Investigation of Serum Amyloid A, Haptoglobin and Fibrinogen Levels in Sheep Infected With Fasciola Hepatica

Abstract

The present study aimed to determine the changes in serum haptoglobin, serum amyloid A and fibrinogen levels in pathological disorders of sheep liver with Fasciola hepatica. Sixty sheep (50 with fascioliasis and 10 healthy) were used in the present study. Statistical analysis results demonstrated that SAA, Hp and fibrinogen concentration levels of the sheep infected with Fasciola hepatica were higher when compared to SAA, Hp and fibrinogen concentration levels in healthy sheep (P <0.05). While ALT, AST and GGT values of sheep infected with Fasciola hepatica were found to be higher than those of the healthy sheep, serum TP, ALB and glucose levels were lower. In statistical analysis, it was found that WBC, Neu and Eo values of sheep infected with Fasciola hepatica were higher when compared to WBC, Neu and Eo values in the control group. In conclusion, serum haptoglobin, serum amyloid A, and fibrinogen levels were significantly higher in sheep infected with Fasciola hepatica when compared to the healthy group. Due to the fact that increases in serum haptoglobin, serum amyloid A and fibrinogen levels in sheep with fasciolosis were similar to those observed in liver disorders, it was suggested that these parameters could be useful in determination of the liver damage levels and prognosis and in studies on liver disorders.