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Toxic Effects of Sodium Lauryl Sulfate on Antioxidant Defense System and Dna Damage in Fish Primary Hepatocyte Cultures

dc.authorscopusid 56189749500
dc.authorscopusid 17344352500
dc.contributor.author Yeltekin, A.Ç.
dc.contributor.author Oǧuz, A.R.
dc.date.accessioned 2025-05-10T16:54:00Z
dc.date.available 2025-05-10T16:54:00Z
dc.date.issued 2022
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp Yeltekin A.Ç., Department of Chemistry, Faculty of Science, University of Van Yuzuncu Yil, 65080, Turkey; Oǧuz A.R., Department of Biology, Faculty of Science, University of Van Yuzuncu Yil, 65080, Turkey en_US
dc.description.abstract Synthetic detergents which have a major role in environmental pollution accumulate over time and reach levels that harm nature. The surfactants which are abundantly used as cleaning components are discharged into the Van Lake with the sewage water. These chemicals accumulating in the lake may reach a level that could affect the only fish species of the lake, the Van fish. This study aimed to determine the antioxidant levels of Van fish hepatocyte cell culture medium treated with sodium lauryl sulphate (SLS) and to assess the DNA damage. The effect of SLS was assessed by its dose (1×10-5, 1×10-6, 1×10-7 M) and treatment time (24 h, 48 h). Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), and DNA damage (8-OHdG) were determined in the SLS hepatocyte culture. SOD and GSH-Px were higher on 24 h and 48 h compared to the control group. A significant increase was observed in CAT level in the first 24 h, especially in 1×10-6 and 1×10-5 M concentration. At 48 h, it was observed that the CAT level decreased significantly as the concentration increased. It was determined that MDA and 8-OHdG levels increased depending on concentration and time. In conclusion, different concentrations of SLS affected antioxidant levels in the primary hepatocyte culture of Van Fish and were found to cause an increase in the levels of MDA and 8-OHdG. © 2022 Asll Ç. Yeltekin et al., published by Sciendo. en_US
dc.identifier.doi 10.2478/macvetrev-2022-0027
dc.identifier.endpage 175 en_US
dc.identifier.issn 1409-7621
dc.identifier.issue 2 en_US
dc.identifier.scopus 2-s2.0-85143418087
dc.identifier.scopusquality Q3
dc.identifier.startpage 169 en_US
dc.identifier.uri https://doi.org/10.2478/macvetrev-2022-0027
dc.identifier.uri https://hdl.handle.net/20.500.14720/2983
dc.identifier.volume 45 en_US
dc.identifier.wosquality N/A
dc.language.iso en en_US
dc.publisher Sciendo en_US
dc.relation.ispartof Macedonian Veterinary Review en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Antioxidants en_US
dc.subject Dna Damage en_US
dc.subject Fish en_US
dc.subject Mda en_US
dc.subject Sls en_US
dc.title Toxic Effects of Sodium Lauryl Sulfate on Antioxidant Defense System and Dna Damage in Fish Primary Hepatocyte Cultures en_US
dc.type Article en_US

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