Carotid Intima Media Thickness in Patients With Nephrotic Syndromethe Relationship Between Mean Platelet Volume
Abstract
Nefrotik Sendrom (NS), son dönem böbrek yetmezliğine yol açabilen önemli bir hastalıktır. NS hastalarda da hiperkoagülopati, proteinüri, düşük serum albümin seviyesi, dislipidemi ile ilişkili olarak kardiyovasküler hastalık sıklığı artmıştır. Ateroskleroz kardi yovasküler, serebral ve periferik arterler hastalığına neden olan patolojik bir süreçtir. Karotis arter intima media kalınlığı (KİMK), aterosklerozun değerlendirilmesinde yaygın olarak kullanılmaktadır. Ortalama trombosit hacmi (MPV), aterotromboz ile ilişkili yeni bir belir teçtir. Bu çalışmamızda, kliniğimizdeki nefrotik sendrom hastalarında ateroskleroz göster gesi olabilecek ortalama trombosit hacmi değerinin karotis arter intima media kalınlığı ile ilişkisinin belirlenmesi amaçlandı. Gereç ve Yöntem: Çalışmamızda Van YYÜ Tıp Fakültesi Hastanesi Nefroloji Kli niği'ne başvuran hastaların 01.01.2021-01.12.2022 tarihleri arasındaki verileri retrospektif olarak incelendi. Nefrotik sendrom tanısı olan (n: 30) olmak üzere toplam 30 hasta üzerinde çalışma yapıldı. Hastaların demografik özellikleri, kan basıncı, serebrovasküler hastalık, ko roner arter hastalık, periferik arter hastalık, kreatinin,,immunsüpresif tedavi kullanımı, fibrat kullanımı hemoglobin, hematokrit, trombosit, ortalama trombosit hacmi değerleri dosyala rından retrospektif olarak elde edildi. Çalışma retrospektif olarak planlandığı için örneklem büyüklüğü hesaplanmamıştır. Bütün verilere ulaşılmaya çalışıldı. Elde edilen tüm bilgiler bilgisayar ortamına taşındı. Verilerin analizinde tanımlayıcı istatistikler kullanıldı. Tanım layıcı istatistiklere bakıldığında; ortalama, standart sapma, minimum, maksimum, sayı (n) ve yüzde (%) olarak ifade edildi. Bütün analizlerde SPSS (IBM SPSS for Windows, ver.25) istatistik paket programı kullanılmış ve anlamlılık düzeyi için p <0.05 değeri anlamlı kabul edildi. Bulgular: Retrospektif olarak yaptığımız çalışmamızda toplam 30 hastanın 14'ü (%46) erkek, 16'sı (%54) kadındı. Bu 30 hastanın 7'sinde (%23) plak olup,23'ünde (%77') plak tespit edilmedi. Yaş değişkeninde plak varlığı olan grup ile olmayan grup arasında an lamlı fark saptandı (p<0,05). Plak varlığında yaş ortalaması 52.8 iken olmayan grupta 38.5 tur. Plak bulunan grupta ortalama 9.8 iken olmayan grupta mpv 10,08 olarak ölçüldü. MPV değerlerinde gruplar arasında anlamlı fark bulunmadı. Plak bulunan grupta sol KİMK 0.9 fl iken plak olmayan grupta 0.88 fl ölçüldü.Sağ KİMK plak olan grupta 1.03 fl ölçülürken plak olmayan grupta 0.86 fl ölçüldü.Sağ ve sol KİMK değerlerinde gruplar arasında anlamlı fark bulunmadı fakat sağ Kimk sola göre daha kalın olarak tespit edildi. Plak olan grupta ortalama tansiyon 121/74 mmHg, olmayan grupta ise 123/76 mmHg olarak ölçüldü. Kreatinin vi ortalaması plak varlığında 1.1 mg/dliken plak olmayan grupta 0.96 mg/dl 'dir. Diğer değiş kenlerde gruplar arasında anlamlı fark saptanmadı. Sonuç: Aterokleroz belirteci olan karotis arter intima media kalınlığı ile ortalama trombosit hacmi arasında ilişki tespit edilmemiştir
Nephrotic Sydrome (NS) is an important disease that can cause end stage renal failure. The frequency of cardiovascular diseases in NS patients is increased due to hypercoagulopathy, proteinuria, low serum albumin level and dyslipidemia. Atheroscle rosis is an pathological period that causes cardiovascular, cerebral and peripheral arterial diseases. Carotid artery intima-media thickness (CIMT) is being used widespreadly to esti mate atherosclerosis. Mean platelet volume (MPV) is a new marker related to atherothrom bosis. In this study, showing the relationship between the mean platelet volume, which may be a sign for atherosclerosis, and carotid artery intima-media thickness in nephrotic synd rome patients in our clinic was aimed. Method: The data of the patients applied to Van YYU Medical School Dursun Oda baş Medical Center Nephrology Clinic between 01.01.2021-01.12.2022 were analyzed ret rospectively. The study involved total of 30 individuals (n:30) with nephrotic syndrome di agnosis. Demographic characteristics, blood pressure level, cerebrovascular disease, coro nary arterial disease, peripheral arterial disease, creatinine, use of immunosuppressive the rapy, use of fibrates, hemoglobin, hematocrit, platelets, mean platelet volume values were obtained retrospectively from patient files. The sample size was not determined since the study was planned retroactively. It was aimed to aggregate all data and every data that agg regated was moved to computing environment. Descriptive statistics were used to analyze data collected. Mean values, standard deviation, minimum, maximum were stated with num bers (n) and percentages (%) in descriptive statistics. SPSS (IBM SPSS for Windows, ver.25) statistical package program was used in all analyzes and p < 0.05 value was taken significant for significance level. Results: Total of 30 patients including 14 males (46%) and 16 females (54%) parti cipated in this retrospectively study. Plaque was determined in 7 (23%) of 30 patients , while the remaining 23 (77%) had no plaque. The difference between the group with and without plaque was seen in the age variant. (p<0.05). The group with plaque had an average age value of 52.8 meanwhile the group without plaque had an average age value of 38.5. Mean platelet volume was determined 9.8 in the group with plaque meanwhile it was determined 10.08 in the group without plaque. There was no significant difference of mean platelet vo lume values between the two groups. Left carotid artery intima-media thickness was viii measured as 0.9 fl in the group with plaque meanwhile it was measured in the group without plaque as 0.88 fl and there was no significant difference was seen in right carotid artery intima-media thickness between the groups even though the right CIMT was determined thicker than the left CIMT. The group with plaques had an mean blood pressure value of 121/74 mmHg meanwhile the group without plaques had a value of 123/76 mmHg. Mean value of creatinine was 1.1 mg/dl in the group with plaque meanwhile it was in 0.96 mg/dl in the group without plaque. There was no significant difference determined in other vari ants. Conclusion: In conclusion, no relationship between the atherosclerosis marker caro tid artery intima-media thickness and the mean platelet volume.
Nephrotic Sydrome (NS) is an important disease that can cause end stage renal failure. The frequency of cardiovascular diseases in NS patients is increased due to hypercoagulopathy, proteinuria, low serum albumin level and dyslipidemia. Atheroscle rosis is an pathological period that causes cardiovascular, cerebral and peripheral arterial diseases. Carotid artery intima-media thickness (CIMT) is being used widespreadly to esti mate atherosclerosis. Mean platelet volume (MPV) is a new marker related to atherothrom bosis. In this study, showing the relationship between the mean platelet volume, which may be a sign for atherosclerosis, and carotid artery intima-media thickness in nephrotic synd rome patients in our clinic was aimed. Method: The data of the patients applied to Van YYU Medical School Dursun Oda baş Medical Center Nephrology Clinic between 01.01.2021-01.12.2022 were analyzed ret rospectively. The study involved total of 30 individuals (n:30) with nephrotic syndrome di agnosis. Demographic characteristics, blood pressure level, cerebrovascular disease, coro nary arterial disease, peripheral arterial disease, creatinine, use of immunosuppressive the rapy, use of fibrates, hemoglobin, hematocrit, platelets, mean platelet volume values were obtained retrospectively from patient files. The sample size was not determined since the study was planned retroactively. It was aimed to aggregate all data and every data that agg regated was moved to computing environment. Descriptive statistics were used to analyze data collected. Mean values, standard deviation, minimum, maximum were stated with num bers (n) and percentages (%) in descriptive statistics. SPSS (IBM SPSS for Windows, ver.25) statistical package program was used in all analyzes and p < 0.05 value was taken significant for significance level. Results: Total of 30 patients including 14 males (46%) and 16 females (54%) parti cipated in this retrospectively study. Plaque was determined in 7 (23%) of 30 patients , while the remaining 23 (77%) had no plaque. The difference between the group with and without plaque was seen in the age variant. (p<0.05). The group with plaque had an average age value of 52.8 meanwhile the group without plaque had an average age value of 38.5. Mean platelet volume was determined 9.8 in the group with plaque meanwhile it was determined 10.08 in the group without plaque. There was no significant difference of mean platelet vo lume values between the two groups. Left carotid artery intima-media thickness was viii measured as 0.9 fl in the group with plaque meanwhile it was measured in the group without plaque as 0.88 fl and there was no significant difference was seen in right carotid artery intima-media thickness between the groups even though the right CIMT was determined thicker than the left CIMT. The group with plaques had an mean blood pressure value of 121/74 mmHg meanwhile the group without plaques had a value of 123/76 mmHg. Mean value of creatinine was 1.1 mg/dl in the group with plaque meanwhile it was in 0.96 mg/dl in the group without plaque. There was no significant difference determined in other vari ants. Conclusion: In conclusion, no relationship between the atherosclerosis marker caro tid artery intima-media thickness and the mean platelet volume.
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İç Hastalıkları, Internal diseases
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