Do the Levels of Hepcidin and Tenascin-C Change in Patients With Preterm Premature Rupture of Membranes? Can These Markers Help in Diagnosis? Hepcidin and Tenascin-C Levels in Preterm Premature Rupture of Membranes

Abstract

Aim: In this study, it was aimed to investigate the role of tenascin-C and hepcidin levels in the diagnosis of preterm premature rupture of membranes (PPROM). Material and Methods: This study is a prospective cohort study conducted at Van Yuzuncu Yil University (YYU), Dursun Odabasi Medical Center Gynecology and Obstetrics outpatient clinic between 31.03.2021 and 15.03.2022. One hundred patients aged 18 to 45 years diagnosed with PPROM at 24 to 37 weeks of gestation were included in the study as the "case group", and 100 healthy pregnant women were included as a "control group". Demographic data and laboratory parameters of the patients, such as C-reactive protein (CRP), leukocyte, neutrophil, hepcidin, and tenascin-C levels, were recorded. Results: Compared to the control group, CRP, leukocytes, and neutrophil levels were statistically significantly higher in the PPROM group (p<0.05). Hepcidin value was statistically significantly lower in the PPROM group compared to the control group (p = 0.003); tenascin-C levels between the two groups were not statistically different (p = 0.161). Discussion: Hepcidin levels can be used in the diagnosis of PPROM. Multicenter randomized controlled studies with more cases and parameters are needed.