Effects of Ellagic Acid on Levels of Sialic Acid and Cardiac Markers in Rats With Myocardial Infarction

Abstract

It has been shown that ellagic acid (EA) normalizes the activities of antioxidative enzymes, decreases the levels of inflammatory cytokines, and modulate the expression of apoptotic protein. The aim of this study was to evaluate the effect of EA on levels of sialic acid (SA) and cardiac markers in isoproterenol (ISO)-induced MI in rats. 32 female Wistar-albino rats were divided into 4 groups each containing 8 rats: group I (healthy control group), group II (ISO group), group III (EA ISO group), and group IV (EA group). Serum total SA (TSA). lipit-bound SA (LSA), and creatine kinase-myocardial band (CK-MB) levels were lower in EA+ISO group than in ISO group. Remarkably. serum LSA levels showed a significant positively correlation with all cardiac markers (CKMB, cardiac troponin I (cTnI), and lactate dehydrogenase (LDH)). In the histopathological examination, there was less degeneration in myocardial tissue of the rat in EA+ISO group than in those of ISO group. This study shows that EA has a protective effect in ISO -induced MI in rats. Also, it is seen that serum levels of SA, especially LSA, can be used as a cardiac damage marker.