Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14720/4

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The Effect of Web-Based COPE Healthy Lifestyles Teen Program on Hearing-Impaired Adolescents: A Randomized Controlled Trial
(W.B. Saunders, 2026) Orakçi, H.; Ardiç, A.
Background Hearing-impaired children and adolescents face increased risks of chronic diseases due to insufficient physical activity, unhealthy diets, substance use, and high stress. Health promotion programs targeting these risks can improve their health knowledge and lifestyle behaviors. Objective This study evaluated the effect of the Web-based COPE Healthy Lifestyles TEEN Programme on nutrition, physical activity, stress management, and mental health in hearing-impaired (HI) adolescents. Methods Seventy-two HI adolescents aged 12–18 years were randomly assigned. A web-based COPE Healthy Lifestyles TEEN program integrated with sign language was delivered online to the experimental group for 8 weeks. Physical, behavioral, and cognitive measurements were completed pre-intervention and at 1 week, 3 months, and 6 months post-intervention. Results The experimental group showed a significant increase in healthy lifestyle choices, nutrition and physical activity knowledge, physical activity behavior scores, weekly step counts, and daily water, fruit, and vegetable consumption, alongside a significant decrease in sugary beverage consumption compared to the control group. While stress management, anxiety, and depression scale scores were not statistically significant, a positive effect size was observed as scores decreased over time. Conclusion The sign-language-delivered, web-based COPE program demonstrated positive effect sizes, indicating improvements in nutrition and physical activity knowledge/behaviors and reductions in stress, anxiety, and depression among HI adolescents. Implications for practice Nurses can develop practical strategies using accessible, technology-based health promotion programs to encourage HI adolescent participation, support their healthy lifestyle behaviors and psychological well-being, and strengthen equitable access to health education. Trial registration This study was prospectively registered ClinicalTrials.gov (ID: NCT05329207 ). © 2025 Elsevier Inc.
Comprehensive Review of Analytical Approaches for Vinblastine and Vincristine in Cancer Research
(John Wiley and Sons Ltd, 2026) Barzani, H.; Omer, R.; Barzani, K.; Jawhar, Z.; Sulaiman, S.; Ali, H.
Vinblastine (VBL) and vincristine (VCR) are vinca alkaloids derived from Catharanthus roseus and are among the most widely used chemotherapeutic agents for treating hematological malignancies and solid tumors. Due to their narrow therapeutic index and complex structural nature, accurate, sensitive, and selective analytical methods are crucial for quantifying these drugs in pharmaceutical formulations, biological matrices, and environmental samples. This review provides a comprehensive overview of reported analytical techniques for VBL and VCR, drawing on major databases such as Scopus, Web of Science, ScienceDirect, PubMed, and Google Scholar, with a focus on the English-language literature. The discussed methods include chromatographic, spectroscopic, electroanalytical, and capillary electrophoretic techniques. High-performance liquid chromatography (HPLC), particularly when coupled with LC–MS/MS, offers exceptional sensitivity, with detection limits as low as 0.025 ng/mL in plasma. Conventional HPLC-UV methods, though less sensitive, remain widely applied in plant extract analysis. Electroanalytical approaches, such as voltammetry using nanomaterial-modified electrodes, offer eco-friendly and cost-effective alternatives with detection limits as low as 0.3 nM. Key analytical considerations include light sensitivity, pH and temperature control, and matrix interferences. Overall, recent methodological advancements enable reliable quantification of VBL and VCR, supporting safer clinical application, toxicity monitoring, and environmental surveillance. © 2025 John Wiley & Sons Ltd.
The Nonlinear Optical Characteristics of Nickel and Lanthanum Phthalocyanine Complexes Possessing Sulfonylphenoxy Functionalities
(Elsevier B.V., 2026) Cabir, B.; Kabakci, Y.G.; Kılıç, H.Ş.
Two novel sulfonylphenoxy-substituted lanthanum (LaPc) and nickel (NiPc) phthalocyanine complexes were synthesized and thoroughly characterized by FT-IR, 1H NMR, UV-Vis, fluorescence spectroscopy, XRD, and XPS analyses. Their third-order nonlinear optical (NLO) properties were evaluated via femtosecond laser Z-scan measurements. Structural and spectroscopic results confirmed the successful incorporation of sulfonylphenoxy groups and coordination of the respective metal centers. Comparative analysis revealed that the central metal ion strongly influenced molecular geometry, optical absorption, emission characteristics, and crystal organization. LaPc exhibited red-shifted absorption bands, enhanced fluorescence intensity, and prolonged emission lifetimes, whereas NiPc showed blue-shifted spectra and diminished quantum yields due to efficient intersystem crossing facilitated by the Ni2+ center. XRD and XPS data further substantiated these distinctions by indicating divergent coordination environments and crystal packing arrangements. The nonlinear absorption coefficient (β), nonlinear refractive index (n2), and third-order susceptibility (χ3) for both complexes were on the order of 10-11 cm/W, 10-16 cm2/W, and 10-14 esu, respectively. These results demonstrate that rational metal ion selection can effectively tailor the electronic and photophysical properties of phthalocyanines, highlighting their potential as advanced optical limiting materials for optoelectronic and photonic technologies. © 2025 Elsevier B.V.
The Effect of Moulage Supported Standardised Patient Simulation on Nursing Students' Self-Efficacy and Clinical Practice Attitudes Towards Pressure Injuries: A Randomised Controlled Study
(Elsevier Ltd, 2026) Sarpdağı, Y.; Kaplan, E.; Sir, Ö.; Askan, F.; Yıldız, M.
Aim: The aim of this study was to investigate the effect of a moulage -supported standardised patient simulation (MSSPS) on nursing students' self-efficacy and clinical practice attitudes towards PIs. Background: Pressure injuries (PIs) are preventable yet remain a major global patient safety concern and an indicator of nursing care quality. Enhancing nursing students’ knowledge and skills through simulation-based education is essential for PIs prevention. Design: Pre- and post-test, single-blind, randomised controlled trial (ClinicalTrials.gov ID: NCT06634095). Methods: This study was conducted with Nursing Department students at a university in eastern Turkey. The sample of the study was determined by power analysis method and consisted of 94 nursing students including 47 experimental and 47 control groups. The experimental group received pressure injury training based on a MSSPS. ‘Descriptive Information Form’, “Attitudes Towards Clinical Practice Scale for Nursing Students”, “Pressure Injury Management Self-Efficacy Scale for Nurses”, “Pressure Injury Knowledge Test”, “Pressure Injury Skill Evaluation Form” and “Pressure Injury Assessment Form” were used to collect the data. Results: The experimental group demonstrated significant improvements in clinical practice attitudes, self-efficacy, PIs knowledge, skill performance and wound assessment scores compared with the control group (p < 0.05). Conclusion: MSSPS effectively enhanced nursing students’ knowledge, self-efficacy, clinical attitudes and skills in PIs prevention and management. © 2025 Elsevier Ltd
Earthquake-Focused Disaster Management İn Turkey: A Qualitative Research to Identify Existing Problems and Propose Strategic Solutions
(Ankara University, 2025) Erol, Fırat
The purpose of this study is to identify problems (deficiencies/inadequacies) in the operating mechanism of Turkey's current earthquake-focused disaster management system and to identify strategic solutions to these problems. The study employed descriptive research methods, purposive sampling, and content analysis techniques, all of which are qualitative research methods. Face-to-face interviews were conducted with 25 subject matter experts using semi-structured questions. The interviews were subjected to content analysis and analyzed using the MAXQDA24 package program. The findings of the study identify serious implementation problems that require improvement in many key areas, including disaster preparedness, risk management, education, economy, planning, auditing, coordination, environmental/natural damage, building stock, soil, and current habits, as reflected in the field of the current disaster management system in Turkey. Since these implementation problems reflected in the field can only be resolved through the implementation of an effective risk management strategy, the study proposes strategic solutions to these identified problems. © 2025, Ankara University. All rights reserved.
AI in Digital Communication Practices: The Reconstruction of Symbolic Capital within Digital Diplomacy
(IGI Global, 2025) Oztay, Oguz Han; Yurdakul, Hasan
The primary objective of this study is to investigate the role of artificial intelligence (AI) in generating symbolic capital in the era of digital diplomacy. Focusing on the role of communication technologies in this transformation, this research examines the impact of AI- supported public diplomacy activities on the struggle for prestige, legitimacy, and recognition in the international arena within the context of Pierre Bourdieu's theory of capital. Conducted using a qualitative research strategy, the study concludes that AI accelerates the process of transforming economic, cultural, and social capital into symbolic capital, thereby expanding the diplomatic spheres of influence of states. Examples such as the Antalya Diplomacy Forum, the United Arab Emirates' (UAE) virtual ambassador application, and South Korea's metaverse diplomacy reveal how critical communication and technological competence are in the process of creating symbolic power. However, this process also deepens existing inequalities between technologically advanced and developing countries. © 2026, IGI Global Scientific Publishing.
Advances in Understanding Plant–Microbe Symbiosis in Stressful Environments
(Association of Agricultural Technology in Southeast Asia, 2025) Rezaee Danesh, Y.
In recent years, the interplay between plants and microbes has gained significant attention in understanding resilience mechanisms under stressful environmental conditions. Plant-microbe symbioses, including mycorrhizal associations and beneficial bacteria interactions, play crucial roles in enhancing plant tolerance to abiotic stresses such as drought, salinity, and nutrient deficiency. Advances in molecular and genomic technologies have facilitated the exploration of these complex interactions, revealing the underlying genetic and biochemical pathways that mediate plant responses to stress. Studies have demonstrated that beneficial microbes can modulate plant hormone levels, activate stress-responsive genes, and enhance nutrient uptake, thereby improving growth and productivity in adverse conditions. Furthermore, the concept of the phytomicrobiome emphasizes the collective influence of microbial communities associated with plants, highlighting their dynamic and interactive nature. This review synthesizes recent findings on the mechanisms of plant-microbe interactions and their implications for agricultural sustainability in the face of climate change. By leveraging these insights, researchers aim to develop innovative strategies for enhancing crop resilience and productivity, ultimately contributing to food security. The integration of microbiome management in agricultural practices holds promise for improving crop performance under varying environmental stressors, paving the way for a new paradigm in sustainable agriculture. © 2025, Association of Agricultural Technology in Southeast Asia. All rights reserved.
Preliminary Phytochemical Analysis and DNA Protective Activities of Ephedra Major and Ephedra Equisetina Species
(Pamukkale University, 2025) Yeskendirov, F.; Mukhitdinov, N.; Ünal, M.; Demirkuş, N.; Bati, B.; Yenilmez, A.
Worldwide, the Ephedra plant is one of the oldest medicinal herbs used in traditional alternative medicine. The medicinal varieties are utilized as stimulants and antiasthmatic agents for the treatment of colds, bronchial asthma, cough, fever, influenza, headache, edema, and allergies. In our study, it was aimed to determine the preliminary phytochemical composition of Ephedra major and Ephedra equisetina species belonging to the Ephedra genus and to determine their antioxidant and DNA protective activity. Ephedra major is known to contain components such as flavonoids and tannins with a moderate ephedrine content and has been traditionally used in the treatment of respiratory diseases. Ephedra equisetina, on the other hand, contains higher concentrations of ephedrine and other bioactive compounds and is widely used in traditional medicine for the treatment of asthma, bronchitis, and allergic reactions. When we look at the study findings, the total phenolic and flavonoid substance amounts in both plant species were determined at close levels in both tests, and it was seen that they contained phenolic and flavonoid substances and had antioxidant activity and DNA protection effect. In addition, it was observed that there was a DNA protection effect at a concentration of 0.5 mg/mL in the presence of Fenton in the medium. © 2025 Pamukkale University. All rights reserved.
Endophytic Fungi in Agriculture: Diversity, Functions, and Prospects for Bioprotection
(Association of Agricultural Technology in Southeast Asia, 2025) Rezaee Danesh, Y.
Endophytic fungi, residing within plant tissues without causing harm, play a pivotal role in agricultural ecosystems by enhancing plant health and resilience. This review explores the diverse taxa of endophytic fungi and their multifaceted functions, including promotion of plant growth, enhancement of nutrient uptake, and facilitation of stress tolerance against biotic and abiotic challenges. Through symbiotic interactions, these fungi can induce systemic resistance in plants, offering a natural alternative to chemical pesticides for the management of plant pathogens and pests. Recent advances in molecular techniques have unveiled the complex diversity of endophytic communities, revealing their ecological significance and potential for biotechnological applications. The integration of endophytic fungi into sustainable agricultural practices holds promise for bioprotection, contributing to food security while minimizing environmental impacts. This review discusses various strategies for harnessing the beneficial properties of endophytic fungi, including inoculation protocols and the selection of compatible plant-fungal combinations. Furthermore, it addresses the challenges and prospects for future research, emphasizing the need for a greater understanding of the interactions between endophytes, host plants, and environmental factors. By leveraging the potential of endophytic fungi, agriculture can transition towards more resilient, sustainable, and environmentally friendly practices, paving the way for innovative solutions in crop management and protection. © 2025, Association of Agricultural Technology in Southeast Asia. All rights reserved.
Why Students Do Not Prefer Online Learning: The Role of E-Learning Readiness and Community of Inquiry
(Duzce University, Faculty of Education, 2025) Keskin, S.; Tat, O.
This study examines at how e-learning readiness and the Community of Inquiry framework affect higher education students' preferences for various teaching delivery modes. In the study, Latent Class Analysis was used to profile the participants based on autonomous learning attributes, which is the pedagogical sub-dimension of e-learning readiness. As a result of this analysis, three classes were obtained as LC1 (high self-directed learning, low e-learning motivation), LC2 (high self-directed learning, medium-high e-learning motivation) and LC3 (medium level in all factors). When students' overall teaching mode preferences were analyzed using the Bradley-Terry model, a hierarchy of preferences was found, with blended learning, followed by face-to-face and finally online learning. Blended learning was widely preferred by LC2 and LC3, while LC1 showed an overwhelming preference for face-to-face. The inclusion of Community of Inquiry in the model made these differences in preferences even more pronounced. For LC1, face-to-face learning dominated preferences for social presence, while, remarkably, it showed an almost exclusive preference for teaching presence and cognitive presence. The findings highlight the importance of direct guidance and interaction in face-to-face settings, which may be more effective than the flexibility of online environments for certain learner profiles. Moreover, they may emphasize the necessity of varied instructional methods in higher education to meet the diverse demands of students. © 2025, Duzce University, Faculty of Education. All rights reserved.
Evaluation of Hypermobility in Rhinoplasty: A Case-Control and Cross-Sectional Study
(College of Physicians and Surgeons Pakistan, 2025) Koçak, O.F.; Alpaycı, M.; Demir, C.Y.; Ilter, S.; Bozan, N.
Objective: To determine the frequency and severity of joint hypermobility (JH) in rhinoplasty patients and to assess rhinoplasty satisfaction in rhinoplasty cases with JH. Study Design: Comparative cross-sectional study. Place and Duration of the Study: Department of Plastic and Aesthetic Surgery, Yuzuncu Yil University Hospital, Van, Turkiye, between February and May 2024. Methodology: A total of 108 participants (54 rhinoplasty patients and 54 matched healthy controls) were examined in this study. Patients and healthy controls were compared in terms of the frequency and severity of JH. The Beighton scoring system was used to assess hypermobility. Rhinoplasty patients with JH (Beighton score ≥4) and without JH (Beighton score <4) were compared in terms of rhinoplasty outcomes. The rhinoplasty outcome evaluation (ROE) questionnaire was used as an outcome measure. Results: Rhinoplasty patients and healthy controls were statistically similar in terms of frequency (p = 1.0) and severity (p = 0.754) of JH. No significant correlation was found between hypermobility scores and rhinoplasty results in rhinoplasty patients (n = 54; r = 0.015; p = 0.916; Spearman’s correlation test). Rhinoplasty patients with and without JH were similar in terms of rhinoplasty results (15.30 ± 6.82 vs. 16.16 ± 4.92; p = 0.645). No significant correlation was found between JH scores and rhinoplasty results (p = 0.916). Conclusion: JH does not appear to be associated with rhinoplasty and should not be a concern in rhinoplasty. It is not necessary to consider JH to ensure rhinoplasty satisfaction. © 2025 College of Physicians and Surgeons Pakistan. All rights reserved.
Carboxypeptidase D Deficiency Causes Hearing Loss Amenable To Treatment
(American Society for Clinical Investigation, 2025) Ramzan, M.; Ortiz-Vega, N.; Zafeer, M.F.; Lobato, A.G.; Atik, T.; Abad, C.; Vadgama, N.
Genetic factors contributing to hearing loss (HL) are heterogeneous, and effective medical treatments remain limited. We identified 3 distinct missense variants in CPD, encoding carboxypeptidase D, in 5 individuals with congenital deafness from 3 unrelated families, affecting the catalytically active CP domain 2 of this protein. Subsequent analysis of a larger cohort from the 100,000 Genomes Project revealed an enrichment of rare protein-altering CPD variants in individuals with HL. We show that CPD localizes to sensory epithelium and nerve cells in the mouse cochlea, and the enzymatic activity of CPD, crucial for nitric oxide (NO) production through arginine processing, is impaired in affected individuals. The levels of arginine, NO, and cGMP in patient-derived fibroblasts are also decreased, leading to endoplasmic reticulum stress–mediated responses being triggered in the cells. Silencing of Cpd in organotypic mouse cochlea cultures leads to increased apoptosis. Finally, Drosophila models of CPD deficiency display defective Johnston's organ, impaired auditory transduction, and sensory and movement abnormalities. Notably, these phenotypes are partially rescued by supplementation with arginine or sildenafil, a cGMP enhancer. Our findings establish CPD mutations as a cause of congenital HL, highlighting that the NO signaling pathway offers a promising therapeutic avenue. © (2025), (American Society for Clinical Investigation). All rights reserved.
Radiomorphometric Analysis of Patients with Osseous Dysplasia
(Ataturk Universitesi, 2025) Kaya, S.; Koc, A.
Objective: The aim of this study was to examine the radiomorphometric parameters of trabecular and cortical bone of the mandible in patients of osseous dysplasia. Methods: A total of 43 patients (40 females and 3 males) patients of osseous dysplasia and age-gender matched healthy 43 individuals (control group) were included in this study. The analyzed radiomorphometric parameters were fractal dimension, mandibular cortical width, and mandibular cortical index. Results:There were not significant differences in the mean fractal dimensions of selected regions between the two groups (P>.005). However in mandible, especially bone quality of condyle region was significantly lower in patients of osseous dysplasia (P<.005). There were no significant differences in mandibular cortical width between the two groups (P> .05). The mean mandibular cortical width was 2.3 mm in the patients of osseous dysplasia and 2.4 mm in the control group. Therefore there were no significant differences in mandibular cortical index between the two groups (P> .05). Conclusion: Especially fractal dimension of condyle region was significantly lower in patients of osseous dysplasia. Therefore, precaution is needed before surgical interventions in this region. It was also observed that the bone quality of the patients with the three variants of cemental dysplasia in the mandible was similar. © 2025, Ataturk Universitesi. All rights reserved.
Knowledge, Attitudes, and Practices (KAP) Relating to Brucellosis: Unveiling the Vital Role of Public Awareness
(Elsevier, 2025) Akar, K.
Brucellosis is a neglected, complex, and difficult-to-diagnose zoonotic disease caused by Brucella spp. It is a highly pathogenic and highly prevalent disease worldwide. National eradication policies need to be developed to reduce the negative impact of this disease on public health and the economy, and to control the disease. Therefore, the disease's prevalence, distribution, and economic impact should be investigated comprehensively. In many societies around the world, knowledge, attitude, and practice studies (KAP) are used to measure the level of knowledge about pathogenic infections and their risks and to determine the most appropriate strategy to implement. For this purpose, reference laboratories in the countries where the disease is observed have a significant role in diagnosing the disease. It is known that the incidence of the disease can be reduced by the efforts of these institutions to increase the level of knowledge in society, together with the diagnosis of the disease. Biosecurity measures should be taken in doing so, starting with people at high risk of occupational exposure. It is crucial to create public health awareness about brucellosis. Therefore, it is thought that it can be used in determining an effective eradication strategy for the prevention of the disease by evaluating the KAP of shepherds with the help of questionnaires and determining the risk factors related to the disease. This study evaluated the importance of brucellosis in public awareness globally and the differences or diversity in the KAP of communities regarding animal brucellosis. © 2026 Elsevier Inc. All rights reserved.
Utilitarian Moral Agents Are Perceived as Braver and More Moral When Judged in a Foreign Language: Evidence From Tanzania
(Cambridge University Press, 2025) Białek, M.; Milczarski, W.; Borkowska, A.; Tekşam, H.K.; Butovskaya, M.; Sorokowski, P.
We examined how language affects moral judgments in a non-WEIRD population. Tanzanian participants (N = 103) evaluated utilitarian agents in moral dilemmas, either in native Chagga or foreign Swahili. Agents were rated significantly more moral and braver when evaluated in a foreign language. Bravery predicted morality more strongly in the foreign language than in the native language. Indirect sacrifices were judged more moral than direct ones, but equally brave. These findings extend the moral foreign language effect to informally acquired languages and highlight methodological implications for cross-cultural research. © The Author(s), 2025. Published by Cambridge University Press.
A New Characterization of the Weighted Composition–Differentiation Operators on Bloch Spaces
(Brno University of Technology, 2025) Topal, H.
This paper characterizes the boundedness and compactness of the weighted composition differentiation operator on the Bloch space ℬ and the little Bloch space ℬ0 on the unit disk. © 2025 Brno University of Technology. All rights reserved.
Neurobiology of Suicide in Depressive Disorders
(Springer Science+Business Media, 2025) Sönmez, D.; Kurhan, F.; Hocaoǧlu, Çç.
Suicide is a complex phenomenon that arises from the interaction of biological, social, and psychological risk factors and is considered a serious health problem worldwide. Recent research has revealed the complexity underlying the neurobiological mechanisms of suicide. In particular, genetic factors, dysfunction of the serotonergic system, hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, stress system, and lipid metabolism are implicated. Findings have highlighted the association between noradrenergic hyperactivity, abnormalities in glial cells, and signaling errors with suicidal behavior. Additionally, differences in cognitive functions have been observed in individuals who attempted suicide, and morphological changes in the frontolimbic network have been detected in brain neuroimaging studies. Identification of neurobiological risk factors can play a crucial role in preventing suicide and developing treatment strategies. This book chapter aims to examine the neurobiological basis of suicidal behavior. © 2025 Springer Nature Switzerland AG.
On the Ulam-Type Stability of Impulsive Differential Equations With Multiple Time Delays
(Taylor and Francis Ltd., 2025) Tunç, C.; Tunç, O.
In this article, we conduct a rigorous analysis of the Ulam-type stability of first-order impulsive delay differential equations (IP-D-D-Es) with multiple time-dependent delays. Employing a Gronwall-type integral inequality tailored for piecewise continuous functions, we derive two new theorems concerning the generalized Ulam–Hyers–Rassias (G-U-H-R) stability of the first-order IP-D-D-E incorporating several constant time delays. To illustrate the applicability of the theoretical results, a concrete example is presented. The outcomes of this study offer significant and complementary contributions to the qualitative theory of the IP-D-D-Es with multiple constant delays. © 2025 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of the University of Bahrain.
Doxorubicin and Gallic Acid Induce Oxidative Stress-Induced Cell Death in Laryngeal Cancer Cells via the TRPM2 Channel
(Yuzuncu Yil Universitesi Tip Fakultesi, 2025) Çınar, R.; Çakır, T.; Yazğan, B.; Yıldızhan, K.
Laryngeal squamous cell carcinoma is one of the most common fatal cancers. The chemotherapeutic agent doxorub icin (DOX) has limited efficacy due to frequent side effects and the development of drug resistance during treatment. Therefore, we aimed to investigate whether Gallic acid (GA) has a synergistic effect on the chemotherapeutic effects of DOX and the mechanisms of its action. In order to do this, we looked at how GA stimulates the death of HEp-2 laryngeal cancer cells caused by DOX through the activation of TRPM2 channels. For the study, HEp-2 cells were divided into four groups: Control, GA, DOX, and GA+DOX. Cell viability, antioxidant and oxidant enzyme activity levels, inflammation markers, intracellular ROS levels, apoptosis markers, PARP-1 and TRPM2 expression values were evaluated. DOX treatment caused cytotoxic effects in laryngeal cancer cells and increased apoptosis markers, intracellular ROS, inflammation markers, oxidant enzyme activity levels, PARP-1 and TRPM2 values, while decreasing cell viability and antioxidant enzyme activity values. The therapy was significantly more successful when GA and DOX were used together. In summary, this study discovered that TRPM2 activation caused the synergistic impact of GA+DOX combination therapy on cancer cell death. © 2025, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Obsessive-Compulsive Disorder and DNA Damage
(Springer Science+Business Media, 2025) Kurhan, F.; Arslan, M.; Hocaoǧlu, Çç.
Obsessive-compulsive disorder (OCD) is a multifaceted neuropsychiatric condition influenced by genetic, neurobiological, and environmental factors. Genetic studies emphasize the heritability of OCD, especially in early-onset cases, yet specific genes remain elusive. Neurobiological research implicates alterations in cortico-striato-thalamo-cortical (CSTC) circuits and dysregulation of neurotransmitter systems, shedding light on OCD symptomatology. Environmental factors like infectious diseases, hormonal fluctuations, and traumatic experiences contribute to symptom development. Additionally, dysregulation of DNA repair mechanisms, particularly in response to oxidative stress, has been linked to OCD pathogenesis. Genetic polymorphisms in DNA repair genes such as XPD, XRCC1, and XRCC3 suggest susceptibility to OCD. Elevated levels of oxidative DNA damage, like 8-hydroxy-2′-deoxyguanosine (8-OHdG), are observed in OCD, influencing neurobiological alterations. Understanding the interplay between DNA damage and OCD symptoms offers insights into potential therapeutic targets, including antioxidant strategies and neurotransmitter-targeting medications, necessitating further research for personalized treatment approaches. © 2025 Springer Nature Switzerland AG.

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