Caspase-3 Activation in Cytotoxicity of Isolated Rainbow Trout (Oncorhyncus Mykiss) Hepatocytes Induced by Bisphenol a
| dc.authorwosid | Kaptaner, Burak/Aag-6698-2019 | |
| dc.contributor.author | Kaptaner, Burak | |
| dc.contributor.author | Kankaya, Ertugrul | |
| dc.date.accessioned | 2025-05-10T16:59:39Z | |
| dc.date.available | 2025-05-10T16:59:39Z | |
| dc.date.issued | 2016 | |
| dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| dc.department-temp | [Kaptaner, Burak] Yuzuncu Yil Univ, Fac Sci, Dept Biol, TR-65080 Tusba, Van, Turkey; [Kankaya, Ertugrul] Yuzuncu Yil Univ, Fac Fisheries, TR-65080 Tusba, Van, Turkey | en_US |
| dc.description.abstract | The present study was carried out to examine caspase-3 activity in cytotoxicity of isolated rainbow trout (Oncorhyncus mykiss) hepatocytes induced by bisphenol A. For this purpose, cultured hepatocytes were exposed to various concentrations of BPA (10, 50, 100, 250, 500, and 1000 M) for 24 and 48 h. Cell viability was detected by measuring lactate dehydrogenase release into the medium. BPA demonstrated a cytotoxic effect on hepatocytes in a dose- and time-dependent manner, and was found to be severely toxic for hepatocytes with concentrations of 250 mu M BPA and higher at both 24 and 48 h. Caspase-3 activity was significantly induced by BPA with 100 and 2501 mu M concentrations at 24 h, and 50 and 100 mu M concentrations at 48 h. The results suggest that cytotoxicity of rainbow trout hepatocytes induced by BPA is mediated by caspase-3 activation. | en_US |
| dc.description.sponsorship | Yuzuncu Yil University, Directorate of Scientific Research Projects [2013-FEN-B045]; Directorate of Scientific Research Projects | en_US |
| dc.description.sponsorship | This work was supported by the Yuzuncu Yil University, Directorate of Scientific Research Projects, under project number: 2013-FEN-B045. The authors wish to thank the Directorate of Scientific Research Projects for providing financial assistance. | en_US |
| dc.description.woscitationindex | Science Citation Index Expanded | |
| dc.identifier.endpage | 1174 | en_US |
| dc.identifier.issn | 1018-4619 | |
| dc.identifier.issn | 1610-2304 | |
| dc.identifier.issue | 4 | en_US |
| dc.identifier.scopusquality | N/A | |
| dc.identifier.startpage | 1167 | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/4714 | |
| dc.identifier.volume | 25 | en_US |
| dc.identifier.wos | WOS:000375826700021 | |
| dc.identifier.wosquality | N/A | |
| dc.language.iso | en | en_US |
| dc.publisher | Parlar Scientific Publications (p S P) | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Oncorhyncus Mykiss | en_US |
| dc.subject | Bisphenol A | en_US |
| dc.subject | Cytotoxicity | en_US |
| dc.subject | Caspase-3 | en_US |
| dc.subject | Isolated Fish Hepatocytes | en_US |
| dc.title | Caspase-3 Activation in Cytotoxicity of Isolated Rainbow Trout (Oncorhyncus Mykiss) Hepatocytes Induced by Bisphenol a | en_US |
| dc.type | Article | en_US |