Intracranial Plasmacytomas

Abstract

Background: Solitary plasmacytoma of the central nervous system is a rarely reported pathology in the literature, and mostly are in the form of case reports. We retrospectively evaluated six cases of intracranial plasmacytoma. Method: Six patients' files were evaluated retrospectively. Their presenting symtomps and signs, laboratory and radiological findings, surgical intervention, adjuvant treatment protocols and outcomes were analysed. Results: All six patients were diagnosed clinically, radiologically and histologically as solitary intracranial plasmacytoma. All of the patients underwent radiotherapy regardless of the extensivity of the surgical resection. Two patients whose tumors were resected subtotally were put on chemotherapy postoperatively. Of these six patients, three died in the follow up period with the diagnosis of dissemination into the multiple myeloma, three patients had a good outcome. Conclusion: Intracranial solitary plasmacytoma, eventhough, is a rare pathology, may be mortal if it is not properly handled. Total resection it must be the aim of surgery. Radiotherapy, and in partially resected cases, chemotherapy as adjuvant are helpful. Although everykind of treatment regiment has been applied, change into multiple myeloma may occur in follow up period.