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Renal Protective Effect of Grape Seed Extract in Streptozotocin-Induced Diabetic Rats

dc.authorid Sogutlu, Inci/0000-0002-9957-4738
dc.authorwosid Mert, Handan/Aae-7425-2020
dc.authorwosid Mert, Nihat/Hjh-5486-2023
dc.authorwosid Sogutlu, Inci/Lzg-4091-2025
dc.authorwosid Yildirim, Serkan/Aah-6721-2020
dc.contributor.author Sogutlu, Inci
dc.contributor.author Irak, Kivanc
dc.contributor.author Mert, Handan
dc.contributor.author Yildirim, Serkan
dc.contributor.author Mert, Nihat
dc.date.accessioned 2025-05-10T16:58:49Z
dc.date.available 2025-05-10T16:58:49Z
dc.date.issued 2022
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Sogutlu, Inci] Turkey Minist Agr & Forestry, Dept Food Estab & Codex Republ, Ankara, Turkey; [Irak, Kivanc] Siirt Univ, Fac Vet Med, Dept Biochem, Siirt, Turkey; [Mert, Handan; Mert, Nihat] Yuzuncu Yil Univ, Dept Biochem, Fac Vet Med, Van, Turkey; [Yildirim, Serkan] Ataturk Univ, Dept Pathol, Fac Vet Med, Erzurum, Turkey en_US
dc.description Sogutlu, Inci/0000-0002-9957-4738 en_US
dc.description.abstract It was aimed to investigate the effects of grape seed extract (GSE) on structural changes that occur in renal tissues of rats with streptozocin (STZ)-induced diabetes. Rats were randomly divided into four groups (Control, Diabetes Mellitus (DM), GSE, Diabetes Mellitus+ GSE (DM + GSE) groups) each containing 8 rats. When GSE was given, the values of serum creatinine, BUN and uric acid in diabetics were decreased. Kidneys of diabetic group were found to have mild interstitial nephritis, tubular dilatation, hydropic degeneration, clotting necrosis in the tubular epithelium, dilatation in glomerulus and Bowman capsule, and hyperemia in glomerular capillaries. In the DM + GSE group, the glomeruli were normal, but hydropic degeneration was observed in some of the tubule epithelium. Only a few 8-OhDG positive cells were detected in tubule epithelium in the diabetes + grape seed group. The administration of GSE to diabetic patients helped to heal the deteriorated of kidney condition and DNA damage. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.endpage 1599 en_US
dc.identifier.issn 1018-4619
dc.identifier.issn 1610-2304
dc.identifier.issue 2 en_US
dc.identifier.scopusquality N/A
dc.identifier.startpage 1592 en_US
dc.identifier.uri https://hdl.handle.net/20.500.14720/4401
dc.identifier.volume 31 en_US
dc.identifier.wos WOS:000760842200001
dc.identifier.wosquality N/A
dc.language.iso en en_US
dc.publisher Parlar Scientific Publications (p S P) en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Diabetes Mellitus en_US
dc.subject Grape Seed Extract en_US
dc.subject Creatinine en_US
dc.subject Histopathology en_US
dc.subject Immunohistochemical Alterations en_US
dc.title Renal Protective Effect of Grape Seed Extract in Streptozotocin-Induced Diabetic Rats en_US
dc.type Article en_US

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