The Histopathological Effects of Intraarticular Administration of Tramadol on Rabbit's Sinovia

Abstract

The analgesic effect of tramadol is due to it's effect on opioid receptor together with the enhancing function of the spinal descending inhibitory pathway by inhibition of reuptake of both 5 hydroxytryptamine and norepinephrine. In this study we aim to invastigate the effects of intraarticular tramadol on synovia. Eighteen healtyh rabbits 0.5-1 years old and weighted between 1.8-2.5 kg were included in the study. All rabbits were divided into five groups as follow; Group 1 (n=4), group 2 (n=4), Group 3 (n=4), Group 4 (n=4), and control group (n=2). Tramadol (12.5 mg/0.5 mL), or saline (0.5 mL) were given, intraarticularly in to the back knees of the rabbits in the study groups and control group respectively. Rabbits in group 1 and control groups were sacrified at first day, group 2 at 7th day, group 3 at 15th day, and group 4 at 21 th day by letal dose of sevoflurane. Examination of sinovia of the all rabbits were normal and there was no differences between groups. In conclusion; Tramadol has no histopathological effect on rabbits sinovia and may be safely administered intraarticularly in human.