Angiocentric Glioma Manifesting as Psychotic Symptoms in an Adolescent: a Case Report

Abstract

Cerebral cortical malformations can be associated with psychotic symptoms, and frontal, temporal, and limbic lesions may lead to psychosis-like symptoms. Therefore, these regions have a role in the pathogenesis of psychosis and related symptoms. Here, we report a 13-year-old adolescent who presented with auditory and visual hallucinations, persecutory delusions, and aggression. The patient's symptoms remitted after the resection of the left temporal lobe, fusiform gyrus, uncus, amygdala, and hippocampus. Histological examination revealed angiocentric glioama. We discuss the relationship between psychotic symptoms and the neural network that links the frontal lobe with limbic structures and how it can be disturbed by developmental abnormalities. © 2013 Elsevier GmbH.