Scopus İndeksli Yayınlar Koleksiyonu

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Interaction Activity of Metal-Free Phthalocyanine Compound Bearing Tetra -(2-(N-2'-Cyanoethyl)aminoethylsulfanyl) Units with DNA
(Chemical Society of Pakistan, 2025) Arslantaş, Ali; Aǧirtaş, Mehmet Salih
The phthalocyanine having 4-(2-(N-2'-cyanoethyl)aminoethylsulfanyl) group had been reported earlier in the literature. In this current studying, DNA binding activity of 1Pc phthalocyanine bearing 4-(2-(N-2'-cyanoethyl)aminoethylsulfanyl units was examined spectroscopically via elctronic absoption, fluorescence titration, melting point profile, electrophoresis and viscosity methods. The interaction activity of 1Pc compound was examined at differing concentrations. UV/Vis spectrometer, viscosity, fluorescence spectroscopy and thermal melting temperature confirmed that 1Pc binds to the DNA. The Kb of 1Pc is also estimated via UV/Vis titration and Kb of 1Pc was computed as 2.1394 x 106 M-1. The Kb value demonstrated that 1Pc reacts with DNA by an intercalative mechanism. Alongside this research, the mechanism by which the compound binds to DNA was investigated by determining Tm. The Tm of DNA + 1Pc complex was identified as 74.31. This data confirmed that 1Pc binds to DNA intercalatively. All the results obtained from the used methods demonstrated that 1Pc phthalocyanine compound has an efficient DNA interaction activity and 1Pc phthalocyanine compound interacts with DNA via an intercalative mechanism. As a result, the compound may be a therapeutic agent due to its DNA interaction property. © 2025 Elsevier B.V., All rights reserved.
Tomography of the Source Zone of the February 6, 2023, Kahramanmaraş Earthquake Doublets of Southern Anatolia
(Elsevier Ltd, 2026) Salah, Mohamed K.; Alkan, Hamdi; Öztürk, Serkan; Guney, Recep
On February 6, 2023, two destructive earthquakes and many posterior aftershocks hit the Kahramanmaraş area in southern Anatolia. The Kahramanmaraş earthquake sequence (KMES) caused extensive damage and economic losses in Türkiye and Syria. In this study, the 3-D crustal seismic velocities surrounding the hypocentral region of the KMES are determined using a large dataset of body wave arrival times obtained from local earthquakes. To better constrain the physical properties and seismogenic behavior of the KMES source region, the Vp/Vs ratio is calculated and correlated with Poisson's ratio using the obtained velocity models. To gain a better understanding of the stress conditions and regional earthquake activity in the study area, the depth variation of the b-value is also examined. The velocity structure is generally heterogeneous with both low and high velocities at upper crustal depths. Along the East Anatolian Fault Zone and its environs, low-velocity anomalies are charted. Also, small b-values (<1.0) are estimated in the region encompassing the KMES, especially at upper crustal depths. The KMES source zone is characterized by low b-value, low to average Vp, low Vs, and average/high Vp/Vs ratios. Hit count rates and the resolution test show that the mapped velocity anomalies are robust down to a depth of 45 km. Therefore, the moderate/high Vp/Vs and small b-values at the upper and middle crustal depths along the EAFZ may give constraints on the next earthquake hazards of the study region. The present findings provide deeper insight into the physical properties and the seismogenic potential of the crustal zones in proximity to the active fault segments of the Anatolian Plateau and the northwestern part of Arabia. © 2025 Elsevier B.V., All rights reserved.
A Novel and Facilitator Virtual Phase Generating Technique for Microcontrollers in Electric Vehicle Powertrain Systems
(Elsevier B.V., 2026) Çeli̇k, Doǧan; Meral, Mehmet Emin
In light of the increasing need for efficient and dependable electric vehicle (EV) powertrain systems, the development of advanced control techniques is essential for improving performance and energy efficiency to fulfil industry standards and consumer expectations. With the rapid expansion of high and new information technologies, computer and microprocessor control-based electric machinery (EM) and power electronic converter (PEC) devices are increasingly utilized in EV powertrain systems. Therefore, it's important to sample and acquire three-phase information to control these devices. Considering this aspect, this paper proposes a new and facilitator virtual phase-generating technique with a π/12 delay time to improve the operational performance of the EMs and PECs in EV powertrain systems. The proposed methodology quickly generates virtual phases by utilizing calculated and simplified trigonometric expressions. The proposed technique provides significant improvements in speed, tracking accuracy, minimal peak overshoot, phase tracking, and frequency adaptation, while remaining simpler to implement than existing methods. Specifically, it reduces delay time by 87.5 %, lowers buffer requirements from 3600 to 450 samples, and thereby enhances system responsiveness and reduces RAM usage—making it well suited for microcontrollers with limited memory. Additionally, by relying on single-phase voltage sensing, the method eliminates the need for multi-phase sensing circuitry, reducing analog-to-digital conversion overhead and power consumption, which is especially critical for battery-powered EV applications where efficient resource utilization directly impacts operational runtime and system reliability. Detailed theoretical and quantitative results are conducted to show the efficiency and feasibility of the proposed technique over the existing literature. The obtained real microcontroller including eZdsp TMS320F28335 board and processor-in-the-loop (PIL)-based quasi-real-time test results provide that the proposed technique meets its objectives with high performance. © 2025 Elsevier B.V., All rights reserved.
Post-Disaster Permanent Housing and Life Satisfaction in Van, Turkey: Impacts of Housing Satisfaction, Socioeconomic and Demographic Factors
(Elsevier Ltd, 2026) Uǧurlar, Aysu; Alkan-Gökler, Leyla; Çenesiz, Gaye Zeynep
This study investigates the factors influencing life satisfaction among residents of post-disaster permanent housing in Van, Turkey, following the 2011 earthquake. Data were collected through a survey of 382 households across five districts, examining socioeconomic factors, housing satisfaction, and their impact on overall life satisfaction. Multiple regression analysis revealed that income, satisfactions from housing attributes, neighborhood characteristics and social activities, and demographic factors significantly influence residents' life satisfaction. Households facing fewer difficulties meeting housing expenditures reported higher levels of life satisfaction. The study highlights that both objective housing attributes, such as housing quality, and subjective perceptions, such as neighborhood satisfaction and sense of community, significantly influence residents' overall life satisfaction. These findings, consistent with existing research, underscore the importance of addressing socioeconomic disparities and improving housing quality to enhance residents' well-being. The study emphasizes the need to incorporate residents' needs and preferences into post-disaster permanent housing policies to promote successful resettlement and ensure the long-term well-being of disaster-affected communities. © 2025 Elsevier B.V., All rights reserved.
Urea Based Derivatives as Anticancer Agents: Cytotoxicity, GST Inhibition, Molecular Docking, ADME, and Molecular Dynamics Approaches
(John Wiley and Sons Inc, 2025) Demir, Zahide; Cetin, Adnan; Oguz, Ercan; Kazancioglu, Mustafa Zahrittin; Kazancioglu, Elif Akin; Türkan, Fikret
The primarily the inhibition effects of four urea derivatives (10a–d) were evaluated against glutathione S-transferase (GST) enzyme. The IC50 values of 10a–d molecules were determined to be in the range of 1.69–2.21 µM. Lineweaver-Burk graphs of 10a–d inhibitor molecules were drawn and the Ki constant of the molecules was calculated to be in the range of 0.54–6.62 µM. The IC50 value of the ethacrynic acid (INN) was found to be 3.26 µM and the Ki constant was 9.25 µM. The antiproliferative effects of 10a–d molecules were investigated in hepatocellular carcinoma (HepG2) cell lines using MTT assay. Their inhibition concentrations were found to be a 50% decrease in cell viability. The in vitro experimental data for 10a–d molecules were supported by extensive in silico analyses such as molecular docking, molecular dynamics simulation and ADME profiling, and their biological effects were explained at the molecular level. © 2025 Elsevier B.V., All rights reserved.
Fate of Blastocystis in Homemade Koruk (Unripe Grape) Juice and on Juice-Treated Green Leafy Vegetables
(John Wiley and Sons Inc, 2025) Aydemi̇r, Selahattin; Aydemir, Mehmet Emin; Barlık, Fethi; Ekici, Abdurrahman; Necip, Adem
This study aimed to evaluate the viability of Blastocystis in naturally produced koruk juice and on leafy salad greens treated with the juice. Additionally, the antiparasitic effect of koruk juice is to be evaluated by molecular docking analysis. Koruk juice was produced from unripe grapes. Blastocystis isolates were inoculated with koruk juice at different concentration levels. The isolates were also inoculated onto different salad greens, and the greens were dressed with koruk juice. Molecular docking was used to investigate the interactions between the organic acids found in koruk juice and the 6NO0 protein, which plays a critical role in Blastocystis physiology. In the control group, Blastocystis maintained viability for 60 min. However, treatment with 50% koruk juice reduced the number of viable Blastocystis cells by 100% within 30 min in culture. The number of live Blastocystis decreased from 73.25 (curly lettuce) to 97.65 (parsley), depending on the type of greenery, after 5 min in green salads dressed with 50% concentration of koruk juice. Molecular docking analysis revealed that the organic acids found in koruk juice exhibit a high binding affinity for the active site of the Blastocystis target protein. Citric acid showed the highest interaction score (−6.486 kcal/mol), whereas the control drug metronidazole had the weakest (−4.065 kcal/mol). The fact that all the organic acids exhibit a higher affinity than metronidazole confirms the antiparasitic effect of koruk juice at a molecular level. In conclusion, koruk juice has an anti-Blastocystis effect and can be used as a salad dressing on greens to improve and eliminate the risk of Blastocystis. Practical Applications: This study shows that homemade koruk (unripe grape) juice can effectively reduce Blastocystis contamination on leafy salad greens. Using 50% koruk juice as a natural salad dressing may help improve the microbial safety of fresh salads in home kitchens, restaurants, or food service settings. 50% koruk juice eliminated Blastocystis in culture within 30 min. Koruk juice was the most effective on Blastocystis viability on parsley. Molecular docking showed strong binding of organic acids to Blastocystis protein. © 2025 Elsevier B.V., All rights reserved.
Molecular Detection of Intestinal Protozoa and Microsporidia in HIV/AIDS Patients
(Elsevier Inc., 2026) Yürektürk, Şehriban; Damar-Cakirca, Tuba; Gürbüz, Esra; Aydemi̇r, Selahattin; Ekici, Abdurrahman
Introduction: This study investigate opportunistic pathogens Cryptosporidium spp, Giardia intestinalis, Blastocystis, and microsporidia species in patients with human immunodeficiency virus (HIV) infection using molecular methods, and to identify associated risk factors. Methods: The study included 100 randomly selected HIV-seropositive patients, along with 50 healthy individuals as the control group. Participants who reported receiving antiparasitic treatment during the study period were excluded. Conventional polymerase chain reaction (PCR) was used to detect Blastocystis and microsporidia, while nested PCR was employed to identify Cryptosporidium spp. and G. intestinalis. Results: Blastocystis was found in 22% of the of HIV/acquired immunodeficiency syndrome (AIDS) patients, as was microsporidia in 17%, Cryptosporidium spp. in 12%, and G. intestinalis in 11%. In the control group, Blastocystis was detected in 8%, microsporidia in 6% and Cryptosporidium spp. in 2%, while G. intestinalis was not detected. The differences in the prevalence of G. intestinalis (p = 0.001), Cryptosporidium spp. (p = 0.009), microsporidia (p = 0.013), and Blastocystis (p = 0.029) between the patient and control groups were statistically significant. Multiple parasitic infections were identified in 12% of HIV/AIDS patients, whereas no cases of multiple parasitism were observed in the control group. Conclusion: HIV/AIDS patients were found to be at increased risk for G. intestinalis, Cryptosporidium spp., microsporidia, and Blastocystis. Given the presence of multiple parasitism, stool samples from HIV/AIDS patients should be routinely screened using comprehensive diagnostic methods targeting all major intestinal parasites. © 2025 Elsevier B.V., All rights reserved.
Plant-Fungus Synergy Against Soil Salinity: The Cellular and Molecular Role of Arbuscular Mycorrhizal Fungi
(Elsevier Inc., 2025) Boyno, Gökhan; Rezaee Danesh, Younes; Çevik, Rojbin; Teniz, Necmettin; Demir, Semra; Calayır, Oktay; Farda, Beatrice
Arbuscular mycorrhizal fungi (AMF) play a crucial role in disease control by establishing symbiotic relationships with plant roots. AMF improve salinity tolerance in plants by regulating the Na+/K+ ratio through selective ion transport and mediate osmotic regulation by inducing the accumulation of osmotic-compatible solutes such as glycine betaine and proline to enable plant cells to maintain water content and the metabolic balance. AMF can also activate antioxidant defense responses by stimulating enzymes that protect plant cells from harmful oxidation and pathological infections. Plant salinity tolerance induced by AMF depends on abscisic acid (ABA)-dependent signaling mechanisms, calcium-calmodulin-dependent pathways, and reactive oxygen species (ROS)-modulated mitogen-activated protein kinase (MAPK) cascades. Therefore, future research should focus on optimizing the production and field efficacy of AMF-based inoculants, including their combined use with microbial biostimulants, to support the implementation of sustainable agricultural practices. © 2025 Elsevier B.V., All rights reserved.
Frequency of Intestinal Protozoa in Patients Receiving Treatment at Van Special Physioactive Special Education and Rehabilitation Center
(2025) Saygin, Murat; Aydemir, Selahattin; Ekici, Abdurrahman; Yilmaz, Hasan
Objective: The aim of this study is to determine the frequency of intestinal protozoa in disabled patients attending a rehabilitation center, thereby highlighting the significance of intestinal protozoa in individuals with disabilities. Methods: The study included a total of 300 individuals, comprising 200 disabled patients and 100 non-disabled individuals. Stool samples were collected from all participants and examined using the native-Lugol and modified acid-fast methods. Results: In the study, intestinal protozoa were detected in 41% of disabled individuals and in 9% of individuals in the control group (p=0.001). Blastocystis was detected in 18% of patients, Cryptosporidium spp. in 15%, Giardia intestinalis in 9%, Cyclospora cayetanensis in 5%, and Entamoeba coli in 4%. Among the subgroups, spina bifida patients had a protozoan infection rate of 83.3%, while the rates in other groups were lower. A significant relationship was detected between the presence of parasites and diarrhea, constipation, and loss of appetite (p<0.05). Conclusion: Disabled individuals, especially those with spina bifida, are at risk for intestinal protozoa, and regular screening for opportunistic protozoa is essential for these patients.; Amaç: Bu çalışmanın amacı, bir rehabilitasyon merkezine devam eden engelli hastalarda intestinal protozoonlarınsıklığını belirleyerek intestinal protozoonların engelli bireylerdeki önemini ortaya koymaktır. Yöntemler: Çalışmaya, 200 engelli hasta ve 100 engelsiz birey olmak üzere toplam 300 kişi dahil edildi. Çalışmaya dahil edilen tüm bireylerden dışkı örnekleri alınarak, nativ-Lugol ve modifiye asit fast yöntemleriyle incelendi. Bulgular: Çalışmada, engelli bireylerin %41’inde ve kontrol grubundaki bireylerin %9’unda bir ya da daha fazla intestinal protozoon saptandı (p=0,001). Hastaların %18’inde Blastocystis, %15’inde Cryptosporidium spp., %9’unda Giardia intestinalis, %5’inde Cyclospora cayetanensis ve %4’ünde Entamoeba coli saptandı. Hasta alt gruplarından spina bifida hastalarının %83,3’ünde intestinal protozoon bulunurken diğer gruplardaki oranlar daha düşük bulundu. Ayrıca engelli bireylerde protozoon varlığı ile ishal, kabızlık ve iştahsızlık arasında anlamlı bir ilişki olduğu belirlendi (p<0,05). Sonuç: Engelli bireylerin, özellikle de spina bifida hastalarının intestinal protozoonlar açısından risk altında olduğu ve bu hastaların özellikle fırsatçı protozoonlar yönünden düzenli olarak taranması gerektiği kanaatine varıldı. This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
Determination of Retinol, Cholecalciferol, Α-Tocopherol and Phylloquinone Levels in Dogs With Dilated Cardiomyopathy: A Preliminary Study
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Bilgiç, Bengü; Isik, Muhammed Zeyd; Bakir, Ahmet; Suat, Ekin; Kozat, Süleyman; Pugliese, Michela; Or, Erman M.
Lipid-soluble vitamins are essential micronutrients that play a vital role in processes such as growth, reproduction, immune regulation, antioxidant defense, anti-inflammatory response and cardiovascular health. This study aimed to evaluate the plasma levels of retinol, cholecalciferol, α-tocopherol and phylloquinone in dogs with dilated cardiomyopathy (DCM). Six dogs diagnosed with DCM and ten healthy control dogs were selected based on clinical, echocardiographic, electrocardiographic and radiographic examinations. Chromatographic analysis was performed to analyze the content of lipid-soluble vitamins. The mean plasma retinol levels were 0.0285 μg/mL and 0.0495 μg/mL in the DCM and control groups, respectively, and the mean cholecalciferol levels were 0.0739 μg/mL and 0.1045 μg/mL in the DCM and control groups, respectively. Retinol and cholecalciferol levels were both statistically lower in the DCM group than in the control group (p < 0.05). The mean plasma α-tocopherol levels were 0.3103 and 0.4322 μg/mL, and the mean plasma phylloquinone levels were 0.03780 and 0.04082 μg/mL in the DCM and control groups, respectively. However, no statistical significance was observed between the two groups for α-tocopherol or phylloquinone levels. Based on our findings, alterations in vitamin A and D metabolism could be associated with the development of idiopathic DCM in dogs. However, given the limited sample size, further investigation in larger populations is needed. © 2025 Elsevier B.V., All rights reserved.
Factors Influencing the Transition Time From Psoriasis to Psoriatic Arthritis: A Real-World Multicenter Analysis
(Springer Science and Business Media Deutschland GmbH, 2025) Kiliç, Gamze; Kılıç, Erkan; Tekeoǧlu, Ibrahim; Sargın, Betul; Cengiz, Gizem; Balta, Nihan Cüzdan; Alkan, Hakan
To identify clinical and demographic predictors associated with the timing of transition from psoriasis (PsO) to psoriatic arthritis (PsA), and to compare the characteristics of patients with concurrent PsO-PsA onset versus those with prolonged transition. A multi-center, observational study was conducted using data from the Turkish League Against Rheumatism (TLAR) network including PsA patients fulfilling CASPAR criteria. Patients were categorized into two groups: Group 1 (concurrent PsO and PsA onset within ± 1 year) and Group 2 (prolonged transition to PsA, > 1 year after PsO). Demographic, clinical, and laboratory characteristics, disease activity, and patient-reported outcomes were compared between groups. Logistic regression was employed to determine independent predictors of prolonged transition. Among 799 patients (mean age 46.8 ± 12.3 years), 237 (29.7%) had concurrent onset and 562 (70.3%) had a prolonged transition, with a mean PsO-to-PsA interval of 12.9 ± 9.6 years. Depression (p = 0.005) and fatigue levels (p = 0.011) were significantly higher in patients with prolonged transition to PsA. Multivariate analysis revealed that scalp psoriasis (OR = 7.162), nail psoriasis (OR = 3.270), family history of PsO (OR = 1.813), and enthesitis ever (OR = 2.187) were associated with prolonged transition. Conversely, family history of PsA (OR = 0.421) and older age at PsO onset (OR = 0.957) predicted shorter transition. Prolonged transition from PsO to PsA is influenced by distinct clinical and demographic factors. Scalp/nail psoriasis, family history of PsO, and enthesitis ever may signal higher risk for prolonged PsA onset. Recognizing these markers can support timely referral and intervention, minimizing diagnostic delay and improving long-term patient outcomes. © 2025 Elsevier B.V., All rights reserved.
Efficacy of Preemptive Intravenous Ibuprofen and Dexketoprofen on Postoperative Opioid Consumption in Laparoscopic Cholecystectomy: Randomized Controlled Study
(Public Library of Science, 2025) Soyalp, Celaleddin; Yayik, Ahmet Murat; Oksüz, Ersoy; Yüzkat, Nureddin
Background To compare the effects of preemptive single-dose intravenous (IV) ibuprofen and dexketoprofen on postoperative pain and opioid consumption in patients undergoing laparoscopic cholecystectomy (LCC). Methods The study included 90 patients aged 18–65 years with an ASA score of I or II who underwent LCC. Patients were equally divided into three groups: Control Group (Group P), 100 cc 0.9% NaCl was infused intravenously over 30 min, Dexketoprofen Group (Group D), 50 mg dexketoprofen in 100 cc 0.9% NaCl was infused intravenously over 30 min, and Ibuprofen Group (Group I), 800 mg ibuprofen in 100 cc 0.9% NaCl was administered intravenously over 30 min. Visual Analog Scale (VAS) scores and opioid requirement were recorded at 1, 2, 4, 6, 12 and 24 hours postoperatively. Results There was no significant difference between the Dexketoprofen and Ibuprofen groups with regard to VAS scores, whereas VAS scores were higher in the control group than other groups in the 1st, 2nd, 4th, 6th,12th, and 24th hours. In addition, fentanyl consumption was higher in the control group at 0–6 hours and at 24 hours compared to the other two groups. Conclusion Preemptive ibuprofen and dexketoprofen administration reduce pain scores and opioid consumption compared with the control group, however, they are non-inferiority to each other. © 2025 Elsevier B.V., All rights reserved.
Effect of Different Doses of Transdermal Fentanyl on the Reproductive System in Male Rats
(Pakistan Journal of Pharmaceutical Sciences, 2025) Koşal, Volkan; Kurt, Nurettin; Okulmus, Caglar; Keleş, Omer Faruk
Fentanyl, a potent synthetic opioid analgesic, is commonly used to manage severe pain. However, the effects of fentanyl use on male reproductive health have not been adequately studied. This study aimed to investigate the effects of different doses of transdermal fentanyl patches on various reproductive parameters in male rats. Adult male Albino Wistar rats were divided into four groups. The treatment groups received transdermal fentanyl at doses of 25 mcg/h (Group II), 50 mcg/h (Group III), and 100 mcg/h (Group IV) for 9 days, respectively. Sperm motility, sperm concentration, abnormal sperm, live/dead sperm, testicular apoptosis, testicular oxidative stress, and androgen receptor levels were evaluated. The results showed that fentanyl administration decreased the oxidative stress parameters CAT and SOD1 levels in all treatment groups (p<0.001). No significant changes were observed in sperm motility, abnormal sperm ratio, or live/dead sperm ratio. However, Group IV showed a significant increase in sperm concentration compared to the other groups (p<0.001). In addition, all fentanyl treatment groups showed a significant increase in apoptosis-related Caspase 3/8/9 enzymes (p<0.001). This study reveals the effects of fentanyl on male reproductive health. This is the first study to demonstrate an increase in sperm concentration associated with high fentanyl doses. © 2025 Elsevier B.V., All rights reserved.
The Mediating Role of Moral Resilience in the Relationship Between Moral Distress and End-Of Care Attitudes and Behaviours Among Intensive Care Nurses
(John Wiley and Sons Inc, 2025) Sir, Özkan; Kaşıkçı, Maǧfiret Kara; Kaplan, Ebubekir
Background: Intensive care nurses experience moral distress due to moral conflicts, which negatively impact their attitudes and behaviours towards end-of-life care. Moral resilience is considered a potential factor in mitigating these negative effects. Aim: This study aims to examine the mediating role of moral resilience in the relationship between moral distress and intensive care nurses' attitudes and behaviours towards end-of-life care. Study Design: A descriptive and cross-sectional study was conducted in accordance with the guidelines for observational studies (STROBE). The study was conducted with 228 intensive care nurses between December 2024 and February 2025. Data were collected using the ‘Personal Information Form’, ‘Moral Distress Scale’, ‘Moral Resilience Scale’ and ‘Scale of Attitudes and Behaviours of Intensive Care Nurses Towards End-of-Life Care’. Statistical analyses were performed using SPSS 26.0 and AMOS V 24.0. Results: The moral distress levels of female nurses were higher and significantly higher than male nurses (OR 0.245; 95% CI 0.074–0.598; p = 0.011). Nurses with 11 years or more of work experience had a higher and significant level of moral distress compared to other nurses (OR 0.053; 95% CI 0.080–0.115; p = 0.012). The moral resilience level of nurses with 3–6 years of work experience was higher and significantly higher than other nurses (OR 0.067; 95% CI 0.048–0.107; p = 0.023). Moral distress negatively affects nurses' attitudes and behaviours towards end-of-life care. Moral resilience has a significant and positive effect on attitudes and behaviours. Moreover, moral resilience mediated the relationship between moral distress and attitudes and behaviours towards end-of-life care (β;-0.266, CI 95% −0.301–0.197). Conclusions: Moral distress negatively influences intensive care nurses' attitudes and behaviours in end-of-life care. Enhancing moral resilience can help mitigate these effects. The findings highlight the need for nursing education programmes and workplace interventions to strengthen nurses' moral resilience and improve their ability to manage moral distress. Relevance to Clinical Practice: While moral distress damages intensive care nurses' attitudes towards end-of-life care, moral resilience may help to reduce its negative effects. Supporting nurses is thought to improve the quality of adverse end-of-life care. © 2025 Elsevier B.V., All rights reserved.
A Comprehensive Hybrid Approach for Indoor Scene Recognition Combining CNNs and Text-Based Features
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Uckan, Taner; Aslan, Cengiz; Hark, Cengiz
Highlights: What are the main findings? Proposed an innovative two-channel hybrid model by integrating convolutional neural networks (CNNs) with a text-based classifier. Leveraged an extended dataset derived from multiple object recognition models, increasing input data diversity and achieving a text-based classifier accuracy of 73.30%. Achieved a significant improvement of 8.33% in accuracy compared to CNN-only models, with the hybrid model attaining an accuracy of 90.46%. What is the implication of the main finding? Efficient and Scalable Methodology: Utilized EfficientNet for CNN-based feature extraction and Bag-of-Words for text representation, ensuring computational efficiency and scalability. Application Potential: Addressed challenges in indoor scene recognition, such as complex backgrounds and object diversity, demonstrating significant potential for applications in robotics, intelligent surveillance, and assistive systems. Indoor scene recognition is a computer vision task that identifies various indoor environments, such as offices, libraries, kitchens, and restaurants. This research area is particularly significant for applications in robotics, security, and assistance for individuals with disabilities, as it enables the categorization of spaces and the provision of contextual information. Convolutional Neural Networks (CNNs) are commonly employed in this field. While CNNs perform well in outdoor scene recognition by focusing on global features such as mountains and skies, they often struggle with indoor scenes, where local features like furniture and objects are more critical. In this study, the “MIT 67 Indoor Scene” dataset is used to extract and combine features from both a CNN and a text-based model utilizing object recognition outputs, resulting in a two-channel hybrid model. The experimental results demonstrate that this hybrid approach, which integrates natural language processing and image processing techniques, improves the test accuracy of the image processing model by 8.3%, achieving a notable success rate. Furthermore, this study offers contributions to new application areas in remote sensing, particularly in indoor scene understanding and indoor mapping. © 2025 Elsevier B.V., All rights reserved.
Management of Abdominal Gunshot Injuries: Surgical Intervention or Conservative Follow-Up? A Single-Center Experience
(Turkish Association of Trauma and Emergency Surgery, 2025) Binici, Serhat; Aslan, Fırat; Beǧer, Burhan; Beger, Orhan; Aras, Abbas; Eryılmaz, Iklil; Oğuz, Enis
BACKGROUND: This study aims to retrospectively evaluate treatment approaches and clinical outcomes in patients with penetrating abdominal trauma caused by gunshot injuries—one of the most complex and controversial areas in trauma surgery. METHODS: A total of 101 patients diagnosed and treated for penetrating abdominal trauma due to gunshot injuries between 2015 and 2025 were included in the study. Demographic data (age and sex); vital signs at admission to the emergency department (blood pressure, pulse, respiratory rate, body temperature); level of consciousness (Glasgow Coma Scale); hemodynamic status (stability/ instability, need for fluid or inotropic support); intra-abdominal (liver, spleen, small intestine, colon, etc.) and extra-abdominal (thorax, extremities, head, etc.) organ injuries; laboratory findings (hemoglobin, leukocyte count, creatinine, pH level); treatment modality (surgical intervention or conservative management); surgical techniques used; blood and blood product transfusions; and hospital length of stay were retrospectively analyzed. Patients were divided into two groups: those who underwent surgical treatment and those managed conservatively. Factors influencing treatment decisions and variables affecting mortality were evaluated statistically. RESULTS: Of the patients, 83.2% were male, with a mean age of 28.3±10.5 years. Surgical treatment was performed in 81.2% of cases, while 18.8% received conservative management. No mortality occurred in the conservatively managed group, whereas the surgically treated group had a mortality rate of 15.9%. Mortality among female patients (29.4%) was significantly higher than among males (9.5%) (p=0.026). Hemodynamic instability, intra-abdominal organ injury, presence of free air in the abdomen, and the need for blood product transfusion were associated with both the decision for surgical intervention and higher mortality. Additionally, damage control surgery and multiple organ injuries were linked to increased mortality. CONCLUSION: Management of abdominal trauma caused by gunshot injuries requires a multidisciplinary approach to ensure appropriate patient selection and treatment planning. In hemodynamically stable patients, selective non-operative management (SNOM) is a safe and effective option, whereas surgical intervention—particularly in cases requiring damage control surgery—is associated with higher mortality. The increased mortality rate among female patients underscores the need for closer monitoring of this subgroup and further investigation into potential additional risk factors. These findings align with current literature and provide practical guidance for clinical decision-making. © 2025 Elsevier B.V., All rights reserved.
Characteristics of Pain in Patients With NMOSD and MOGAD: Impact on Mental Health, Sleep and Quality of Life
(Springer-Verlag Italia S.R.L., 2025) Koç, Emine Rabia; Sarıdaş, Furkan; Yetkin, Mehmet Fatih; Bilge, Nuray; Dinç, Yasemin; Oǧuz Akarsu, Emel; Lazrak, Sarra Elhamida
Neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein-associated disease (MOGAD) are autoimmune disorders frequently accompanied by chronic, often neuropathic, pain, which significantly impacts the quality of life, sleep, and mental health. This study evaluated the incidence and characteristics of neuropathic pain in 106 patients with NMOSD or MOGAD and assessed its effects on mental health, sleep quality, and overall quality of life. Using clinical evaluation and MRI findings to localize lesions, pain classification revealed that chronic pain was more common in NMOSD patients (78.4%) than in MOGAD patients (52.7%), with a significant impact on both groups. Patients with MOGAD who experienced neuropathic pain reported notably poorer sleep quality and higher anxiety and depression levels. Pain severity was strongly associated with spinal cord lesion length and thoracic location, particularly in MOGAD patients. Current treatments provide insufficient pain relief, highlighting the need for more effective management strategies. This study emphasized that neuropathic pain substantially diminishes both physical and mental well-being in NMOSD and MOGAD patients, highlighting the importance of personalized pain management approaches to improve quality of life and mental health in these populations. © 2025 Elsevier B.V., All rights reserved.
Effects of Formaldehyde on Cytotoxicity and Antioxidant Defense/Oxidative Stress Biomarkers in Hepatocytes Isolated From Rainbow Trout (Oncorhynchus Mykiss)
(Pleiades Publishing, 2025) Yıldız, Fatoş; Kaptaner, Burak
Abstract: Formaldehyde (FA) is a widespread disinfectant in the aquaculture industry that is utilized in the treatment of diseases and control of external parasites in fish. Although numerous studies have investigated the toxic effects of FA, as far as is known, there has been no in vitro work characterizing its cytotoxic mechanism of action using fish cells in the literature. Therefore, herein, it was aimed to examine FA toxicity on hepatocytes that were isolated from rainbow trout (Oncorhynchus mykiss) in vitro. For this purpose, the cells were exposed to increasing concentrations of FA (0, 12.50, 50, 100, 200, and 400 µM) for 24 h. Next, the cytotoxic effects were evaluated via lactate dehydrogenase assay in addition to the use of antioxidant defense system markers, including the catalase (CAT), superoxide dismutase (SOD), glutathione S-tranferase (GST), glutathione peroxidase (GPx) activities and the glutathione (GSH) and malondialdehyde (MDA) levels. According to the obtained results, the FA caused small increases in the percentage of cytotoxicity with significant differences at a concentration of 50 µM and above. Moreover, significant decreases in the SOD, CAT, and GST activities and GSH content were determined. Meanwhile, the GPx activity showed remarkable increases. In addition, the MDA level was increased by the FA treatments. In conclusion, FA caused cytotoxicity by depressing antioxidant defenses and leading to oxidative stress in the hepatocytes. Considering these results, human and environmental health should be taken into account during its utilization and its unconscious usage should be avoided. © 2025 Elsevier B.V., All rights reserved.
Protein-Based Preservative Nanotube: Viability of Yogurt Bacteria in Different Environments
(Elsevier Ltd, 2025) Demirci, Abdullah; Ocak, Elvan; Ceylan, Zafer
Probiotics are living organisms that are beneficial for human health and are defined as microorganisms responsible for the fermentation of foods. In order for microorganisms to be probiotic, they must be resistant to gastrointestinal system and adverse environmental conditions. In this study, the viability stability of yogurt starter bacteria (Lactobacillus delbrueckii subsp. bulgaricus (Ab1) and Streptococcus thermophilus (As2) at different temperatures was investigated in vitro by using Whey protein isolate (WPI) and salep glucomannan (SG) by electrospinning method by taking advantage of the development of technology; while trying to protect them in low pH, bile salt and simulated gastric fluid environments. Morphological characterization analyses (SEM, TEM, TGA and FTIR) of the formed nanoencapsulation material were performed and it was revealed that it was in the form of “Nanotube”. Thus, the first protein-based nanotube structure is formed. It was shown that the nanotube encapsulation can be a commercial yogurt culture by maintaining significant viability of yogurt bacteria both in the gastrointestinal system and at room temperature. © 2025 Elsevier B.V., All rights reserved.
Role of Chronic Toxoplasmosis in Substance Abuse in Humans and Its Effect on Dopamine Levels
(Wolters Kluwer Medknow Publications, 2025) Gürbüz, Esra; Kara, Aysu; Yürektürk, Şehriban; Saygin, Murat; Aydemi̇r, Selahattin; Ekici, Abdurrahman
Background: Toxoplasma gondii is a common parasitic infection agent that, in its chronic phase, forms persistent tissue cysts in neuronal cells, potentially leading to neurological and behavioral alterations. Aim: To investigate the role of chronic toxoplasmosis in human substance abuse and investigate its effect on dopamine levels, which is associated with substance abuse. Materials and Methods: The study was designed with a substance abuse group comprising 90 patients with substance addiction and a control group consisting of 75 individuals without substance addiction. The substance abuse group consisted of patients who were addicted to alcohol, cannabis, cocaine, heroin, or amphetamines. Anti-Toxoplasma gondii IgG and dopamine levels in the blood sera and anti-T. gondii immunoglobulin G (IgG) levels in the blood samples taken from the participants were analyzed via enzyme-linked immunosorbent assay. Results: T. gondii IgG was detected in 52 (57.8%) of 90 patients in the substance abuse group and 22 (29.3%) of 75 patients in the control group. There was a statistically significant relationship between T. gondii positivity and substance addiction (P = 0.001). However, no correlation was found between T. gondii positivity and the subgroups for the addiction type, criminal offense, imprisonment, or suicide attempt. Dopamine levels were statistically different between the groups. In the pairwise comparison of the groups, the dopamine levels in the T. gondii-positive substance abuse group were lower than in the other three groups, and this was statistically significant. Conclusion: In conclusion, the prevalence of T. gondii was higher in those with substance addiction than in those without. The fact that T. gondii alters dopamine levels was among the results. Since T. gondii can affect some behaviors of the host through changes in neurotransmitter levels, it was concluded that there is a significant relationship between T. gondii infection and substance abuse. © 2025 Elsevier B.V., All rights reserved.

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