Serum Level of Soluble Vascular Adhesion Molecule 1 in Patients With Rectal Cancer
| dc.authorscopusid | 6504566099 | |
| dc.authorscopusid | 35332340400 | |
| dc.authorscopusid | 36477329400 | |
| dc.authorscopusid | 19033400300 | |
| dc.authorscopusid | 6504310163 | |
| dc.authorscopusid | 36476941100 | |
| dc.authorscopusid | 36476941100 | |
| dc.contributor.author | Kemik, O. | |
| dc.contributor.author | Kemik, A.S. | |
| dc.contributor.author | Hasirci, I. | |
| dc.contributor.author | Adaş, M. | |
| dc.contributor.author | Purisa, S. | |
| dc.contributor.author | Dülger, A.C. | |
| dc.contributor.author | Tüzün, S. | |
| dc.date.accessioned | 2025-05-10T17:07:06Z | |
| dc.date.available | 2025-05-10T17:07:06Z | |
| dc.date.issued | 2011 | |
| dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| dc.department-temp | Kemik O., Yuzuncu Yil University Medical Faculty, Departments of General Surgery, Van, Turkey; Kemik A.S., University of Istanbul, Cerrahpasa Medical Faculty, Departments of Biostatistics, Istanbul, Turkey; Hasirci I., Yuzuncu Yil University Medical Faculty, Departments of General Surgery, Van, Turkey; Adaş M., Okmeydani Education and Training Hospital, Department of Endocrinology, Istanbul, Turkey; Purisa S., University of Istanbul, Cerrahpasa Medical Faculty, Departments of Biostatistics, Istanbul, Turkey; Dülger A.C., Yuzuncu Yil University Medical Faculty, Departments of Gastroeneterology, Van, Turkey; Tüzün S., Haseki Education and Training Hospital, II, General Surgery, Istanbul, Turkey | en_US |
| dc.description.abstract | Aim: Vascular adhesion molecule 1 (VCAM-1) plays an important role in solid tumor enlargement and/or metastases. This study evaluated the clinical significance of measuring serum levels of soluble VCAM-1 in rectal cancer and aimed to clarify the biologic significance of its local expression. Method: Serum was collected from 90 patients with rectal cancer and 40 healthy volunteers. Cancer tissue was collected from 84 patients. The level of soluble VCAM-1 in serum and cancer tissue was measured enzyme linked immunosorbent assay.Result: The mean soluble VCAM-1 level in patients was significantly higher than that in control subjects. Elevated serum soluble VCAM-1 was significantly associated with clinicopathologic paramaters such as tumor size, lymph node metastasis, distant metastasis, and poor prognosis. The prognosis for stage 2 patients positive for soluble VCAM-1 level was comparable to that for stage 3 patients. In addition, the serum level of soluble VCAM-1 level was not found correlation with the cancer tissue level. Conclusion: The preoperative level of soluble VCAM-1 level reflected disease progression and was a sensitive biomarker for rectal cancer. | en_US |
| dc.identifier.doi | 10.29333/ejgm/82709 | |
| dc.identifier.endpage | 109 | en_US |
| dc.identifier.issn | 1304-3889 | |
| dc.identifier.issue | 2 | en_US |
| dc.identifier.scopus | 2-s2.0-79960105514 | |
| dc.identifier.scopusquality | N/A | |
| dc.identifier.startpage | 105 | en_US |
| dc.identifier.uri | https://doi.org/10.29333/ejgm/82709 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/6652 | |
| dc.identifier.volume | 8 | en_US |
| dc.identifier.wosquality | N/A | |
| dc.language.iso | en | en_US |
| dc.publisher | TIP ARASTIRMALARI DERNEGI | en_US |
| dc.relation.ispartof | European Journal of General Medicine | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Preoperative Levels | en_US |
| dc.subject | Rectal Cancer | en_US |
| dc.subject | Vcam-1 | en_US |
| dc.title | Serum Level of Soluble Vascular Adhesion Molecule 1 in Patients With Rectal Cancer | en_US |
| dc.type | Article | en_US |