Evaluation of Preoperative and Postoperative Serum Total Sialic Acid Levels in Colon Cancer Patients
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2014
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Amaç: Bu çalışmamızın amacı; kolon kanserli hastaların preoperatif ve postoperatif (48.saat) serum total sialik asit düzeylerinin karşılaştırılması ile serum total sialik asitin kolon kanserlerinde bir belirteç olup olamayacağını araştırmaktır. Hastalar ve Yöntemler: Kolon kanseri teşhisi konmuş 100 hastanın ve 70 sağlıklı bireyin preoperatif ve postoperatif (48.saat) serum düzeyleri incelendi. Tüm serumlarda total sialik asit düzeyleri Warren yöntemi ile belirlendi. Sonuçlar: Her iki hasta grubunun total sialik asit düzeyleri kontrol grubuna göre anlamlı derecede yüksek bulundu (p<0.0001). Aynı şekilde, preoperatif ve postoperatif serumlarda total sialik asit düzeyleri arasında ileri derecede anlamlılık saptandı (p<0.001). Tartışma: Serum total sialik asit düzeylerinin değerlendirilmesi kolon kanserlerinde kritik bir rol oynayabilir. Serum total sialik asit düzeyleri kolon kanserinin erken tanısında invazif olmayan bir yöntem olarak hizmet verebilir.
Objectives: The aim of this study was to investigate whether total sialic acid levels can be used as tumor marker for distinguish in colon cancer patients with or preoperative and postoperative serum (48.h). Patients and Methods: Preoperative and postoperative (48.h) serum total sialic acid levels were examined 100 patients with colon cancer and 70 healthy volunteers. All serum total sialic acid levels were determined by the methods of Warren. Results: Significantly increased total sialic acid levels were found in both patient groups (p<0.0001). Also, significantly differences total sialic acid levels were found in the preoperative and postoperative serum (p<0.001). Conclusion: Evaluation of serum total sialic acid levels may play a critical role in the colon cancer. Serum total sialic acid levels may serve as a non-invasive tool for early diagnosis of colon cancer. Key words: Colon Cancer; Preoperative; Postoperative; Total sialic acid.
Objectives: The aim of this study was to investigate whether total sialic acid levels can be used as tumor marker for distinguish in colon cancer patients with or preoperative and postoperative serum (48.h). Patients and Methods: Preoperative and postoperative (48.h) serum total sialic acid levels were examined 100 patients with colon cancer and 70 healthy volunteers. All serum total sialic acid levels were determined by the methods of Warren. Results: Significantly increased total sialic acid levels were found in both patient groups (p<0.0001). Also, significantly differences total sialic acid levels were found in the preoperative and postoperative serum (p<0.001). Conclusion: Evaluation of serum total sialic acid levels may play a critical role in the colon cancer. Serum total sialic acid levels may serve as a non-invasive tool for early diagnosis of colon cancer. Key words: Colon Cancer; Preoperative; Postoperative; Total sialic acid.
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Genel Cerrahi, Biyobelirteçler, Biyobelirteçler-Tümör, Kolon Neoplazmları, Neoplazmlar, Postoperatif Dönem, Preoperatif Dönem, Siyalik Asitler, General Surgery, Biomarkers, Biomarkers-Tumor, Colonic Neoplasms, Neoplasms, Postoperative Period, Preoperative Period, Sialic Acids
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98