Scopus İndeksli Yayınlar Koleksiyonu

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Theoretical Description for Firocoxib Cathodic Electrochemical Determination in Meat and Milk
(AMG Transcend Association, 2025) Tkach, Volodymyr V.; Morozova, Tetiana V.; de Oliveira, Sílvio C.; Domnich, Valerii P.; Biryuk, Igor G.; Sykyrytska, Tetiana B.; Karakoyun, Necdet
In this work, the possibility of firocoxib electrochemical determination in meat and milk has been theoretically described. The electroanalytical process is performed at the cathode, providing an efficient method. The analysis of the corresponding model, using linear stability theory and bifurcation analysis, has confirmed that the conducting polymer can serve as an efficient electrode modifier for the electrochemical determination of firocoxib. As for oscillatory and monotonic intabilities, they will depend on the nature of the monomer used to yield the conducting polymer. © 2025 by the authors.
Detailed Chemical Investigation of the Essential Oil and Aroma Contents of 21 Hypericum Triquetrifolium Turra Species Collected From Different Localities via a Chemometric Approach
(John Wiley and Sons Ltd, 2026) Yigitkan, Serkan; Yigitkan S.; Akdeniz, Mehmet; Olmez, Ozge Toku; Cavusoglu, Mehmet; Yener, Ismail; Firat, Mehmet
Hypericum species have been used for medicinal purposes since ancient times because of their important pharmacological properties. Hypericum triquetrifolium Turra belongs to the Hypericaceae family and is native to Eastern Europe and the Mediterranean region. In this study, the essential oil and aroma contents of H. triquetrifolium collected from 21 different localities in the eastern region of Turkey were determined via GC–MS/FID. In addition, the antioxidant and enzyme inhibition activities (cholinesterase, tyrosinase and urease) of the essential oils and major components were determined. Finally, the essential oil and aroma contents were evaluated chemically. The major components of H. triquetrifolium collected from 21 different locations were generally determined to be octane, 2-methyl (1.35%–25.18%), α-pinene (1.32%–19.1%), nonane, 3-methyl (2.43%–24.59%) and caryophyllene (3.79%–30.78%). When the aroma content was examined, octane, 2-methyl (14.22%–44%), nonane (6.37%–18.29%), nonane, 3-methyl (7.62–23.12%) and decane, 2-methyl (3.46%–22.74%) were generally identified as the major components. Overall, all samples were found to have moderate antioxidant capacity. In the AChE enzyme inhibition test, at a concentration of 100 μg/mL, samples S-19, S-9 and S-11 (inhibition %: 87.61 ± 0.63; 84.29 ± 1.51; 82.28 ± 0.53, respectively), and in the BChE enzyme inhibition test, the S-1, S-4 and S-6 samples (88.76 ± 0.79; 91.29 ± 1.58; 93.15 ± 2.16, respectively) were found to be more active than the reference galantamine. In the tyrosinase enzyme inhibition test, samples S-5 and S-13 (inhibition %: 57.09 ± 2.53 and 66.86 ± 0.50, respectively) were found to have greater activity than the other samples. A total of 21 H. triquetrifolium samples collected from different regions of Diyarbakır, Mardin, Elazığ, Siirt, Batman and Şanlıurfa Provinces were analysed via principal component analysis (PCA) and cluster analysis (CA) techniques on the basis of volatile and aroma components. PCA revealed that the dominant volatile components in the samples formed three groups, and regional differences had no significant effect on the samples. The first two principal components explained 59.2% of the variance. The antioxidant capacities of essential oils, their high contents of compounds such as α-pinene and caryophyllene, and their strong acetyl and butyrylcholinesterase enzyme inhibition activities are considered to have potential for use in the food, cosmetics and pharmaceutical industries. © 2026 John Wiley & Sons Ltd.
Young Plasma Transfer Enhances Antioxidant Defense and Preserves Structural Integrity in Aged Lung Tissue
(2026) Düvenci Birben, Özlem; Teker, Hikmet Taner; Keskin, Seda; Baba, Burcu; Koçpınar, Enver Fehim; Yıldırım, Vesila; Kabayer, Sevcan
BACKGROUND: Heterochronic plasma exchange is widely used to investigate systemic aging; however, its pulmonary consequences particularly regarding oxidative stress, antioxidant defense, and tissue architecture have not been systematically examined. METHODS: Twenty-four-month-old male Sprague-Dawley rats received 0.5 mL of young plasma intravenously daily for 30 days, while 8-week-old rats received 0.25 mL of aged plasma. After treatment, lung tissues were analyzed histologically, biochemically, and molecularly. RESULTS: Quantitative PCR showed that young plasma markedly upregulated antioxidant defenses, with SOD and CAT expression increasing by ∼2.5-fold and 1.8-fold, respectively (p < 0.01), accompanied by higher SOD and GPX enzyme activities (p < 0.05). Additional antioxidant genes (GR, GST, TXN/TXNR) were also significantly upregulated, confirming a broad activation of the antioxidant network. In contrast, aged plasma suppressed antioxidant responses, reducing CAT activity by ∼35% (p < 0.01) and similarly decreasing other enzymes. Histological analyses revealed preserved alveolar structure, thinner septa, and reduced inflammation in old + young plasma rats, while young + old plasma transfer caused structural deterioration. Immunohistochemistry confirmed increased GPX, SOD, and CAT expression in aged rats receiving young plasma, consistent with transcriptional and protein-level activation. Moreover, heterochronic plasma exchange attenuated collagen accumulation, suggesting reduced fibrillar matrix deposition, and restored the balance between alveolar epithelial Type I (AT1) and Type II (AT2) cells, indicating improved epithelial homeostasis. Toluidine Blue staining showed decreased mast-cell density after young plasma treatment (p < 0.05), reinforcing its anti-inflammatory effect. CONCLUSIONS: Young plasma exerts regenerative and anti-inflammatory actions in the aged lung, highlighting it as a key target of systemic rejuvenation. © The Author(s) 2026. Published by Oxford University Press on behalf of the Gerontological Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please cont
Impact of IPARD Support on Beekeeping Performance: The Case of Van Province, Türkiye
(Universidad del Zulia, Facultad de Ciencias Veterinarias, 2026) Gezginc, Ömer; Çevrimli, Mustafa Bahadır; Mat, Burak
This article examines the structural, productive, and managerial changes in beekeeping enterprises that have benefited by the European Union’s Instrument for Pre-Accession Assistance in Rural Development. The research was conducted using data obtained from 72 beekeeping businesses operating in Van province and receiving Instrument for Pre-Accession Assistance in Rural Development support, and the production capacity, productivity and management indicators of the businesses were compared in the pre-support and post-support periods. The Wilcoxon signed-rank test and the McNemar test were performed using SPSS 25.0 software in the analysis of the data. Analysis results showed that the number of hives, honey yield per hive, and total honey production increased statistically significantly in the post-support period compared to the pre-support period (P < 0.001). The effect size coefficients calculated for these statistically significant variables revealed that the observed differences are also practically important. While the increase in the number of employees was statistically significant, it remained at a lower level compared to other indicators (P < 0.01). Furthermore, the production of secondary bee products, the adoption of quality control practices, and the rate of hive insurance increased significantly in the post-support period (P < 0.001). Although the impact on marketing activities was limited, Instrument for Pre-Accession Assistance in Rural Development support substantially enhanced production performance and technical capacity. In conclusion, the study findings demonstrate that Instrument for Pre-Accession Assistance in Rural Development is an effective tool for promoting sustainable development and provides valuable information for the formulation of future rural support policies. © (2026), (Revista Cientifica de la Facultad de Veterinaria). All rights reserved.
Using R Topological Indices for QSPR Analysis of Octanes
(Walter de Gruyter GmbH, 2026) Denizler, İsmail Hakkı; Çiftçi, İdris
Mathematical chemistry is the study of a chemical substance’s molecular structure as a graph and the use of computational methods and graph theory to mathematical problems. One important tool in this field that gives a network structure a numerical value is the topological index. It can be thought of as a mathematical process that gives a chemical compound’s physico-chemical properties a numerical number. R topological indices are the most recent indices that are based on the sum and multiplication of degrees in a neighborhood. In this work, we first investigate the prediction ability of the R indices for octane isomers in order to assess their potential usefulness. R indices of octanes were found to be highly correlated with entropy and acentric factor characteristics. Furthermore, stronger associations between R indices and the Randic, Wiener, and Zagreb indices of octanes were found. These results suggest that R indices will play a significant role in QSPR research. © 2026 the author(s), published by De Gruyter, Berlin/Boston.
Metastatic Pancreatic Neuroendocrine Tumor Mimicking Interstitial Lung Disease Diagnosed by Transbronchial Lung Biopsie: A Case Report
(NLM (Medline), 2022) Sünnetçioğlu, A.; Mermit Çilingir, B.M.; Demirbas, A.; Bayram, I.; Özgökçe, M.
Pancreatic neuroendocrine tumors (PNETs) are rare malignancies characterized by insidious onset and mostly present with metastasis at the diagnosis. Lung metastasis manifesting diffuse ground-glass opacity is a very rare pattern that is difficult to distinguish from nonmalignant pulmonary diseases. Recognition of this atypical metastases pattern and avoidance of this potential pitfall are crucial. We report a unique case of the Metastatic Pancreatic Neuroendocrine Tumor Mimicking Interstitial Lung Disease diagnosed by transbronchial lung biopsie. Keywords: Neuroendocrine Tumor, Metastasis, Groundglass opacity, interstitial lung disease.
Fractal Riemann-Stieltjes Calculus
(Springer Nature, 2026) Golmankhaneh, Alireza Khalil; Castillo, René Erlín; Zayed, Ahmed I.; Jørgensen, Palle E. T.
In this paper, we provide an overview of fractal calculus, extending the Riemann-Stieltjes calculus to functions supported on fractal sets. We define fractal derivatives of functions with respect to other fractal functions and discuss their properties. Additionally, we present the fractal mean value theorem, including its maximum and minimum values. The fundamental theorem of calculus is demonstrated within this fractal context, establishing the relationship between integrals and derivatives for Fϕ(x)α-differentiable functions. Examples are provided and illustrated through plots to highlight the details of these concepts. © Diogenes Co.Ltd 2026.
Composition-Tuned PdXvY/G-C3N4 Anodes for Alkaline Glycerol Electrooxidation
(Springer, 2026) Ecer, Ümit; Yılmaz, Şakir; Ulas, Berdan; Oruç, Mehmet; Yayla, Sedat
We report a new family of bimetallic anode catalysts, PdxVy/g-C3N4, synthesized via NaBH4 reduction at varying Pd:V ratios for glycerol electrooxidation (GOR). SEM–EDX, XRD, ICP-MS, and XPS confirm uniform dispersion and Pd–V interaction: g-C3N4 (1 0 0)/(0 0 2) reflections are retained, while a slight 2θ shift and FWHM broadening of Pd (1 1 1) indicate alloying and reduced crystallite size. Electrochemical testing in 1 M KOH and 0.1 M glycerol + 1 M KOH (CV, LSV, EIS, CA) identifies Pd90V10/g-C3N4 as the top performer, delivering current density up to 7.55 mA cm−2 in CV and 2.72 mA cm−2 in LSV with an onset of ~ 0.87 V. The smallest EIS semicircle evidences the lowest charge-transfer resistance; the linear dependence of current on the square of scan rate together with a discernible Warburg element indicates pronounced mass transfer limitations under the tested conditions. Despite this partial mass transfer limitation, optimization of catalyst-layer thickness and loading, electrode porosity, and electrolyte flow is required to fully exploit the current density of Pd90V10/g-C3N4 in practical alkaline glycerol fuel cells. Pd90V10/g-C3N4 shows good operational stability, according to chronoamperometry in 0.1 M glycerol + 1 M KOH; following an initial decay within the first 10 s due to surface poisoning, the current density followed a steady course throughout the remainder of the 3600 s period. Overall, Pd-V synergy coupled with the conductive g-C3N4 support enhances active surface and charge transport, yielding markedly improved GOR activity; Pd90V10/g-C3N4 emerges as a promising anode for direct glycerol fuel cells. © The Author(s) 2026.
Development of a Cobalt Tetra (Diethoxycarbonylmethyl) Phthalocyanine-Based Benzydamine-Selective Poly Vinyl Chloride Membrane Potentiometric Sensor
(John Wiley and Sons Inc, 2026) Kanberoğlu, G.S.; Kaya, N.; Aǧirtaş, M.S.
Benzydamine (BNZ) overdose can lead to serious adverse effects, including hallucinations, urticaria, bronchospasm, and renal dysfunction. Therefore, its selective and sensitive determination is essential. In this study, a novel potentiometric sensor for BNZ was developed using cobalt tetra(diethoxycarbonylmethyl)phthalocyanine (CoPc) as the ionophore. The surface morphology of the sensor was confirmed by scanning electron microscopy (SEM). The developed sensor exhibited a Nernst slope of 59.6 mV/decade in the concentration range of 1.0 × 10−8−1.0 × 10−2 M, a detection limit of 9.5 × 10−9 M, a fast response time of 10 s, and stable performance in the pH range of 2.10–8.00. It demonstrated a 34-day operational lifetime and high selectivity, with stability further confirmed by water layer tests and potential drift measurements. Successful application in pharmaceutical formulations and physiological serum samples validated its practical utility. Compared to previously reported potentiometric sensors, this sensor offers a wider linear range and lower detection limit, providing a rapid, selective, and reliable tool for BNZ determination. © 2026 Wiley-VCH GmbH.
TRPM2 Channel Involvement in the Hesperidin-Mediated Potentiation of Cisplatin’s Antitumor Action in Laryngeal Carcinoma Cells
(Multidisciplinary Digital Publishing Institute (MDPI), 2026) Çınar, R.; Yıldızhan, K.; Altiner, H.İ.; Yaǧci, T.
Cisplatin (CSP) is a first-line chemotherapeutic for laryngeal squamous cell carcinoma (LSCC), but its clinical effectiveness is limited by resistance and toxicity. Hesperidin (HESP), a citrus flavonoid, may enhance chemotherapeutic efficacy through pro-apoptotic properties. This study investigated the involvement of the transient receptor potential melastatin-2 (TRPM2) channel in the HESP-mediated potentiation of CSP-induced cytotoxicity in human laryngeal carcinoma (Hep-2) cells. Hep-2 cells were treated with CSP (25 µM), HESP (25 µM), or their combination for 24 h. The findings showed that the combined application of HESP and CSP reduced cell viability by approximately 50% (p < 0.001), which was the lowest compared to CSP alone. Western blot analysis revealed that TRPM2 protein expression was higher in the CSP+HESP group compared to the control group (p < 0.001). This synergistic treatment resulted in an increase in ROS production and a decrease in MDA levels, accompanied by a reduction in cellular GSH levels (p < 0.001). Furthermore, the combination therapy increased pro-inflammatory cytokines such as IL-1β and TNF-α (p < 0.001). Functional analyses showed that HESP treatment enhanced CSP-induced Ca2+ influx and altered mitochondrial membrane potential (p < 0.001). The pharmacological inhibition of TRPM2 with ACA and 2-APB reversed these effects, restoring redox balance and reducing cellular damage. In conclusion, HESP amplifies CSP-induced apoptosis in Hep-2 cells through TRPM2-dependent oxidative stress, Ca2+ dysregulation, and mitochondrial dysfunction. These findings identify TRPM2 as a mechanistic mediator of HESP-enhanced chemosensitivity in LSCC. © 2026 by the authors.
Pediatric Tracheotomy: Indications, Timing, and Clinical Outcomes
(Yuzuncu Yil University Tip Fakultesi, 2026) Yalınkılıç, A.; Yürektürk, E.; Aydın, M.; Beǧer, B.; Ağırbaş, S.; Kaçmaz, F.; Beger, O.
This study aimed to evaluate the indications, timing, and clinical outcomes of pediatric tracheotomy cases managed at a single tertiary center over a 13-year period. A retrospective review was conducted of 110 pediatric patients (1 day–18 years) who underwent tracheotomy between 2010 and 2023. Demographic data, indications, tracheotomy timing (TIT), duration of hospitalization, complications, and mortality were analyzed. Statistical analyses included Mann-Whitney U, Kruskal-Wallis, and chi-square tests, with p<0.05 considered significant. Among 110 pediatric patients, 66 were male, and 44 were female. The most common indication for tracheotomy was prolonged mechanical ventilation (80.9%), followed by airway obstruction (19.1%), which was more frequent in newborns (p=0.004). Hospital stay duration and tracheotomy timing were significantly shorter in airway obstruction cases than in prolonged ventilation (p<0.001), with significant differences among age groups (p=0.008 and p<0.001). Overall mortality was 31.8%, predominantly among patients with congenital or neurological comorbidities; no statistically significant association was found between mortality and tracheotomy indication (p=0.445). Pediatric tracheotomy remains a safe and effective intervention when performed with appropriate timing and multidisciplinary care. Our study reveals that early tracheotomy does not impact mortality rates; however, it does shorten hospital stay duration and reduce complications. © 2026, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Biological Activities of Green-Synthesized Iron Oxide Nanoparticles Using Salvia Sclarea and Lotus Corniculatus Extracts
(John Wiley and Sons Inc, 2026) Ödemiş, Ö.; Giray, G.; Özdemir, S.; Aǧirtaş, M.S.
This research article focuses on the biological activities of iron oxide nanoparticles (FeONPs) successfully synthesized using a completely environmentally friendly approach with plant extracts from Lotus corniculatus (LC) and Salvia sclarea (SS). The synthesized nanoparticles were thoroughly characterized, and their biological activities were evaluated. UV-Vis spectroscopy confirmed the formation of FeONPs by the appearance of characteristic absorption peaks at 305 nm for LC-FeONPs and 318 nm for SS-FeONPs. The band gap energies calculated for both nanoparticles in the Tauc plot analysis being 3.5 eV indicated that these materials possess semiconductor-like properties. Morphological analysis of nanoparticles magnified at high resolution using a TEM device revealed that they were predominantly spherical in shape and exhibited agglomeration. Measurements performed using an XRD device confirmed that the magnetite structure of the nanoparticles consisted of cubic crystals. The biological activities of FeONPs were investigated as detailed. © 2026 Wiley-VCH GmbH.
Antidiabetic and Anti-Alzheimer Potential of Three Tymbra Species Rich In Hesperidin and Rosmarinic Acid
(University of Ankara, 2026) Yiğitkan, S.; Çavuş Kaya, E.; Fırat, M.; Yılmaz, P.; Yener, I.; Yilmaz, M.A.; Ertaş, A.
Objective: Lamiaceae is a cosmopolitan family of aromatic and medicinal plants. There are many well-known aromatic, ornamental and weed plants in this family. Many aromatic species in the Lamiaceae family are currently used in traditional medicine, pharmaceutical and food industries due to their biological properties. In this study, it was aimed to examine the ethanol extracts (roots and aerial parts) of Thymbra spicata var. spicata (TS), Thymbra sintenisii Bornm. &Aznav. subsp. sintenisii Bornm. &Aznav (TSS) and Thymbra sintenisii Bornm. & Azn. subsp. isaurica P.H.Davis (TSI) in the terms of their biological activity and chemical content. Material and Method: The phenolic content of the species was analyzed by LC-MS/MS. In addition, cytotoxic, antioxidant, acetylcholinesterase, butyrylcholinesterase, urease, tyrosinase, elastase, collagenase, angiotensin I-converting and α-amylase enzymes activities were investigated. Result and Discussion: It was determined that all ethanol extracts were rich in hesperidin (3900.28-32910.02µg analyte/g extract) and rosmarinic acid (5343.08-11571.54µg analyte/g extract). In addition, the aerial part of TS species showed high a-amylase enzyme inhibition activity (inhibition%: 97.57±2.59 at 50 µg/ml). Due to their high antioxidant, anticholinesterase and α-amylase enzyme inhibition activities and rich phenolic content, tymbra species have potential for use in the pharmaceutical and food industry. © 2026, University of Ankara. All rights reserved.
Investigation of the Aging of Post-Traumatic Bruises Using Traditional and Computerized Digital Color Comparison Methods
(Yuzuncu Yil Üniversitesi Tıp Fakültesi, 2026) Guler, C.; Kartal, E.; Ünal, S.; Aybar, G.; Arslan, M.; Gökalp, M.A.; Aşırdizer, M.
Estimating bruise age by color is unreliable due to low accuracy and confounding variables. The aims of the current study were 1) to compare the RGB values, obtained for age determination of post-traumatic bruises, as identified by four methods in sequence: traditional naked eye and photographic color identifi cation, ImageJ analysis, and artificial intelligence (AI)-supported color identification; 2) to statistically determine the accuracy prediction rates of the bruise aging phase using discriminant function analysis (DFA) of these RGB values; and 3) to assess the usability of these methods in forensic medicine and clinical practice. We examined 407 photographs from 43 patients with traumatic bruises at the University Hospital (2023 –2024). One researcher recorded RGB values during patient examination; two resea rchers used a scale to assess RGB values from photographs; two researchers used ImageJ; and AI analyzed bruise photos. Discriminant function analysis (DFA) assessed bruise-aging group classification using RGB means. The AI-assisted program demonstrated the highest overall accuracy in bruise age estimation (50.1%). In the yellow-dominant group, the 65-year-old researcher exhibited the lowest accuracy (18.3%), whereas the AI-assisted program achieved perfect accuracy (100.0%). Visual identification by the naked eye was more accurate compared to other non-AI digital methods. These findings indicate that AI-based color analysis, which uses computational techniques to assess bruising, outperforms traditional and digital met hods across specific bruise color groups. Determining bruise age remains unreliable with current methods, but AI-supported programs offer higher prediction rates in some color groups. These results suggest AI may improve accuracy as technology advances. © 2026, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Antiproliferative Effects of Pyranopyrazole Analogs: In Vitro and Molecular Docking Analysis
(KeAi Communications Co., 2026) Nalci, K.A.; Cetin, A.; Bildirici, I.; Bayram, U.F.
Background Glioblastoma multiforme is the most aggressive primary brain tumor in adults, and current multimodal therapies provide only limited survival benefit. There is an urgent need for new small-molecule scaffolds with improved anticancer activity against glioblastoma. Objective To evaluate the antiproliferative effects of pyranopyrazole analogs on human U-87 MG glioblastoma cells and to explore their potential molecular interactions with a glioblastoma-related protein target by molecular docking. Methods A series of pyranopyrazole analogs ( 12a – o ) was synthesized using a previously reported green-chemistry protocol. U-87 MG cells were treated with increasing concentrations of the analogs for 24, 48, and 72 h, and cell viability was measured by a colorimetric tetrazolium-based assay. Half-maximal inhibitory concentration values were determined for the most active analogs and compared with those of a reference chemotherapeutic agent. Molecular docking was performed with the 6c1c protein structure to assess binding energies and interaction profiles. Results Several pyranopyrazole analogs produced dose- and time-dependent cytotoxicity in U-87 MG cells. Analog 12 g showed the strongest antiproliferative effect and lower half-maximal inhibitory concentration values than the reference agent at earlier time points, whereas 12 h , 12o , and 12i displayed moderate activity. Docking analysis indicated favorable binding of active analogs to the 6c1c active site, with multiple hydrogen-bond and π-type interactions involving key residues. Conclusion Pyranopyrazole analogs, particularly 12 g , exhibit promising antiproliferative activity against glioblastoma cells in vitro, supported by compatible molecular docking findings. These compounds may represent useful lead structures for the development of new chemotherapeutic options for glioblastoma. © 2026 The Authors.
The Effect of Omalizumab on Allergic Rhinitis Symptoms: A Comparative Study
(Yuzuncu Yil Üniversitesi Tıp Fakültesi, 2026) Ağırbaş, S.; Kiroǧlu, A.F.; Çetin, Y.S.; Erdem, M.Z.; Yalınkılıç, A.
Both Omalizumab and (Montelukast+Desloratadine) are effective treatments for allergic rhinitis. However, these treatments have not been compared clinically. Therefore, we aimed to compare their efficacy on allergic rhinitis symptoms. Between December 2018 and November 2019, 25 patients with both allergic rhinitis and chronic urticaria and 25 patients with allergic rhinitis alone were included in the study. Patients with both allergic rhinitis and chronic urticaria received Omalizumab (300 mg/month) (Omalizumab group), while patients with allergic rhinitis alone received (Montelukast+Desloratadine)/daily (Desloratadine group). In addition, both groups received fluticasone pr opionate nasal spray (100 mcg/day in each nostril). At baseline and after 8-10 weeks (follow-up), symptoms and quality of life were assessed. A visual analogue scale was used for the assessments. Compared to baseline, both groups showed significant symptomatic improvements at follow-up. When the change from baseline to follow-up was compared, the groups were similar in terms of nasal congestion, rhinorrhoea, sneezing and quality of life. However, Omalizumab group was superior to Desloratadine group in term s of eye itching (68.55±17.62 vs 55.46±20.42; p=0.010). In conclusion, Omalizumab is more effective than Montelukast plus Desloratadine for eye itching in allergic rhinitis. © 2026, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Retrospective Evaluation of Eosinophil Counts and Total IgE Levels in Children With Scabies
(Yuzuncu Yil Üniversitesi Tıp Fakültesi, 2026) Mercan, A.; Başaranoǧlu, M.
Scabies is a common parasitic skin infestation in children that may cause elevated eosinophil counts and total IgE levels. Because these findings resemble those of atopic dermatitis and other allergic diseases, scabies is often misdiagnosed, leading to unnecessary allergy referrals. This study aimed to determine eosinophil counts and total IgE levels in children diagnosed with scabies, assess their frequency, and highlight the importance of considering scabies in the differential diagnosis of atopic and allergic conditions. This retrospective cross-sectional study included children aged 0–18 years diagnosed with scabies according to the 2020 International Alliance for Scabies Control criteria before October 30, 2024, who were referred to the Pediatric Allergy and Immunology Clinic of Osmaniye State Hospital. Data on patients’ demographics, family history of scabies, bacterial skin infections, eosinophil counts, total IgE levels, and treatment were collected from medical records. Of all patients, 32.2% were female and 67.8% male, with a median age of 30 months. The median eosinophil count was 516.88/µL, and the mean total IgE level was 427.44 IU/mL. The median eosinophil percentage was 5.58%; 53.9% had eosinophil percentages ≥4%, and 53% had total IgE levels ≥100 IU/mL. Additionally, 40% had no family history of scabies, and 23% had bacterial skin infections. More than half of the patients exhibited elevated eosinophil counts and total IgE levels. In children presenting with pruritus and rash, scabies should be considered in the differential diagnosis, especially when eosinophilia or high IgE is present. © 2026, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
The Influence of Altitude and Ambient Temperatures on Suicide Deaths in Türkiye From 2007 To 2022
(Yuzuncu Yil Üniversitesi Tıp Fakültesi, 2026) Demir, U.; Can, H.N.; Utku, Z.; Keskin, S.; Aşırdizer, M.
The high rate of suicide worldwide is one of biggest obstacles to meet the WHO goal of reducing deaths by one-third by 2030. Previous studies have proven that suicide risk factors have an intertwined impact on suicide rates. The aim of this study was to define the relationship between the suicide rates in all provinces in Türkiye and the altitudes of these provinces, annual average winter and summer temperatures, temperature differences between winter a nd summer, and to investigate the relationship between suicide rates and gender, age group, socioeconomic scores of the provinces, reasons for suicide and types of suicide. The crude data for the current study were obtained from the Turkish Statistical Institute (TUIK) public website. Between 2007 and 2022, there were 52,300 suicides in 81 cities in Türkiye, comprising 38,564 males and 13,736 females. An increase in altitude was found to be associated with higher suicide rates in females and young people. For children aged <15 years, a low ambient temperature increased suicide rates. A positive correlation was detected between an increase in mean temperature and suicide committed by jumping from a high place, and between an increase in the seasonal temperature difference and suicide by hanging. The variations in suicide rates associated with altitude and ambient temperature may provide an opportunity to identify times of high risk for individuals with suicidal tendencies and thereby enable them to receive in creased psychological support during these times of change. © 2026, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Pediculus Humanus Capitis Infestation Among Primary School Children in Van Province, Türkiye
(Yuzuncu Yil Üniversitesi Tıp Fakültesi, 2026) Emre-Beyhan, Y.E.; Özkan, S.
This study aimed to determine the prevalence of Pediculus humanus capitis infestation among primary school students in the Başkale town of Van Province and to evaluate associated demographic and behavioral factors. This cross-sectional study was conducted in March 2018 among 530 students from four primary schools. Hair and scalp examinations were performed visually; suspicious samples were confirmed microscopically. Sociodemographic and hygiene-related data were collected through a structured questionnaire. Statistical analyses were performed using chi-square and Fisher’s exact tests. The overall prevalence of head lice infestation was 3.8% (20/530). Infestation was significantly higher among girls (6.8%) compared with boys (1.5%) (p=0.003). The highest prevalence occurred among third-grade students (12.2%). Medium (6.2%) and long hair (5.7%) were associated with significantly higher infestation rates (p=0.005). Wavy and curly hair demonstrated a higher tendency for infestation, although the association was not statistically significant. Larger household size (4–7 individuals) showed a noticeable clustering of cases. Although the prevalence in Başkale was lower than many national and international figures, head lice infestation remains a relevant public-health issue. Female sex, younger age, longer hair, and crowded households were identi fied as key risk factors. School-based screening, parental education, and early detection programs are recommended to reduce transmission. © 2026, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Evaluation of the Conus Medullaris with 2D and 3D Ultrasonography in Fetal Neural Tube Defect Anomalies
(Yuzuncu Yil Üniversitesi Tıp Fakültesi, 2026) Karaaslan, O.; Bağcı, M.; Demir, İ.Z.; Şahin, H.G.; Karaman, O.; Ates, Ç.; Onat, E.
This study aimed to evaluate the fetal conus medullaris (CM) using 3D ultrasonography in fetuses with central nervous system (CNS) anomalies and in healthy fetuses. The aim was to evaluate the vertebral ending levels of CM and its utility as a biomarker in prenatal diagnosis. This prospective study, conducted at the Obstetrics and Perinatology Clinic of Van Yüzüncü Yıl University, Faculty of Medicine, included 80 pregnant women between 11 and 22 weeks of gestation with a singleton pregnancy, aged 18 to 45, and with a body mass index (BMI) <30. 40 women with fetal CNS anomalies were included in the patient group, while 40 healthy pregnant women were included in the control group. All pregnant women underwent 2D ultrasonography followed by 3D ultrasonography. The ending level of the CM relative to the vertebral column and various biometric measurements were recorded. Data were analyzed using SPSS 27.0. When demographic data were analyzed, no significant difference was found between the two groups in terms of age, height, weight, and gestational age (p>0.05). The distances between the CM and the lower end of the sacrum (CM –Os Sacrum) and the anterior abdominal wall (CM–Abdomen) were also similar (p=0.279 and p=0.299). When the ending levels of the CM relative to the lumbar vertebrae were evaluated, it was observed that the CM most frequently ended at the L4 level in 23 patients (53.5%) in the patient group, at the L3 level in 15 patients (37.5%), and at the L2 level in 2 patients (5%). In the control group, it was observed that the CM ended at the L3 level in 23 patients (57.5%) and at the L2 level in 17 patients (42.5%). While it was found that the CM extended to the L4 level in the patient group, this ending was not observed in the control group. Ending at the L2 level was more frequently observed in the control group (42.5% vs 5%). In subgroup analyses, it was determined that the CM ending was more caudal in cases with anomalies such as spina bifida and anencephaly. The ending level of the CM at the vertebral end, particularly its extension to the L4 level, may be a powerful biomarker for identifying CNS anomalies prenatally. This study demonstrates the utility of prenatal 3D ultrasound assessment of the CM ending level in the early diagnosis of CNS anomalies. © 2026, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.

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