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Diagnostic Accuracy of Iga Anti-Tissue Transglutaminase in Celiac Disease in Van-Turkey

dc.authorscopusid 23488098800
dc.authorscopusid 7003589214
dc.authorscopusid 12039555100
dc.authorscopusid 55560130600
dc.authorscopusid 57193326202
dc.authorscopusid 37039212200
dc.contributor.author Bayram, Y.
dc.contributor.author Parlak, M.
dc.contributor.author Aypak, C.
dc.contributor.author Bayram, İ.
dc.contributor.author Yılmaz, D.
dc.contributor.author Çıkman, A.
dc.date.accessioned 2025-05-10T16:43:23Z
dc.date.available 2025-05-10T16:43:23Z
dc.date.issued 2015
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp Bayram Y., Department of Medical Microbiology, Yuzuncu Yil University Faculty of Medicine, Van, Turkey; Parlak M., Department of Medical Microbiology, Yuzuncu Yil University Faculty of Medicine, Van, Turkey; Aypak C., Department of Family Medicine, Dıskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey; Bayram İ., Department of Pathology, Yuzuncu Yil University Faculty of Medicine, Van, Turkey; Yılmaz D., Department of Pathology, Yuzuncu Yil University Faculty of Medicine, Van, Turkey; Çıkman A., Department of Medical Microbiology, Erzincan University Faculty of Medicine, Erzincan, Turkey en_US
dc.description.abstract Although the IgA anti-tissue transglutaminase test (IgA anti-tTG) has been recommended as the first step in the diagnosis of celiac disease (CD), there are controversial data about the real accuracy of the test in clinical practice. Therefore we evaluated the sensitivity and specificity of the IgA anti-tTG in a group of patients who were suspected of having CD. The study was performed at Van Training and Research Hospital, Van-Turkey. Details of patients in whom the IgA anti-tTG was requested from January 2009 to April 2012 were obtained from databases. Duplicate requests were excluded. Histopathologic examination of duodenal biopsies and serologic evaluations were compared. A total of 1614 IgA anti-tTG were requested from different patients. In all, 49.6% of requests were in females and 29.8% from children under the age of sixteen. A total of 192 (11.9%) requests were found to be positive. Duodenal biopsies were performed to 61 (31.8%) of seropositive patients. The overall sensitivity and specificity of IgA antitTG were 93.3% and 9.5%. Our data have revealed that clinicians should be aware of solely relying on the results of the IgA anti-tTG test could result in unnecessary diagnostic procedures and treatments. © 2015 Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved. en_US
dc.identifier.endpage 23 en_US
dc.identifier.issn 1301-0883
dc.identifier.issue 1 en_US
dc.identifier.scopus 2-s2.0-85013472565
dc.identifier.scopusquality Q4
dc.identifier.startpage 20 en_US
dc.identifier.uri https://hdl.handle.net/20.500.14720/152
dc.identifier.volume 20 en_US
dc.identifier.wosquality N/A
dc.language.iso en en_US
dc.publisher Yuzuncu Yil Universitesi Tip Fakultesi en_US
dc.relation.ispartof Eastern Journal of Medicine en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Celiac Disease en_US
dc.subject Sensitivity en_US
dc.subject Serologic Tests en_US
dc.subject Specificity en_US
dc.subject Tissue Transglutaminase en_US
dc.title Diagnostic Accuracy of Iga Anti-Tissue Transglutaminase in Celiac Disease in Van-Turkey en_US
dc.type Article en_US

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