Serum Antioxidant Enzyme and Oxidative Stress Levels in Patients With Developmental Dysplasia of the Hip: a Preliminary Study

Abstract

This study was conducted based on the hypothesis that serum antioxidant activity and oxidative stress could be associated with developmental dysplasia of the hip. The purpose of this study was to investigate prospectively the relationship between serum antioxidant levels and developmental dysplasia of the hip. This study included 27 patients with developmental dysplasia of the hip (18 females, 9 males; mean age 24.3 +/- 6.3 months, range 18-36 months) and 26 healthy controls (15 females, 11 males; mean age 23.8 +/- 5.4 months, range 18-36 months) who were free of symptoms. Venous blood samples were taken all of the participants and serum superoxide dismutase, malondialdehyde, glutathione, and catalase levels were evaluated. The serum malondialdehyde level was found to be statistically significantly higher in patients with developmental dysplasia of the hip than controls. Serum superoxide dismutase, glutathione and catalase levels were found to be statistically significantly lower in patients with developmental dysplasia of the hip than controls. Our results may show that serum antioxidant activity and oxidative stress parameters may be adjunctive tools for the diagnosis in patients with developmental dysplasia of the hip. This is a preliminary study, and further prospective randomized clinical studies with larger sample sizes are needed to elucidate whether these alterations are consistent and clinically relevant.