that multiple parameter seismo-tectonic analyses are important in determining the earthquake hazard for the September 25, 2024 earthquake, and that regions with small b-values and seismic quiescence and regions with positive Coulomb stress changes may indicate current hazard and possible earthquake zones in the future. © 2025 Elsevier B.V., All rights reserved.
Multidimensional Scaling Analysis of Morphological Spike Traits in Local Wheat Genotypes from the Van Lake Basin
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Altuner, F.; Jamal-Salih, S.; Ozdemir, B.; Oral, E.; Mendeş, M.; Ülker, M.; Najafi, S.
Wheat landraces are considered a valuable resource of potential phenotypic variation that could be used in germplasm improvement. Here, we examined 588 local wheat genotypes collected from farmers’ fields at 127 locations around Van Lake Basin and evaluated the morphological diversity and trait associations using Multidimensional Scaling Analysis. Spike and yield traits were measured and scored according to the UPOV and ICARDA phenotypic characterization criteria. Multidimensional Scaling Analysis divided the wheat samples into four main groups based on the number of spikelets (NOS), number of fertile spikelets (NFS), thousand-grain weight (TGW), and number of seeds per spike (NSS) and indicated a strong correlation between NOS and NFS. Furthermore, the analysis revealed that the glume and awn color of most of the genotypes was black, and they were within the locally known Karakılçık group. Only two genotypes were excluded from the Karakılçık group; No. 231 was within the Geverik local wheat group, and genotype No. 579 was found to be Tir. The Hevidik and Kirik groups had the same spike color, but the Hevidik group had spikes similar to compactum wheat, whereas the Kirik group had larger spikes. Finally, genotype No. 57 varied from all other genotypes when all the measured traits were taken into consideration. Overall, the Van Lake Basin landraces combine broad similarity with meaningful phenotypic heterogeneity shaped by local environments and traditional on-farm selection. These findings provide practical cues for conservation efforts and for the use of landraces as valuable resources in future wheat breeding programs. © 2025 Elsevier B.V., All rights reserved.
Great Deluge-Based Metaheuristic Incorporating Integer Nonlinear Programming for Modeling and Solving Dynamic Capability-Based Machine Layout Problem
(Elsevier Ltd, 2026) Baykasoğlu, A.; Subulan, K.; Hamzadayı, A.
This paper introduces a novel Dynamic Capability-Based Machine Layout (DCB-ML) problem by integrating the Quadratic Assignment Problem (QAP) formulation with a Dynamic Capability-Based Part Flow Assignment (DCB-PFA) problem. This integration enables the simultaneous consideration of machines’ processing capabilities, routing flexibility, dynamic flow assignment, and machine capacity utilization. First, a new Integer Nonlinear Programming (INLP) model is developed. The dynamic part flows are determined via the DCB-PFA sub-problem, while machine–location assignments are obtained by solving QAP. To address the complex nature of this problem, a hybrid solution approach is proposed that combines a Great Deluge Algorithm (GDA) with a Mixed-Integer Linear Programming (MILP) model, complemented by local search procedures. Since the problem has a decomposable structure, the proposed approach allows each sub-problem to be addressed independently, while the overall solution quality is jointly evaluated. Decomposition reduces the size of the resulting MILP model, as several binary variables and assignment constraints are eliminated. The proposed hybrid approach is also compared with the INLP and its linearized equivalent on several test problems. For large-scale problems with medium to high capability overlaps, nonlinear and MIP solvers fail to obtain feasible solutions, whereas the proposed approach can efficiently generate high-quality solutions within reasonable times. Moreover, when the effects of different machine-capability overlaps are investigated, it is observed that the solution of the problem will be more complex in the case of higher machine-capability overlaps. However, considering machine capabilities improves overall layout scores and eliminates the necessity of frequent reconfigurations, which is costly and time-consuming. © 2025 Elsevier B.V., All rights reserved.
Does Institutional Quality Shape Agricultural Credit Orientation? Evidence from D-8 Nations
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Keskin, Ö.; Medetoğlu, B.; Kavas, Y.B.; Gün, M.
The agricultural sector, which has long been overshadowed by industrialization, has reemerged with renewed strategic significance in the face of global crises, including pandemics and armed conflicts. This study examines the causal relationship between institutional quality and agricultural credit orientation in the Developing-Eight countries from 2002 to 2023. Using the agriculture orientation index for credit as a key indicator, this study investigates how disaggregated institutional dimensions—control of corruption, government effectiveness, political stability and absence of violence, rule of law, regulatory quality, and voice and accountability—affect the allocation of commercial bank credit to agriculture. Both the standard Kónya panel causality test and its time-varying extension are employed to capture static and dynamic causal patterns. The findings demonstrate that institutional quality exerts a substantial effect on credit orientation, although the magnitude and characteristics of this influence differ across countries. Türkiye, Indonesia, Nigeria, and Egypt exhibit consistent causal relationships, whereas other countries reveal episodic or latent effects linked to specific political or legal shifts. By combining dynamic methodology with a policy-relevant indicator, this study offers novel insights into how governance shapes agricultural finance. The results underscore the need for country-specific and institution-sensitive credit strategies to increase resilience and equity in financial systems. © 2025 Elsevier B.V., All rights reserved.
Investigation of Effects of Low Ruminal pH Values on Serum Concentrations of Macrominerals, Trace Elements, and Vitamins and Oxidative Status of Dairy Cows
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Katsoulos, P.D.; Bilgiç, B.; Tarhan, D.; Ates, F.; Suat, S.; Kozat, S.; Dokuzeylul, B.
Due to the feeding system (high-concentrate diet) during the early lactation stage, ruminal pH in dairy cows follows a diurnal pattern and can remain below the critical level of 5.5 for extended periods of the day. This study aimed to evaluate the effect of low ruminal pH on blood concentrations of certain macrominerals, trace minerals, and fat-soluble vitamins and on the oxidative status of dairy cows during the first half of lactation. Fifty-three randomly selected lactating Holstein cows were used; blood and ruminal fluid samples were collected from all cows on days 30, 90 and 150 of lactation. Blood samples were obtained via coccygeal venipuncture, while the ruminal fluid was obtained by rumenocentesis and the pH was measured immediately after collection. Using a threshold pH of 5.5, samples were classified as normal (pH > 5.5) or low pH (pH ≤ 5.5). Serum concentrations of Ca, Mg, K, Cr, Mn, Zn, Se, and vitamins A, D3, E, and K were not significantly affected by ruminal pH, either by days in milk or by their interaction (p > 0.05). Plasma malondialdehyde and reduced glutathione followed the same trend (p > 0.05). Copper concentration was significantly higher (p < 0.05), and Fe concentration tended to be higher in cows with low pH compared to those with normal pH (p = 0.052). On day 150 of lactation, Cu, Fe, and Co concentrations were significantly higher in low-pH cows compared to normal-pH cows (p < 0.05). Low ruminal pH is associated with significant changes in serum concentrations of copper, iron, and cobalt but has no significant effect on the oxidative status of the animals or on the serum concentrations of the macro elements and fat-soluble vitamins studied. © 2025 Elsevier B.V., All rights reserved.
Addiction and Misogyny: A Case Report of a Woman Coerced into Addiction by Her Husband
(Kare Publishing, 2025) Aktaş, S.
[No abstract available]
Synergistic Effects of Endophytic Bacteria and Silicon on Controlling Common Bacterial Blight Disease in Beans; Fasulye Bakteriyel Adi Yanıklık Hastalığının Kontrolünde Endofitik Bakteri ve Silisyumun Sinerjistik Etkileri
(Plant Protection Central Research Institute, 2025) Çelik, R.; Akköprü, A.
Enhancing the effectiveness of environmentally friendly and sustainable practices in plant disease management is crucial for promoting their wider adoption and use. In this context, the combined use of bacterial biocontrol agents and silicon applications holds significant potential. This study aimed to evaluate the effects of individual and combined applications of endophytic bacteria (EB) and silicon on controlling common leaf blight disease caused by Xanthomonas axonopodis pv. phaseoli (Xap) in beans. Additionally, the effects of these treatments on plant biomass and chlorophyll content were investigated. Bean plants (Phaseolus vulgaris cv. Gina) were grown in a peat/perlite medium under soilless conditions in a climate chamber. Silicon dioxide (SiO₂) (30 mM) and endophytic bacteria were applied to the root collar using the drenching method. The pathogen Xap was inoculated by spraying the leaves, and disease severity was assessed using a 1–5 scale. Plant growth parameters were also recorded. Among the tested EB isolates, Pseudomonas caspiana V30G2 was the most effective in suppressing disease severity. Disease severity was reduced by 31% with V30G2 and by 21% with SiO₂ when applied individually. Notably, the combined application of both agents exhibited a synergistic effect, reducing disease severity by 55%. Although some improvements were observed in specific parameters, such as leaf number, neither the individual nor the combined treatments significantly influenced overall plant biomass or chlorophyll content. Nevertheless, the results suggest that the combined application of silicon and endophytic bacteria, when appropriately selected, has significant potential for environmentally friendly and sustainable disease management, enhancing the disease suppression efficacy of each treatment. © 2025 Elsevier B.V., All rights reserved.
Gum Arabic Suppresses Proliferation and Induces Mitochondrial-Mediated Apoptosis in MCF-7 Breast Cancer Cells via the Bcl-2/Bax Signaling Pathway
(Ondokuz Mayis Universitesi, 2025) Evyapan, G.; Özdem, B.
Breast cancer is the most frequently diagnosed cancer among women worldwide, and despite advances in treatment modalities, there remains a critical need for more effective therapeutic strategies. This study investigated the impact of Gum Arabic (GA) on the proliferation and apoptosis of MCF-7 breast cancer cells. The impact of Gum Arabic on cellular viability was assessed using an MTS assay, while its effect on long-term proliferative potential was evaluated via a colony formation assay. To determine the mode of cell death, caspase-3/7 activity assays and Annexin V-FITC/propidium iodide staining were employed. Since MCF-7 cells lack functional caspase-3, the observed caspase-3/7 activity is likely attributable to caspase-7. Additionally, Western blotting was conducted to analyze changes in the expression of key apoptotic proteins. The results revealed that treatment with Gum Arabic led to a dose-dependent reduction in both cell viability and colony formation ability. Moreover, apoptosis was significantly induced in the treated cells. At the molecular level, Gum Arabic administration resulted in a pronounced downregulation of the anti-apoptotic protein B-cell lymphoma 2, along with upregulation of the pro-apoptotic proteins Bcl-2-associated X and caspase-9. These findings demonstrate that Gum Arabic not only suppresses proliferation but also promotes programmed cell death in breast cancer cells through modulation of intrinsic apoptotic pathways. While the results provide preliminary evidence of anticancer potential, further studies in additional breast cancer models, as well as in vivo and clinical investigations, are required before any translational or therapeutic conclusions can be drawn. © 2025 Elsevier B.V., All rights reserved.
Effects of Sentinel Lymph Node Dissection on Sexual Function After Endometrial Cancer Surgery
(Galenos Publishing House, 2025) Simsek, E.; Yildiz, S.; Karakaş, S.; Karaaslan, O.; Gündüz, S.; Yıldız, O.A.; Keskin, N.
Aim: The purpose of this research was to determine whether endometrial cancer (EC) patients’ sexual function (SF) and quality of life (QoL) were affected by sentinel lymph node dissection (SLND). The effects on SF of SLND and pelvic and paraaortic lymph node dissection (LND) in the surgical treatment of EC were compared. Methods: This prospective, single-center research comprised 82 individuals who had LND for endometrial cancer. Patients were categorized into two groups based on the extent of LND: Group A SLND and Group B (pelvic and/or para-aortic lymphadenectomy). The Female Sexual Function Index (FSFI) and the Functional Assessment of Cancer Therapy (FACT-G) were used to measure SF and QoL, respectively, six months after surgery. Results: Among the 82 patients, 14 (17%) retained normal SF (FSFI ≥26.55), while 68 (83%) experienced sexual dysfunction. While no substantial difference was seen in overall FSFI scores among the groups, patients in the SLN group had significantly higher ratings in the desire (p=0.036) and orgasm (p=0.042) subdomains compared to the other groups. Quality of life, as assessed by the FACT-G, was negatively impacted by lower SF scores, particularly among highly educated patients (p=0.013). Conclusion: Sentinel lymph node dissection may preserve aspects of female SF in patients undergoing surgery for endometrial carcinoma, especially in younger and more educated patients. © 2025 Elsevier B.V., All rights reserved.
Cu(II)-Aminotetrazole Complex Anchored on SBA-15: A High-Performance Catalyst for the Synthesis of 1,4-Disubstituted
(Springer, 2025) Taghavi, N.; Mansoori, Y.; Fekri, S.; Akinay, Y.; Cetin, T.
This research focuses on developing and thoroughly analyzing a copper catalyst anchored to SBA-15. The catalyst was prepared via stepwise functionalization of SBA-15, involving successive treatments with (3-aminopropyl)triethoxysilane (APTES), trichlorotriazine, and 5-aminotetrazole to form SBA@bis(ATET). Coordination with Cu(OAc)2 in acetonitrile yielded the final complex, SBA@bis(ATET)-Cu(II). Characterization techniques included FT-IR, Brunauer-Emmett-Teller (BET) surface analysis, cross-polarization/magic angle spinning 13C NMR (CP/MAS 13C NMR), thermogravimetric analysis (TGA), and X-ray photoelectron spectroscopy (XPS). Catalytic studies demonstrated that SBA@bis(ATET)-Cu(II) efficiently catalyzed the synthesis of 1,4-disubstituted-1,2,3-triazoles through the reaction of acetylenes, benzyl or alkyl halides, and sodium azide, achieving excellent yields under optimized conditions. The catalyst exhibited excellent recyclability, maintaining activity over five cycles with minimal deactivation and low copper leaching (1.25%) in the first cycle, highlighting its robustness and sustainability for organic synthesis applications. © 2025 Elsevier B.V., All rights reserved.
Response to “Letter to Editor”
(John Wiley and Sons Inc, 2025) Coskun-Demirkalp, A.N.; Tekcan, A.; Çakır, M.; Dönmez-Altuntaş, H.
[No abstract available]
On Van Molecular Topological Modelling of Fullerenes’ Chemical Properties
(AMG Transcend Association, 2025) Yamaç, K.; Ediz, S.; Aldemir, M.Ş.; Çiftçi, İ.
In addition to graphite, diamond, and nanotubes, fullerenes are a fundamental allotrope of carbon that has received significant attention in the fields of nanoscience, nanotechnology, condensed matter physics and chemistry, biological physics, materials science and technology, mechanical and electrical sciences, biomedical engineering, and most recently, medical nanotechnology and nano-neuroscience. Molecular topological indices are essential tools to relate the theoretical and physical properties of chemical substances. Investigation of the chemical and physical properties of fullerenes' topological indices has been started in recent years. This study presents topological modelling of fullerenes’ binding energies, the heat of formation, shape resonances, and Ramsauer-Townsend minima using the Van molecular topological index. © 2025 Elsevier B.V., All rights reserved.
Effects of Gastrocnemius Functional Massage on Lower Extremity Spasticity, Spatio-Temporal Gait Variables and Fall Risk in Patients with Stroke: A Randomized Controlled Trial
(Public Library of Science, 2025) Dengiz, A.; Şekeröz, S.; Baskan, E.; Kara-Cakici, G.
Aim This randomized controlled clinical trial investigated the effects of gastrocnemius functional massage (GFM) combined with neurodevelopmental treatment (NDT) on spasticity, gait parameters, and functional mobility in stroke patients. Methods A total of 28 chronic stroke survivors were randomized into an experimental group (EG, n = 13) and a control group (CG, n = 15). Both groups received NDT twice a week for six weeks, while the EG received additional GFM. Spasticity (Modified Ashworth Scale), gait parameters (LegSys), and functional mobility (Timed Up and Go test) were assessed pre- and post-treatment. Results The results showed significant improvements in spasticity within the EG for the hip adductor (p = 0.002), knee extensor (p = 0.006), and ankle plantar flexor muscles (p = 0.002), compared to minimal changes in the CG (p > 0.05). Gait analysis revealed significant improvements in the EG for stride number (p = 0.0001), stride length (p = 0.006), stride time (p = 0.001), and stride velocity (p = 0.002), whereas the CG showed no significant changes (p > 0.05). Functional mobility improvements in the EG included reduced sit-to-stand time (p = 0.021) and total Timed Up and Go time (p = 0.001), indicating enhanced dynamic balance and lower extremity strength. Conclusion These findings suggest that combining GFM with NDT significantly enhances spasticity reduction, gait parameters, and functional mobility in stroke patients. Future studies are needed to explore the long-term effects and underlying mechanisms of this combined approach. © 2025 Elsevier B.V., All rights reserved.
How Do Young Turkish Children Perceive the Gender of Their Teachers? A Case Study
(Taylor and Francis, 2025) Sak, R.; Şahin-Sak, I.T.
This chapter presents findings from a case study in a public kindergarten consisting of five headteachers (one man and four women) and a female school director in a Muslim lower-class poorly educated district in a city in the eastern part of Türkiye. The findings show that adults are more aware of gender and think more about this issue than children. However, the children's expressions when describing their teachers did not highlight gender; rather, they preferred to describe activities in which the teachers tended to engage. They have a more egalitarian and partially unbiased perspective as related to their teachers. Especially considering that this study was conducted in a district with a low socioeconomic level and a relatively more traditional perspective in Türkiye, it was found that children placed more importance on their interactions and sharing with their teachers rather than their gender. © 2025 Elsevier B.V., All rights reserved.
Innovative Pyrazole–thiazole–oxadiazole Hybrid Compounds for Targeted EGFR/VEGFR2 Inhibition in Cancer Treatment
(John Wiley and Sons Inc, 2025) Kuzu, B.; Osmani̇ye, D.; Karaduman, A.B.; Oz̈kay, Y.
A new series of pyrazole–thiazole–oxadiazole hybrid compounds targeting the EGFR and VEGFR2 enzymes was designed and synthesized using innovative approaches. The compounds were characterized through spectral methods, and their cytotoxic activities were evaluated against the A549 lung and HT-29 colon cancer cell line using the MTT assay. Among them, compounds 17i and 17m exhibited notable cytotoxicity, with 17i demonstrating approximately threefold greater activity compared to the reference drug sorafenib for A549 cells. Flow cytometry analysis revealed that 17i induced extensive necrotic cell death, while 17m triggered a more targeted and controlled apoptotic mechanism. In vitro enzyme inhibition assays demonstrated that 17i inhibited EGFR and VEGFR2 with IC50 values of 0.158 and 0.128 µM, respectively. In contrast, 17m exhibited more potent inhibition of EGFR (IC50 = 0.012 µM) and moderate activity against VEGFR2 (IC50 = 0.309 µM). Molecular docking and molecular dynamics simulations further supported the structural stability of the complexes formed by these compounds with their target enzymes, highlighting their potential as effective enzyme inhibitors. Collectively, these findings suggest that pyrazole–thiazole–oxadiazole hybrids represent promising candidates for targeted cancer therapy at the cellular level. © 2025 Elsevier B.V., All rights reserved.
Inhibition of Autophagy by ATG5 siRNA Transfection Enhances Anti-Cancer Effects of Gum Arabic, Promotes Oxidative Stress-Mediated Apoptosis and Affects DNA Damage and Mitochondrial Membrane Potential in Ovarian Cancer Cells
(Springer International Publishing, 2025) Evyapan, G.; Özdem, B.
Gum Arabic (GA) is a clinically safe plant-derived polysaccharide with potential anti-cancer activity. We evaluated the effects of GA alone and in combination with ATG5 siRNA-mediated inhibition of autophagy in chemoresistant A2780-ADR ovarian cancer cells. GA at a concentration of 30.68 µM reduced cell viability to 47 ± 3% at 72 h and increased intracellular ROS 2.3-fold (n = 3, p < 0.001). The GA + ATG5 siRNA combination further decreased viability to ~ 30% and markedly enhanced apoptosis (Annexin V/PI, p < 0.001). Western blot analysis revealed increased p53 protein levels and decreased Bcl-2 protein levels, as well as altered P-Chk1 protein levels, which are consistent with apoptosis associated with DNA damage. GA also caused a loss of mitochondrial membrane potential and treatment-dependent changes in UCP4/5 expression, indicating mitochondrial stress. These findings identify GA, particularly in combination with autophagy inhibition, as a low-toxicity agent with significant anti-proliferative effects in vitro. The study is limited to cell models; in-vivo validation and pharmacokinetic/delivery studies are required before clinical translation. © 2025 Elsevier B.V., All rights reserved.
Reliability Generalization Meta-Analysis of the Internal Consistency and Test-Retest Reliability of the Body Awareness Questionnaire
(SAGE Publications Ltd, 2025) Husain, W.; Ebrahim, A.H.; Alobaidi, S.; Ali Ghazzawi, H.; Trabelsi, K.; Pourdeh, E.F.; Sarı, E.
The Body Awareness Questionnaire (BAQ) measures attentiveness to normal body processes and is widely used with both healthy and patient samples. Meta-analysis of 10 articles involving 15 studies (4078 participants) examined BAQ reliability. Random-effects models pooled Cronbach’s alpha and test-retest coefficients. Heterogeneity was assessed via I² statistic; publication bias via funnel plots, Egger’s and Begg’s tests, and trim-and-fill method. Pooled Cronbach’s alpha was 0.84 (95% CI: 0.81–0.87), indicating high internal consistency despite substantial heterogeneity (I² = 92.20%). Pooled test-retest reliability was strong at 0.84 (95% CI: 0.78–0.89), though with significant heterogeneity (I² = 95.42%). Egger’s test suggested potential publication bias. Despite heterogeneity and potential bias issues, findings support BAQ’s cross-population applicability. © 2025 Elsevier B.V., All rights reserved.
Comparison of the Analgesic Efficacy of Dexketoprofen Trometamol and Paracetamol with Naproxen Sodium and Codeine Phosphate Combinations in Acute Toothache
(Nature Research, 2025) Doğru, İ.; Cigerim, L.
The aim of this study was to evaluate the efficacy of naproxen sodium + codeine phosphate and dexketoprofen trometamol + paracetamol combinations in the treatment of acute dental pain during the preoperative period. Patients with complaints of acute pericoronitis caused by a semi-erupted lower impacted third molar were included in the study. Patients were randomly divided into two groups, naproxen sodium + codeine phosphate (550/30 mg) in group A and dexketoprofen trometamol + paracetamol (25/300 mg) in group B, and pain was assessed by VAS. The collected data were statistically analysed and interpreted using SPSS. The Friedman test (a non-parametric test) was used to analyse data within groups. The independent groups t-test and Mann–Whitney U-test were used to analyse data between groups. Of the 62 patients included in the study, 51 (82.3%) were female and 11 (17.7%) were male, with a mean age of 22.94 years. As a result of the 7-day evaluation, the VAS average in group A decreased from 7.61 to 1.26, representing an 83.44% decrease, while in group B, it decreased from 7.19 to 0.61, representing an 91.52% decrease. When the VAS averages of groups A and B were compared over time, statistically significant differences were only found between the values on day 7 (p < 0.05). Both analgesics were effective in acute dental pain. The results of this study support the use of dexketoprofen trometamol + paracetamol and naproxen sodium + codeine phosphate combinations in the treatment of acute dental pain during preoperative period. Clinical Trial Registration: This trial was retrospectively registered on http://www.clinicaltrials.gov/ on 21 March 2025 under the title ‘Evaluation of the Analgesic Efficacy of the Combination of Dexketoprofen + Paracetamol and the Combination of Naproxen Sodium + Codeine in Patients With Acute Dental Pain’ and number NCT06916234. © 2025 Elsevier B.V., All rights reserved.

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