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Oxidative Stress Markers in Ivf Patients and Their Association With Pregnancy Results

dc.authorscopusid 56185523700
dc.authorscopusid 7006409671
dc.authorscopusid 35204100300
dc.authorscopusid 56798833200
dc.authorscopusid 56185523800
dc.authorscopusid 7005541487
dc.contributor.author Güler Okyay, A.
dc.contributor.author Aslan, M.
dc.contributor.author Taşkin, A.
dc.contributor.author Selek, S.
dc.contributor.author Ceng Altin, G.
dc.contributor.author Kahraman, S.
dc.date.accessioned 2025-05-10T17:00:05Z
dc.date.available 2025-05-10T17:00:05Z
dc.date.issued 2014
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp Güler Okyay A., Department of Obstetrics and Gynecology, Mustafa Kemal University, Hatay, Turkey; Aslan M., Department of Internal Medicine, Yüzüncü Yil University, Van, Turkey; Taşkin A., Department of Clinical Biochemistry, Harran University, Şanliurfa, Turkey; Selek S., Department of Clinical Biochemistry, Harran University, Şanliurfa, Turkey; Ceng Altin G., Embryology Laboratory, Istanbul Memorial Hospital, Istanbul, Turkey; Kahraman S., Department of Obstetrics and Gynecology, Istanbul Memorial Hospital, Istanbul, Turkey en_US
dc.description.abstract Objective: Oxidative stress has been well recognized as a component in the pathogenesis of many diseases, including female infertility. In this study, we aimed to investigate serum paraoxonase (PON1), arylesterase and myeloperoxidase (MPO) activities, and lipid hydroperoxide (LOOH) levels as oxidative stress markers along with their relationship with the pregnancy rate in women undergoing in vitro fertilization (IVF) treatment. Material and Methods: Serum samples of 179 subjects were collected immediately before starting ovarian stimulation and on ovum pick-up (OPU) day during IVF treatment. Stimulation protocol and starting doses were determined individually. When the leading follicle reached at least 17 mm in size, recombinant human chorionic gonadotropin (Ovitrelle, 250 mcg, Serono) was administered for ovulation induction. Serum basal/salt-stimulated paraoxonase, arylesterase activities, myeloperoxidase activity, and lipid hydroperoxide levels were compared between two samples. Subjects were also divided into two groups according to the presence of pregnancy, and the groups were compared in terms of oxidative stress markers studied. Results: Serum MPO activity and LOOH levels were significantly higher on ovum pick up day (p<0.05, p<0.001, respectively), while basal/salt-stimulated paraoxonase and arylesterase activities were significantly lower (p=0.012, p=0.041, respectively) than those before ovarian stimulation. Serum LOOH levels on OPU day were significantly higher in non-pregnant group than pregnant one (p<0.001). Although basal/salt-stimulated paraoxonase, arylesterase and myeloperoxidase activities were higher in the non-pregnant group compared to the pregnant group, it was not statistically significant (p>0.05). Conclusion: Ovarian stimulation during IVF treatment resulted in increased oxidative stress and decreased PON1 activity. However, changes in the studied parameters were not found to be significantly associated with the pregnancy results. Further studies are required to clarify our results. © 2014 by Türkiye Klinikleri. en_US
dc.identifier.doi 10.5336/medsci.2013-36880
dc.identifier.endpage 209 en_US
dc.identifier.issn 1300-0292
dc.identifier.issue 2 en_US
dc.identifier.scopus 2-s2.0-84901685317
dc.identifier.scopusquality Q4
dc.identifier.startpage 204 en_US
dc.identifier.uri https://doi.org/10.5336/medsci.2013-36880
dc.identifier.uri https://hdl.handle.net/20.500.14720/4876
dc.identifier.volume 34 en_US
dc.identifier.wosquality N/A
dc.language.iso en en_US
dc.publisher Turkiye Klinikleri en_US
dc.relation.ispartof Turkiye Klinikleri Journal of Medical Sciences en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Human en_US
dc.subject In Vitro Fertilization en_US
dc.subject Lipid Peroxides en_US
dc.subject Peroxidase en_US
dc.subject Pon1 Protein en_US
dc.title Oxidative Stress Markers in Ivf Patients and Their Association With Pregnancy Results en_US
dc.type Article en_US

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