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Is Neutrophil/Lymphocyte and Platelet/Lymphocyte Ratioa Predictive Factor for the Fibrous Stage in Patients Withchronic Hepatitis B

dc.contributor.author Özkahraman, Adnan
dc.contributor.author Kayar, Yusuf
dc.contributor.author Konür, Şevki
dc.contributor.author Akçadağ, Neslihan Sürmeli
dc.contributor.author Dertli, Ramazan
dc.date.accessioned 2025-05-10T17:53:46Z
dc.date.available 2025-05-10T17:53:46Z
dc.date.issued 2021
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp Sağlik Bi̇li̇mleri̇ Üni̇versi̇tesi̇,Sağlik Bi̇li̇mleri̇ Üni̇versi̇tesi̇,Sağlik Bi̇li̇mleri̇ Üni̇versi̇tesi̇,Van Yüzüncü Yil Üni̇versi̇tesi̇,Sağlik Bi̇li̇mleri̇ Üni̇versi̇tesi̇ en_US
dc.description.abstract Aim: Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are an inexpensive inflammatory marker that can beeasily obtained from the blood count and can be used in many chronic diseases. In our study, we aimed to investigate the relationshipbetween fibrosis stage and NLR, PLR in patients with chronic hepatitis B virus (HBV). Materials and Methods: 173 patients with chronic HBV were included in the study. The demographic data and hemogram parameters ofall patients were recorded. Histopathological data of the patients were documented. Accompanying comorbid diseases, medicationsand previous operations were questioned. In chronic HBV patients, fibrosis level was compared with hematological parameters. Results: A total of 173 patients, 100 (57.8%) of whom were male, were included in the study. As a result of the liver biopsy; mildfibrosis (steage/1-2) in 83(47.9%) patients, moderate fibrosis (steage/3-4) in 35(20.3%) patients and advanced fibrosis (stage/5-6)in 55(31.8%) patients. In advanced fibrosis group, liver function tests and bilirubin levels were significantly higher and albumin levelwas significantly lower (p<0.05). It was found that NLR level was significantly higher in moderate fibrosis than mild fibrosis, and PLRlevel was significantly lower in the advanced fibrosis group than in the mild and moderate fibrosis groups (p<0.05). Conclusions: We showed that there is a significant relationship between fibrosis level and NLR, PLR. However, with the availabledata, it does not seem possible to say that noninvasive methods can completely replace invasive procedures such as liver biopsy.Prospectively designed studies with larger patient participation are needed. en_US
dc.identifier.doi 10.5455/annalsmedres.2020.05.440
dc.identifier.endpage 1138 en_US
dc.identifier.issn 2636-7688
dc.identifier.issue 6 en_US
dc.identifier.scopusquality N/A
dc.identifier.startpage 1134 en_US
dc.identifier.trdizinid 463571
dc.identifier.uri https://doi.org/10.5455/annalsmedres.2020.05.440
dc.identifier.uri https://search.trdizin.gov.tr/en/yayin/detay/463571/is-neutrophillymphocyte-and-plateletlymphocyte-ratioa-predictive-factor-for-the-fibrous-stage-in-patients-withchronic-hepatitis-b
dc.identifier.uri https://hdl.handle.net/20.500.14720/18875
dc.identifier.volume 28 en_US
dc.identifier.wosquality N/A
dc.language.iso en en_US
dc.relation.ispartof Annals of Medical Research en_US
dc.relation.publicationcategory Diğer en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Gastroenteroloji Ve Hepatoloji en_US
dc.title Is Neutrophil/Lymphocyte and Platelet/Lymphocyte Ratioa Predictive Factor for the Fibrous Stage in Patients Withchronic Hepatitis B en_US
dc.type Other en_US

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