Oxidative Dna Damage, Lipid Peroxidation and Antioxidant Enzymes in Patients With Coronary Artery Ectasia
Abstract
Bu çalışmayı koroner arter ektazi(CAE) oksidatif DNA hasarı (8-OH-dGua), malondialdehit (MDA) ve antioksidant enzimler arasındaki ilişkiyi ortaya çıkarmak amacı ile planladık. Serum MDA, plazma 8-OH-dGua, süperoksit dismutaz (SOD) ve glutatyon peroksidaz gibi antioksidant enzim aktiviteleri CAE'li ve sağlıklı bireylerle karşılaştırılarak tayin edildi. Çalışma popülasyonu 51 koroner arter ektazi (CAE) hasta ve 41 sağlıklı bireyden oluşturuldu. Serum SOD aktivitelerinde gruplar arasında istatistiki açıdan farklılık bulunmadı. Serum MDA (p=0.216) aktivitelerinin CAE grubunda arttığı saptandı. Plazma 8-OH-dGua seviyesi CAE grubu kontrol grubundan önemli derecede daha yüksek bulundu. Serum SOD (p=0.638) aktivitelerinin kontrol grubunda arttığı saptandı. Serum Gpx (p<0.001) CAE grubu kontrol grubundan önemli derecede daha düşük bulundu. MDA, oksidatif DNA hasarı ve antioksidant enzim aktiviteleri koroner arter ektazi (CAE) hastalığının patogenezinde önemli rol oynayabilir. Ayrıca, bu çalışma CAE' de oksidatif DNA hasarı ve MDA ilişkisini gösteren ilk çalışmadır.
In this study we aimed to evaluate the relationship between oxıdative DNA damage (8-OH-dGua), malondialdehyde (MDA) and antioxidant enzymes in coronary artery ectasia (CAE). Serum MDA, plasma 8-OH-dGua, activities of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) were measured in CAE patients to compare with healthy subjects. The study population included 51 coronary artery ectasia (CAE) patients and 41 healthy subjects. There were not statistically significant differences in the levels of serum SOD activity. Serum MDA (p=0.216) and serum SOD levels (p=0.638) were increased in the CAE group. Plasma 8-OH-dGua levels (p<0.001) were significantly higher in the CAE group than control group. Serum GPx activity (p<0.001) were significantly lower in the control group than CEA group. MDA, oxıdative DNA damage, and activities of antioxidant enzymes may play a role in the pathogenesis of coronary artery ectasia (CAE). In addition, this study is the first one to show the relationship of oxıdative DNA damage and MDA in CAE.
In this study we aimed to evaluate the relationship between oxıdative DNA damage (8-OH-dGua), malondialdehyde (MDA) and antioxidant enzymes in coronary artery ectasia (CAE). Serum MDA, plasma 8-OH-dGua, activities of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) were measured in CAE patients to compare with healthy subjects. The study population included 51 coronary artery ectasia (CAE) patients and 41 healthy subjects. There were not statistically significant differences in the levels of serum SOD activity. Serum MDA (p=0.216) and serum SOD levels (p=0.638) were increased in the CAE group. Plasma 8-OH-dGua levels (p<0.001) were significantly higher in the CAE group than control group. Serum GPx activity (p<0.001) were significantly lower in the control group than CEA group. MDA, oxıdative DNA damage, and activities of antioxidant enzymes may play a role in the pathogenesis of coronary artery ectasia (CAE). In addition, this study is the first one to show the relationship of oxıdative DNA damage and MDA in CAE.
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Keywords
Biyokimya, Dna Hasarı, Kardiyovasküler Sistem, Koroner Damarlar, Lipid Peroksit, Biochemistry, Dna Damage, Cardiovascular System, Coronary Vessels, Lipid Peroxide
Turkish CoHE Thesis Center URL
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