The Importance of Creatine Phosphokinase (Cpk) and Lactate Dehydrogenase (Ldh) in the Early Diagnosis of Testicular Torsion

Abstract

We aimed to reveal the value of serum CPK and LDH levels in he early diagnosis of testicular tortion in this study. 15 adult male New Zealand rabbits were divided into 2 groups. The first group included 7 animals that experienced sham operation and approved as control animals. In the second group (n=8), the left testes were just twisted 720 degrees and fixed by a transmesorchial suture like Ryan described. Blood samples were obtained by venapuncture at O, 4, 8, 24 hours and 4 weeks in each group; creatine phosphokinase (CPK) and lactate de-hydrogenase (LDH) were determined. There was slight increase in LDH level in the second group but not statistically significant (p>0.05). On the other hand, significant increase in CPK levels (p>0.05) in 4 hours after torsion were seen (mean 6297±2012 compared to the level in the first sample, 2768±982). CPK tended to decrease after 8 hours (mean 4459±1867). No significant alterations were noted in both enzyme levels in those having sham operation (p>0.05). Thus, determination of serum CPK may be an auxiliary alternative in the diagnosis of testicular torsion.